GB2279742A - Apparatus for monitoring ultrasonic surgical ablation - Google Patents
Apparatus for monitoring ultrasonic surgical ablation Download PDFInfo
- Publication number
- GB2279742A GB2279742A GB9313346A GB9313346A GB2279742A GB 2279742 A GB2279742 A GB 2279742A GB 9313346 A GB9313346 A GB 9313346A GB 9313346 A GB9313346 A GB 9313346A GB 2279742 A GB2279742 A GB 2279742A
- Authority
- GB
- United Kingdom
- Prior art keywords
- monitoring
- lesioning
- tissue
- transducer
- pulses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0858—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving measuring tissue layers, e.g. skin, interfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
- A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Surgical Instruments (AREA)
Abstract
Apparatus for monitoring ablations in tissue during surgery. Pulses of ultrasound are emitted from an imaging transducer (4) which receives echoes back from the ablated tissue (14) and tissue (12, 16) adjacent to it. The received signals are then monitored with regard to backscatter and/or attenuation to determine whether or not they indicate changes in the absorption coefficient of the tissue which result from lesioning of that tissue. By this a surgeon may know whether or not to move on to other areas of tissue to ablate them. <IMAGE>
Description
APPARATUS FOR MONITORING ULTRASONIC SURGICAL ABLATION
The present invention relates to apparatus for monitoring the ablation of tissue during surgery, to determine whether or not all the target tissue, or even that target tissue has been ablated.
It has been known for some time that strongly focused beams of ultrasound at a frequency of about 1MHz can be used to ablate, that is destroy, selected volumes of living human or animal tissue at some depth in the body, apparently without damage to the overlying tissues. This characteristic is now being investigated for surgical applications.
Ablated regions of tissue, or ablative lesions, can sometimes be visualised by means of ultrasonic B-scan (pulse-echo) imaging procedures. If this is done a surgeon must then look at the produced image in order to determine whether or not he has made a sufficient lesion. This is not, however, a reliable method of making such a determination since limitations of the imager and/or the human eye mean that it is not always possible to detect from these images whether or not changes have occurred, and further these images do not necessarily represent the changes that have occurred in the tissue.
It was unclear what specific changes in tissue properties, related to the ablation process, give rise to detectable changes in ultrasonic echo properties of the tissue. The present invention is a result of an investigation into this feature and a search for other potentially useful and available ultrasonic signals that would complement the simple echo amplitude signals used in conventional imaging.
It is an aim of the present invention to provide apparatus which is able to overcome disadvantages of the prior art and to provide non-invasive and near instantaneous information on both the occurrence and location of tissue alteration resulting preferably from focused ultrasonic surgery.
Further it is an aim that the information should be presented in a more readily comprehensible form than that provided by studying an image by eye, and instead, or as well, it should be of a quantative nature.
According to the present invention there is provided apparatus for monitoring surgical ablations comprising means for monitoring backscattering and/or attenuation coefficients of a candidate ablation region and anterior and posterior regions adjacent thereto.
Preferably this apparatus is combined with ablating means, possibly in the form of a lesioning transducer, for near immediate feedback.
The present invention makes use of the fact that the absorbtion co-efficient of tissue changes when it is ablated and a lesion forms.
The present invention will be further described, by way of non-limitative example, with reference to the accompanying drawings, in which:
Figure 1 shows the configuration geometry of a lesioning transducer and imaging transducer relative to tissue volumes, together with a schematic representation of the control circuitry, according to one embodiment of the present invention; and
Figures 2a and 2b show a series of transmitted and received signal sequences in the transducers of Figure 1.
Figure 1 illustrates a configuration of two associated ultrasonic transducer assemblies, a strongly focused lesioning transducer (2) and a weakly focused imaging transducer (4), in an array (1), and is generally similar to arrangements used in some forms of commercial extracorporeal ultrasonic lithotriptors. The lesioning transducer (2) is controlled by a treatment processor (7).
This in turn is controlled by the display/controls (9) which the surgeon uses to control the process. The imaging transducer (4) is controlled by an imaging processor (6) which again is controlled by the surgeon using the display/controls (9). A memory (8) is used to store images and pulse echoes received by the imaging transducer (4).
The focus of the array (1) is shifted by a motor (3). This is controlled by the position controller (5) which reacts in response to signals from the imaging processor (6) and the display/controls (9). The lesioning transducer (2) is generally arranged to be co-axial and confocal with the imaging transducer (4) and brings energy to a focus within the lesioning region (14) of a tissue (10). Additionally the imaging transducer (4) emits a pencil-like beam of pulses that irradiate the lesioning region (14) as well as an adjacent anterior region (12) and an adjacent posterior region (16) in the same order as those regions are encountered by the pulses, that is first the anterior region (12), then the lesioning region (14) and finally the posterior region (16). In this arrangement the same transducer receives pulse echoes from those regions in the same time sequence order.
The effect of the strongly focused ultrasonic radiation is to heat up the tissue. This may result in the "cooking" of tissue in the lesioning volume (14) and/or in the stimulation of a phenomenon known as cavitation in that volume. Cavitation is caused by the breakdown of the tissue or liquid and the lowering of local pressure. It also occurs when the ultrasound radiation boils liquids within the fluids and vapour expands. Cavitation results in the emission of characteristic acoustic emission which can be received by either or both of the two transducers (2,4).
The reflective characteristics of such affected tissue also change and thus this effect can be detected quickly.
Figures 2a and 2b show an example of a time sequence of signals transmitted and received by the different transducers. Figure 2a shows two lines of signals. The first indicates the signals transmitted by the lesioning transducer (2) and the second indicates those it receives. Similarly Figure 2b shows the signals transmitted and received by the imaging transducer (4).
By the operation of the controls (9), or by an automatic operation in the imaging processor (6) an imaging pulse (20) is transmitted by the imaging transducer (4) before any lesioning radiation is transmitted by the lesioning transducer (2). This first imaging pulse (20) results in three pulse-echoes (22,24,26) received by the imaging transducer (4) from the three tissue regions (12,14,16) shown in Figure 1. These first received pulseechoes (22,24,26) are stored in the memory (8) to be used to provide a datum to decide the effect of subsequent lesioning. Subsequently lesioning irradiation (28) is transmitted by the lesioning transducer (2) as controlled by the surgeon, or possibly automatically; and focused on a particular volume (14) of the tissue (10). This causes changes in the physiology of the tissue in that volume (14) and may eventually stimulate cavitation. If cavitation occurs then it results in an acoustic emission which is received by both the transducers (2,4) and which can be stored in the memory (8). Either the signals (30,32) as are, or selected frequency components of these signals can be indicative of the occurrence of cavitation. The emissions can be displayed on the display (9) and if these signals are noticed they can be used as an indication that lesioning has been effected. Alternatively the processors can determine whether the signals indicate lesioning.
At some point after the lesioning radiation has been transmitted and possibly after cavitation emissions have been detected a further imaging pulse (34) is transmitted from the imaging transducer (4), again either as determined by the surgeon or automatically, which results in a new set of pulse echoes (36, 38, 40) in which the amplitudes of at least some of the echo pulses will have changed. These echoes too can be stored in the memory.
Comparisons can then be made in the imaging processor (6) between the amplitudes of received signals to determine whether the changes indicate sufficient ablation in the lesioned volume (14). All these signals and this whole sequence may be repeated if the comparison shows that is required.
The amplitudes of signals (38,24) from the target lesioning volume (14), before and after lesioning, or the amplitudes of the ratios between the signals (38/36, 24/22) from the target lesioning volume (14) and the anterior volume (12) before and after lesioning, may be compared and will indicate any changes resulting from the lesioning process which show themselves in the alteration of the tissue echogenicity, or back scattering co-efficient.
Correspondingly, comparisons of the amplitudes of signals (40,26) from the posterior volume (16) or of the amplitudes of the ratios between the signals (40/36, 26/22) from the posterior volume (16) and the anterior volume (12), before and after lesioning, will indicate changes in the attenuation coefficient of the target lesioning volume (14).
In this procedure the anterior tissue volume (12), closest to the imaging transducer, is, by definition unaffected by the lesioning process and thus the amplitude of the signal echoed back from it will not be affected by that process. Therefore the signals (22,36) from the anterior region (12) are, in principle, identical to each other and may be used as a baseline. Thus, in principle and within the limits of measurement accuracy, the position of the anterior limit of observable lesioning damage is given as the maximum distance from, in this case, the imaging transducer (2) for which the before and after echo signals (22,36) remain equal.
All or any of these signals may be displayed on a monitor in the display (9), as they are shown in Figures 2a and 2b, or may be displayed for the surgeon as relative amplitudes or in any other desired form. It is therefore possible for the surgeon to see the results of the lesioning process almost immediately after it has occurred and before moving on to the next area of tissue which needs ablating.
The surgeon may control all the aspects of the imaging and lesioning. And thus the imaging may be interleaved with the lesioning until the results are as required.
Normally the surgeon, having decided that an area is sufficiently ablated will control the array (1) to focus on a new target volume using the controls. However, if the deciding process is automatic the position controller can be instructed by the imaging processor (6) instead.
The signals exemplified in Figures 2a and 2b may be replaced with others or may be repeated in various permutations.
There may be more than one imaging transducer and/or different transducers may transmit and receive the imaging and echo pulses for imaging. Further, a separate transducer may be introduced to provide specific reception of a characteristic component of the cavitation-related acoustic emission and may be tuned to the frequency of that emission, that is, for example, 0.5 times the driving frequency. Also, there is no need for the imaging and lesioning transducers to be coaxial. The imaging transducer may be arranged to scan either a plane or a volume containing the axis of the lesioning transducer (2), in which case the sets of data or some combination of them, derived from the above procedures may be displayed as twodimensional or three-dimensional maps of tissue alteration features, for example as overlays on convectional pulseecho image maps of tissue anatomy.
Claims (13)
1. Apparatus for monitoring surgical ablations comprising means for monitoring backscattering and/or attenuation coefficients of a candidate ablation region and anterior and posterior regions adjacent thereto.
2. Apparatus according to claim 1 wherein said backscattering and/or attenuation coefficients monitoring means comprise means to emit pulses towards said regions and means to receive pulse-echoes back therefrom.
3. Apparatus according to claim 2 wherein said pulse emitting and pulse-echo receiving means comprise weakly focused imaging transducers.
4. Apparatus according to claim 2 or 3 wherein said pulses are pulses of ultrasound and said coefficients are ultrasound coefficients.
5. Apparatus according to any one of the preceding claims further comprising means for ablating said candidate ablation region.
6. Apparatus according to claim 5 wherein said ablation means emits beams of ultrasound.
7. Apparatus according to claim 5 or 6 wherein said ablating means comprises a strongly focused lesioning transducer.
8. Apparatus according to claims 2, 3 or 4 and 5, 6 or 7 wherein said emitted pulses are interleaved with ablating emissions from said ablating means.
9. Apparatus according to claims 3 and 5 or claim 8 when dependent thereon wherein said lesioning transducer and imaging transducers are confocal and coaxial.
10. Apparatus according to any one of the preceding claims further comprising means for monitoring the occurrence of cavitation within the candidate ablation region.
11. Apparatus according to claim 10 wherein said coefficient monitoring means include said cavitation occurrence monitoring means.
12. Apparatus according to any one of the preceding claims further comprising display means for displaying outputs from said coefficient monitoring and/or cavitation occurrence monitoring means.
13. Apparatus as hereinbefore described with reference to and as illustrated in the accompanying drawings.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9313346A GB2279742A (en) | 1993-06-29 | 1993-06-29 | Apparatus for monitoring ultrasonic surgical ablation |
PCT/GB1994/001404 WO1995001126A1 (en) | 1993-06-29 | 1994-06-29 | Apparatus for monitoring ultrasonic surgical ablation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9313346A GB2279742A (en) | 1993-06-29 | 1993-06-29 | Apparatus for monitoring ultrasonic surgical ablation |
Publications (2)
Publication Number | Publication Date |
---|---|
GB9313346D0 GB9313346D0 (en) | 1993-08-11 |
GB2279742A true GB2279742A (en) | 1995-01-11 |
Family
ID=10737951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9313346A Withdrawn GB2279742A (en) | 1993-06-29 | 1993-06-29 | Apparatus for monitoring ultrasonic surgical ablation |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB2279742A (en) |
WO (1) | WO1995001126A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2313969A (en) * | 1996-06-06 | 1997-12-10 | Univ Bristol | Detecting reflective object in reflective medium |
WO1999058062A1 (en) * | 1998-05-13 | 1999-11-18 | Technomed Medical Systems | Method for evaluating therapy on a tissue |
EP1476080A1 (en) * | 2002-02-20 | 2004-11-17 | Liposonix, Inc. | Ultrasonic treatment and imaging of adipose tissue |
WO2010017419A3 (en) * | 2008-08-06 | 2010-07-15 | Mirabilis Medica Inc. | Optimization and feedback control of hifu power deposition through the analysis of detected signal characteristics |
US8216161B2 (en) | 2008-08-06 | 2012-07-10 | Mirabilis Medica Inc. | Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals |
US8480600B2 (en) | 2008-10-24 | 2013-07-09 | Mirabilis Medica Inc. | Method and apparatus for feedback control of HIFU treatments |
US9248318B2 (en) | 2008-08-06 | 2016-02-02 | Mirabilis Medica Inc. | Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995029737A1 (en) * | 1994-05-03 | 1995-11-09 | Board Of Regents, The University Of Texas System | Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy |
US10335192B2 (en) | 2010-04-28 | 2019-07-02 | Koninklijke Philips N.V. | Apparatus for determining a property of an object using ultrasound scatter |
Citations (6)
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EP0091768A2 (en) * | 1982-04-07 | 1983-10-19 | Fujitsu Limited | Measuring characteristics of living tissues by ultrasonic waves |
EP0139235A2 (en) * | 1983-10-06 | 1985-05-02 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Ultrasonic measurement method and apparatus therefor |
US4763661A (en) * | 1986-02-11 | 1988-08-16 | Stanford University | Filtered ultrasonic wave method and apparatus for detecting diseased tissue |
US4803994A (en) * | 1987-08-12 | 1989-02-14 | General Electric Company | Backscatter data collection technique for ultrasound |
US4887605A (en) * | 1988-02-18 | 1989-12-19 | Angelsen Bjorn A J | Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining |
EP0383288A1 (en) * | 1989-02-16 | 1990-08-22 | Fujitsu Limited | Ultrasound diagnostic equipment for characterising tissue by analysis of backscatter |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS61209643A (en) * | 1985-03-15 | 1986-09-17 | 株式会社東芝 | Ultrasonic diagnostic and medical treatment apparatus |
DE3607949A1 (en) * | 1986-03-11 | 1987-09-17 | Wolf Gmbh Richard | METHOD FOR DETECTING POSSIBLE TISSUE DAMAGE IN THE MEDICAL APPLICATION OF HIGH-ENERGY SOUND |
JPS63164944A (en) * | 1986-12-26 | 1988-07-08 | 株式会社東芝 | Ultrasonic remedy apparatus |
US5031627A (en) * | 1989-10-17 | 1991-07-16 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method and apparatus for characterizing reflected ultrasonic pulses |
FR2685211B1 (en) * | 1991-12-20 | 1997-05-30 | Technomed Int Sa | ULTRASONIC THERAPY APPARATUS EMITTING ULTRASONIC WAVES PRODUCING THERMAL AND CAVITATION EFFECTS. |
-
1993
- 1993-06-29 GB GB9313346A patent/GB2279742A/en not_active Withdrawn
-
1994
- 1994-06-29 WO PCT/GB1994/001404 patent/WO1995001126A1/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0091768A2 (en) * | 1982-04-07 | 1983-10-19 | Fujitsu Limited | Measuring characteristics of living tissues by ultrasonic waves |
EP0139235A2 (en) * | 1983-10-06 | 1985-05-02 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Ultrasonic measurement method and apparatus therefor |
US4763661A (en) * | 1986-02-11 | 1988-08-16 | Stanford University | Filtered ultrasonic wave method and apparatus for detecting diseased tissue |
US4803994A (en) * | 1987-08-12 | 1989-02-14 | General Electric Company | Backscatter data collection technique for ultrasound |
US4887605A (en) * | 1988-02-18 | 1989-12-19 | Angelsen Bjorn A J | Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining |
EP0383288A1 (en) * | 1989-02-16 | 1990-08-22 | Fujitsu Limited | Ultrasound diagnostic equipment for characterising tissue by analysis of backscatter |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2313969A (en) * | 1996-06-06 | 1997-12-10 | Univ Bristol | Detecting reflective object in reflective medium |
EP0812028A2 (en) * | 1996-06-06 | 1997-12-10 | University Of Bristol | Apparatus for and method of detecting a reflector within a medium |
EP0812028A3 (en) * | 1996-06-06 | 1999-12-08 | University Of Bristol | Apparatus for and method of detecting a reflector within a medium |
WO1999058062A1 (en) * | 1998-05-13 | 1999-11-18 | Technomed Medical Systems | Method for evaluating therapy on a tissue |
FR2778574A1 (en) * | 1998-05-13 | 1999-11-19 | Technomed Medical Systems | Method to determine effect of ultrasonic treatment therapy on tissue |
EP1476080A4 (en) * | 2002-02-20 | 2010-06-02 | Medicis Technologies Corp | Ultrasonic treatment and imaging of adipose tissue |
EP1476080A1 (en) * | 2002-02-20 | 2004-11-17 | Liposonix, Inc. | Ultrasonic treatment and imaging of adipose tissue |
US7841984B2 (en) | 2002-02-20 | 2010-11-30 | Medicis Technologies Corporation | Ultrasonic treatment and imaging of adipose tissue |
WO2010017419A3 (en) * | 2008-08-06 | 2010-07-15 | Mirabilis Medica Inc. | Optimization and feedback control of hifu power deposition through the analysis of detected signal characteristics |
US8216161B2 (en) | 2008-08-06 | 2012-07-10 | Mirabilis Medica Inc. | Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals |
US9248318B2 (en) | 2008-08-06 | 2016-02-02 | Mirabilis Medica Inc. | Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics |
EP3165167A1 (en) * | 2008-08-06 | 2017-05-10 | Mirabilis Medica Inc. | Optimization and feedback control of hifu power deposition through the analysis of detected signal characteristics |
US10226646B2 (en) | 2008-08-06 | 2019-03-12 | Mirabillis Medica, Inc. | Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics |
US8480600B2 (en) | 2008-10-24 | 2013-07-09 | Mirabilis Medica Inc. | Method and apparatus for feedback control of HIFU treatments |
Also Published As
Publication number | Publication date |
---|---|
GB9313346D0 (en) | 1993-08-11 |
WO1995001126A1 (en) | 1995-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |