GB2321246A - Screening for disorders of serotonergic dysfunction - Google Patents

Screening for disorders of serotonergic dysfunction

Info

Publication number
GB2321246A
GB2321246A GB9805376A GB9805376A GB2321246A GB 2321246 A GB2321246 A GB 2321246A GB 9805376 A GB9805376 A GB 9805376A GB 9805376 A GB9805376 A GB 9805376A GB 2321246 A GB2321246 A GB 2321246A
Authority
GB
United Kingdom
Prior art keywords
screening
disorders
serotonergic dysfunction
alleles
serotonergic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9805376A
Other versions
GB9805376D0 (en
GB2321246B (en
Inventor
Sharon Battersby
George Fink
Guy Manning Goodwin
Anthony John Harmar
Alan David Ogilvie
Christopher Albert Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9519458.5A external-priority patent/GB9519458D0/en
Priority claimed from GBGB9520113.3A external-priority patent/GB9520113D0/en
Priority claimed from GBGB9611473.1A external-priority patent/GB9611473D0/en
Application filed by Medical Research Council filed Critical Medical Research Council
Priority to GB9805376A priority Critical patent/GB2321246B/en
Priority claimed from PCT/GB1996/002360 external-priority patent/WO1997011175A1/en
Publication of GB9805376D0 publication Critical patent/GB9805376D0/en
Publication of GB2321246A publication Critical patent/GB2321246A/en
Application granted granted Critical
Publication of GB2321246B publication Critical patent/GB2321246B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Three novel alleles of the serotonin transporter gene are disclosed and shown to be effective markers for screening and diagnosis of migraine and psychiatric disorders. The sequences of the alleles are given. Methods for in vitro screening of individuals using DNA taken from blood samples are taught.
GB9805376A 1995-09-23 1996-09-23 Screening for disorders of serotonergic dysfunction Expired - Fee Related GB2321246B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9805376A GB2321246B (en) 1995-09-23 1996-09-23 Screening for disorders of serotonergic dysfunction

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9519458.5A GB9519458D0 (en) 1995-09-23 1995-09-23 Method
GBGB9520113.3A GB9520113D0 (en) 1995-10-03 1995-10-03 Method
GBGB9611473.1A GB9611473D0 (en) 1996-06-01 1996-06-01 Method
GB9805376A GB2321246B (en) 1995-09-23 1996-09-23 Screening for disorders of serotonergic dysfunction
PCT/GB1996/002360 WO1997011175A1 (en) 1995-09-23 1996-09-23 Screening for disorders of serotonergic dysfunction

Publications (3)

Publication Number Publication Date
GB9805376D0 GB9805376D0 (en) 1998-05-06
GB2321246A true GB2321246A (en) 1998-07-22
GB2321246B GB2321246B (en) 1999-11-24

Family

ID=27451344

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9805376A Expired - Fee Related GB2321246B (en) 1995-09-23 1996-09-23 Screening for disorders of serotonergic dysfunction

Country Status (1)

Country Link
GB (1) GB2321246B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008261A1 (en) * 1991-10-22 1993-04-29 Emory University SEROTONIN TRANSPORTER cDNA

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008261A1 (en) * 1991-10-22 1993-04-29 Emory University SEROTONIN TRANSPORTER cDNA

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Neural Transm. Vol. 95 1994. Lesch K P et. al. pages 157-162 *
Lancet Vol. 347 1996. Ogilvie A D et.al. pages 731-733 *
Neuroreport Vol. 7 (10) 1996. Collier D A et. al. pages 1675-1679 *

Also Published As

Publication number Publication date
GB9805376D0 (en) 1998-05-06
GB2321246B (en) 1999-11-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20020923