GB2230418A - Dietary supplement - Google Patents
Dietary supplement Download PDFInfo
- Publication number
- GB2230418A GB2230418A GB9007399A GB9007399A GB2230418A GB 2230418 A GB2230418 A GB 2230418A GB 9007399 A GB9007399 A GB 9007399A GB 9007399 A GB9007399 A GB 9007399A GB 2230418 A GB2230418 A GB 2230418A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- parts
- supplement
- carnitine
- per
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 8
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 33
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical group CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 14
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims abstract description 12
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims abstract description 11
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 8
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 7
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 7
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 7
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000013589 supplement Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 9
- 229930003571 Vitamin B5 Natural products 0.000 claims description 7
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 7
- 229960002079 calcium pantothenate Drugs 0.000 claims description 7
- 235000009492 vitamin B5 Nutrition 0.000 claims description 7
- 239000011675 vitamin B5 Substances 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 6
- 235000019160 vitamin B3 Nutrition 0.000 claims description 5
- 239000011708 vitamin B3 Substances 0.000 claims description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 4
- 229930003537 Vitamin B3 Natural products 0.000 claims description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
- 229930003779 Vitamin B12 Natural products 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 3
- 229960000304 folic acid Drugs 0.000 claims description 3
- 235000019152 folic acid Nutrition 0.000 claims description 3
- 239000011724 folic acid Substances 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 229960002477 riboflavin Drugs 0.000 claims description 3
- 229910052711 selenium Inorganic materials 0.000 claims description 3
- 239000011669 selenium Substances 0.000 claims description 3
- 229960003495 thiamine Drugs 0.000 claims description 3
- 235000019163 vitamin B12 Nutrition 0.000 claims description 3
- 239000011715 vitamin B12 Substances 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 2
- 229930003471 Vitamin B2 Natural products 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims description 2
- 235000019157 thiamine Nutrition 0.000 claims description 2
- 239000011721 thiamine Substances 0.000 claims description 2
- 235000019164 vitamin B2 Nutrition 0.000 claims description 2
- 239000011716 vitamin B2 Substances 0.000 claims description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract description 8
- 235000001968 nicotinic acid Nutrition 0.000 abstract description 4
- 239000011664 nicotinic acid Substances 0.000 abstract description 4
- 229940055726 pantothenic acid Drugs 0.000 abstract description 4
- 235000019161 pantothenic acid Nutrition 0.000 abstract description 4
- 239000011713 pantothenic acid Substances 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 abstract description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 239000004472 Lysine Substances 0.000 description 3
- 235000019766 L-Lysine Nutrition 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229940091258 selenium supplement Drugs 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- FCASKLHVRFDIJB-UHFFFAOYSA-N Riboflavine Natural products Cc1cc2N=C3C(NC(=O)NC3=O)N(CC(O)C(O)C(O)CO)c2cc1C FCASKLHVRFDIJB-UHFFFAOYSA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 235000006486 human diet Nutrition 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- -1 substance Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 235000003563 vegetarian diet Nutrition 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A health supplement for humans or animals comprises Co Enzyme Q10 and L-carnitine. Typically the health supplement will comprise Co Enzyme Q10, L-carnitine, and for each 100 parts by weight (pbw) of L-carnitine, Niacin 25-90 pbw Pantothenic acid 10-80 pbw Vitamin B6 Group 20-80 pbw e
Description
HEALTH SUPPLEMENT
The present invention relates to a health supplement for humans or animals.
According to the present invention there is provided a health supplement comprising Co Enzyme Q10 and L-carnitine.
Preferably the amount of Co Enzyme Q10 in the composition is 35 to 120 parts by weight (pbw) based on 100 pbw L-carnitine.
Typically, the composition will also contain at least one of
Niacin (Vitamin B3), Pantothenic Acid (Vitamin B5), and Vitamin B6
Group. These additional components when used may be present in the following indicated amounts, all based on 100 pbw of L-carnitine.
Niacin 25-90 pbw
Pantothenic acid 10-80 pbw
Vitamin B6 Group 20-80 pbw
Co Enzyme Q10 is a biochemical nutrient found in certain foods.
It controls the flow of oxygen within individual cells and thus plays a critical role in the production of energy in nearly every cell of the body. CoQ is an integral part of the mechanism which, by means of
Adenosine Triphosphate synthesis (A.T.P.), generates about 95% of the total energy extracted from food. Research indicates that the body's ability to extract CoQ from food declines as we get older.
L-carnitine is a natural, vitamin like substance, of special nutritional value. The liver and kidney produce L-carnitine (from L
Lysine) but this is influenced by diet, age and hormonal status. The functioning of the heart and other bodily muscles depend on Lcarnitine for the production of metabolic energy from the oxidation of fatty acids. Physical effort reduces L-carnitine levels and because it is found mainly in meat, deficiencies can arise due to diet. This results in fatigue, muscle weakness and the accumulation of fat in muscle fibres.
L-carnitine is the primary molecule responsible for transformation of fat into metabolic energy by means of a complex process in which Co Enzyme Q10 plays a vital part. This process,
known as Carnitine Acyl Transferase (C.A.T.) regulates the rate at which fat is converted into energy.
Obviously, the rate at which fat is burned ultimately determines
the amount of muscle energy we can produce. This in turn controls
our capacity for physical activity.
The human diet is often deficient in L-Lysine, necessary for the biosynthesis of L-carnitine, because L-Lysine is destroyed by heat in the preparation of food. L-carnitine itself is mainly derived from meat - so a vegetarian diet is particularly likely to create a deficiency.
L-Lysine and Vitamins B3 and B6 help the body to make its own supply of L-carnitine by means of biosynthesis but, whether supplied by biosynthesis or as a supplement, L-carnitine cannot be utilised without Vitamin B5. Thus, the incorporation of Vitamin B5 in the supplement of the invention is advantageous in that it supplements the body's own Vitamin B5.
When the composition of the invention is taken as a daily supplement it can produce noticeable improvements in health, energy and vitality. It helps to increase the basal metabolic rate (B.M.R.) which can lead to sustained weight control by reducing body fat and firming up muscles. Furthermore, it can strengthen the heart muscle and increase blood flow, thus helping to lower blood pressure.
A preferred composition is shown in Table 1 and comprises:
L-carnitine 100 pbw
Co Enzyme Q10 52-88 pbw
Niacin (Vitamin B3) 37.5-62.5 pbw
Pantothenic Acid 18.0-45 pbw
(Vitamin B5)
Vitamin B6 Group 30.0-50.0 pbw
(Pyridoxine)
The references in parentheses are to alternative names of certain components of the composition.
It is also preferred that the composition includes trace elements which are beneficial to health. Such trace elements which may be included are calcium, phosphorus, magnesium, zinc and/or selenium.
Additional components which may be present include further vitamins (eg Vitamin B1, Vitamin B2, and Vitamin B12) as well as biotin and folic acid.
Thus, the composition may include any or all of the following additional components listed in Table 2 each of which is (when present) preferably used in the amount indicated (based on 100 pbw of
L-carnitine).
Table 2
Thiamine (B1) 13-38 (eg 18-30)
Riboflavine (B2) 16-47 (eg 22.5-37.5)
Vitamin B12 (Cyanocobalamin) 0.005-0.016 (eg 0.0075-0.0125)
Biotin .3-.94 (eg 0.45-0.75)
Folic Acid .45-1.25 (eg 0.6-1.0)
Calcium (Tricalcium 81-225 (eg 108.0-178.0)
Phosphorous
Phosphate) 42-115 (eg 56.0-92.0)
Magnesium (Magnesium Oxide) 16-47 (eg 22.5-37.5)
Zinc (Zinc Citrate) 2-7 (eg 3.0-5.0)
Selenium (Sodium Selenite) .050-.160 (eg 0.075-0.125)
The trace metals may be provided by the compounds indicated in parentheses.
For convenience, the composition may be produced in unit dosage form (eg as a tablet or capsule). For preference each such dose will comprise about 50mg of L-carnitine and may be taken at the rate of 1 per day.
Claims (22)
1. A health supplement comprising Co Enzyme Q10 and L-carnitine.
2. A supplement as claimed in claim 1 wherein the amount of Co
Enzyme Q10 in the composition is 35 to 120 pbw (based on 100 pbw Lcarnitine).
3. A supplement as claimed in claim 2 wherein the amount of Co
Enzyme Q10 is 52-88 parts by weight per 100 parts by weight of Lcarnitine.
4. A supplement as claimed in any one of claims 1 to 3 comprising 20-80 parts by weight of Vitamin B6 group per 100 parts by weight of
L-carnitine.
5. A supplement as claimed in claim 4 comprising 30-50 parts by weight of the Vitamin B6 Group per 100 parts by weight of L-carnitine.
6. A supplement as claimed in any one of claims 1-5 comprising 25 to 90 parts by weight of Vitamin B3 per 100 parts by weight of Lcarnitine.
7. A supplement as claimed claim 6 comprising 37.5 to 62.5 parts by weight of Vitamin B3 per 100 parts by weight of L-carnitine.
8. A supplement as claimed in any one of claims 1 to 7 comprising 10 to 80 parts by weight of Vitamin B5 per 100 parts by weight of Lcarnitine.
9. A supplement as claimed in claim 8 comprising 18 to 45 parts by weight of Vitamin B5 per 100 parts by weight of L-carnitine.
10. A supplement as claimed in any one of the preceding claims comprising 13 to 38 parts by weight of Thiamine per 100 parts by weight of L-carnitine.
11. A supplement as claimed in any one of the preceding claims comprising 16 to 47 parts by weight of Vitamin B2 per 100 parts by weight of L-carnitine.
12. A supplement as claimed in any one of the preceding claims comprising .005 to 0.016 parts by weight of Vitamin B12 per 100 parts by weight of L-carnitine.
13. A supplement as claimed in any one of the preceding claims comprising 0.3 to 0.94 parts per weight of Biotin per 100 parts by weight of L-carnitine.
14. A supplement as claimed in any one of the preceding claims comprising 0.45 to 1.25 parts by weight of Folic Acid per 100 parts by weight of L-carnitine.
15. A supplement as claimed in any one of the preceding claims comprising 81 to 225 parts by weight of Calcium per 100 parts by weight of L-carnitine.
16. A supplement as claimed in any one of the preceding claims comprising 42 to 115 parts by weight of Phosphorous per 100 parts by weight of L-carnitine.
17. A supplement as claimed in any one of the preceding claims comprising 16 to 47 parts by weight of Magnesium per 100 parts by weight of L-carnitine.
18. A supplement as claimed in any one of the preceding claims comprising 2 to 7 parts by weight of Zinc per 100 parts by weight of
L-carnitine.
19. A supplement as claimed in any one of the preceding claims comprising 0.05 to 0.16 parts by weight of Selenium per 100 parts by weight of L-carnitine.
20. A supplement as claimed in any one of the preceding claims in unit dosage form.
21. A supplement as claimed in claim 17 comprising about 50mg of Lcarnitine.
22. A health supplement substantially as hereinbefore described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898907276A GB8907276D0 (en) | 1989-03-31 | 1989-03-31 | Health supplement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9007399D0 GB9007399D0 (en) | 1990-05-30 |
| GB2230418A true GB2230418A (en) | 1990-10-24 |
Family
ID=10654244
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB898907276A Pending GB8907276D0 (en) | 1989-03-31 | 1989-03-31 | Health supplement |
| GB9007399A Withdrawn GB2230418A (en) | 1989-03-31 | 1990-04-02 | Dietary supplement |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB898907276A Pending GB8907276D0 (en) | 1989-03-31 | 1989-03-31 | Health supplement |
Country Status (1)
| Country | Link |
|---|---|
| GB (2) | GB8907276D0 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0379936A2 (en) * | 1989-01-17 | 1990-08-01 | Vesta Medicines (Proprietary) Limited | Pyridoxal for use in enzyme deficiencies, and a diagnostic kit for their diagnosis |
| WO1998043617A3 (en) * | 1997-03-27 | 1998-12-17 | Michael J Sole | Nutritional composition for improvements in cell energetics |
| WO1999007388A1 (en) * | 1997-08-08 | 1999-02-18 | Mccarty Mark F | Method for promoting weight and fat loss with a composition comprising hydroxycitrate, carnitine and a pyruvate promotor |
| US6080788A (en) * | 1997-03-27 | 2000-06-27 | Sole; Michael J. | Composition for improvement of cellular nutrition and mitochondrial energetics |
| WO2006012329A2 (en) * | 2004-06-25 | 2006-02-02 | Joel Schock | Health supplement |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2137088A (en) * | 1983-02-16 | 1984-10-03 | Sigma Tau Ind Farmaceuti | Pharmaceutical compositions containing a carnitine compound and a ubiquinone coenzyme |
| WO1989001740A1 (en) * | 1987-08-27 | 1989-03-09 | Sockerbolaget Ab | Diet fortification |
-
1989
- 1989-03-31 GB GB898907276A patent/GB8907276D0/en active Pending
-
1990
- 1990-04-02 GB GB9007399A patent/GB2230418A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2137088A (en) * | 1983-02-16 | 1984-10-03 | Sigma Tau Ind Farmaceuti | Pharmaceutical compositions containing a carnitine compound and a ubiquinone coenzyme |
| WO1989001740A1 (en) * | 1987-08-27 | 1989-03-09 | Sockerbolaget Ab | Diet fortification |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0379936A2 (en) * | 1989-01-17 | 1990-08-01 | Vesta Medicines (Proprietary) Limited | Pyridoxal for use in enzyme deficiencies, and a diagnostic kit for their diagnosis |
| EP0379936A3 (en) * | 1989-01-17 | 1991-11-06 | Vesta Medicines (Proprietary) Limited | Pyridoxal for use in enzyme deficiencies, and a diagnostic kit for their diagnosis |
| WO1998043617A3 (en) * | 1997-03-27 | 1998-12-17 | Michael J Sole | Nutritional composition for improvements in cell energetics |
| US6080788A (en) * | 1997-03-27 | 2000-06-27 | Sole; Michael J. | Composition for improvement of cellular nutrition and mitochondrial energetics |
| WO1999007388A1 (en) * | 1997-08-08 | 1999-02-18 | Mccarty Mark F | Method for promoting weight and fat loss with a composition comprising hydroxycitrate, carnitine and a pyruvate promotor |
| WO2006012329A2 (en) * | 2004-06-25 | 2006-02-02 | Joel Schock | Health supplement |
| WO2006012329A3 (en) * | 2004-06-25 | 2006-04-06 | Joel Schock | Health supplement |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9007399D0 (en) | 1990-05-30 |
| GB8907276D0 (en) | 1989-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |