GB2311009A - Pharmaceutical compositions containing extracts of Tagetes (Marigolds) - Google Patents
Pharmaceutical compositions containing extracts of Tagetes (Marigolds) Download PDFInfo
- Publication number
- GB2311009A GB2311009A GB9604736A GB9604736A GB2311009A GB 2311009 A GB2311009 A GB 2311009A GB 9604736 A GB9604736 A GB 9604736A GB 9604736 A GB9604736 A GB 9604736A GB 2311009 A GB2311009 A GB 2311009A
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- leaf
- extract
- pharmaceutical
- preparation according
- pharmaceutical preparation
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
Abstract
Pharmaceutical base preparations comprise extracts of Asteraceae Tagetes , erecta (African Marigold), patula (French Marigold) or signata (Dwarf Marigold) or minuta . Preferably the compositions also contain extracts of any or a combination of the following: Bennis perennis , Hypericum perforatum , Symphytum officinalis , Thuja occidentalis , Thuja plicata , Ruta graveolens , Rosmarinus officinalis or Calendula arvensis . The preparations are particularly intended for the treatment of fungal infections of the nails, skin lesions, or disorders of the bones or joints.
Description
A PHARMACEUTICAL PREPARATION
This invention relates to a pharmaceutical base preparation, and to pharmaceutical preparations containing the base preparation. The pharmaceutical preparations are useful in the treatment of lesions of the skin, bones, joints and nails including, for example, hyperkeratosis, dry eczema, psoriasis, inflammatory conditions and viral and fungal infections.
There are numerous topical medicaments and treatments available to practitioners for the treatment of lesions of the skin, bones, joints and nails. There are disadvantages in that some medicaments and treatments are not painless, are invasive and may be palliative or short-term in effect. There may also be painful complications.
In addition, some treatments are inappropriate for patients with certain systemic diseases and for patients 'at risk'.
it is an aim of the present invention to provide pharmaceutical preparations useful in the treatment of lesions of the skin, bones, joints and nails, which pharmaceutical preparations are painless, non invasive and effective in the longer term.
In accordance with a first aspect of the present invention, there is provided a pharmaceutical base preparation comprising flavonoids or glycosides of Asteraceae, the
Asteraceae being Tagetes erect a orange, yellow or lemon-yellow, Tagetes minuta, Tagetes patula and Tagetes signata.
Preferably, the pharmaceutical base preparation is one in which the proportion of each individual component is 20%.
Preferably, the pharmaceutical base preparation is one in which the ingredients are fresh whole plant material. Preferably, the fresh plant material will be minced fresh plant material.
The pharmaceutical base preparation may include as a solvent 85% strength isopropyl alcohol. The pharmaceutical base preparation may be one in which the proportion of isopropyl alcohol is 20%.
In accordance with a second aspect of the present invention there is provided a pharmaceutical preparation for use in the treatment of skin lesions, which pharmaceutical preparation comprises the pharmaceutical base preparation, caretenoids of Compositae and Hypericeae, and terpenoids of Cupressaceae.
In the second aspect of the invention, the pharmaceutical preparation may be one in which the Compositae is Bellis perennis flowerhead or leaf, in which the
Hypericeae is Hypericum perforatum flowerhead or leaf, and in which the Cupressaceae is
Thuja occidentalis leaf.
The pharmaceutical preparation may include at least one of isopropyl alcohol, soft white paraffin, arachis oil, aqueous cream and aqueous gel.
Preferably, the pharmaceutical preparation is one in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
In accordance with a third aspect of the invention, there is provided a pharmaceutical preparation for use in the treatment of bone and joint disorders, which pharmaceutical preparation comprises the pharmaceutical base preparation, alkaloids of
Boraginaceae and Rutaceae, and terpenoids of Labiatae.
In the third aspect of the invention, the pharmaceutical preparation may be one in which the Boraginaceae is Symphytum officinalis flowerhead or leaf, in which the
Rutaceae is Ruta graveolens flowerhead or leaf, and in which the Labiatae is Rosemary officinalis leaf.
The pharmaceutical preparation may include at least one of isopropyl alcohol, arachis oil and aqueous cream.
Preferably, the pharmaceutical preparation is one in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
In accordance with a fourth aspect of the present invention, there is provided a pharmacentical preparation for use in the treatment of fungal infections of nails, which pharmaceutical preparation comprises the pharmaceutical base preparation, terpenoids of
Cupressaceae, and terpenoids or carotenoids of Compositae.
In the fourth aspect of the invention, the pharmaceutical preparation may be one in which the Cupressaceae are Thuja occidentalis leaf and Thuja plicata leaf, and in which the Compositae is Calendula arvensis flowerhead or leaf.
The pharmaceutical preparation may include at least one of isopropyl alcohol, arachis oil and aqueous cream.
Preferably, the pharmaceutical preparation is one in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
The pharmaceutical preparations may have a keralytic, surface analgesic, antipsoriatic, anti-eczematic, anti-viral, anti-inflammatory and anti-fungal effect and may be used to treat hyperkeratotic lesions, dry eczema, psoriasis, inflammation of the skin, bones and joints, viral infections of the skin and fungal infections of the nails.
The pharmaceutical preparations may be such that the percentage weight or volume of each component in a preparation is from 3% to 10% depending on the form of the preparation.
The pharmaceutical preparations may include:
a) 3% of extract of minced fresh or powdered dried Tagetes erecta orange,
yellow or lemon-yellow whole plant; (b) 3% of extract of minced fresh or powdered dried Tagetes minuta whole
plant;
(c) 3% of extract of minced fresh or powdered dried Tagetes patula whole plant;
(d) 3% of extract of minced fresh or powdered dried Tagetes signata whole plant;
(e) 3% to 5% of extract of minced fresh or powdered dried Bellis perennis
flowerhead or leaf; (f) 3% to 5% of extract of minced fresh or powdered dried Hypericum perforatum
flowerhead or leaf; (g) 3% to 5% of extract of minced fresh or powdered dried Symphytum officinalis
flowerhead or leaf; (h) 3% to 6% of extract of minced fresh or powdered dried Thuja occidentalis leaf; (i) 5% to 10% of extract of minced fresh or powdered dried Ruta graveolens
flowerhead or leaf; (j) 5% of extract of minced fresh or powdered dried Rosmarinus offidnalis leaf; (k) 3% to 5% of extract of minced fresh or powdered dried Calendula arvensis
flowerhead or leaf; (1) 6% of extract of minced fresh or powdered dried Thuja plicata leaf; (m) 73% to 76% isopropyl alcohol or arachis oil or soft white paraffin or aqueous cream or aqueous gel.
The pharmaceutical preparations may be such that they include as said flavonoids or glycosides or terpenoids or alkaloids or carotenoids one or more of kaempferol, quercetagetrin, thiophene, tagetiin, symphytine, carotene, bellisoponin, thujone, thujaplicin, hypericine, borneol and graveoline.
Preferably, the pharmaceutical preparations are in the form of a paste, tincture, oil, ointment, cream or gel. The pharmaceutical preparations may be prepared as a paste with the pharmaceutical base preparation, a tincture with isopropyl alcohol, an oil with arachis oil, an ointment with soft white paraffin, a cream with aqueous cream, or a gel with aqueous gel.
The pharmaceutical preparations of the present invention have the important advantage over known compositions that they are non-invasive, painless and effective in the longer term in resolution of hyperkeratotic lesions, inflammatory conditions of the skin, bones and joints, in relief of pain, in the elimination of viral and fungal infections and in the resolution of psoriatic and eczematic lesions of the skin.
The composition of the invention comprises preferably the flavonoids or glycosides or terpenoids or carotenoids or alkaloids contained in the preferred plants set out in the following table.
Table
Plant family Latin name of Name of
preferred plant chemical compound
Asteraceae Tagetes erect a kaempferol
Tagetes minuta quercetagetrin
Tagetes patula thiophene
Tagetes signata tagetiin
Boraginaceae Symphytum officinalis symphytine
Compositae Calendula arvensis carotene
Bellis perennis bellisoponin
Cupressaceae Thuja occidentalis thujone
Thuja plicata thujaplicin
Hypericeae Hypericum perforatum hypericine
Labiatae Rosemary offidnalis borneol
Rutaceae Ruta graveolens graveoline
The pharmaceutical preparations of the present invention may be used in allopathic or homoeopathic or herbal form as topical applications alone or in conjunction with podiatry, induding a cavity pad made up of chiropody felt according to the lesion and its location.
The invention will now be described with reference to the following non-limiting
Examples.
EXAMPLE 1
The following ingredients were mixed to prepare a pharmaceutical base preparation which is useful in the preparation of a pharmaceutical preparation for the treatment of lesions of the skin, bones and nails.
Minced fresh T.erecta whole plant (orange, yellow or lemon-yellow) 20%
Minced fresh T.minuta whole plant 20%
Minced fresh T.patula whole plant 20%
Minced fresh T.signata whole plant 20%
85% isopropyl alcohol 20%
100%
EXAMPLE 2
The following ingredients were mixed to prepare a pharmaceutical paste preparation which is useful in the treatment of skin lesions.
Pharmaceutical base preparation according to Example 1 80%
Extract of Bellis perennis flowerhead or leaf 5%
Extract of Hypericum perforatum flowerhead or leaf 5%
Extract of Symphytum officinalis flowerhead or leaf 5%
Extract of Thuja occidentalis leaf 5%
100%
The pharmaceutical paste preparation was prepared and used as a surface analgesic and a keralytic, anti-eczematic, anti-psoriatic and anti-viral agent in the treatment of hyperkeratotic lesion, dry eczema, psoriasis and viral infections of the skin.
EXAMPLE 3
The following ingredients were mixed to prepare a pharmaceutical tincture preparation which is useful in the treatment of skin lesions.
Extract of T.erecta orange/yellow/lemon-yellow whole plant 3%
Extract of T.minuta whole plant 3%
Extract of T.patula whole plant 3%
Extract of T.signata whole plant 3%
Extract of Bellis perennis flowerhead or leaf 3%
Extract of Hypericum perforatum flowerhead or leaf 3%
Extract of Symphytum officinalis flowerhead or leaf 3%
Extract of Thuja occidentalis leaf 3%
70% isopropyl alcohol 76%
100%
The pharmaceutical tincture preparation was prepared and used as a surface analgesic and keralytic, anti-eczematic, anti-psoriatic and anti-viral agent in the treatment of skin lesions.
EXAMPLE 4
The ingredients in Example 3, with the exception of isopropyl alcohol which was replaced by arachis oil, were mixed to prepare a pharmaceutical oil preparation which is useful in the treatment of skin lesions and used as a post-treatment emollient.
EXAMPLE 5
The ingredients in Example 3, with the exception of isopropyl alcohol which was replaced by soft white paraffin, were mixed to prepare a pharmaceutical ointment preparation which is useful in the treatment of skin lesions.
EXAMPLE 6
The ingredients in Example 5, with the exception of isopropyl alcohol which was replaced by aqueous cream, were mixed to prepare a pharmaceutical cream preparation which is useful in the treatment of skin lesions.
EXAMPLE 7
The ingredients in Example 5, with the exception of isopropyl alcohol which was replaced by an aqueous gel, were mixed to prepare a pharmaceutical gel preparation which is useful in the treatment of skin lesions.
Case history 1: Skin Condition
A female patient aged 70 suffered for 20 years from painful corn and callosity (hyperkeratosis) in the plantar area of both feet. She was treated with a pharmaceutical paste preparation prepared according to Example 2, a pharmaceutical tincture preparation prepared according to Example 3, and a pharmaceutical oil preparation prepared according to Example 4 for skin conditions in conjunction with protective pad once a week for three weeks. The patient experienced relief of pain within 48 hours and the corn and callosity on both feet completely disappeared within three weeks.
Method of application
The pharmaceutical tincture preparation was first applied to the lesion then the overlying callosity was removed with a scalpel. A protective chiropody felt pad with cavity was placed over the lesion and the pharmaceutical paste preparation was placed in the cavity which was then covered with a piece of micropore followed by adhesive strapping. The dressing remained in place for a week when the treatment was repeated once weekly for three more weeks. As brief immersion in water reactivates the chemicals in the paste, thereby enhancing the therapeutic action, during the treatment period the patient was able to take a bath, but for a few moments only. At the end of the clinical treatment the patient received pharmaceutical oil preparation and pharmaceutical tincture preparation for follow-up home treatment. The tincture was applied first over the treated area following which a few drops of oil were applied by gentle massage during the first week three times a day, the second week twice a day, the third week once a day and, as required, continued three times a week as preventive treatment.
EXAMPLE 8
The following ingredients were mixed to prepare a pharmaceutical paste preparation useful in the treatment of disorders of the bones and joints.
Pharmaceutical base preparation according to Example 1 80%
Extract of Symphytum officinalis flowerhead or leaf 5%
Extract of Ruta graveolens flowerhead or leaf 10%
Extract of Rosmarinus officinalis leaf 5%
100%
The pharmaceutical paste preparation was prepared and used as a surface analgesic and anti-inflammatory agent in the treatment of disorders of the bones and joints and in particular hallux abducto valgus, hallux rigidus, hallux flexus, gout or any painful, inflamed joint or post-operative complication of surgery.
EXAMPLE 9
The following ingredients were mixed to prepare a pharmaceutical tincture preparation useful in the treatment of disorders of the bones and joints.
Extract of T.erecta whole plant orange,yellow or lemon-yellow 3%
Extract of T.minuta whole plant 3%
Extract of T.patula whole plant 3%
Extract of T.signata whole plant 3%
Extract of Symphytum officinalis flowerhead or leaf 5%
Extract of Ruta graveolens flowerhead or leaf 5%
Extract of Rosmarinus officinalis leaf 5%
70% isopropyl alcohol 73%
100%
The pharmaceutical tincture preparation was prepared and used as a surface analgesic and anti-inflammatory agent in the treatment of disorders of the bones and joints and in particular hallux abducto valgus, hallux rigidus, hallux flexus, gout or any painful inflamed joint or post-operative complications of surgery.
EXAMPLE 10
The ingredients in Example 9, with the exception of isopropyl alcohol which was replaced by arachis oil, were mixed to prepare a pharmaceutical oil preparation useful as a post-treatment emollient in the treatment of disorders of the bones and joints and in particular hallux abducto valgus, hallux rigidus, hallux flexus, gout or any inflamed joint or post-operative complications of surgery.
EXAMPLE 11
The ingredients in Example 9, with the exception of isopropyl alcohol which was replaced by aqueous cream, were mixed to prepare a pharmaceutical cream preparation which is useful in the treatment of disorders of the bones and joints and in particular hallux abducto valgus, hallux rigidus, hallux flexus, gout or any inflamed joint or postoperative complication of surgery.
Case history: Bone conditions
A male aged 30 suffered from painful hallux abducto valgus and its associated condition bunion. He was treated with a pharmaceutical paste preparation prepared according to
Example 8, a pharmaceutical paste preparation prepared according to Example 9, and a pharmaceutical oil preparation prepared according to Example 10 in conjunction with protective chiropody pad once a week for four weeks. He experienced relief of pain within 24 hours and reduction of inflamed soft tissues within four weeks.
Method of application
The pharmaceutical tincture preparation was applied over the bunion and a chiropody cavity pad was placed over it. The cavity was filled with the pharmaceutical paste preparation, covered with a piece of micropore and then strapped with adhesive plaster.
The treatment was repeated once a week for four weeks. At the end of four weeks the patient received the pharmaceutical tincture and oil preparations for follow-up home treatment. The pharmaceutical tincture preparation was applied first and then a few drops of oil were applied by gentle massage over the bunion joint, first week three times a day, second week twice a day, third week once a day and therefore as required as a preventive measure.
EXAMPLE 12
The following ingredients were mixed to prepare a pharmaceutical paste preparation useful in the treatment of fungal infections of the nails.
Pharmaceutical base preparation according to Example 1 80%
Extract Calendula arvensis flowerhead and leaf 5%
Extract of Thuja occidentalis leaf 5%
Extract of Thuja plicata leaf 10%
100%
The pharmaceutical paste preparation was prepared and used as an anti-fungal agent in the treatment of fungal infections of the nails.
EXAMPLE 13
The following ingredients were mixed to prepare a pharmaceutical tincture preparation useful in the treatment of fungal infections of the nails.
Extract of T.erecta whole plant orange, yellow or lemon-yellow 3%
Extract of T.minuta whole plant 3%
Extract of T.patula whole plant 3%
Extract of T.signata whole plant 3%
Extract Calendula arvensis flowerhead or leaf 3%
Extract of Thuja occidentalis leaf 6%
Extract of Thuja plicata leaf 6%
70% isopropyl alcohol 73%
100%
The pharmaceutical tincture preparation was prepared and used as an antifungal agent in the treatment of fungal infections of the nails.
EXAMPLE 14
The ingredients in Example 13, with the exception of isopropyl alcohol which was replaced by arachis oil, were mixed to prepare a pharmaceutical oil preparation useful in the treatment of fungal infections of the nails.
EXAMPLE 15
The ingredients in Example 13, with the exception of isopropyl alcohol which was replaced by aqueous cream, were mixed to prepare a pharmaceutical cream preparation useful in the treatment of fungal infection of the nails.
Case history 3: Fungal infection of nails
A male aged 22 suffered with onychomycosis of the fifth toenail. He was treated with a pharmaceutical tincture preparation prepared according to Example 13 and a pharmaceutical paste preparation for nails prepared according to Example 12 once a week for four weeks followed by home treatment using a pharmaceutical tincture preparation prepared according to Example 13 and a pharmaceutical oil preparation prepared according to Example 14 for four months. The fungus in the nail was completely eliminated and the nail grew normally within eight months from the first treatment.
Method of application
The pharmaceutical tincture preparation was applied to the nail which was reduced using a file. A chiropody cavity pad was placed around the nail and the cavity filled with the pharmaceutical paste preparation, covered with a piece of micropore and strapped with adhesive plaster. At the end of four weeks, the patient received the pharmaceutical tincture preparation and pharmaceutical oil preparation for follow-up home treatment.
The pharmaceutical tincture preparation was applied first and then a few drops of pharmaceutical oil preparation by gentle massage, the first week three times a day, second week twice a day, third week once a day and thereafter until the condition was resolved.
Claims (18)
1. A pharmaceutical base preparation comprising flavonoids or glycosides of Asteraceae, the Asteraceae being Tagetes erecta orange, yellow or lemon-yellow, Tagetes minuta,
Tagetes patula and Tagetes signata.
2. A pharmaceutical base preparation according to claim 1 in which the proportion of each individual component is 20%.
3. A pharmaceutical base preparation according to claim 1 or claim 2 in which the ingredients are fresh whole plant material.
4. A pharmaceutical base preparation according to any one of the preceding claims and which includes as a solvent 85% strength isopropyl alcohol.
5. A pharmaceutical base preparation according to any one of the preceding claims and in which the proportion of isopropyl alcohol is 20%.
6. A pharmaceutical preparation for use in the treatment of skin lesions, which pharmaceutical preparation comprises a pharmaceutical base preparation according to any one of the preceding claims, carotenoids of Compositae and Hypericeae, and terpenoids of Cupressaceae.
7. A pharmaceutical preparation according to claim 6 in which the Compositae is Bellis perennis flowerhead or leaf, in which the Hypericeae is Hypericum perforatum flowerhead or leaf, and in which the Cupressaceae is Thuja occidentalis leaf.
8. A pharmaceutical preparation according to daim 6 or claim 7 and including at least one of isopropyl alcohol, soft white paraffin, arachis oil, aqueous cream and aqueous gel.
9. A pharmaceutical preparation according to any one of claims 6 to 8 in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
10. A pharmaceutical preparation for use in the treatment of bone and joint disorders, which pharmaceutical preparation comprises a pharmaceutical base preparation according to any one of claims 1 to 5, alkaloids of Boraginaceae and Rutaceae, and terpenoids of Labiatae.
11. A pharmaceutical preparation according to claim 10 in which the Boraginaceae is
Symphytum officinalis flowerhead or leaf, in which the Rutaceae is Ruta graveolens flowerhead or leaf, and in which the Labiatae is Rosemary officinalis leaf.
12. A pharmaceutical preparation according to claim 10 or claim 11 and including at least one of isopropyl alcohol, arachis oil and aqueous cream.
13. A pharmaceutical preparation according to any one of claims 10 to 12 in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
14. A pharmaceutical preparation for use in the treatment of fungal infections of nails, which pharmaceutical preparation comprises a pharmaceutical base preparation according to any one of claims 1 to 5, terpenoids of Cupressaceae, and terpenoids or carotenoids of Compositae.
15. A pharmaceutical preparation according to claim 14 in which the Cupressaceae are
Thuja occidentalis leaf and Thuja plicata leaf, and in which the Compositae is Calendula arvensis flowerhead or leaf.
16. A pharmaceutical preparation according to claim 14 or claim 16 and including at least one of the ingredients isopropyl alcohol, arachis oil and aqueous cream.
17. A pharmaceutical preparation according to any one of claims 14 to 16 in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
18. A pharmaceutical preparation according to any one of claims 6,9 and 12 and substantially as herein described.
18. A pharmaceutical preparation according to any one of claims 6 to 17 and which
includes: a) 3% of extract of minced fresh or powdered dried Tagetes erecta orange, yellow or
lemon-yellow whole plant; b) 3% of extract of minced fresh or powdered dried Tagetes minuta whole plant; c) 3% of extract of minced fresh or powdered dried Tagetes patula whole plant; d) 3% extract of minced fresh or powdered dried Tagetes signata whole plant; e) 3% to 5% of extract of minced fresh or powdered dried Bellis perennis flowerhead
or leaf; f) 3% to 5% of extract of minced fresh or powdered dried Hypericum perforatum
flowerhead or leaf; g) 3% to 5% of extract of minced fresh or powdered dried Symphytum officinalis
flowerhead or leaf; h) 3% to 6% of extract of minced fresh or powdered dried Thuja occidentalis leaf; i) 5% to 10% of extract of minced fresh or powdered dried Ruta graveolens flowerhead
or leaf; j) 5% of extract of minced fresh or powdered dried Rosmarinus officinalis leaf; k) 3% to 5% of extract of minced fresh or powdered dried Calendula arvensis
flowerhead or leaf; 1) 6% of extract of minced fresh or powdered dried Thuja plicata leaf; and m) 73% to 76% isopropyl alcohol or arachis oil or soft white paraffin or aqueous cream
or aqueous gel.
19. A pharmaceutical preparation according to any one of claims 5 to 17 and induding as said flavonoids or glycosides or terpenoids or carotenoids or alkaloids one or more of kaempferol, quercetagetrin, thiophene, tagetiin, symphytine, carotene, bellisoponin, thujone, thujaplicin, hyperidne, borneol and graveoline.
20. A pharmaceutical preparation according to any one of the preceding claims 5 to
18 and which is in the form of a paste, tincture, oil, ointment, cream or gel.
21. A pharmaceutical base preparation according to claim 1 and substantially as herein described.
22. A pharmaceutical preparation according to any one of claims 6 ,1 0 and l 4 and substantially as herein described.
Amendments to the claims have been filed as follows 1. A pharmaceutical base preparation comprising Tagetes erecta orange, yellow or lemon-yellow, Tagetes minuta, Tagetes patula and Tagetes signata.
2. A pharmaceutical base preparation according to claim 1 in which the proportion of each individual component is 20%.
3. A pharmaceutical base preparation according to claim I or claim 2 in which the ingredients are fresh whole plant material.
4. A pharmaceutical base preparation according to any one of the preceding claims and which includes as a solvent 85% strength isopropyl alcohol.
5. A pharmaceutical base preparation according to any one of the preceding claims and in which the proportion of isopropyl alcohol is 20%.
6. A pharmaceutical preparation for use in the treatment of skin lesions, which pharmaceutical preparation comprises a pharmaceutical base preparation according to any one of the preceding daims, Bellis perennis flowerhead or leaf, Hypericum perforatum flowerhead or leaf and Thuja occidentalis leaf.
7. A pharmaceutical preparation according to claim 6 and including at least one of isopropyl alcohol, soft white paraffin, arachis oil, aqueous cream and aqueous gel.
8. A pharmaceutical preparation according to claim 6 or claim 7 in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
9. A pharmaceutical preparation for use in the treatment of bone and joint disorders, which pharmaceutical preparation comprises a pharmaceutical base preparation according to any one of claims I to 5, Symphytum officinalis flowerhead or leaf, Ruta graveolens flowerhead or leaf and Rosmarinus officinalis leaf.
10. A pharmaceutical preparation according to claim 9 and including at least one of isopropyl alcohol, arachis oil and aqueous cream.
11. A pharmaceutical preparation according to claim 9 or claim 10 in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
12. A pharmaceutical preparation for use in the treatment of fungal infection of nails, which pharmaceutical preparation comprises a pharmaceutical base preparation according to any one of claims 1 to 5, Thuja occidentalis leaf, Thuja plicata leaf and Calendula arvensis flowerhead or leaf.
13. A pharmaceutical preparation according to daim 12 and induding at least one of the ingredients isopropyl alcohol, arachis oil and aqueous cream.
14. A pharmaceutical preparation according to daim 12 or daim 13 in which the ingredients are in the form of an extract of minced fresh or powdered dried plant material.
15. A pharmaceutical preparation according to any one of claims 6 to 14 and
which includes: a) 3% of extract of minced fresh or powdered dried Tagetes erecta orange,
yellow or lemon-yellow whole plant; b) 3% of extract of minced fresh or powdered dried Tagetes minuta whole plant; c) 3% of extract of minced fresh or powdered dried Tagetes patula whole plant; d) 3% of extract of minced fresh or powdered dried Tagetes signata whole plant; e) 3% to 5% of extract of minced fresh or powdered dried Bellis perennis
flowerhead or leaf; f) 3% to 5% of extract of minced fresh or powdered dried Hypericum
perforatum flowerhead or leaf; g) 3% to 5% of extract of minced fresh or powdered dried Symphytum officinalis
flowerhead or leaf; h) 3% to 6% of extract of minced fresh or powdered dried Thuja occidentalis
leaf; i) 5% to 10% of extract of minced fresh or powdered dried Ruta graveolens
flowerhead or leaf; j) 5% of extract of minced fresh or powdered dried Rosmarinus officinalis leaf; k) 3% to 5% of extract of minced fresh or powdered dried Calendula arvensis
flowerhead or leaf; 1) 6% of extract of minced fresh or powdered dried Thuja plicata leaf; and m) 73% to 76% isopropyl alcohol or arachis oil or soft white paraffin or aqueous cream or aqueous gel.
16. A pharmaceutical preparation according to any one of the preceding claims 5 to 15 and which is in the form of a paste, tincture, oil, ointment, cream or gel.
17. A pharmaceutical base preparation according to claim 1 and substantially as herein described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9604736A GB2311009B (en) | 1996-03-06 | 1996-03-06 | Pharmaceutical compositions containing tagetes plants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9604736A GB2311009B (en) | 1996-03-06 | 1996-03-06 | Pharmaceutical compositions containing tagetes plants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB9604736D0 GB9604736D0 (en) | 1996-05-08 |
| GB2311009A true GB2311009A (en) | 1997-09-17 |
| GB2311009B GB2311009B (en) | 2000-01-26 |
Family
ID=10789927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9604736A Expired - Lifetime GB2311009B (en) | 1996-03-06 | 1996-03-06 | Pharmaceutical compositions containing tagetes plants |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2311009B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030660A2 (en) * | 1998-11-25 | 2000-06-02 | Universitätsklinikum Freiburg | Hyperforin as cytostatic agent and hyperforin ointment or cream as application form |
| US6576269B1 (en) * | 2001-09-06 | 2003-06-10 | Alexander Y. Korneyev | Treating open skin lesions using extract of sea buckthorn |
| WO2003053456A1 (en) * | 2001-12-21 | 2003-07-03 | Phenion Gmbh & Co. Kg | Use of hyperforin or st john's wort extracts against anaphylactic states of shock and for maintaining and improving bone health |
| WO2004082597A2 (en) * | 2003-03-14 | 2004-09-30 | Nutrition Research, Inc. | Homeopathic formulations useful for treating pain and/or inflammmation |
| US7195781B2 (en) | 2003-04-21 | 2007-03-27 | Bronhilda Miketin | Method for treatment of skin disorders |
| GB2406790B (en) * | 2003-10-10 | 2008-01-16 | Mohammad Tariq Khan | A herbal analgesic preparation |
| US7700137B1 (en) | 2007-07-18 | 2010-04-20 | Kiani Iraj E | Anti-viral compositions and method |
| US7850998B2 (en) | 2007-07-18 | 2010-12-14 | Kiani Iraj E | Method of treating viral conditions |
| US7871648B2 (en) * | 2007-04-02 | 2011-01-18 | Alfredo Avila | Herbal formulation for the treatment of bone fractures and osseous defects |
| US8637094B2 (en) | 2007-07-18 | 2014-01-28 | Iraj E. Kiani | Composition and method for treating viral conditions |
| US9545429B1 (en) | 2011-09-03 | 2017-01-17 | Biolyte Laboratories, Llc | Homeopathic formulations |
| US10617634B1 (en) | 2017-03-10 | 2020-04-14 | Biolyte Laboratories, Llc | Topical homeopathic formulations for menstrual cramps |
| US10828251B1 (en) | 2017-01-14 | 2020-11-10 | Biolyte Laboratories, Llc | Homeopathic formulations |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU741880A1 (en) * | 1978-02-13 | 1980-06-25 | Запорожский государственный медицинский институт | Flavonoid preparing method |
| GB2083356A (en) * | 1980-09-08 | 1982-03-24 | Khan Mohd Taufiq | A marigold preparation |
| JPH01151504A (en) * | 1987-12-08 | 1989-06-14 | Shikoku Chem Corp | Production of nematocide |
| US4842859A (en) * | 1986-09-08 | 1989-06-27 | Yaguang Liu | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation |
| RU2059698C1 (en) * | 1992-07-14 | 1996-05-10 | Нина Андриановна Черкашина | Balsam buket taighi (taiga bouquet) |
-
1996
- 1996-03-06 GB GB9604736A patent/GB2311009B/en not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU741880A1 (en) * | 1978-02-13 | 1980-06-25 | Запорожский государственный медицинский институт | Flavonoid preparing method |
| GB2083356A (en) * | 1980-09-08 | 1982-03-24 | Khan Mohd Taufiq | A marigold preparation |
| US4842859A (en) * | 1986-09-08 | 1989-06-27 | Yaguang Liu | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation |
| JPH01151504A (en) * | 1987-12-08 | 1989-06-14 | Shikoku Chem Corp | Production of nematocide |
| RU2059698C1 (en) * | 1992-07-14 | 1996-05-10 | Нина Андриановна Черкашина | Balsam buket taighi (taiga bouquet) |
Non-Patent Citations (6)
| Title |
|---|
| Encyclopaedia of common natural ingredients used in Food, Drugs and Cosmetics. 1980 pages 302-303 * |
| J. Pharm. Sci. Vol. 62 (6) 1973 Ickes G R pages 1009-1011 * |
| WPI Abstract Acc. No. 81-13163D & SU 741 880 A (ZAPORO MED. INST.) 1980 * |
| WPI Abstract Acc. No. 89-215842 & JP 01 151 504 A (SHIKOKU CHEM. IND. CO.) 1989 * |
| WPI Abstract Acc. No. 94-331252 & SU 1 819 619 A (ZAPORO MED. INST.) 1993 * |
| WPI Abstract Acc. No. 97-050291 & RU2059698 C1 (CHERKASHINA N A) 1996 * |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030660A2 (en) * | 1998-11-25 | 2000-06-02 | Universitätsklinikum Freiburg | Hyperforin as cytostatic agent and hyperforin ointment or cream as application form |
| WO2000030660A3 (en) * | 1998-11-25 | 2001-03-01 | Universitaetsklinikum Freiburg | Hyperforin as cytostatic agent and hyperforin ointment or cream as application form |
| US7179495B1 (en) | 1998-11-25 | 2007-02-20 | Universitaetsklinikum Freiburg | Hyperforin as cytostatic agent and hyperforin ointment or cream as application form |
| US6576269B1 (en) * | 2001-09-06 | 2003-06-10 | Alexander Y. Korneyev | Treating open skin lesions using extract of sea buckthorn |
| WO2003053456A1 (en) * | 2001-12-21 | 2003-07-03 | Phenion Gmbh & Co. Kg | Use of hyperforin or st john's wort extracts against anaphylactic states of shock and for maintaining and improving bone health |
| WO2004082597A2 (en) * | 2003-03-14 | 2004-09-30 | Nutrition Research, Inc. | Homeopathic formulations useful for treating pain and/or inflammmation |
| WO2004082597A3 (en) * | 2003-03-14 | 2007-09-20 | Nutrition Res Inc | Homeopathic formulations useful for treating pain and/or inflammmation |
| US7195781B2 (en) | 2003-04-21 | 2007-03-27 | Bronhilda Miketin | Method for treatment of skin disorders |
| GB2406790B (en) * | 2003-10-10 | 2008-01-16 | Mohammad Tariq Khan | A herbal analgesic preparation |
| US7871648B2 (en) * | 2007-04-02 | 2011-01-18 | Alfredo Avila | Herbal formulation for the treatment of bone fractures and osseous defects |
| US8337910B2 (en) | 2007-04-02 | 2012-12-25 | Alfredo Avila | Herbal formulation for the treatment of bone fractures and osseous defects |
| US7700137B1 (en) | 2007-07-18 | 2010-04-20 | Kiani Iraj E | Anti-viral compositions and method |
| US7850998B2 (en) | 2007-07-18 | 2010-12-14 | Kiani Iraj E | Method of treating viral conditions |
| US8637094B2 (en) | 2007-07-18 | 2014-01-28 | Iraj E. Kiani | Composition and method for treating viral conditions |
| US9545429B1 (en) | 2011-09-03 | 2017-01-17 | Biolyte Laboratories, Llc | Homeopathic formulations |
| US10828251B1 (en) | 2017-01-14 | 2020-11-10 | Biolyte Laboratories, Llc | Homeopathic formulations |
| US10617634B1 (en) | 2017-03-10 | 2020-04-14 | Biolyte Laboratories, Llc | Topical homeopathic formulations for menstrual cramps |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2311009B (en) | 2000-01-26 |
| GB9604736D0 (en) | 1996-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Expiry date: 20160305 |