GB2318056A - Composition for enhanced uptake of polar drugs from the colon - Google Patents

Composition for enhanced uptake of polar drugs from the colon

Info

Publication number
GB2318056A
GB2318056A GB9801507A GB9801507A GB2318056A GB 2318056 A GB2318056 A GB 2318056A GB 9801507 A GB9801507 A GB 9801507A GB 9801507 A GB9801507 A GB 9801507A GB 2318056 A GB2318056 A GB 2318056A
Authority
GB
United Kingdom
Prior art keywords
colon
composition
salt
mixture
dispersing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9801507A
Other versions
GB2318056B (en
GB9801507D0 (en
Inventor
Peter James Watts
Lisbeth Illum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Danbiosyst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9516268.1A external-priority patent/GB9516268D0/en
Application filed by Danbiosyst UK Ltd filed Critical Danbiosyst UK Ltd
Priority to GB9801507A priority Critical patent/GB2318056B/en
Publication of GB9801507D0 publication Critical patent/GB9801507D0/en
Publication of GB2318056A publication Critical patent/GB2318056A/en
Application granted granted Critical
Publication of GB2318056B publication Critical patent/GB2318056B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a drug delivery composition for colonic delivery comprising a polar drug, an absorption promoter which (a) comprises a mixture of a fatty acid having 6 to 16 carbon atoms or a salt thereof and a dispersing agent, or (b) comprises a mixture of mono/diglycerides of medium chain fatty acids and a dispersing agent, and means adapted to release the polar drug and absorption promoter in the colon following oral administration. A preferred fatty acid is capric acid or a salt thereof. Colon specific delivery can be achieved by providing the composition in a capsule, tablet or pellet which is coated with a material which dissolves in the small intestine or is degraded by the conditions in the colon.
GB9801507A 1995-08-08 1996-08-08 Composition for enhanced uptake of polar drugs from the colon Expired - Fee Related GB2318056B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9801507A GB2318056B (en) 1995-08-08 1996-08-08 Composition for enhanced uptake of polar drugs from the colon

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9516268.1A GB9516268D0 (en) 1995-08-08 1995-08-08 Compositiion for enhanced uptake of polar drugs from the colon
PCT/GB1996/001933 WO1997005903A2 (en) 1995-08-08 1996-08-08 Composition for enhanced uptake of polar drugs from the colon
GB9801507A GB2318056B (en) 1995-08-08 1996-08-08 Composition for enhanced uptake of polar drugs from the colon

Publications (3)

Publication Number Publication Date
GB9801507D0 GB9801507D0 (en) 1998-03-25
GB2318056A true GB2318056A (en) 1998-04-15
GB2318056B GB2318056B (en) 1999-05-26

Family

ID=26307543

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9801507A Expired - Fee Related GB2318056B (en) 1995-08-08 1996-08-08 Composition for enhanced uptake of polar drugs from the colon

Country Status (1)

Country Link
GB (1) GB2318056B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1954066A1 (en) * 1969-10-23 1971-04-29 Siemens Ag Electrical contact arrangement for interrupting a circuit with arcing
EP0332222A2 (en) * 1988-03-11 1989-09-13 Teikoku Seiyaku Co., Ltd. Intravaginal delivery of biologically active polypeptides
EP0418674A1 (en) * 1989-09-11 1991-03-27 F. Hoffmann-La Roche Ag Pharmaceutical preparations for enhanced absorption of antibacterial compounds
WO1991011175A1 (en) * 1990-01-29 1991-08-08 Danbiosyst Uk Ltd Process for the preparation of azo- and/or disulfide-containing polymers
WO1994008622A1 (en) * 1992-10-20 1994-04-28 Smithkline Beecham Farmaceutici S.P.A. Pharmaceutical compositions containing a calcitonin
WO1995014037A1 (en) * 1993-11-17 1995-05-26 Ibah, Inc. Transparent liquid for encapsulated drug delivery

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1954066A1 (en) * 1969-10-23 1971-04-29 Siemens Ag Electrical contact arrangement for interrupting a circuit with arcing
EP0332222A2 (en) * 1988-03-11 1989-09-13 Teikoku Seiyaku Co., Ltd. Intravaginal delivery of biologically active polypeptides
EP0418674A1 (en) * 1989-09-11 1991-03-27 F. Hoffmann-La Roche Ag Pharmaceutical preparations for enhanced absorption of antibacterial compounds
WO1991011175A1 (en) * 1990-01-29 1991-08-08 Danbiosyst Uk Ltd Process for the preparation of azo- and/or disulfide-containing polymers
WO1994008622A1 (en) * 1992-10-20 1994-04-28 Smithkline Beecham Farmaceutici S.P.A. Pharmaceutical compositions containing a calcitonin
WO1995014037A1 (en) * 1993-11-17 1995-05-26 Ibah, Inc. Transparent liquid for encapsulated drug delivery

Also Published As

Publication number Publication date
GB2318056B (en) 1999-05-26
GB9801507D0 (en) 1998-03-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20050808