GB2318056A - Composition for enhanced uptake of polar drugs from the colon - Google Patents
Composition for enhanced uptake of polar drugs from the colonInfo
- Publication number
- GB2318056A GB2318056A GB9801507A GB9801507A GB2318056A GB 2318056 A GB2318056 A GB 2318056A GB 9801507 A GB9801507 A GB 9801507A GB 9801507 A GB9801507 A GB 9801507A GB 2318056 A GB2318056 A GB 2318056A
- Authority
- GB
- United Kingdom
- Prior art keywords
- colon
- composition
- salt
- mixture
- dispersing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a drug delivery composition for colonic delivery comprising a polar drug, an absorption promoter which (a) comprises a mixture of a fatty acid having 6 to 16 carbon atoms or a salt thereof and a dispersing agent, or (b) comprises a mixture of mono/diglycerides of medium chain fatty acids and a dispersing agent, and means adapted to release the polar drug and absorption promoter in the colon following oral administration. A preferred fatty acid is capric acid or a salt thereof. Colon specific delivery can be achieved by providing the composition in a capsule, tablet or pellet which is coated with a material which dissolves in the small intestine or is degraded by the conditions in the colon.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9801507A GB2318056B (en) | 1995-08-08 | 1996-08-08 | Composition for enhanced uptake of polar drugs from the colon |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9516268.1A GB9516268D0 (en) | 1995-08-08 | 1995-08-08 | Compositiion for enhanced uptake of polar drugs from the colon |
PCT/GB1996/001933 WO1997005903A2 (en) | 1995-08-08 | 1996-08-08 | Composition for enhanced uptake of polar drugs from the colon |
GB9801507A GB2318056B (en) | 1995-08-08 | 1996-08-08 | Composition for enhanced uptake of polar drugs from the colon |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9801507D0 GB9801507D0 (en) | 1998-03-25 |
GB2318056A true GB2318056A (en) | 1998-04-15 |
GB2318056B GB2318056B (en) | 1999-05-26 |
Family
ID=26307543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9801507A Expired - Fee Related GB2318056B (en) | 1995-08-08 | 1996-08-08 | Composition for enhanced uptake of polar drugs from the colon |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2318056B (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1954066A1 (en) * | 1969-10-23 | 1971-04-29 | Siemens Ag | Electrical contact arrangement for interrupting a circuit with arcing |
EP0332222A2 (en) * | 1988-03-11 | 1989-09-13 | Teikoku Seiyaku Co., Ltd. | Intravaginal delivery of biologically active polypeptides |
EP0418674A1 (en) * | 1989-09-11 | 1991-03-27 | F. Hoffmann-La Roche Ag | Pharmaceutical preparations for enhanced absorption of antibacterial compounds |
WO1991011175A1 (en) * | 1990-01-29 | 1991-08-08 | Danbiosyst Uk Ltd | Process for the preparation of azo- and/or disulfide-containing polymers |
WO1994008622A1 (en) * | 1992-10-20 | 1994-04-28 | Smithkline Beecham Farmaceutici S.P.A. | Pharmaceutical compositions containing a calcitonin |
WO1995014037A1 (en) * | 1993-11-17 | 1995-05-26 | Ibah, Inc. | Transparent liquid for encapsulated drug delivery |
-
1996
- 1996-08-08 GB GB9801507A patent/GB2318056B/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1954066A1 (en) * | 1969-10-23 | 1971-04-29 | Siemens Ag | Electrical contact arrangement for interrupting a circuit with arcing |
EP0332222A2 (en) * | 1988-03-11 | 1989-09-13 | Teikoku Seiyaku Co., Ltd. | Intravaginal delivery of biologically active polypeptides |
EP0418674A1 (en) * | 1989-09-11 | 1991-03-27 | F. Hoffmann-La Roche Ag | Pharmaceutical preparations for enhanced absorption of antibacterial compounds |
WO1991011175A1 (en) * | 1990-01-29 | 1991-08-08 | Danbiosyst Uk Ltd | Process for the preparation of azo- and/or disulfide-containing polymers |
WO1994008622A1 (en) * | 1992-10-20 | 1994-04-28 | Smithkline Beecham Farmaceutici S.P.A. | Pharmaceutical compositions containing a calcitonin |
WO1995014037A1 (en) * | 1993-11-17 | 1995-05-26 | Ibah, Inc. | Transparent liquid for encapsulated drug delivery |
Also Published As
Publication number | Publication date |
---|---|
GB2318056B (en) | 1999-05-26 |
GB9801507D0 (en) | 1998-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20050808 |