GB2300188A - Metalloproteinase inhibitors - Google Patents
Metalloproteinase inhibitorsInfo
- Publication number
- GB2300188A GB2300188A GB9611282A GB9611282A GB2300188A GB 2300188 A GB2300188 A GB 2300188A GB 9611282 A GB9611282 A GB 9611282A GB 9611282 A GB9611282 A GB 9611282A GB 2300188 A GB2300188 A GB 2300188A
- Authority
- GB
- United Kingdom
- Prior art keywords
- metalloproteinase inhibitors
- group
- formula
- matrix metalloproteinase
- amide bonds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a -CO 2 H or -CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9611282A GB2300188B (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
GB9721061A GB2315750B (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9401416A GB9401416D0 (en) | 1994-01-22 | 1994-01-22 | Metalloproteinase inhibitors |
GB9413566A GB9413566D0 (en) | 1994-07-06 | 1994-07-06 | Metalloproteinase inhibitors |
GB9611282A GB2300188B (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
PCT/GB1995/000121 WO1995019961A1 (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9611282D0 GB9611282D0 (en) | 1996-07-31 |
GB2300188A true GB2300188A (en) | 1996-10-30 |
GB2300188B GB2300188B (en) | 1998-07-01 |
Family
ID=27267031
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9611282A Expired - Fee Related GB2300188B (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
GB9721061A Expired - Fee Related GB2315750B (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9721061A Expired - Fee Related GB2315750B (en) | 1994-01-22 | 1995-01-23 | Metalloproteinase inhibitors |
Country Status (1)
Country | Link |
---|---|
GB (2) | GB2300188B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0497192A2 (en) * | 1991-02-01 | 1992-08-05 | F. Hoffmann-La Roche Ag | Amino acid derivatives |
EP0575844A2 (en) * | 1992-06-25 | 1993-12-29 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives and pharmaceutical compositions thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9308695D0 (en) * | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
AU6575394A (en) * | 1993-04-27 | 1994-11-21 | Celltech Therapeutics Limited | Peptidyl derivatives as metalloproteinase inhibitors |
GB2316078B (en) * | 1994-01-20 | 1998-06-03 | British Biotech Pharm | L-tert-leucine-2-pyridylamide |
-
1995
- 1995-01-23 GB GB9611282A patent/GB2300188B/en not_active Expired - Fee Related
- 1995-01-23 GB GB9721061A patent/GB2315750B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0497192A2 (en) * | 1991-02-01 | 1992-08-05 | F. Hoffmann-La Roche Ag | Amino acid derivatives |
EP0575844A2 (en) * | 1992-06-25 | 1993-12-29 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives and pharmaceutical compositions thereof |
Also Published As
Publication number | Publication date |
---|---|
GB2300188B (en) | 1998-07-01 |
GB2315750B (en) | 1998-07-01 |
GB9611282D0 (en) | 1996-07-31 |
GB9721061D0 (en) | 1997-12-03 |
GB2315750A (en) | 1998-02-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20000123 |