GB2311288A - Herbicidal pentafluorosulfanyl compounds - Google Patents

Abstract

Compounds of formulae (Ia), (Ib) or (Ic): ```in which the various symbols are as defined in the description, and salts and metal complexes thereof are useful as herbicides. Certain intermediates are also novel compounds.

Description

New Herbicides This invention relates to novel isoxazole derivatives and 2-cyano-1,3-dione derivatives, compositions containing them, processes for their preparation, intermediates in their preparation and their use as herbicides.

Herbicidal 4-benzoylisoxazoles are described in European Patent Publication Numbers 0418175, 0487357, 0527036, 0527037, 0560482 and 0560483.

Herbicidal 2-cyano-1,3-diones are described in European Patent Publication Numbers 0213892, 0496630, 0496631, 0625505 and 0625508 and International Patent Publication No. WO 95/25099. Herbicidal 5-phenylisoxazoles are described in European Patent Publication Number 0524018. However, none of the above publications disclose or suggest the presence of a pentafluorosulphanyl group as a substituent on the phenyl ring.

The present invention provides 4-benzoylisoxazole derivatives of formula (Ia), 5-phenylisoxazole derivatives of formula (Ib) and 2-cyano-1,3-dione derivatives of formula (Ic):

wherein: R represents hydrogen or -CO2R3; R1 represents: a straight- or branched- chain alkyl group containing up to six carbon atoms which is optionally substituted by one or more halogen atoms; or a cycloalkyl group containing from three to six ring carbon atoms optionally substituted by one or more groups selected from R4 and halogen; R2 represents: halogen; a straight- or branched- chain alkyl group containing up to six carbon atoms which is substituted by one or more groups -OR5; a cycloalkyl group containing from three to six carbon atoms; or a group selected from nitro, cyano, -Co2R5, -NR5R6, -S(o)pR7, -O(CH2) mOR5, - COR5, -N(R8)So2R7, -oR7, -OH, -oS02R7, -(CR9R10)tSOqR7a, -CONR5R6, -N(R8)-C(Z)=Y, -(CR9R10)NR8Rll and R4; n represents zero or an integer from one to three; where n is greater than one the groups R2 may be the same or different; m represents one, two or three; p represents zero, one or two; q represents zero, one or two; t represents an integer from one to four (preferably one); R3 represents a straight- or branched- chain alkyl group containing up to six carbon atoms optionally substituted by one or more groups selected from halogen, -OR5, -C02R5, -S(o)pR7, phenyl or cyano; or phenyl optionally substituted by one or more groups selected from halogen, -OR5 and R4; R4 represents a straight- or branched- chain alkyl, alkenyl or alkynyl group containing up to six carbon atoms optionally substituted by one or more halogen atoms; R5 and R6 which may be the same or different, each represents hydrogen or R4; R7 and R7a independently represent R4 or a cycloalkyl group containing from three to six ring carbon atoms; or a group -(CH2)w-[phenyl optionally substituted by from one to five groups R12 which may be the same or different]; w represents zero or one; R8 represents: hydrogen; a straight- or branched- chain alkyl, alkenyl or alkynyl group containing up to ten carbon atoms optionally substituted by one or more halogen atoms; a cycloalkyl group containing from three to six ring carbon atoms; -(CH2)w-[phenyl optionally substituted by from one to five groups R12 which may be the same or different]; or a group -OR13; R9 and R10 independently represent hydrogen or a straight- or branched- chain alkyl group containing up to six (preferably up to three) carbon atoms optionally substituted by one or more halogen atoms; Rll represents -S(O)9R7 or -C(Z)=Y; R12 represents: a halogen atom; a straight- or branched- chain alkyl group containing up to three carbon atoms optionally substituted by one or more halogen atoms; or a group selected from nitro, cyano, -S(o)pR3 and -OR5; Y represents oxygen or sulphur (preferably Y represents oxygen); Z represents R4, -NR8R13, -NR8-NR13R14, -SR7 or -OR7; R13 and R14 independently represent R8; and agriculturally acceptable salts and metal complexes thereof, which possess valuable herbicidal properties.

Compounds of formula (Ic) may exist in enolic tautomeric forms that may give rise to geometric isomers around the enolic double bond.

It will also be appreciated that certain substituents in the compounds of the invention may contribute to optical isomerism and/or stereoisomerism. All such forms are embraced by the present invention.

It will be understood that in the description that follows, reference to compounds of formula (I) means reference to compounds of formula (Ia), (Ib) or (Ic).

By the term "agriculturally acceptable salts" is meant salts the cations or anions of which are known and accepted in the art for the formation of salts for agricultural or horticultural use. Preferably the salts are water-soluble. Suitable salts with bases include alkali metal (eg. sodium and potassium) alkaline earth metal (eg. calcium and magnesium), ammonium and amine (eg.

diethanolamine, triethanolamine, octylamine, morpholine and dioctylmethylamine) salts.

Suitable acid addition salts, formed by compounds of formula (I) containing an amino group, include salts with inorganic acids, for example hydrochlorides, sulphates, phosphates and nitrates and salts with organic acids, for example acetic acid.

By the term "metal complexes" is meant compounds in which one or both of the oxygen atoms of the 1,3-dione of formula (Ic) act as chelating agents to a metal cation. Examples of such cations include zinc, manganese, cupric, cuprous, ferric, ferrous, titanium and aluminium.

Compounds of formula (Ia) are preferred.

Compounds in which the 2-position of the phenyl group is substituted are also preferred.

Preferably the 5- and 6- positions of the phenyl group are unsubstituted.

Preferably R1 represents: a straight- or branched- chain alkyl group containing up to three carbon atoms which is optionally substituted by one or more halogen atoms; or cyclopropyl or l-methylcyclopropyl.

Most preferably R1 represents cyclopropyl.

Preferably R2 represents: halogen; a straight- or branched- chain alkyl or alkenyl group containing up to four carbon atoms optionally substituted by one or more halogen atoms; or a group selected from nitro, cyano, -S(O)pR7, -OR7 and -CR9R10SOqR7 Preferably n represents zero, one or two.

Preferably R3 represents a straight- or branched- chain alkyl group containing up to six carbon atoms optionally substituted by one or more halogen atoms.

Preferably R7 represents a straight- or branched- chain alkyl group containing up to six carbon atoms which is optionally substituted by one or more halogen atoms; or phenyl optionally substituted by halogen, a straight- or branched- chain alkyl containing tip to three carbon atoms optionally substituted by one or more halogen atoms, or -S(O)pR3.

A particularly preferred class of compounds of formula (Ia) are those having one or more of the following properties: R represents hydrogen or -Co2R3; R1 represents cyclopropyl or 1methylcyclopropyl; R2 represents: halogen; a straight- or branched- chain alkyl group containing up to three carbon atoms optionally substituted by one or more halogen atoms; -S(O)pR7 group; -CH2S (O) qR7a; n represents zero, one or two; R3 represents a straight- or branched- chain alkyl group containing from one to three carbon atoms; R7 represents methyl or ethyl optionally substituted by one or more halogen atoms; R7a represents a straight- or branchedchain alkyl group containing up to four carbon atoms optionally substituted by one or more halogen atoms,or phenyl optionally substituted by one or more halogen atoms or -S(o)pR7.

Another particularly preferred class of compounds of formula (Ia) are those wherein: R represents hydrogen, or -Co2R3; R1 represents cyclopropyl; R2 represents: halogen; methyl optionally substituted by from one to three halogen atoms (preferably fluorine); nitro; or -S(O)pCH3; n represents zero, one or two; and R3 represents methyl or ethyl.

Another particularly preferred class of compounds of formula (Ia) are those wherein: R represents hydrogen; R1 represents cyclopropyl; R2 represents: methyl optionally substituted by from one to three halogen atoms (preferably fluorine); nitro; or -S(O)pCH3; n represents zero, one or two.

Particularly important compounds of formula (I) include the following: 1. 5-cyclopropyl-4-(4pentafluorosulphanylbenzoyl)isoxazole; 2. 4-cyclopropylcarbonyl-5- (4- pentafluorosulphanylphenyl)isoxazole; 3. 2-cyano-3-cyclopropyl-1- (4- pentafluorosulphanylphenyl)propan-1,3-dione; 4. 5-cyclopropyl-4-(2-nitro-4pentafluorosulphanylbenzoyl)isoxazole; 5. 5-cyclopropyl-4-(2-methylthio-4pentafluorosulphanylbenzoyl)isoxazole; 6. 5-cyclopropyl-4-(2-methylsulphinyl-4pentafluorosulphanylbenzoyl)isoxazole; 7. 5-cyclopropyl-4-(2-methylsulphonyl-4pentafluorosulphanylbenzoyl)isoxazole; 110. 4-cyclopropylcarbonyl-5-(2-methylthio4-pentafluorosulphanylphenyl)isoxazole; 111. 2-cyano-3-cyclopropyl-1- (2-nitro-4- pentafluorosulphanylphenyl)propan-1,3-dione; 112. 2-cyano-3-cyclopropyl-1- (2-methylthio- 4-pentafluorosulphanylphenyl)propan-1,3-dione; 113. 2-cyano-3-cyclopropyl-1-(2methylsulphonyl-4 pentafluorosulphanylphenyl) propan-1, 3 -dione; 114. 2-cyano-3-cyclopropyl-1- (2- methylsulphinyl-4 pentafluorosulphanylphenyl)propan-l, 3-dione; and 115. 4-cyclopropylcarbonyl-5- (2- methylsulphonyl-4pentafluorosulphanylphenyl)isoxazole.

The following compounds of formula (Ia) in which the SF5 group is attached to the 4-position of the phenyl ring form part of the present invention.

In the table that follows Me' means methyl, 'Et' means ethyl, c-Pr' means cyclopropyl, Ph' means phenyl. Where subscripts do not appear in the Table it is understood that in appropriate cases they are present. For example, CF3' is understood to mean -CF3; NO2' is understood to mean -NO2 etc.

Cpd.No. R R1 (R2)n 4 H c-Pr 2-NO2 5 H c-Pr 2-SMe 6 H c-Pr 2-SOMe 7 H c-Pr 2-SO2Me 8 H l-Me-c-Pr 2-SMe 9 H 1-Me-c-Pr 2-SOMe 10 H l-Me-c-Pr 2-SO2Me 11 CO2Et c-Pr 2-SMe 12 CO2Et c-Pr 2-SOMe 13 CO2Et c-Pr 2-SO2Me 14 H c-Pr 2-CH2SMe 15 H c-Pr 2-CH2SOMe 16 H c-Pr 2-CH2SO2Me 17 H c-Pr 2-C1 18 CO2Et c-Pr 2-C1 19 H l-Me-c-Pr 2-C1 20 H c-Pr 2-SMe-3-C1 21 H c-Pr 2-SOMe-3-Cl 22 H c-Pr 2-SO2Me-3-Cl 23 H c-Pr 2-SEt 24 H c-Pr 2-SOEt 25 H c-Pr 2-SO2Et 26 H c-Pr 2-SMe-3-Br 27 H c-Pr 2-SMe-3-F 28 H c-Pr 2-F-3-SMe 29 H c-Pr 2-SMe-3-OMe 30 H 7 7 c-Pr 2-SOMe-3-OMe 31 H c-Pr 2-SO2Me-3-OMe 32 H c-Pr 2-SMe-3-SMe 33 H c-Pr 2-F 34 H c-Pr 2-Me 35 H c-Pr 2-Et 36 H c-Pr 2-OMe 37 H c-Pr 2-Me-3-C1 38 H c-Pr 2-Me-3-F 39 H c-Pr 2-Me-3-SMe 40 H c-Pr 2-Me-3-SOMe 41 H c-Pr 2-Me-3-SO2Me 42 H c-Pr 2-OMe-3-SMe 43 H c-Pr 2-OMe-3-SOMe 44 H c-Pr 2-OMe-3-SO2Me 45 H c-Pr 2-CH2S(2-SMe-Ph) 46 H c-Pr 2-CH2S(2-SOMe-Ph) 47 H c-Pr 2-CH2S(2-SO2Me-Ph) 48 H c-Pr 2-CH2SPh 49 H c-Pr 2-CH2SOPh 50 H c-Pr 2-CH2SO2Ph

Cpd.No. R R1 (R2)n 51 H c-Pr 2-C1-3-OCH2CH2OMe 52 H c-Pr 2-C1-3-CONMe2 53 H c-Pr 2-Cl-3-C02Me 54 H c-Pr 2-NMeS02Me 55 H c-Pr 2-OSO2Me 56 H c-Pr 2-NMeC02Me 57 H c-Pr 2-CH2NMeS02Me 58 H c-Pr 2-CH2NMeCO2Me 59 H c-Pr 2-CH2S-iBu 60 H c-Pr 2-CH2SO-iBu 61 H c-Pr 2-CH2S02-iBu The following compounds of formula (Ia) in which the -SF5 group is attached to the 2-position of the phenyl ring also form part of the present invention.

Cpd. No. R Ri (R2)n 62 H c-Pr 4-NO2 63 H c-Pr 4-Cl 64 H c-Pr 4-Br 65 H c-Pr 4-SMe 66 H c-Pr 4-SOMe 67 H c-Pr 4-S02Me 68 H l-Me-c-Pr 4-SMe 69 CO2Et c-Pr 4-SMe 70 CO2Et c-Pr 4-SOMe 71 CO2Et c-Pr 4-S02Me 72 H l-Me-c-Pr 4-SOMe 73 H l-Me-c-Pr 4-SO2Me 74 H c-Pr 3-F-4SMe 75 H c-Pr 3-F-4-SOMe 76 H c-Pr 3-F-4-S02Me 77 H c-Pr 3-OMe-4-SMe 78 H c-Pr 3-OMe-4-SOMe 79 H c-Pr 3-OMe-4-S02Me 80 H c-Pr 3-SMe-4-SMe 81 H c-Pr 3-SMe-4-Cl 82 H c-Pr 3-SOMe-4-Cl 83 H c-Pr 3-S02Me-4-Cl 84 H c-Pr 3-Cl-4-SMe 85 H c-Pr 3-Cl-4-SOMe 86 H c-Pr 3-Cl-4-S02Me 87 H c-Pr 3-Me-4-SMe 88 H c-Pr 3-Me-4-SOMe

Cpd. No. R R1 (R2)n 89 H c-Pr 3-Me-4-SO2Me 90 H c-Pr 3-SMe-4-Me 91 H c-Pr 3-SOMe-4-Me 92 H c-Pr 3-SO2Me-4-Me 93 H c-Pr 3-SMe-4-OMe 94 H c-Pr 3-SOMe-4-OMe 95 H c-Pr 3-SO2Me-4-OMe 96 c-Pr 3-SMe 97 c-Pr 3-SOMe 98 H c-Pr 3-SO2Me 99 H c-Pr 4-CH2SMe 100 H - c-Pr 4-CH2SOMe 101 c-Pr 4-CH2SO2Me 102 CO2Et c-Pr 3-F-4-SMe 103 CO2Et c-Pr 3-OMe-4-SMe 104 CO2Et c-Pr 3-SMe-4-SMe 105 CO2Et c-Pr 3-SMe-4-Cl 106 CO2Et c-Pr 3-Cl-4-SOMe 107 CO2Et c-Pr 3-Me-4-SOMe 108 CO2Et c-Pr 3-SO2Me-4-Me 109 CO2Et c-Pr 3-SO2Me Compounds of formula (I) may be prepared by the application or adaptation of known methods (i.e. methods heretofore used or described in the literature), for example as hereinafter described.

In the following description where symbols appearing in formulae are not specifically defined, it is to be understood that they are "as hereinbefore defined" in accordance with the first definition of each symbol in the specification.

It is to be understood that in the descriptions of the following processes the sequences may be performed in different orders, and that suitable protecting groups may be required to achieve the compounds sought.

It is understood that when a process of the invention leads to the formation of a mixture of (Ia) and (Ib), these compounds may be separated by known methods.

According to a feature of the present invention compounds of formula (Ia) or (Ib) in which R represents hydrogen and R1, R2 and n are as defined above may be prepared by the reaction of a compound of formula (II):

wherein L is a leaving group and R1, R2 and n are as hereinbefore defined, with hydroxylamine or a salt of hydroxylamine.

Hydroxylamine hydrochloride is generally preferred. Generally L is alkoxy, for example ethoxy, or N,N-dialkylamino, for example dimethylamino. The reaction is generally carried out in an organic solvent such as ethanol or acetonitrile or a mixture of a water-miscible organic solvent and water, preferably in a ratio of organic solvent: water of from 1:99 to 99:1, optionally in the presence of a base or acid acceptor such as triethylamine or sodium acetate at a temperature from room temperature to the boiling point of the solvent.

Intermediates of formula (II) are novel and as such form a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ia) in which R represents hydrogen and R1, R2 and n are as defined above may be prepared by the reaction of a compound of formula (III):

wherein R1 is as hereinbefore defined and Y' represents a carboxy group or a reactive derivative thereof (such as a carboxylic acid chloride or carboxylic ester), or a cyano group, with an appropriate organometallic reagent such as a Grignard reagent or an organolithium reagent. The reaction is generally carried out in an inert solvent such as ether or tetrahydrofuran at a temperature from OOC to the reflux temperature of the mixture.

According to a further feature of the present invention compounds of formula (Ia) wherein R represents a group -Co2R3 and R1, R2 and n are as defined above, may be prepared by the reaction of a compound of formula (IV):

wherein R1, R2 and n are as hereinbefore defined and pl is a leaving group such as N,N-dialkylamino, with a compound of formula R3O2CC(Z1)=NOH wherein R3 is as hereinbefore defined and Z1 is a halogen atom. Generally zl is chlorine or bromine. The reaction is generally performed in an inert solvent such as toluene or dichloromethane either in the presence of a base such as triethylamine or a catalyst such as a 4 Angstrom molecular sieve or fluoride ion. Intermediates of formula (IV) are novel and as such form a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ia) in which R represents a group -C02R3 and R1, R2 and n are as defined above may be prepared by the reaction of a compound of formula (V):

wherein R1, R2 and n are as hereinbefore defined, with a compound of formula R302CC(Z1)=NOH wherein Z1 and R3 are as hereinbefore defined. The reaction is generally performed in an inert solvent such as toluene or dichloromethane optionally in the presence of a base such as triethylamine or a catalyst such as a 4 Angstrom molecular sieve or fluoride ion.

The reaction is preferably carried out at a temperature between room temperature and the reflux temperature of the mixture.

Intermediates of formula (V) are novel and as such form a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ia) or (Ib) wherein R represents -Co2R3 and R1, R2 and n are as defined above, may be prepared by the reaction of a salt of compounds of formula (VI):

wherein R11 R2 and n are as hereinbefore defined with a compound of formula R302CC(Z1)=NOH wherein R3 and Z1 are as hereinbefore defined. Preferred salts include sodium or magnesium salts. The reaction is generally performed in an inert solvent such as dichloromethane or acetonitrile at a temperature between room temperature and the reflux temperature of the mixture. The salt of a compound of formula (VI) is generally prepared in situ by treating the compound of formula (VI) with a base. Examples of suitable bases include alkaline earth metal alkoxides such as magnesium methoxide. Intermediates of formula (VI) are novel and as such form a further feature of the invention.

According to a feature of the present invention compounds of formula (Ib) in which R, R11 R2 and n are as defined above, may be prepared by the metallation of a compound of general formula (VII):

wherein R, R2 and n are as defined above and A is a halogen atom, followed by reaction of the compound thus obtained with an acid chloride of formula R1COCl wherein R1 is as defined above.

Generally A is bromine or iodine and the reaction performed with for example nbutyllithium in an inert solvent such as ether or tetrahydrofuran at a temperature from -780C to OOC. Compounds of formula (VII) are novel and as such constitute a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ib) in which R, R11 R2 and n are as defined above may be prepared by the oxidation of a compound of formula (VIII):

wherein R, R1, R2 and n are as defined above, to convert the hydroxy group to a ketone group. The reaction is generally performed using an appropriate oxidising agent, for example, a mixture prepared from chromium trioxide and aqueous sulphuric acid. Compounds of formula (VIII) are novel and as such constitute a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ib) in which R represents hydrogen and R1, R2 and n are as defined above may be prepared by the reaction of a compound of formula (IX)

in which R2 and n are as defined above and D represents a carboxy group, or a reactive derivative thereof (such as a carboxylic acid chloride or carboxylic ester), or a cyano group, with an appropriate organometallic reagent such as a Grignard reagent or an organolithium reagent. The reaction is generally carried out in an inert solvent such as ether or tetrahydrofuran, at a temperature from OOC to the reflux temperature of the solvent.

Intermediates of formula (IX) are novel and as such form a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ib) in which R represents a -C02R3 group and R1, R2 and n are as defined above, may be prepared by the reaction of a compound of general formula (X):

wherein R1, R2 and n are as defined and pl is as defined above, with a compound of formula R3O2CC(Z )=NOH wherein Z and R3 are as hereinbefore defined. Generally Z1 is chlorine or bromine. The reaction is preferably performed in an inert solvent such as toluene or dichloromethane either in the presence of a base such as triethylamine or a catalyst such as a 4 Angstrom molecular sieve or fluoride ion.

Intermediates of formula (X) are novel and as such form a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ib) in which R represents a group -Co2R3 and R1, R2 and n are as defined above may be prepared by the reaction of a compound of formula (XI):

wherein R1,R2 and n are as defined above, with a compound of formula R3O2CC(Z1)=NOH wherein Z1 and R3 are as hereinbefore defined.

Generally Z1 is chlorine or bromine. The reaction is preferably performed in an inert solvent such as toluene or dichloromethane, either in the presence of a base such as triethylamine, or a catalyst such as a 4 Angstrom molecular sieve or fluoride ion.

Intermediates of formula (XI) are novel and as such form a futher feature of the invention.

According to a feature of the present invention compounds of formula (Ic) may be prepared from the corresponding compound of formula (Ia) or (Ib) in which R is as defined above, or in which R is replaced by an amide or nitrile. Where R represents a hydrogen atom the reaction is preferably carried out by treatment with a base. Examples of suitable bases include alkali or alkaline earth metal hydroxides, alkoxides such as sodium ethoxide or organic bases such as triethylamine. Where R represents -Co2R3, or where R is replaced by amide or nitrile, the conversion is generally carried out by a hydrolytic reaction. The hydrolytic reaction may be performed in the presence of an acid or base. Acidic hydrolysis may be achieved for example using aqueous hydrochloric acid.

Basic hydrolysis may be achieved for example using sodium hydroxide in a mixture of alcohol and water. The reactions are preferably carried out at a temperature between room temperature and the reflux temperature of the mixture.

Compounds of formula (Ia) or (Ib) in which R is replaced by amide or nitrile are novel and thus constitute a further feature of the invention.

According to a further feature of the present invention, compounds of formula (Ic) in which R1, R2 and n are as defined above may also be prepared by the reaction of a benzoyl chloride of formula (XII):

wherein R2 and n are as hereinbefore defined1 with a beta-ketonitrile of formula (XIII).:

wherein R1 is as hereinbefore defined. The reaction is generally performed in the presence of a base, in a solvent or solvent mixture.

Suitable bases include metal hydrides, hydroxides or alkoxides (e.g. sodium or lithium hydride, sodium hydroxide, potassium hydroxide, magnesium ethoxide or magnesium methoxide).

Suitable solvents include for example tetrahydrofuran; hydrocarbons such as toluene; or halogenated hydrocarbons such as dichloromethane. The reaction is generally performed at a temperature from OOC to the reflux temperature. A number of compounds of formula (XII) are novel and thus form a further feature of the invention.

According to a further feature of the present invention, compounds of formula (Ic) in which R1, R2 and n are as defined above may also be prepared by the reaction of an acid chloride of formula R1COCl wherein R1 is as hereinbefore defined, with a beta-ketonitrile of formula (XIV):

wherein R2 and n are as hereinbefore defined. The reaction is generally performed under the same conditions as described above for the reaction of compounds of formula (XII) with compounds of formula (XII I) . Intermediates of formula (XIV) are novel and as such form a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ic) in which R1, R2 and n are as defined above may also be prepared by the reaction of a benzoyl chloride of formula (XII) above wherein R2 and n are as hereinbefore defined, with a betaketonitrile of formula (XIII) wherein R1 is as hereinbefore defined, via an intermediate of formula (XV):

wherein R1, R2 and n are as hereinbefore defined. The formation of the intermediate of formula (XV) may be carried out in the presence of a mild base such as an organic base e.g.

triethylamine, in an inert solvent such as acetonitrile or dichloromethane at a temperature between room temperature and the reflux temperature of the mixture. The rearrangement of the intermediate of formula (XV) to a compound of formula (Ic) is generally carried out in situ in an inert solvent such as acetonitrile or dichloromethane in the presence of a catalyst such as a source of cyanide.

Examples of such sources of cyanide are acetone cyanohydrin or an alkali metal cyanide such as potassium cyanide, optionally in the presence of a crown ether such as 18-crown-6. Intermediates of formula (XV) are novel and as such constitute a further feature of the invention.

According to a further feature of the present invention compounds of formula (Ic) in which R11 R2 and n are as defined above, may be prepared by the reaction of an acid chloride of formula R1COC1 wherein R1 is as hereinbefore defined, with a beta-ketonitrile of formula (XIV) wherein R2 and n are as hereinbefore defined via an intermediate of formula (XVI):

wherein R1, R2 and n are as hereinbefore defined. The formation and rearrangement of the intermediate of formula (XVI) is generally carried out under the same conditions as described above for the formation and rearrangement of compounds of formula (XV).

Intermediates of formula (XVI) are novel and as such form a further feature of the invention.

Intermediates in the preparation of compounds of formula (Ia), (Ib) and (Ic) may be prepared by the application or adaptation of known methods.

Intermediates of formula (Ia) or (Ib) in which R is replaced by an amide or nitrile may be prepared by the reaction of a salt of a compound of formula (VI) with a compound of formula P2C(Z1)=NOH in which P2 is amide or nitrile. The reaction is performed using the same conditions as described for the preparation of compounds of formula (Ia) or (Ib) in which R is -C02R3 from compounds of formula (VI).

Compounds of formula (II) may be prepared by the reaction of compounds of formula (VI) with either a trialkyl orthoformate such as triethyl orthoformate or a dimethylformamide dialkyl acetal such as dimethylformamide dimethyl acetal. The reaction with a trialkyl orthoformate can be carried out in the presence of acetic anhydride at the reflux temperature of the mixture and the reaction with dialkylformamide dialkyl acetal is carried out optionally in the presence of an inert solvent at a temperature from room temperature to the reflux temperature of the mixture.

Compounds of formula (IV) may be prepared by the reaction of a compound of formula (XVII) with a benzoyl chloride of formula (XII): R1C(pl=CH2 (XVII) wherein R1 and pl are as defined above.

The reaction is generally carried out in the presence of an organic base such as triethylamine in an inert solvent such as toluene or dichloromethane at a temperature between -200C and room temperature.

Compounds of formula (V) may be prepared by the metallation of the appropriate acetylene of formula (XVI II) R1,CH (XVIII) followed by reaction of the metal salt thus obtained with a benzoyl chloride of formula (XII). The metallation is generally performed using n-butyl lithium in an inert solvent such as ether or tetrahydrofuran at a temperature from -780C to OOC. The subsequent reaction with the benzoyl chloride is carried out in the same solvent at a temperature between -780C and room temperature.

Compounds of formula (VI) may be prepared by the reaction of an acid chloride of formula (XII) with the metal salt of a compound of formula (XIX):

wherein R1 is as hereinbefore defined, to give a compound of formula (XX):

wherein R1, R2 and n are as hereinbefore defined, which is subsequently decarboxylated to give a compound of formula (VI). Generally the reaction to produce the compound of formula (XX) is performed in a solvent such as a lower alcohol, preferably methanol, in the presence of a metal, preferably magnesium. The reaction may also be performed using a pre-prepared metal salt of a compound of formula (XIX). The decarboxylation is generally performed by reflexing the compound of formula (XX) in the presence of a catalyst, such as para-toluenesulphonic acid or trifluoroacetic acid, in an inert solvent e.g. toluene or 1,2-dichloroethane.

Compounds of formula (VI) may also be prepared by the reaction of a benzoic acid ester of formula (XXI):

wherein R2 and n are as hereinbefore defined and R15 represents straight- or branched- chain C16 alkyl, with a compound of formula (XXII): R1-C(O)-CH3 (XXII) wherein R1 is as hereinbefore defined. The reaction is generally performed in a solvent such as ether, tetrahydrofuran or N,Ndimethylformamide, in the presence of a base, preferably an alkali metal base such as sodium hydride, at a temperature from OOC to the reflux temperature.

Acid chlorides of formula (XII) may be prepared by the reaction of a benzoic acid of formula (XXIII):

with a chlorinating agent, for example thionyl chloride at the reflux temperature of the mixture. In some cases the benzoyl chlorides may also be prepared by reaction of the benzoic acid with oxalyl chloride in a solvent such as 1,2-dichloroethane at from ambient to reflux temperature.

Benzoic acids of formula (XXIII) are novel with the exclusion of those in which n is zero and the -SF5 group is located m- or p- to the carboxy group (these compounds being reported by W.A.Sheppard in J.Am.Chem.Soc. 1962, 84, 30643072) and as such constitute a further feature of the present invention.

Esters of formula (XXI) are novel and as such constitute a further feature of the present invention.

Esters of formula (XXI) may be prepared from acids of formula (XXIII) by known methods.

Compounds of general formula (VIII) may be prepared by metallation of compounds of general formula (VII) wherein A represents bromine or iodine with for example n-butyllithium in an inert solvent such as ether or tetrahydrofuran at a temperature from -780C to OOC, followed by reaction with an aldehyde of general formula R1CHO.

Compounds of general formula (IX) wherein D is -CO2-alkyl or -CN may be prepared by the reaction of compounds of general formula (XXIV):

wherein D' represents CO2-alkyl or -CN and L is as hereinbefore defined, with a salt of hydroxylamine such as hydroxylamine hydrochloride, in a solvent such as ethanol or acetonitrile, optionally in the presence of a base or acid acceptor such as triethylamine or sodium acetate.

Compounds of general formula (IX) in which D represents a carboxylic acid or carboxylic acid chloride may be prepared from the corresponding compound of general formula (IX) in which D represents a carboxylic ester group by the hydrolysis of said ester group and conversion, as necessary, of the acid thus obtained to the acid chloride, e.g. by heating with thionyl chloride.

Compounds of general formula (XXIV) may be prepared by the reaction of a ketoester or ketonitrile of general formula (XXV):

with either triethyl orthoformate in the presence of acetic anhydride at the reflux temperature of the mixture or with dimethylformamide dimethylacetal optionally in an inert solvent such as toluene at a temperature from room temperature to the reflux temperature of the mixture.

Compounds of general formula (X) may be prepared by the reaction of a compound of general formula (XXVI):

wherein P1 is as hereinbefore defined, with an acid chloride of general formula R1COCl in an inert solvent such as dichloromethane or toluene, in the presence of a base such as triethylamine.

Compounds of general formula (XI) may be prepared by the metallation of the appropriate phenylacetylene of general formula (XXVII):

wherein Q represents hydrogen or a bromine or iodine atom, using for example n-butyllithium in an inert solvent such as ether or tetrahydrofuran at a temperature from -780C to OOC, followed by treatment with an acid chloride of general formula R1COCl.

Compounds of general formula (VII) may be prepared by the halogenation of compounds of general formula (XXVIII):

for example by heating with bromine or iodine in the presence of concentrated nitric acid.

Compounds of general formula (XXVIII) may be prepared by the reaction of compounds of general formula (XXIX):

with a salt of hydroxylamine such as hydrochloride, in a solvent such as ethanol or acetonitrile, optionally in the presence of a base or acid acceptor such as triethylamine or sodium acetate.

Beta-ketonitriles of formula (XIII) may be prepared from acid chlorides of formula R1COC by a number of methods well known in the chemical literature. For example, see Krauss, et al, Synthesis, 1983, 308, or Muth, et al, J.

Org. Chem, 1960, 25, 736. Alternatively betaketonitriles of formula (XVIII) may be prepared by the reaction of an ester of formula R1-CO2Et, wherein R1 is as hereinbefore defined, with acetonitrile. This reaction is described in the literature, for example see the article by Abramovitch and Hauser, J.Am. Chem. Soc., 1942, 64 2720.

Beta-ketonitriles of formula (XIV) may be prepared from benzoyl chlorides of formula (XII) or from corresponding ethyl benzoates in a manner analogous to the preparation of betaketonitriles of formula (XIII) set forth above.

According to a further feature of the invention benzoic acids of formula (XXIII) may be prepared by the reaction of a compound of formula (XXX):

wherein X represents an iodine, chlorine or preferably bromine atom and R2 is as defined above, with an organometallic reagent, generally a Grignard or organolithium reagent. Preferably butyl lithium is employed (in which case X is an iodine or bromine atom) in an inert solvent, for example ether at a temperature from -78 0C to 200C, followed by reaction with carbon dioxide or a source thereof.

The intermediate halides of formula (XXX) may be prepared according to known methods, for example as described in J.Am.Chem.Soc. 84 3064 (1962).

Intermediates of formula (III), (XVII), (XVIII), (XIX) and (XXII) are known or may be prepared by the application or adaptation of known methods.

Those skilled in the art will appreciate that some compounds of formula (I) may be prepared by the interconversion of other compounds of formula (I) and such interconversions constitute yet more features of the present invention.

According to a further feature of the present invention compounds in which p or q is one or two may be prepared by the oxidation of the sulphur atom of the corresponding compounds in which p or q is zero or one. The oxidation of the sulphur atom is generally carried out using for example 3-chloroperoxybenzoic acid in an inert solvent such as dichloromethane at a temperature from -400C to room temperature.

Agriculturally acceptable salts or metal complexes of compounds of formulae (Ia), (Ib) or (Ic) can be prepared using known methods, or by the application of known methods.

The following non-limiting Examples illustrate the preparation of compounds of formula (I) and the Reference Examples illustrate the preparation of intermediates in their synthesis. NMR Spectra are recorded as 6 (ppm) in deuterochloroform as solvent.

Example 1 Hydroxylamine hydrochloride (0.42 g) was added to a stirred solution of 3-cyclopropyl-2 ethoxymethylene-l- (4-pentafluorosulphanyl- phenyl)-propan-1,3-dione (0.97 g) in ethanol.

Anhydrous sodium acetate (0.49 g) was then added and stirring maintained for 1 hour. The solvent was evaporated and the residue distributed between dichloromethane and water. The organic phase was dried (magnesium sulphate) and evaporated, and the residual oil purified by chromatography eluting with ethyl acetate/hexane to give after trituration with hexane 5cyclopropyl-4-(4-pentafluorosulphanylbenzoyl)isoxazole (Compound 1) as a white solid, m.p.57-580C. Further elution gave, after trituration with hexane, 4-cyclopropylcarbonyl 5- (4-pentafluorosulphanylphenyl) isoxazole (Compound 2) as a white solid, m.p.53-550C.

The following compounds were prepared in a similar manner: 5-cyclopropyl-4-(2-methylthio-4pentafluorosulphanylbenzoyl)isoxazole (Compound 5), m.p.80-81 C and 4-cyclopropylcarbonyl-5-(2methylthio-4pentafluorosulphanylphenyl)isoxazole (Compound 110), NMR 0.98 (m,2H), 1.21 (m,2H), 2.0 (m,lH), 2.5 (s,3H), 7.58 (d,lH), 7.68-7.73 (m,2H), 8.8 (s,lH); and 5-cyclopropyl-4-(2-nitro-4pentafluorosulphanylbenzoyl)isoxazole (Compound 4),m.p. 132-1330C.

Example 2 Triethylamine (0.73 g) was added to a stirred solution of 4-cyclopropylcarbonyl-5- (4- pentafluorosulphanylphenyl)isoxazole (Compound 2, 0.4 g) in dichloromethane. After 16 hours the solution was washed (2M hydrochloric acid), dried (magnesium sulphate) and evaporated to dryness. The residue was purified by chromatography eluting with ethyl acetate/hexane to give a residue which was suspended in dichloromethane and shaken with hydrochloric acid until dissolved. The organic phase was evaporated and triturated with hexane to give 2cyano-3-cyclopropyl-1-(4 pentafluorosulphanylphenyl)propan-1, 3-dione as a white solid (Compound 3, m.p.108-1100C.

The following compounds were prepared in a similar manner: 2-cyano-3-cyclopropyl-1-(2-nitro-4- pentafluorosulphanylphenyl) propan-1, 3 -dione (Compound 111), m.p.120-1210C; 2-cyano-3-cyclopropyl-1- (2-methylthio-4- pentafluorosulphanylphenyl) propan-1, 3 -diane (Compound 112), m.p.930C; 2-cyano-3-cyclopropyl-l- (2-methylsulphonyl- 4-pentafluorosulphanylphenyl)propan-1,3-dione (Compound 113), m.p.189-1900C; and 2-cyano-3 -cyclopropyl-1- (2-methylsulphinyl- 4-pentafluorosulphanylphenyl)propan-1,3-dione (Compound 114), m.p.146-1480C.

Ixa=cle 3 3-Chloroperbenzoic acid (0.95g of 70%) was added to a solution of 5-cyclopropyl-4-(2 methylthio-4 -pentafluorosulphanyl - benzoyl)isoxazole (0.6g) in dichloromethane and stirred overnight at 200C, cooled, filtered and the filtrate washed in turn with sodium metabisulphite solution, sodium acetate solution and water. The organic phase was dried (magnesium sulphate), evaporated and the residue washed (hexane) to give 5-cyclopropyl-4-(2methylsulphonyl-4 pentafluorosulphanylbenzoyl)isoxazole (0.37g, Compound 7), m.p.168-170 OC.

By proceeding in a similar manner but employing the appropriate amount of 3chloroperbenzoic acid there was obtained: 5-cyclopropyl-4-(2-methylsulphinyl-4pentafluorosulphanylbenzoyl)isoxazole (0.37g, Compound 6), m.p.174-1750C.

Example 4 By proceeding according to the method of Example 3 there was prepared from 4-cyclopropylcarbonyl-5-(2-methylthio-4pentafluorosulphanylphenyl)isoxazole the following compound: 4-cyclopropylcarbonyl-5-(2-methylsulphonyl- 4-pentafluorosulphanylphenyl)isoxazole (Compound 115), m.p.143-145 C.

Reference SxasDle 1 A mixture of 3-cyclopropyl-1-(4 pentafluorosulphanylphenyl) -propan- 1, 3 -dione (0.82 g) and triethylorthoformate (3.1 g) in acetic anhydride (40 ml) was heated at reflux temperature for 6 hours. The excess reagent and solvent were evaporated to give 3-cyclopropyl-2 ethoxymethylene-l- (4- pentafluorosulphanylphenyl)-propan-1,3-dione (1.0 g) as an orange oil. This was used directly in the subsequent reaction stage.

By proceeding in a similar manner the following compounds were prepared: 3-cyclopropyl-2-ethoxymethylene-l-(2methylthio-4-pentafluorosulphanylphenyl)propan 1,3-dione; and 3-cyclopropyl-2-ethoxymethylene-l- (2-nitro- 4-pentafluorosulphanylphenyl)propan-1,3-dione.

Reference Examnle 2 A solution of t-butyl 3-cyclopropyl-3oxopropionate magnesium enolate (1.43 g, prepared from t-butyl 3-cyclopropyl-3oxopropionate and magnesium turnings in methanol) in toluene was stirred at room temperature. A solution of 4pentafluorosulphanylbenzoyl chloride (1.07 g) in toluene was added. After 2 hours, hydrochloric acid (2 M) was added and the mixture vigorously stirred for 15 minutes. The organic phase was dried by azeotropic removal of solvent.

4-Toluenesulphonic acid (0.1 g) was added and the solution heated at reflux for 3.5 hours.

The cooled solution was washed (water), dried (magnesium sulphate) and evaporated.

Purification of the residue by chromatography, eluting with ethyl acetate/hexane gave 3 cyclopropyl-1- (4- pentafluorosulphanylphenyl)propan-1, 3-dione as a fawn solid (1.0 g), m.p.70-720C.

By proceeding in a similar manner the following compounds were prepared: 3-cyclopropyl-l-(2-methylthio-4 pentafluorosulphanylphenyl)propan-l, 3-dione, NMR 1.02 (m,2H), 1.25 (m,2H), 1.8 (m,lH), 2.52 (s,3H), 6.11 (s,2H), 7.55-7.65 (m,3H); and 3-cyclopropyl-l- (2-nitro-4- pentafluorosulphanylphenyl)propan-1,3-dione, m.p.108-110 C.

Reference Example 3 Oxalyl chloride (1.53 g) was added to a stirred solution of 4-pentafluorosulphanylbenzoic acid (0.99 g) in dichloroethane. A solution of N,N-dimethylformamide in dichloromethane (3 ml of a solution prepared by the addition of 2 drops of N,N-dimethylformamide to 10 ml of dichloromethane) was added. After 15 minutes the solution was heated for a further 15 minutes at 45 0C, and evaporated to dryness to give 4-pentafluorosulphanylbenzoyl chloride as an orange oil (1.07 g). This was used directly in the subsequent reaction stage.

By proceeding in a similar manner the following compounds were prepared: 2 -methylthio-4 -pentafluorosulphanylbenzoyl chloride; and 2-nitro-4-pentafluorosulphanylbenzoyl chloride.

Reference Example 4 A solution of n-butyllithium (9.4 ml of a 1.6 M solution in hexane) was added to a stirred solution of 4-bromophenylsulphur pentafluoride (3.87 g) in ether at -780C under an inert atmosphere. After maintaining at -780C for 1 hour, solid carbon dioxide (20 g) was added and the mixture allowed to warm to 5 C during 1.5 hours. Hydrochloric acid (2 M) was added, the mixture stirred for 0.5 hour and the organic phase separated and itself extracted with sodium carbonate solution. The basic extract was washed (ether) and acidified (hydrochloric acid). The precipitated solid was extracted (ether), dried (magnesium sulphate) and evaporated. The residue was triturated (hexane) to give 4-pentafluorosulphanylbenzoic acid as a fawn solid (1.2 g), m.p.188-1900C.

Reference ExamPle 5 A solution of 4-aminophenylsulphur pentafluoride (4.38 g) in acetonitrile was added dropwise at -20C to 10C during 15 minutes to a stirred mixture of copper (II) bromide (4.46 g) and t-butyl nitrite (5.15 g) in acetonitrile.

Stirring was continued at 0 0C for 15 minutes and then at ambient temperature for 4 hours. The mixture was poured into water, acidified to pH 1 with 2 M hydrochloric acid, and extracted (ether). The extract was washed (water), dried (magnesium sulphate) and evaporated to dryness to give 4-bromophenylsulphur pentafluoride as a dark oil (5.9 g), NMR (CDCl3) 7.66 (s,4H).

By proceeding in a similar manner 4-bromo-3nitrophenylsulphur pentafluoride as an orange oil was prepared, single peak by gas chromatography (Megabore OV1 type column).

Reference Example 6 A mixture of 2-methylthio-4pentafluorosulphanylbenzonitrile (0.47g) and sodium hydroxide (0.2g) in a mixture of water and ethylene glycol (1:5) was heated at reflux for 5 hours. The cooled mixture was diluted (water), acidified (hydrochloric acid) and the solid filtered, washed (water) and dried to give 2 -methylthio-4 -pentafluorosulphanylbenzoic acid (0.38g), m.p.150-1520C.

Reference Example 7 2 -Nitro-4 -pentafluorosulphanylbenzonitrile (6.6g) was added to a mixture of water and sulphuric acid (1:1) and the mixture stirred and heated at reflux for 3.5 hours. The cooled mixture was poured onto ice/water, extracted (ether) and the organic phase then extracted into sodium carbonate solution (2N). The basic extract was washed (ether), acidified (hydrochloric acid) and extracted (ether). The ethereal layer was washed (water), dried (magnesium sulphate) and evaporated to give 2 nitro-4-pentafluorosulphanylbenzoic acid.

(5.97g), m.p.165-1670C.

Reference Example 8 Sodium thiomethoxide (8.97g) was added to a solution of 2-nitro-4pentafluorosulphanylbenzonitrile (11.7g) in acetone and stirred at 200C overnight, then evaporated and purified by column chromatography on silica gel eluting with ethyl acetate/hexane (3:97) to give 2-methylthio-4pentafluorosulphanylbenzonitrile (4.65g), m.p.101-102 C.

Reference Example 9 Copper (I) cyanide (5.05g) was added to a stirred solution of 4-bromo-3-nitrophenylsulphur pentafluoride (18.5g) in N,Ndimethylformamide and heated at 1400C for 4 hours. A mixture of ferric chloride (20.0g),concentrated hydrochloric acid and water was added at 105 C and heating continued for 1.25 hours. The cooled mixture was diluted with water, extracted (ether) and the organic phase washed (water), dried (magnesium sulphate) and evaporated to give 2-nitro-4pentafluorosulphanylbenzonitrile (14.7g), m.p.57-59 C.

Reference Example 10 4-Acetamido-3-nitrophenylsulphur pentafluoride (29.0g) was heated at reflux with hydrochloric acid (6N) and dioxan for 40 minutes and concentrated to low volume, basified with sodium carbonate solution and extracted (ether).

The extract was washed (water), dried (magnesium sulphate) and evaporated to give 4-amino-3nitrophenylsulphur pentafluoride (24.7g), m.p.132-1350C.

Reference Example ii 4-Acetamidophenylsulphur pentafluoride (27.0g) was added during 5 minutes to a stirred mixture of concentrated nitric acid and concentrated sulphuric acid (1 part:2 parts by volume) at 0-50C. After 5 minutes acetic acid (1 part) was added and stirring continued at SOC for 1.5 hours. The mixture was added to ice/water, extracted (ethyl acetate) and the extract washed (sodium carbonate solution), dried (magnesium sulphate) and evaporated. The residue was triturated with ether to give 4acetamido-3-nitrophenylsulphur pentafluoride (30.0g), m.p.135-138 C.

Reference ExamPle 12 Acetic anhydride was added during 5 minutes to a stirred solution of 4-aminophenylsulphur pentafluoride (30.2g) in acetic acid at 400C and then heated at 650C for 0.5 hour. The cooled mixture was added to water, stirred for 1 hour and filtered. The solid was washed with water, sodium bicarbonate solution and water, dried and purified by stirring with hexane to give 4acetamidophenylsulphur pentafluoride (27.0g), m.p.131-1320C.

According to a feature of the present invention, there is provided a method for controlling the growth of weeds (i.e. undesired vegetation) at a locus which comprises applying to the locus a herbicidally effective amount of at least one isoxazole or 2-cyano-1,3-dione derivative of formula (I) or an agriculturally acceptable salt or metal complex thereof. For this purpose, the isoxazole or 2-cyano-1,3-dione derivatives are normally used in the form of herbicidal compositions (i.e. in association with compatible diluents or carriers and/or surface active agents suitable for use in herbicidal compositions), for example as hereinafter described.

The compounds of formula (I) show herbicidal activity against dicotyledonous (i.e. broadleafed) and monocotyledonous (i.e. grass) weeds by pre- and/or post-emergence application.

By the term "pre-emergence application" is meant application to the soil in which the weed seeds or seedlings are present before emergence of the weeds above the surface of the soil. By the term "post-emergence application" is meant application to the aerial or exposed portions of the weeds which have emerged above the surface of the soil.

For example, the compounds of formula (I) may be used to control the growth of: broad-leafed weeds, for example, Abutilon theophrasti, Amaranthus retroflexus, Bidens tilosa, Chenopodium album, Galium aparine, Ipomoea son. e.g. Ipomoea purpurea, Sesbania exaltata, Sinapis arvensis, Solanum niqrum and Xanthium strumarium, and grass weeds, for example Alopecurus myosuroides, Avena fatua, Diqitaria sansuinalis, Echinochloa crus-qalli, Sorghum bicolor, Eleusine indica and Setaria son, e.g. Setaria faberii or Setaria viridis, and sedges, for example, Cyperus esculentus.

The amounts of compounds of formula (I) applied vary with the nature of the weeds, the compositions used, the time of application, the climatic and edaphic conditions and (when used to control the growth of weeds in crop-growing areas) the nature of the crops. When applied to a crop-growing area, the rate of application should be sufficient to control the growth of weeds without causing substantial permanent damage to the crop. In general, taking these factors into account, application rates between 0.01kg and 5kg of active material per hectare give good results. However, it is to be understood that higher or lower application rates may be used, depending upon the particular problem of weed control encountered.

The compounds of formula (I) may be used to control selectively the growth of weeds, for example to control the growth of those species hereinbefore mentioned, by pre- or postemergence application in a directional or nondirectional fashion, e.g. by directional or nondirectional spraying, to a locus of weed infestation which is an area used, or to be used, for growing crops, for example cereals, e.g. wheat, barley, oats, maize and rice, soya beans, field and dwarf beans, peas, lucerne, cotton, peanuts, flax, onions, carrots, cabbage, oilseed rape, sunflower, sugar beet, and permanent or sown grassland before or after sowing of the crop or before or after emergence of the crop. For the selective control of weeds at a locus of weed infestation which is an area used, or to be used, for growing of crops, e.g.

the crops hereinbefore mentioned, application rates between 0.01kg and 4.0kg, and preferably between 0.01kg and 1.0keg, more preferably from 0.01kg to 0.5kg of active material per hectare are particularly suitable.

The compounds of formula (I) may also be used to control the growth of weeds, especially those indicated above, by pre- or post-emergence application in established orchards and other tree-growing areas, for example forests, woods and parks, and plantations, e.g. sugar cane, oil palm and rubber plantations. For this purpose they may be applied in a directional or nondirectional fashion (e.g. by directional or nondirectional spraying) to the weeds or to the soil in which they are expected to appear, before or after planting of the trees or plantations at application rates between 0.25kg and 5.0kg, and preferably between 0.5kg and 4.0kg of active material per hectare.

The compounds of formula (I) may also be used to control the growth of weeds, especially those indicated above, at loci which are not crop-growing areas but in which the control of weeds is nevertheless desirable.

Examples of such non-crop-growing areas include airfields, industrial sites, railways, roadside verges, the v

Pre- or post-emergence application, and preferably pre-emergence application, in a directional or non-directional fashion (e.g. by directional or non-directional spraying) at application rates between 1.0keg and 20.0kg, and preferably between 5.0 and 10.0kg, of active material per hectare are particularly suitable for this purpose.

When used to control the growth of weeds by pre-emergence application, the compounds of formula (I) may be incorporated into the soil in which the weeds are expected to emerge. It will be appreciated that when the compounds of formula (I) are used to control the growth of weeds by post-emergence application, i.e. by application to the aerial or exposed portions of emerged weeds, the compounds of formula (I) will also normally come into contact with the soil and may also then exercise a pre-emergence control on later-germinating weeds in the soil.

Where especially prolonged weed control is required, the application of the compounds of formula (I) may be repeated if required.

According to a further feature of the present invention, there are provided herbicidal compositions comprising one or more of the isoxazole or 2-cyano-l,3-dione derivatives of formula (I) or agriculturally acceptable salts or metal complexes thereof, in association with, and preferably homogeneously dispersed in, one or more compatible agriculturally- acceptable diluents or carriers and/or surface active agents [i.e. diluents or carriers and/or surface active agents of the type generally accepted in the art as being suitable for use in herbicidal compositions and which are compatible with compounds of formula (I)]. The term "homogeneously dispersed" is used to include compositions in which the compounds of formula (I) are dissolved in other components. The term "herbicidal compositions" is used in a broad sense to include not only compositions which are ready for use as herbicides but also concentrates which must be diluted before use.

Preferably, the compositions contain from 0.05 to 90% by weight of one or more compounds of formula (I) The herbicidal compositions may contain both a diluent or carrier and surface-active (e.g.

wetting, dispersing, or emulsifying) agent.

Surface-active agents which may be present in herbicidal compositions of the present invention may be of the ionic or non-ionic types, for example sulphoricinoleates, quaternary ammonium derivatives, products based on condensates of ethylene oxide with alkyl and polyaryl phenols, e.g. nonyl- or octyl-phenols, or carboxylic acid esters of anhydrosorbitols which have been rendered soluble by etherification of the free hydroxy groups by condensation with ethylene oxide, alkali and alkaline earth metal salts of sulphuric acid esters and sulphonic acids such as dinonyl- and dioctyl-sodium sulphonosuccinates and alkali and alkaline earth metal salts of high molecular weight sulphonic acid derivatives such as sodium and calcium lignosulphonates and sodium and calcium alkylbenzene sulphonates.

Suitably, the herbicidal compositions according to the present invention may comprise up to 10% by weight, e.g. from 0.05% to 10% by weight, of surface-active agent but, if desired, herbicidal compositions according to the present invention may comprise higher proportions of surface-active agent, for example up to 15% by weight in liquid emulsifiable suspension concentrates and up to 25 by weight in liquid water soluble concentrates.

Examples of suitable solid diluents or carriers are aluminium silicate, talc, calcined magnesia, kieselguhr, tricalcium phosphate, powdered cork, absorbent carbon black and clays such as kaolin and bentonite. The solid compositions (which may take the form of dusts, granules or wettable powders) are preferably prepared by grinding the compounds of formula (I) with solid diluents or by impregnating the solid diluents or carriers with solutions of the compounds of formula (I) in volatile solvents, evaporating the solvents and, if necessary, grinding the products so as to obtain powders.

Granular formulations may be prepared by absorbing the compounds of formula (I) (dissolved in suitable solvents, which may, if desired, be volatile) onto the solid diluents or carriers in granular form and, if desired, evaporating the solvents, or by granulating compositions in powder form obtained as described above. Solid herbicidal compositions, particularly wettable powders and granules, may contain wetting or dispersing agents (for example of the types described above), which may also, when solid, serve as diluents or carriers.

Liquid compositions according to the invention may take the form of aqueous, organic or aqueous-organic solutions, suspensions and emulsions which may incorporate a surface-active agent. Suitable liquid diluents for incorporation in the liquid compositions include water, glycols, tetrahydrofurfuryl alcohol, acetophenone, cyclohexanone, isophorone, toluene, xylene, mineral, animal and vegetable oils and light aromatic and naphthenic fractions of petroleum (and mixtures of these diluents) Surface-active agents, which may be present in the liquid compositions, may be ionic or nonionic (for example of the types described above) and may, when liquid, also serve as diluents or carriers.

Powders, dispersible granules and liquid compositions in the form of concentrates may be diluted with water or other suitable diluents, for example mineral or vegetable oils, particularly in the case of liquid concentrates in which the diluent or carrier is an oil, to give compositions ready for use.

When desired, liquid compositions of the compound of formula (I) may be used in the form of self-emulsifying concentrates containing the active substances dissolved in the emulsifying agents or in solvents containing emulsifying agents compatible with the active substances, the simple addition of water to such concentrates producing compositions ready for use.

Liquid concentrates in which the diluent or carrier is an oil may be used without further dilution using the electrostatic spray technique.

Herbicidal compositions according to the present invention may also contain, if desired, conventional adjuvants such as adhesives, protective colloids, thickeners, penetrating agents, stabilisers, sequestering agents, anticaking agents, colouring agents and corrosion inhibitors. These adjuvants may also serve as carriers or diluents.

Unless otherwise specified, the following percentages are by weight. Preferred herbicidal compositions according to the present invention are: aqueous suspension concentrates which comprise from 10 to 70% of one or more compounds of formula (I), from 2 to 10% of surface-active agent, from 0.1 to 5% of thickener and from 15 to 87.9% of water; wettable powders which comprise from 10 to 90% of one or more compounds of formula (I), from 2 to 10% of surface-active agent and from 8 to 88% of solid diluent or carrier; water dispersible granules which comprise from 1 to 75%, e.g. 50 to 75%, of one or more compounds of formula (I), from 2 to 10% of surface-active agent and from 1 to 20%, e.g. 515%, of water soluble binder.

liquid emulsifiable suspension concentrates which comprise from 10 to 70% of one or more compounds of formula (I), from 5 to 15% of surface-active agent, from 0.1 to 5% of thickener and from 10 to 84.9% of organic solvent; granules which comprise from 1 to 90%, e.g.

2 to 10% of one or more compounds of formula (I), from 0.5 to 7%, e.g. 0.5 to 2%, of surfaceactive agent and from 3 to 98.5%, e.g. 88 to 97.5%, of granular carrier and emulsifiable concentrates which comprise 0.05 to 90%, and preferably from 1 to 60% of one or more compounds of formula (I), from 0.01 to 10%, and preferably from 1 to 10%, of surfaceactive agent and from 9.99 to 99.94%, and preferably from 39 to 98.99%, of organic solvent.

Herbicidal compositions according to the present invention may also comprise the compounds of formula (I) in association with, and preferably homogeneously dispersed in, one or more other pesticidally active cbmpounds and, if desired, one or more compatible pesticidally acceptable diluents or carriers, surface-active agents and conventional adjuvants as hereinbefore described. Examples of other pesticidally active compounds which may be included in, or used in conjunction with, the herbicidal compositions of the present invention include herbicides, for example to increase the range of weed species controlled for example alachlor [2-chloro-2,6'-diethyl-N-(methoxymethyl)-acetanilide], atrazine [2-chloro-4 ethylamino-6-isopropylamino-1,3,5-triazine], bromoxynil [3,5-dibromo-4-hydroxybenzonitrile], chlortoluron [N'-(3-chloro-4-methylphenyl)-N,Ndimethylurea], cyanazine [2-chloro-4-(l-cyano-1- methylethylamino)-6-ethylamino-1,3,5-triazine], 2,4-D [2,4-dichlorophenoxy-acetic acid], dicamba [3,6-dichloro-2-methoxybenzoic acid], acetochlor, difenzoquat [1,2- dimethyl-3,5diphenyl-pyrazolium salts], flampropmethyl [methyl N-2-(N- benzoyl-3-chloro-4 fluoroanilino) -propionate], fluometuron [N'-(3trifluoro- methylphenyl) -N,N-dimethylurea], isoproturon [N'-(4-isopropylphenyl)-N,Ndimethylurea], insecticides, e.g. synthetic pyrethroids, e.g. permethrin and cypermethrin, and fungicides, e.g. carbamates, e.g. methyl N (1-butyl-carbamoyl- benzimidazol-2-yl)carbamate, and triazoles e.g. 1- (4-chloro-phenoxy) -3,3- dimethyl-l- (l,2,4-triazol-l-yl) -butan-2-one.

Pesticidally active compounds and other biologically active materials which may be included in, or used in conjunction with, the herbicidal compositions of the present invention, for example those hereinbefore mentioned, and which are acids, may, if desired, be utilized in the form of conventional derivatives, for example alkali metal and amine salts and esters.

According to a further feature of the present invention there is provided an article of manufacture comprising at least one of the isoxazole or 2-cyano-1,3-dione derivatives of formula (I) or, as is preferred, a herbicidal composition as hereinbefore described, and preferably a herbicidal concentrate which must be diluted before use, comprising at least one of the isoxazole or 2-cyano-1,3-dione derivatives of formula (I) within a container for the aforesaid derivative or derivatives of formula (I), or a said herbicidal composition, and instructions physically associated with the aforesaid container setting out the manner in which the aforesaid derivative or derivatives of formula (I) or herbicidal composition contained therein is to be used to control the growth of weeds. The containers will normally be of the types conventionally used for the storage of chemical substances which are solid at normal ambient temperatures and herbicidal compositions particularly in the form of concentrates, for example cans and drums of metal, which may be internally lacquered, and plastics materials, bottles or glass and plastics materials and, when the contents of the container is a solid, for example granular, herbicidal compositions, boxes, for example of cardboard, plastics materials and metal, or sacks. The containers will normally be of sufficient capacity to contain amounts of the derivatives of formnula (I) or herbicidal compositions sufficient to treat at least one acre of ground to control the growth of weeds therein but will not exceed a size which is convenient for conventional methods of handling. The instructions will be physically associated with the container, for example by being printed directly thereon or on a label or tag affixed thereto. The directions will normally indicate that the contents of the container, after dilution if necessary, are to be applied to control the growth of weeds at rates of application between 0.01kg and 20kg of active material per hectare in the manner and for the purposes hereinbefore described.

The following Examples illustrate herbicidal compositions according to the present invention.

The following are trade marks: Arylan; Synperonic; Arkopon; Sopropon; Tixosil; Soprophor; Ethylan; Attagel; Rhodorsil.

Example C1: An emulsifiable concentrate is formed from: Active ingredient (Compound 1) 20% w/v N-Methylpyrrolidone (NMP) 25% w/v Calcium dodecylbenzenesulphonate 70% w/v (CaDDBS) (Arylan CA) 4% w/v Nonylphenol ethylene oxide propylene oxide condensate (NPEOPO) (Synperonic NPE 1800) 6% w/v Aromatic solvent (Solvesso) to 100 volumes by stirring NMP, active ingredient (Compound 1), CaDDBS, NPEOPO and 90% Aromatic solvent until a clear solution is formed, and adjusting to volume with Aromatic solvent.

Similar emulsifiable concentrates may be prepared by replacing Compound 1 with other compounds of formula (Ia), (Ib) or (Ic).

Example C2 A wettable powder is formed from: Active ingredient (Compound 1) 50% w/w Sodium dodecylbenzenesulphonate (Arylan SX85) 3% w/w Sodium methyl oleoyl taurate (Arkopon T) 5% w/w Sodium polycarboxylate Sopropon T36) 1% w/w Microfine silicon dioxide (Tixosil 38) 3% w/w China clay 38% w/w by blending the above ingredients together and grinding the mixture in an air jet mill.

Similar wettable powders may be prepared by replacing Compound 1 with other compounds of formula (Ia), (Ib) or (Ic).

Example C3 A suspension concentrate is formed from: Active ingredient (Compound 1) 50% w/v Antifreeze (Propylene glycol) 5% w/v Ethoxylated tristyrylphenol phosphate(Soprophor FL) 0.5% w/v Nonyl phenol 9 mole ethoxylate (Ethylan BCP) 0.5% w/v Sodium polycarboxylate (Sopropon T36) 0.2% w/v Attaclay (Attagel) 1.5% w/v Antifoam (Rhodorsil AF426R) 0.003% w/v Water to 100 volumes by stirring the above ingredients together and milling in a bead mill.

Similar suspension concentrates may be prepared by replacing Compound 1 with other compounds of formula (Ia), (Ib) or (Ic).

Example C4 A water dispersible granule is formed from: Active ingredient (Compound 1) 50% w/w Sodium dodecylbenzenesulphonate (Arylan SX 85) 3% w/w Sodium methyl oleoyl taurate (Arkopon T) 5% w/w Sodium polycarboxylate Sopropon T36) 1% w/w Binder (Sodium lignosulphonate) 8% w/w China clay 30% w/w Microfine silicon dioxide Tixosil 38) 3% w/w by blending the above ingredients together, grinding the mixture in an air jet mill and granulating by addition of water in a suitable granulation plant (e.g. Fluid bed drier) and drying. Optionally the active ingredient may be ground either on its own or admixed with some or all of the other ingredients.

Similar water dispersible granules may be prepared by replacing Compound 1 with other compounds of formula (Ia), (Ib) or (Ic).

The compounds of the invention have been used in herbicidal applications according to the following procedures.

METHOD OF USE OF HERBICIDAL COMPOUNDS: a) General Appropriate quantities of the compounds used to treat the plants were dissolved in acetone to give solutions equivalent to application rates of up to 1000g test compound per hectare (g/ha).

These solutions were applied from a standard laboratory herbicide sprayer delivering the equivalent of 290 litres of spray fluid per hectare.

b) Weed control : Pre-emersence The seeds were sown in 70 mm square, 75 mm deep plastic pots in non-sterile soil . The quantities of seed per pot were as follows: Weed species Approx number of seeds/pot 1) Broad-leafed weeds Abutilon theophrasti 10 Amaranthus retroflexus 20 Galium aparine 10 Ipomoea purpurea 10 Sinapis arvensis 15 Xanthium strumarium 2 2) Grass weeds Alopecurus myosuroides 15 Avena fatua 10 Echinochloa crus-galli 15 Setaria viridis 20 3) Sedges Cyperus esculentus 3 Crop 1) Broad-leafed Cotton 3 Soya 3 2) Grass Maize 2 Rice 6 Wheat 6 The compounds of the invention were applied to the soil surface, containing the seeds, as described in (a). A single pot of each crop and each weed was allocated to each treatment, with unsprayed controls and controls sprayed with acetone alone.

After treatment the pots were placed on capillary matting kept in a glass house, and watered overhead. Visual assessment of crop damage was made 20-24 days after spraying. The results were expressed as the percentage reduction in growth or damage to the crop or weeds, in comparison with the plants in the control pots.

c) Weed control : Post-emergence The weeds and crops were sown directly into John Innes potting compost in 75 mm deep, 70 mm square pots except for Amaranthus which was pricked out at the seedling stage and transferred to the pots one week before spraying. The plants were then grown in the greenhouse until ready for spraying with the compounds used to treat the plants. The number of plants per pot were as follows : 1) Broad leafed weeds Weed species No.of plants ser Dot Growth stave Abutilon theophrasti 3 1-2 leaves Amaranthus retroflexus 4 1-2 leaves Galium aparine 3 1St whorl Ipomoea purpurea 3 1-2 leaves Sinapis arvensis 4 2 leaves Xanthium strumarium 1 2-3 leaves 2) Grass weeds Weed species No. of plants per Dot Growth stage Alopecurus myosuroides 8-12 1-2 leaves Avena fatua 12-18 1-2 leaves Echinochloa crus-galli 4 2-3 leaves Setaria viridis 15-25 1-2 leaves.

3) Sedges Weed species No. of plants per pot Growth stage Cyperus esculentus 3 3 leaves.

1) Broad leafed Cross No. of plants Der Dot Growth stage Cotton 2 1 leaf Soya 2 2 leaves.

2) Grass CroDs No.of plants per Dot Growth stage Maize 2 2-3 leaves Rice 4 2-3 leaves Wheat 5 2-3 leaves.

The compounds used to treat the plants were applied to the plants as described in (a). A single pot of each crop and weed species was allocated to each treatment, with unsprayed controls and controls sprayed with acetone alone.

After treatment the pots were placed on capillary matting in a glass house, and watered overhead once after 24 hours and then by controlled sub-irrigation. Visual assessment of crop damage and weed control was made 20-24 days after spraying. The results were expressed as the percentage reduction in growth or damage to the crop or weeds, in comparison with the plants in the control pots.

When applied post-emergence at 1000g/ha or less compounds 1-7 and 110-115 gave at least 90 reduction in growth of one or more of the weed species.

When applied pre-emergence at 1000g/ha or less compounds 1-7 and 110-115 gave at least 70% reduction in growth of one or more of the weed species.

At levels of application toxic to the weeds these compounds were selective in at least one of the crop species.

Claims (20)

1. A compound of formula (Ia), (Ib) or (Ic)

wherein: R represents hydrogen or -Co2R3; R1 represents: a straight- or branched- chain alkyl group containing up to six carbon atoms which is optionally substituted by one or more halogen atoms; or a cycloalkyl group containing from three to six ring carbon atoms optionally substituted by one or more groups selected from R4 and halogen; R2 represents: halogen; a straight- or branched- chain alkyl group containing up to six carbon atoms which is substituted by one or more groups -OR5; a cycloalkyl group containing from three to six carbon atoms; or a group selected from nitro, cyano, -Co2R5, -NR5R6, -S(O)pR71 -O(CH2) mOR5, COR5, -N(R8)So2R7, -OR7, -OH, -oso2R7, - (CR9R10) tSOqR7at -CONR5R6, -N(R8)-C(Z)=Y, -(CR9R10)NR8Rll and R4; n represents zero or an integer from one to three; where n is greater than one the groups R2 may be the same or different; m represents one, two or three; p represents zero, one or two; q represents zero, one or two; t represents an integer from one to four; R3 represents a straight- or branched- chain alkyl group containing up to six carbon atoms optionally substituted by one or more groups selected from halogen, -OR5, -Co2R5, -S(o)pR7, phenyl or cyano; or phenyl optionally substituted by one or more groups selected from halogen, -OR5 and R4; R4 represents a straight- or branched- chain alkyl, alkenyl or alkynyl group containing up to six carbon atoms optionally substituted by one or more halogen atoms; R5 and R6 which may be the same or different, each represents hydrogen or R4; R7 and R7a independently represent R4 or a cycloalkyl group containing from three to six ring carbon atoms; or a group -(CH2)w-[phenyl optionally substituted by from one to five groups R12 which may be the same or different]; w represents zero or one; R8 represents: hydrogen; a straight- or branched- chain alkyl, alkenyl or alkynyl group containing up to ten carbon atoms optionally substituted by one or more halogen atoms; a cycloalkyl group containing from three to six ring carbon atoms; -(CH2)w-[phenyl optionally substituted by from one to five groups R12 which may be the same or different]; or a group -OR13; R9 and R10 independently represent hydrogen or a straight- or branched- chain alkyl group containing up to six carbon atoms optionally substituted by one or more halogen atoms; Rll represents -S(O)qR7 or -C(Z)=Y; R12 represents: a halogen atom; a straight- or branched- chain alkyl group containing up to three carbon atoms optionally substituted by one or more halogen atoms; or a group selected from nitro, cyano, -S(o)pR3 and -OR5; Y represents oxygen or sulphur; Z represents R4, -NR8R13, -NR8-NR13R14, -SR7 or -OR7; R13 and R14 independently represent R8; where the compound is of formula (Ic), optionally an enolic tautomeric form thereof; or an agriculturally acceptable salt or metal complex thereof.

2. A compound according to claim 1 of formula (Ia).

3. A compound according to claim 1 or 2 in which the 2-position of the phenyl group is substituted.

4. A compound according to claim 1, 2 or 3 in which the 5- and 6- positions of the phenyl group are unsubstituted.

5. A compound according to any one of the preceding claims in which R1 represents: a straight- or branched- chain alkyl group containing up to three carbon atoms which is optionally substituted by one or more halogen atoms; or cyclopropyl or 1-methylcyclopropyl, most preferably cyclopropyl.

6. A compound according to any one of the preceding claims in which R2 represents: halogen; a straight- or branched- chain alkyl or alkenyl group containing up to four carbon atoms optionally substituted by one or more halogen atoms; or a group selected from nitro, cyano, -S(o)pR7, -OR7 and -CR9R10SOqR7.

7. A compound according to any one of the preceding claims in which n represents zero, one or two.

8. A compound according to any one of the preceding claims in which R3 represents a straight- or branched- chain alkyl group containing up to six carbon atoms optionally substituted by one or more halogen atoms.

9. A compound according to claim 1 of formula (Ia) having one or more of the following properties: R represents hydrogen or -Co2R3; R1 represents cyclopropyl or 1 methylcyclopropyl; R2 represents: halogen; a straight- or branched- chain alkyl group containing up to three carbon atoms optionally substituted by one or more halogen atoms; -S(O)pR7 group; -CH2S (O) qR7a; n represents zero, one or two; R3 represents a straight- or branched- chain alkyl group containing from one to three carbon atoms; R7 represents methyl or ethyl optionally substituted by one or more halogen atoms; R7a represents a straight- or branchedchain alkyl group containing up to four carbon atoms optionally substituted by one or more halogen atoms,or phenyl optionally substituted by one or more halogen atoms or -S(O)pR7.

10. A compound according to claim 1 of formula (Ia) wherein: R represents hydrogen or -Co2R3; R1 represents cyclopropyl; R2 represents: halogen; methyl optionally substituted by from one to three halogen atoms (preferably fluorine); nitro; or -S(O)pCH3; n represents zerar one or two; and R3 represents methyl or ethyl.

11. A compound according to claim 1 of formula (Ia) wherein: R represents hydrogen; R1 represents cyclopropyl; R2 represents: methyl optionally substituted by from one to three halogen atoms (preferably fluorine); nitro; or -S(O)pCH3; and n represents zero, one or two.

12. A composition comprising one or more compounds of formula (Ia), (Ib) or (Ic) as defined in any one of claims 1 to 11 or an agriculturally acceptable salt or metal complex thereof in association with one or more compatible agriculturally- acceptable diluents or carriers and/or surface active agents.

13. A method for controlling the growth of weeds at a locus which comprises applying to the locus a herbicidally effective amount of at least one compound of formula (Ia), (Ib) or (Ic) as defined in any one of claims 1 to 11 or an agriculturally acceptable salt or metal complex thereof, or a composition as defined in claim 12.

14. A process for the preparation of a compound of formula (Ia), (Ib) or (Ic) as defined in claim 1, said process comprising: (a) where the compound is of formula (Ia) or (it , the reaction of a compound of formula (Il)

wherein L is a leaving group and R1, R2 and n are as defined in claim 1, with hydroxylamine or a salt of hydroxylamine; (b) where the compound is of formula (Ia) in which R represents hydrogen and R1, R2 and n are as defined in claim 1, the reaction of a compound of formula (III):

wherein R1 is as defined in claim 1 and Y' represents a carboxy group or a reactive derivative thereof or a cyano group, with an appropriate organometallic reagent; (c) where the compound is of formula (Ia) wherein R represents a group -Co2R3 and R1, R2 and n are as defined in claim 1, the reaction of a compound of formula (IV):

wherein R1, R2 and n are as defined in claim 1 and pl is a leaving group, with a compound of formula R302CC(Z1)=NOH wherein R3 is as defined in claim 1 and Z1 is a halogen atom; (d) where the compound is of formula (Ia) in which R represents a group -Co2R3 and R1, R2 and n are as defined in claim 1, the reaction of a compound of formula (V):

wherein R11 R2 and n are as defined in claim 1, with a compound of formula R302CC(Z1)=NOH wherein Z1 is as defined above and R3 is as defined in claim 1; (e) where the compound is of formula (Ia) or (Ib) wherein R represents -Co2R3 and R1, R2 and n are as defined in claim 1, the reaction of a salt of a compound of formula (VI):

wherein R1, R2 and n are as defined in claim 1 with a compound of formula R302CC(Z1)=NOH wherein R3 is as defined in claim 1 and Z1 is as defined above; (f) where the compound of formula (Ib) in which R, R1, R2 and n are as defined in claim 1, the metallation of a compound of general formula (VII):

wherein R, R1, R2 and n are as defined in claim 1 and A is a halogen atom, followed by reaction of the compound thus obtained with an acid chloride of general formula R1COCl in which R1 is as defined in claim 1; (g) where the compound is of formula (Ib) in which R, R1, R2 and n are as defined in claim 1, the oxidation of a compound of formula (VIII)

wherein R, R1, R2 and n are as defined in claim 1, to convert the hydroxy group to a ketone group; (h) where the compound is of formula (Ib) in which R represents hydrogen and R1, R2 and n are as defined in claim 1, the reaction of a compound of formula (IX):

in which R2 and n are as defined in claim 1 D represents a carboxy group, or a reactive derivative thereof or a cyano group, with an appropriate organometallic reagent; (i) where the compound is of formula (Ib) in which R represents a -Co2R3 group and R1, R2 and n are as defined in claim 1, the reaction of a compound of formula (X):

wherein R1, R2 and n are as defined in claim 1 and pl is as defined above, with a compound of formula R302CC(Z1)=NOH wherein Z1 is as defined above and R3 is as defined in claim 1; (j) where the compound is of formula (Ib) in which R represents a group -C02R3 and R1, R2 and n are as defined in claim 1, the reaction of a compound of formula (XI):

wherein R1, R2 and n are as defined in claim 1, with a compound of formula R302CC(Z1)=NoH wherein Z1 and R3 are as defined above; (k) where the compound is of formula (Ic), the hydrolytic reaction of the corresponding compound of formula (Ia) or (Ib) in which R is as defined in claim 1 or is replaced by an amide or nitrile; (1) where the compound is of formula (Ic) in which R1, R2 and n are as defined in claim 1, the reaction of a benzoyl chloride of formula (XII):

wherein R2 and n are as defined in claim 1, with a beta-ketonitrile of formula (XIII):

wherein R1 is as defined in claim 1; (m) where the compound is of formula (Ic) in which R1, R2 and n are as defined in claim 1, the reaction of an acid chloride of formula R1COCl wherein R1 is as defined in claim 1, with a beta-ketonitrile of formula (XIV):

wherein R2 and n are as defined in claim 1; (n) where the compound is of formula (Ic) in which R1, R2 and n are as defined in claim 1, the reaction of a benzoyl chloride of formula (XII) as defined above with a beta-ketonitrile of formula (XIII) as defined above, via an intermediate of formula (XV):

wherein R1, R2 and n are as defined in claim 1; (o) where the compound is of formula (Ic) in which R11 R2 and n are as defined in claim 1, the reaction of an acid chloride of formula R1COCl wherein R1 is as defined in claim 1 with a beta-ketonitrile of formula (XIV) as defined above via an intermediate of formula (XVI):

wherein R1, R2 and n are as defined in claim 1; or (p) where p or q is one or two, the oxidation of the sulphur atom of the corresponding compound of formula (Ia), (Ib) or (Ic) in which p or q is zero or one; optionally followed by the conversion of the compound of formula (Ia), (Ib) or (Ic) thus obtained into an agriculturally acceptable salt or metal complex thereof.

15. A compound of formula. (Il), (IV), (V) , (VI) , (VII) , (VIII) , (IX) , (X) , (XI) (XII), (XIV) , (XV) or (XVI) as defined in claim 14; or a compound of formula (Ia) or (Ib) in which R11 R2 and n are as defined in claim 1 and R is replaced by an amide or nitrile.

16. A compound of formula (XXI):

which R2 and n are as defined in claim 1 and R15 is a lower alkyl group.

17. A compound of formula (XXIII):

in which R2 and n are as defined in claim 1 with the provided that when n is zero the -SF5 group is not meta or para to carboxy.

18. A compound according to claim 1 substantially as hereinbefore described.

19. A composition according to claim 12 substantially as hereinbefore described.

20. A method according to claim 13 substantially as hereinbefore described.