GB2317562A - Lipid vehicle drug delivery composition containing vitamin E - Google Patents

Lipid vehicle drug delivery composition containing vitamin E

Info

Publication number
GB2317562A
GB2317562A GB9800424A GB9800424A GB2317562A GB 2317562 A GB2317562 A GB 2317562A GB 9800424 A GB9800424 A GB 9800424A GB 9800424 A GB9800424 A GB 9800424A GB 2317562 A GB2317562 A GB 2317562A
Authority
GB
United Kingdom
Prior art keywords
lipid vehicle
drug delivery
delivery composition
composition containing
containing vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9800424A
Other versions
GB9800424D0 (en
GB2317562B (en
Inventor
Lisbeth Illum
Clive Washington
Simon Lawrence
Peter Watts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Danbiosyst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9514878.9A external-priority patent/GB9514878D0/en
Application filed by Danbiosyst UK Ltd filed Critical Danbiosyst UK Ltd
Priority to GB9800424A priority Critical patent/GB2317562B/en
Publication of GB9800424D0 publication Critical patent/GB9800424D0/en
Publication of GB2317562A publication Critical patent/GB2317562A/en
Application granted granted Critical
Publication of GB2317562B publication Critical patent/GB2317562B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Abstract

The present invention provides a drug delivery composition comprising a lipid vehicle containing a drug and Vitamin E to enhance the solubility of the active drug in the lipid vehicle. The composition is particularly useful for drugs which are poorly soluble. The composition may be in the form of a liposome or an oil-in-water emulsion. The Vitamin E may be mixed with a pharmaceutically acceptable oil such as a marine oil or a vegetable oil.
GB9800424A 1995-07-20 1996-07-22 Lipid vehicle drug delivery composition containing vitamin E Expired - Fee Related GB2317562B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9800424A GB2317562B (en) 1995-07-20 1996-07-22 Lipid vehicle drug delivery composition containing vitamin E

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9514878.9A GB9514878D0 (en) 1995-07-20 1995-07-20 Vitamin E as a solubilizer for drugs contained in lipid vehicles
GB9800424A GB2317562B (en) 1995-07-20 1996-07-22 Lipid vehicle drug delivery composition containing vitamin E
PCT/GB1996/001758 WO1997003651A1 (en) 1995-07-20 1996-07-22 Lipid vehicle drug delivery composition containing vitamin e

Publications (3)

Publication Number Publication Date
GB9800424D0 GB9800424D0 (en) 1998-03-04
GB2317562A true GB2317562A (en) 1998-04-01
GB2317562B GB2317562B (en) 1999-08-18

Family

ID=26307433

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9800424A Expired - Fee Related GB2317562B (en) 1995-07-20 1996-07-22 Lipid vehicle drug delivery composition containing vitamin E

Country Status (1)

Country Link
GB (1) GB2317562B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003689A1 (en) * 1987-10-19 1989-05-05 The Liposome Company, Inc. Tocopherol-based pharmaceutical systems
EP0391369B1 (en) * 1989-04-05 1994-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
DE4322826A1 (en) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmaceutical preparation
WO1995031217A1 (en) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Tocopherol compositions for delivery of biologically active agents
US5478860A (en) * 1993-06-04 1995-12-26 Inex Pharmaceuticals Corp. Stable microemulsions for hydrophobic compound delivery

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU215966B (en) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Oral multiple emulsion-preconcentrate containing cyclosporin
JPH11505257A (en) * 1995-05-19 1999-05-18 アボツト・ラボラトリーズ Self-emulsifying formulations of lipophilic drugs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003689A1 (en) * 1987-10-19 1989-05-05 The Liposome Company, Inc. Tocopherol-based pharmaceutical systems
EP0391369B1 (en) * 1989-04-05 1994-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
US5478860A (en) * 1993-06-04 1995-12-26 Inex Pharmaceuticals Corp. Stable microemulsions for hydrophobic compound delivery
DE4322826A1 (en) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmaceutical preparation
WO1995031217A1 (en) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Tocopherol compositions for delivery of biologically active agents

Also Published As

Publication number Publication date
GB9800424D0 (en) 1998-03-04
GB2317562B (en) 1999-08-18

Similar Documents

Publication Publication Date Title
NO975931L (en) Mixture for administration of drug
AU2588597A (en) Cyclosporin emulsions
ES2186715T3 (en) USE OF A LIPOFILIC TENSIOACTIVE IN A PHARMACEUTICAL COMPOSITION.
AU2001287918A1 (en) Preparation of vitamin emulsions and concentrates thereof
KR890700036A (en) Nasal preparations and preparation methods thereof
WO2004041247A3 (en) Geodate delivery vehicles
DE3579069D1 (en) LIPID NANOPELLETS AS A CARRIER SYSTEM FOR MEDICINAL PRODUCTS FOR PERORAL USE.
IL117773A (en) Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
AU3955089A (en) Pharmaceutical composition comprising protein kinase c inhibitor and anti-cancer agent
ES2158084T3 (en) LIPOFILIC VEHICLE PREPARATIONS.
CA2013755A1 (en) Medicinal emulsions
ATE198038T1 (en) COSMETIC SELF-TANNING PRODUCT WITH PHOTOPROTECTION EFFECT
Trotta et al. Investigation of the phase behaviour of systems containing lecithin and 2-acyl lysolecithin derivatives
ES2164339T3 (en) PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION CONTAINING SEXUAL HORMONES.
KR960016904A (en) Cyclosporine-containing soft capsule composition
PT1037666E (en) METHOD FOR INCREASING ABSORPTION AND TRANSPORTATION OF SOLUBLE LIPID COMPOUNDS USING STRUCTURED GLYCERIDES
AU3030801A (en) Fenofibrate galenic formulations and method for obtaining same
CA2244512A1 (en) Dietary supplements containing natural ingredients
Radomska et al. The use of some ingredients for microemulsion preparation containing retinol and its esters
TWI222880B (en) A novel drug delivery system: formulation for fat-soluble drugs
AU4862796A (en) Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
CA2532566A1 (en) Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids
GB2317562A (en) Lipid vehicle drug delivery composition containing vitamin E
WO2001007058A3 (en) Parenteral cisplatin emulsion
DE60120652D1 (en) EMULSION CONTAINS SILICONE OIL AND CO SOLVENT SYSTEM CONTAINING FAT-SOLUBLE COSMETIC ACTIVE SUBSTANCES AND COSMETIC PREPARATIONS MADE THEREFROM

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20020722