GB2321246A - Screening for disorders of serotonergic dysfunction - Google Patents
Screening for disorders of serotonergic dysfunctionInfo
- Publication number
- GB2321246A GB2321246A GB9805376A GB9805376A GB2321246A GB 2321246 A GB2321246 A GB 2321246A GB 9805376 A GB9805376 A GB 9805376A GB 9805376 A GB9805376 A GB 9805376A GB 2321246 A GB2321246 A GB 2321246A
- Authority
- GB
- United Kingdom
- Prior art keywords
- screening
- disorders
- serotonergic dysfunction
- alleles
- serotonergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012216 screening Methods 0.000 title abstract 3
- 230000004064 dysfunction Effects 0.000 title 1
- 230000000862 serotonergic effect Effects 0.000 title 1
- 108700028369 Alleles Proteins 0.000 abstract 2
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Three novel alleles of the serotonin transporter gene are disclosed and shown to be effective markers for screening and diagnosis of migraine and psychiatric disorders. The sequences of the alleles are given. Methods for in vitro screening of individuals using DNA taken from blood samples are taught.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9805376A GB2321246B (en) | 1995-09-23 | 1996-09-23 | Screening for disorders of serotonergic dysfunction |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9519458.5A GB9519458D0 (en) | 1995-09-23 | 1995-09-23 | Method |
GBGB9520113.3A GB9520113D0 (en) | 1995-10-03 | 1995-10-03 | Method |
GBGB9611473.1A GB9611473D0 (en) | 1996-06-01 | 1996-06-01 | Method |
GB9805376A GB2321246B (en) | 1995-09-23 | 1996-09-23 | Screening for disorders of serotonergic dysfunction |
PCT/GB1996/002360 WO1997011175A1 (en) | 1995-09-23 | 1996-09-23 | Screening for disorders of serotonergic dysfunction |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9805376D0 GB9805376D0 (en) | 1998-05-06 |
GB2321246A true GB2321246A (en) | 1998-07-22 |
GB2321246B GB2321246B (en) | 1999-11-24 |
Family
ID=27451344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9805376A Expired - Fee Related GB2321246B (en) | 1995-09-23 | 1996-09-23 | Screening for disorders of serotonergic dysfunction |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2321246B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993008261A1 (en) * | 1991-10-22 | 1993-04-29 | Emory University | SEROTONIN TRANSPORTER cDNA |
-
1996
- 1996-09-23 GB GB9805376A patent/GB2321246B/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993008261A1 (en) * | 1991-10-22 | 1993-04-29 | Emory University | SEROTONIN TRANSPORTER cDNA |
Non-Patent Citations (3)
Title |
---|
J. Neural Transm. Vol. 95 1994. Lesch K P et. al. pages 157-162 * |
Lancet Vol. 347 1996. Ogilvie A D et.al. pages 731-733 * |
Neuroreport Vol. 7 (10) 1996. Collier D A et. al. pages 1675-1679 * |
Also Published As
Publication number | Publication date |
---|---|
GB9805376D0 (en) | 1998-05-06 |
GB2321246B (en) | 1999-11-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20020923 |