GB2318353A - Metalloproteinase inhibitors - Google Patents

Metalloproteinase inhibitors

Info

Publication number
GB2318353A
GB2318353A GB9800151A GB9800151A GB2318353A GB 2318353 A GB2318353 A GB 2318353A GB 9800151 A GB9800151 A GB 9800151A GB 9800151 A GB9800151 A GB 9800151A GB 2318353 A GB2318353 A GB 2318353A
Authority
GB
United Kingdom
Prior art keywords
metalloproteinase inhibitors
formula
iii
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9800151A
Other versions
GB9800151D0 (en
GB2318353B (en
Inventor
Christopher David Floyd
Raymond Paul Beckett
Mark Whittaker
Andrew Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9514867.2A external-priority patent/GB9514867D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Priority to GB9800151A priority Critical patent/GB2318353B/en
Publication of GB9800151D0 publication Critical patent/GB9800151D0/en
Publication of GB2318353A publication Critical patent/GB2318353A/en
Application granted granted Critical
Publication of GB2318353B publication Critical patent/GB2318353B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of general formula (I), wherein X is a group of formula (II) or (III), R 2 , R 1 , R 21 , R 3 , R 4 , and R 5 being as defined in the specification are matrix metalloproteinase inhibitors.
GB9800151A 1995-07-20 1996-07-22 Metalloproteinase inhibitors Expired - Fee Related GB2318353B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9800151A GB2318353B (en) 1995-07-20 1996-07-22 Metalloproteinase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9514867.2A GB9514867D0 (en) 1995-07-20 1995-07-20 Metalloproteinase inhibitors
PCT/GB1996/001737 WO1997003783A1 (en) 1995-07-20 1996-07-22 Metalloproteinase inhibitors
GB9800151A GB2318353B (en) 1995-07-20 1996-07-22 Metalloproteinase inhibitors

Publications (3)

Publication Number Publication Date
GB9800151D0 GB9800151D0 (en) 1998-03-04
GB2318353A true GB2318353A (en) 1998-04-22
GB2318353B GB2318353B (en) 1999-10-06

Family

ID=26307431

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9800151A Expired - Fee Related GB2318353B (en) 1995-07-20 1996-07-22 Metalloproteinase inhibitors

Country Status (1)

Country Link
GB (1) GB2318353B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236872B1 (en) * 1986-03-11 1992-11-25 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
WO1994002446A1 (en) * 1992-07-23 1994-02-03 British Biotech Pharmaceuticals Limited Natural amino acid derivatives as metalloproteinase inhibitors
WO1994010990A1 (en) * 1992-11-13 1994-05-26 British Biotech Pharmaceuticals Limited Inhibition of tnf production
WO1995009841A1 (en) * 1993-10-07 1995-04-13 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as inhibitors of cytokine production
WO1995013289A1 (en) * 1993-11-10 1995-05-18 Chiroscience Limited Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases
WO1996016027A1 (en) * 1994-11-22 1996-05-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236872B1 (en) * 1986-03-11 1992-11-25 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
WO1994002446A1 (en) * 1992-07-23 1994-02-03 British Biotech Pharmaceuticals Limited Natural amino acid derivatives as metalloproteinase inhibitors
WO1994010990A1 (en) * 1992-11-13 1994-05-26 British Biotech Pharmaceuticals Limited Inhibition of tnf production
WO1995009841A1 (en) * 1993-10-07 1995-04-13 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as inhibitors of cytokine production
WO1995013289A1 (en) * 1993-11-10 1995-05-18 Chiroscience Limited Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases
WO1996016027A1 (en) * 1994-11-22 1996-05-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Inorg. Chem. Vol. 31(13) 1992. Hansen et. al. pages 2801-2808 *
J. Nucl. Med. Vol. 35 (7) 1994. Hansen et. al. page 1198-1205 *

Also Published As

Publication number Publication date
GB9800151D0 (en) 1998-03-04
GB2318353B (en) 1999-10-06

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20030722