GB2308844B - Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase - Google Patents

Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase

Info

Publication number
GB2308844B
GB2308844B GB9706212A GB9706212A GB2308844B GB 2308844 B GB2308844 B GB 2308844B GB 9706212 A GB9706212 A GB 9706212A GB 9706212 A GB9706212 A GB 9706212A GB 2308844 B GB2308844 B GB 2308844B
Authority
GB
United Kingdom
Prior art keywords
hydroxamic
derivatives
carboxylic acids
matrix metalloproteinase
metalloproteinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9706212A
Other versions
GB9706212D0 (en
GB2308844A (en
Inventor
Raymond Paul Beckett
Mark Whittaker
Andrew Miller
Fionna Mitchell Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9423914A external-priority patent/GB9423914D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Priority to GB9706212A priority Critical patent/GB2308844B/en
Publication of GB9706212D0 publication Critical patent/GB9706212D0/en
Publication of GB2308844A publication Critical patent/GB2308844A/en
Application granted granted Critical
Publication of GB2308844B publication Critical patent/GB2308844B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polyethers (AREA)
GB9706212A 1994-11-26 1995-11-27 Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase Expired - Fee Related GB2308844B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9706212A GB2308844B (en) 1994-11-26 1995-11-27 Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9423914A GB9423914D0 (en) 1994-11-26 1994-11-26 Polyether derivatives as metalloproteinase inhibitors
PCT/GB1995/002770 WO1996016931A1 (en) 1994-11-26 1995-11-27 Metalloproteinase inhibitors
GB9706212A GB2308844B (en) 1994-11-26 1995-11-27 Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase

Publications (3)

Publication Number Publication Date
GB9706212D0 GB9706212D0 (en) 1997-05-14
GB2308844A GB2308844A (en) 1997-07-09
GB2308844B true GB2308844B (en) 1998-09-02

Family

ID=26306048

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9706212A Expired - Fee Related GB2308844B (en) 1994-11-26 1995-11-27 Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase

Country Status (1)

Country Link
GB (1) GB2308844B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK77487A (en) * 1986-03-11 1987-09-12 Hoffmann La Roche hydroxylamine
US5256657A (en) * 1991-08-19 1993-10-26 Sterling Winthrop, Inc. Succinamide derivative matrix-metalloprotease inhibitors

Also Published As

Publication number Publication date
GB9706212D0 (en) 1997-05-14
GB2308844A (en) 1997-07-09

Similar Documents

Publication Publication Date Title
HK1011536A1 (en) Alpha-substituted arylsulphonamido hydroxamic acids as tnf-alpha and matrix metalloproteinase inhibitors
HUP9903405A3 (en) Cyclic and heterocyclic n-substituted alpha-iminohydroxamic and carboxylic acids with metalloproteinase inhibitor activity, preparation and use thereof
ZA979238B (en) The preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors.
HU9602339D0 (en) Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
ZA979236B (en) The preparation and use of ß-sulfonamido hydroxamic acids as matrix metalloproteinase and tace inhibitors.
ZA979235B (en) The preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
HUP9903687A3 (en) Arylsulfonylamino carboxylic and hidroxamic acid derivatives and pharmaceutical compositions with metalloproteinase inhibitory activity containing them
PL331861A1 (en) Derivatives of propionic acid and their application
PL332720A1 (en) Novel derivatives of piperydinketone carboxylic acids, their production and application
AU5556396A (en) Hydroxamic and carboxylic acids as metalloprotease inhibitor s
AU4026695A (en) Aromatically substituted w-amino-alkanoic acid amides and alkanoic acid diamides
IL113384A0 (en) Alpha-aminolakanoic acids and reduction products
AU2735995A (en) Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents
HUP0100597A3 (en) Hydroxamic and carboxylic acid derivatives
HUP9904165A3 (en) 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase and use thereof
AU4257096A (en) Substituted carboxylic acid amides and their use as fungicides
PL307846A1 (en) Substituted heterocyclic amidoesters of carboxylic acids, methods of obtaining them and their application as therapeutic agents
IL126027A0 (en) Novel carboxylic acid derivatives their preparation and use
IL115995A0 (en) Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
IT1283489B1 (en) AMIDES OF ALPHA-AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE
HUP9600227A2 (en) Use of amides of phenyl-cyclohexyl-carboxylic acids
GB2308844B (en) Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase
GB2318789B (en) Carboxylic acid derivatives,method of manufacturing the same and therapeutic agents containing these compounds
GR3034797T3 (en) Carboxylic acid derivatives, their preparation and their use
SI0873312T1 (en) Alpha-substituted arylsulphonamido hydroxamic acids as tnf-alpha and matrix metalloproteinase inhibitors

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19991127