GB2317340A - Polymeric lamellar substrate particles for drug delivery - Google Patents

Polymeric lamellar substrate particles for drug delivery

Info

Publication number
GB2317340A
GB2317340A GB9800423A GB9800423A GB2317340A GB 2317340 A GB2317340 A GB 2317340A GB 9800423 A GB9800423 A GB 9800423A GB 9800423 A GB9800423 A GB 9800423A GB 2317340 A GB2317340 A GB 2317340A
Authority
GB
United Kingdom
Prior art keywords
drug delivery
substrate particles
particles
lamellar substrate
polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9800423A
Other versions
GB2317340B (en
GB9800423D0 (en
Inventor
Alan Gerald Arthur Coombes
Stanley Stewart Davis
Diane Lisa Major
John Michael Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Danbiosyst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9514285.7A external-priority patent/GB9514285D0/en
Application filed by Danbiosyst UK Ltd filed Critical Danbiosyst UK Ltd
Priority to GB9800423A priority Critical patent/GB2317340B/en
Publication of GB9800423D0 publication Critical patent/GB9800423D0/en
Publication of GB2317340A publication Critical patent/GB2317340A/en
Application granted granted Critical
Publication of GB2317340B publication Critical patent/GB2317340B/en
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a composition for delivery of an active agent comprising a plurality of lamellar particles of a biodegradable polymer which is at least in part crystalline, and an active agent adsorbed to at least most of the particles. Preferably the biodegradable polymer is at least 5 % by weight crystalline. Preferred biodegradable polymers are poly(L-lactide) (L.PLA) or copolymers or blends of L.PLA. The particles are especially useful for the immobilisation of antigens or allergens for vaccines.
GB9800423A 1995-07-13 1996-07-15 Polymeric lamellar substrate particles for drug delivery Revoked GB2317340B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9800423A GB2317340B (en) 1995-07-13 1996-07-15 Polymeric lamellar substrate particles for drug delivery

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9514285.7A GB9514285D0 (en) 1995-07-13 1995-07-13 Polymeric lamellar substrate particles for drug delivery
GB9800423A GB2317340B (en) 1995-07-13 1996-07-15 Polymeric lamellar substrate particles for drug delivery
PCT/GB1996/001695 WO1997002810A2 (en) 1995-07-13 1996-07-15 Polymeric lamellar substrate particles for drug delivery

Publications (3)

Publication Number Publication Date
GB9800423D0 GB9800423D0 (en) 1998-03-04
GB2317340A true GB2317340A (en) 1998-03-25
GB2317340B GB2317340B (en) 1998-12-23

Family

ID=26307389

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9800423A Revoked GB2317340B (en) 1995-07-13 1996-07-15 Polymeric lamellar substrate particles for drug delivery

Country Status (1)

Country Link
GB (1) GB2317340B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011010A1 (en) * 1993-10-22 1995-04-27 Genentech, Inc. Methods and compositions for microencapsulation of antigens for use as vaccines
WO1995035097A1 (en) * 1994-06-18 1995-12-28 University Of Nottingham Polymer microparticles for drug delivery

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011010A1 (en) * 1993-10-22 1995-04-27 Genentech, Inc. Methods and compositions for microencapsulation of antigens for use as vaccines
WO1995035097A1 (en) * 1994-06-18 1995-12-28 University Of Nottingham Polymer microparticles for drug delivery

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 115, no. 6, 12 August 1991, Abstract No. 56995 *
Chemical Abstracts, vol. 93, no. 26, 29 December 1980, Abstract No.240075 *
Chemical Abstracts, vol.122, no. 24, 12 June 1995, Abstract No. 298951 *

Also Published As

Publication number Publication date
GB2317340B (en) 1998-12-23
GB9800423D0 (en) 1998-03-04

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Legal Events

Date Code Title Description
773K Patent revoked under sect. 73(2)/1977

Free format text: PATENT REVOKED ON 20030915