GB2297751A - Binding structures directed against the ca55.1 antigen - Google Patents

Binding structures directed against the ca55.1 antigen

Info

Publication number
GB2297751A
GB2297751A GB9607974A GB9607974A GB2297751A GB 2297751 A GB2297751 A GB 2297751A GB 9607974 A GB9607974 A GB 9607974A GB 9607974 A GB9607974 A GB 9607974A GB 2297751 A GB2297751 A GB 2297751A
Authority
GB
United Kingdom
Prior art keywords
seq
antigen
directed against
binding structures
cdr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9607974A
Other versions
GB2297751B (en
GB9607974D0 (en
GB2297751A8 (en
Inventor
Michael Samuel Rose
Christopher Boot
Clive Graham Copley
Douglas Stephen Paterson
Susan Margaret Hall
Andrew Firmin Wright
David Charles Blakey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939324819A external-priority patent/GB9324819D0/en
Priority claimed from GB9411089A external-priority patent/GB9411089D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to GB9607974A priority Critical patent/GB2297751B/en
Priority claimed from PCT/GB1994/002610 external-priority patent/WO1995015382A1/en
Publication of GB9607974D0 publication Critical patent/GB9607974D0/en
Publication of GB2297751A publication Critical patent/GB2297751A/en
Publication of GB2297751A8 publication Critical patent/GB2297751A8/en
Application granted granted Critical
Publication of GB2297751B publication Critical patent/GB2297751B/en
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Antibodies which recognise a tumour related antigen designated CA55.1 such as hybridoma 55.1 deposited as ECACC deposit No. 93081901 in which the complementary determining regions have the following sequences: a) heavy chain: CDR1: G Y W I H (SEQ ID NO: 27); CDR2: E V N P S T G R S D Y N E K F K N (SEQ ID NO: 28); CDR3: E R A Y G Y D D A M D Y (SEQ ID NO: 29); b) light chain: CDR1: K S S Q S L L N S R T R K N Y L A (SEQ ID NO: 30); CDR2: W A S T R T S (SEQ ID NO: 31); CDR3: K Q S Y T L R T (SEQ ID NO: 32); or a conservative analogue thereof. The peptide ACEHRGSGWC (SEQ ID NO: 26), as displayed on the surface of bacteriophage NCIMB No. 40638, is a mimic of the tumor related antigen CA55.1.
GB9607974A 1993-12-03 1994-11-29 Binding structures directed against the ca55.1 antigen Revoked GB2297751B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9607974A GB2297751B (en) 1993-12-03 1994-11-29 Binding structures directed against the ca55.1 antigen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939324819A GB9324819D0 (en) 1993-12-03 1993-12-03 Proteins
GB9411089A GB9411089D0 (en) 1994-06-03 1994-06-03 Proteins
GB9607974A GB2297751B (en) 1993-12-03 1994-11-29 Binding structures directed against the ca55.1 antigen
PCT/GB1994/002610 WO1995015382A1 (en) 1993-12-03 1994-11-29 Binding structures directed against the ca55.1 antigen

Publications (4)

Publication Number Publication Date
GB9607974D0 GB9607974D0 (en) 1996-06-19
GB2297751A true GB2297751A (en) 1996-08-14
GB2297751A8 GB2297751A8 (en) 1996-09-23
GB2297751B GB2297751B (en) 1997-11-26

Family

ID=27266962

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9607974A Revoked GB2297751B (en) 1993-12-03 1994-11-29 Binding structures directed against the ca55.1 antigen

Country Status (1)

Country Link
GB (1) GB2297751B (en)

Also Published As

Publication number Publication date
GB2297751B (en) 1997-11-26
GB9607974D0 (en) 1996-06-19
GB2297751A8 (en) 1996-09-23

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
773K Patent revoked under sect. 73(2)/1977

Free format text: PATENT REVOKED ON 20050523