GB2299335A - Hydroxamic acid derivatives as metalloproteinase inhibitors - Google Patents

Hydroxamic acid derivatives as metalloproteinase inhibitors

Info

Publication number
GB2299335A
GB2299335A GB9612727A GB9612727A GB2299335A GB 2299335 A GB2299335 A GB 2299335A GB 9612727 A GB9612727 A GB 9612727A GB 9612727 A GB9612727 A GB 9612727A GB 2299335 A GB2299335 A GB 2299335A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
dimethyl
metalloproteinase inhibitors
acid derivatives
hydroxamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9612727A
Other versions
GB9612727D0 (en
GB2299335B (en
Inventor
Raymond Paul Beckett
Mark Whittaker
Andrew Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9401129A external-priority patent/GB9401129D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Priority to GB9612727A priority Critical patent/GB2299335B/en
Publication of GB9612727D0 publication Critical patent/GB9612727D0/en
Publication of GB2299335A publication Critical patent/GB2299335A/en
Application granted granted Critical
Publication of GB2299335B publication Critical patent/GB2299335B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The following compounds: 2S-Hydroxy-3R-[1S-( tert -butylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(N,N-dimethylcarbamoyl)-2,2-dimethyl-propyl-carbamoy l]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(3-hydroxy-2,2-dimethylpropylcarbamoyl)-2,2-dimethyl -propylcarbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(methylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-6-ph enyl-hexanohydroxamic acid and 2S-Hydroxy-3R-[1S-(methylcarbamoyl)-2,2-dimethyl-butylcarbamoyl]-5-met hyl-hexanohydroxamic acid are matrix metalloproteinase inhibitors.
GB9612727A 1994-01-21 1995-01-23 Hydroxamic acid derivatives as metalloproteinase inhibitors Expired - Fee Related GB2299335B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9612727A GB2299335B (en) 1994-01-21 1995-01-23 Hydroxamic acid derivatives as metalloproteinase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9401129A GB9401129D0 (en) 1994-01-21 1994-01-21 Hydroxamic acid derivatives as metalloproteinase inhibitors
GB9612727A GB2299335B (en) 1994-01-21 1995-01-23 Hydroxamic acid derivatives as metalloproteinase inhibitors
PCT/GB1995/000120 WO1995019957A1 (en) 1994-01-21 1995-01-23 Hydroxamic acid derivatives as metalloproteinase inhibitors

Publications (3)

Publication Number Publication Date
GB9612727D0 GB9612727D0 (en) 1996-08-21
GB2299335A true GB2299335A (en) 1996-10-02
GB2299335B GB2299335B (en) 1997-12-17

Family

ID=26304200

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9612727A Expired - Fee Related GB2299335B (en) 1994-01-21 1995-01-23 Hydroxamic acid derivatives as metalloproteinase inhibitors

Country Status (1)

Country Link
GB (1) GB2299335B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236872B1 (en) * 1986-03-11 1992-11-25 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
GB2268933A (en) * 1992-07-23 1994-01-26 British Bio Technology Hydroxysuccinyl hydroxyamines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236872B1 (en) * 1986-03-11 1992-11-25 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
GB2268933A (en) * 1992-07-23 1994-01-26 British Bio Technology Hydroxysuccinyl hydroxyamines

Also Published As

Publication number Publication date
GB9612727D0 (en) 1996-08-21
GB2299335B (en) 1997-12-17

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20040123