GB2263109B - Nitrogen heterocycle PAF receptor antagonists - Google Patents

Nitrogen heterocycle PAF receptor antagonists

Info

Publication number
GB2263109B
GB2263109B GB9226370A GB9226370A GB2263109B GB 2263109 B GB2263109 B GB 2263109B GB 9226370 A GB9226370 A GB 9226370A GB 9226370 A GB9226370 A GB 9226370A GB 2263109 B GB2263109 B GB 2263109B
Authority
GB
United Kingdom
Prior art keywords
receptor antagonists
nitrogen heterocycle
paf receptor
paf
heterocycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9226370A
Other versions
GB9226370D0 (en
GB2263109A (en
Inventor
Andrew Miller
Mark Whittaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Bio Technology Ltd
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology Ltd, British Biotech Pharmaceuticals Ltd filed Critical British Bio Technology Ltd
Publication of GB9226370D0 publication Critical patent/GB9226370D0/en
Publication of GB2263109A publication Critical patent/GB2263109A/en
Application granted granted Critical
Publication of GB2263109B publication Critical patent/GB2263109B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
GB9226370A 1992-01-07 1992-12-16 Nitrogen heterocycle PAF receptor antagonists Expired - Fee Related GB2263109B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929200210A GB9200210D0 (en) 1992-01-07 1992-01-07 Compounds

Publications (3)

Publication Number Publication Date
GB9226370D0 GB9226370D0 (en) 1993-02-10
GB2263109A GB2263109A (en) 1993-07-14
GB2263109B true GB2263109B (en) 1996-05-01

Family

ID=10708190

Family Applications (2)

Application Number Title Priority Date Filing Date
GB929200210A Pending GB9200210D0 (en) 1992-01-07 1992-01-07 Compounds
GB9226370A Expired - Fee Related GB2263109B (en) 1992-01-07 1992-12-16 Nitrogen heterocycle PAF receptor antagonists

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB929200210A Pending GB9200210D0 (en) 1992-01-07 1992-01-07 Compounds

Country Status (1)

Country Link
GB (2) GB9200210D0 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183209B2 (en) 2003-05-15 2012-05-22 Dmi Biosciences, Inc. Treatment of T-cell mediated diseases
US8217047B2 (en) 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
US8268830B2 (en) 2000-08-04 2012-09-18 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
US8980834B2 (en) 2011-10-10 2015-03-17 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
WO1994001430A1 (en) 1992-07-13 1994-01-20 Cytomed, Inc. 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
DE19605766A1 (en) * 1996-02-16 1997-08-21 Basf Ag Substituted 2-phenylpyridines
DK0939628T3 (en) * 1996-07-22 2003-07-07 Monsanto Co Thiolsulfon-metalloprotease inhibitors
US6747027B1 (en) 1996-07-22 2004-06-08 Pharmacia Corporation Thiol sulfonamide metalloprotease inhibitors
DE19719621A1 (en) * 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarboxylic acids
US6800646B1 (en) 1999-02-08 2004-10-05 Pharmacia Corporation Sulfamato hydroxamic acid metalloprotease inhibitor
US6645990B2 (en) 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
JP2005537228A (en) 2002-04-25 2005-12-08 ファルマシア・コーポレーション Piperidinyl- and piperazinyl-sulfonylmethylhydroxamic acids and their use as protease inhibitors
DK1571970T3 (en) 2002-10-02 2011-11-28 Dmi Biosciences Inc Diagnosis and monitoring of diseases
AU2006238933B2 (en) 2005-04-28 2011-12-01 Pfizer Limited Amino acid derivatives
ES2447025T3 (en) 2005-07-12 2014-03-11 Ampio Pharmaceuticals, Inc. Methods and products for the treatment of diseases
PL2554172T3 (en) 2009-06-22 2015-03-31 Ampio Pharmaceuticals Inc Method for treatment of diseases
KR20140075772A (en) 2011-10-10 2014-06-19 앰피오 파마슈티컬스 인코퍼레이티드 Implantable medical devices with increased immune tolerance, and methods for making and implanting
SG10201605205VA (en) 2011-10-28 2016-08-30 Ampio Pharmaceuticals Inc Treatment of rhinitis
AU2013361338A1 (en) 2012-12-19 2015-08-06 Ampio Pharmaceuticals, Inc. Method for treatment of diseases
KR20150132508A (en) 2013-03-15 2015-11-25 앰피오 파마슈티컬스 인코퍼레이티드 Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
RU2736513C2 (en) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Treating pathological conditions of joints
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240899A2 (en) * 1986-04-01 1987-10-14 Boehringer Ingelheim Kg 1,4-Diazepine
US4987132A (en) * 1987-02-20 1991-01-22 Yamanouchi Pharmaceutical Co., Ltd. Saturated heterocyclic carboxamide derivatives
US4992455A (en) * 1987-05-22 1991-02-12 Sumitomo Pharmaceuticals Company, Limited Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240899A2 (en) * 1986-04-01 1987-10-14 Boehringer Ingelheim Kg 1,4-Diazepine
US4987132A (en) * 1987-02-20 1991-01-22 Yamanouchi Pharmaceutical Co., Ltd. Saturated heterocyclic carboxamide derivatives
US4992455A (en) * 1987-05-22 1991-02-12 Sumitomo Pharmaceuticals Company, Limited Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Glycine, alanine, valine & leucine *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841307B2 (en) 2000-08-04 2014-09-23 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US9561226B2 (en) 2000-08-04 2017-02-07 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US8268830B2 (en) 2000-08-04 2012-09-18 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
US8916568B2 (en) 2000-08-04 2014-12-23 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
US8440696B2 (en) 2000-08-04 2013-05-14 Dmi Acquisition Corp. Method of using diketopiperazines and composition containing them
US8455517B2 (en) 2000-08-04 2013-06-04 Dmi Acquisition Corp. Method of using diketopiperazines and composition containing them
US8551953B2 (en) 2003-05-15 2013-10-08 Dmi Acquisition Corp. Treatment of T-cell mediated diseases
US8513196B2 (en) 2003-05-15 2013-08-20 Dmi Acquisition Corp. Treatment of T-cell mediated diseases
US8183209B2 (en) 2003-05-15 2012-05-22 Dmi Biosciences, Inc. Treatment of T-cell mediated diseases
US8324167B2 (en) 2003-05-15 2012-12-04 Dmi Biosciences, Inc. Treatment of T-cell mediated diseases
US8962568B2 (en) 2003-05-15 2015-02-24 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
US8969308B2 (en) 2003-05-15 2015-03-03 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
US8871772B2 (en) 2008-05-27 2014-10-28 Ampio Pharmaceuticals, Inc. Therapeutic methods and compounds
US9522893B2 (en) 2008-05-27 2016-12-20 Ampio Pharmaceuticals, Inc. Therapeutic methods and compounds
US8217047B2 (en) 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
US9034878B2 (en) 2010-09-07 2015-05-19 Ampio Pharmaceuticals, Inc. Treatment of diseases
US8980834B2 (en) 2011-10-10 2015-03-17 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
US9060968B2 (en) 2011-10-10 2015-06-23 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease

Also Published As

Publication number Publication date
GB9226370D0 (en) 1993-02-10
GB9200210D0 (en) 1992-02-26
GB2263109A (en) 1993-07-14

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19971216