GB2197471A - Method for the preparation and examination of multiple samples for microscopical and scientific study and analysis - Google Patents
Method for the preparation and examination of multiple samples for microscopical and scientific study and analysis Download PDFInfo
- Publication number
- GB2197471A GB2197471A GB08725600A GB8725600A GB2197471A GB 2197471 A GB2197471 A GB 2197471A GB 08725600 A GB08725600 A GB 08725600A GB 8725600 A GB8725600 A GB 8725600A GB 2197471 A GB2197471 A GB 2197471A
- Authority
- GB
- United Kingdom
- Prior art keywords
- samples
- examination
- plastic support
- data
- series
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/54—Labware with identification means
- B01L3/545—Labware with identification means for laboratory containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A method and apparatus for examination of a series of samples in which the samples are deposited in succession upon a continuous plastic support and treated to secure, process, protect and preserve them for examination, especially by microscopical study and analysis. Data relevant to the samples is recorded on the plastic support in register with the samples, and further data from the examination of the samples can be recorded on the same support or on a separate record so that data for each sample can be correlated and used for further study or evaluation of the samples. Readily applicable to biological samples, especially those requiring mass study for diagnostic purposes (e.g. cervical smears). Obviates use of bulky glass slides, and facilitates study of large numbers of samples and the use of computer aids for improving speed of evaluating and re-checking samples.
Description
SPECIFICATION
Method for the preparation and examination of multiple samples for microscopical and scientific study and analysis
This invention relates to a method for the preparation and examination of multiple samples for microscopical and scientific study and analysis, and more particularly to a method for the examination of large numbers of scientific samples, of example biological and diagnostic samples.
It is well known, for example, to prepare and examine large numbers of samples of biological material to look for predetermined characteristics (other.faults or abnormalities) and this process including "screening" is commonly applied to the routine examination of biological specimens for microscopical study and analysis for such purposes as checking for cancerous or pre-cancerous conditions in, for example, tests such as tissue samples or smears, for example cervical smears. It is also necessary in most cases for the samples to be stored for some time after examination, so that they can if required be re-examined at a later date.
In dealing with such multiple samples, however, there is the especial problem of doing this speedily and reliably, as the usual samples, for example biological samples, have to be carefully prepared before they can be examined, and this almost inevitably requires their preparation as on individual glass supports (for example glass microscope slides).
Unfortunately, such glass supports are weighty, fragile, inflexible and hazardous, requiring the addition of a glass cover-slip once the sample has been applied and processed.
This procedure does not lend itself readily to the rapid examination of large numbers of samples, or to the introduction of automated processing and analysing instruments. This is partly because of the sheer difficulty of preparing and handling specimens. on individual glass supports/cover-slips and partly because the very large amounts of glass used has to be transported and stored, presenting problems of fragility, excessive weight and hazards.
There is a great need for rapid examination of large numbers of samples in research, screening, diagnosis, teaching, prevention of disease and for general microscopic study. For example, cervical cancer screening, efficacy testing of novel drugs or chemical/physical industrial reagents and products and the routine histological analysis of tissue samples for the study and diagnosis of disease. Increasing the volumes of tests and consequently the number of individual glass supports produces a higher probability of error and difficulties of storage and retrieval of glass-supported (e.g.
glass slide) collections. This is, in part, hampering the adoption of tests and testing systems on as wide a scale as is desirable.
We have now discovered that these difficulties can be overcome by using certain sheet plastic materials in place of the conventional glass supports.
Thus according to our invention we provide a method for the examination of a series of samples which comprises depositing the said samples in succession upon a continuous plastic support, and treating the said samples upon the said plastic support
(i) to secure the said samples to the said plastic support,
(ii) to process the said samples appropriately for examination, and
(iii) to protect and preserve the said samples.
The samples may be, for example, biological samples but alternatively may be any other form of samples which may be suited or required for microscopical examination. The samples may be in any convenient form for examination, for example microtome sections.
The procedure of our invention is especially valuable because it can be used to provide more than just the facility for rapid examination but also the facility for recording the data relevant to each sample, for allowing the results to be scanned quickly, and for searches to be made for identification and easy access to those samples which meet any specified criteria. The invention is thus of especial value to those users preparing large numbers of samples for detailed microscopical study and investigation.
Accordingly, the present invention also comprises methods and apparatus for the microscopical examination of a series of samples, for example biological samples, characterised in that the samples are deposited for examination as a series in succession on a continuous plastic support and data relevant to the said samples is recorded on the said support in register with the said samples.
Thus according to a further feature of our invention we provide a method for the examination of a series of samples which comprises depositing the said samples in succession upon a continuous plastic support, and treating the said samples upon the said plastic support in the manner specified above, and also
(a) marking the said plastic support with in clicia providing characteristic unique data for each sample and correlated with it,
(b) passing the said plastic support, with the samples and indicia thereon, through apparatus which is adapted to examine and analyse the samples, and
(c) recording the data of the examination results (from b) and correlating it with the indicia (a).
As a further step, there can then be added that of:
(d) processing the correlated data (from a and c) to give an output of the relationship between the examination data and the characterising data of samples in selected report form.
According to our invention we also provide apparatus for the examination of a sequential series of samples which comprises:
A. means for depositing the said samples in succession upon a continuous plastic support,
B. means for treating the said samples upon the plastic support to prepare the said samples appropriately for microscopical study and analysis,
C. means for securing the said samples to the said plastic support,
D. means for protecting and preserving the said samples upon the said plastic support,
E. means for marking the said plastic support with indicia providing data characterising each sample and correlated with each sample,
F. means for enabling the said plastic support, with the samples and indicia thereon, to be passed through apparatus which is adapted to allow examination of the samples, especially for microscopical study and analysis,
G. means for recording the data of the examination results (from F) and correlating them with the indicia (from E),
H. means for processing and storing the correlated data (from G) to enable an output of the relationship of examination data to samples to be obtained in selected report form when required.
The apparatus according to the invention may comprise all the features indicated above or any desired combinations of them (or even individual ones) adapted to be combined to assemble an apparatus suitable for putting the invention into practice.
Such apparatus may require to be "custom- ised" i.e. adapted from the conventionally available forms of equipment to make it more suited for use in carrying out the procedures or combinations of procedures of the invention.
The materials for the continuous plastic support (which may be referred to conveniently as a plastic film strip) may be any which are sufficiently durable and stable to survive the processes of treatment and examination to which they may be submitted or may potentially be required to be submitted, either in preparation or use.For example,
(1) they should be resistant to water and any organic solvents or reagents used, so that they do not distort or soften;
(2) they should not contain components which can damage the samples carried nor them oup retain reagents (coloured or otherwise) that may impair the sample for examination or interpretation;
(3) they should not readily absorb water, chemicals or reagents in a comparable manner to the samples they may carry;
(4) they should be flexible enough to facilitate storage, winding and running through apparatus, etc., without embrittlement, wear, tearing or creasing;
(5) they should not be biodegradable or subject to an alteration in optical quality with the passage of time, and should be stable to variations in ambient temperature;
(6) they should be strong, durable and printable, and preferably have a melting point above 200 degrees C.
Such exhaustive criteria are essential for the best operation of the processes and procedures indicated above, so it is preferred that the plastic support possesses as many of them as can be economically or practicably achieved.
Optically clear materials suitable for the purposes of the present invention include polyester and polypropylene films, of which polyester is preferred as more suitable.
The thickness of the plastic support material, and its other dimensions, will depend to some extent upon the particular apparatus and examination procedures to be used, but the following are useful guides to what, in general, these may most conveniently be (but are not necessarily limited to):
(a) the thickness should be less than 175Am and optimally about 100,us.
(b) the width should be less than 100mm, with optimum dimensions of 26mm, 38mm or 51 mum, depending upon the specific application intended.
There is no operational limit on overall length, which may range from single metres to tens of metres, or even longer, so that many glass-support-equivalent lengths may be accommodated.
The treatment procedures (i) to (iii) above may be any conventional ones known in the art. For example, in the preparation of tissues for microscopical study there may be used material infiltrated with paraffin wax, material frozen for sectioning using cryostat or Peltier effect devices or utilising coolant liquids or gases, untreated ambient temperature sections, smears or solutions containing any biological material.
The treatment of the continuous plastic support material to give it the its ability to take up or hold the samples, for example biological samples, may be any conventional method known in the art, for example reagents and/or coatings to modify the surface so as to act as an intermediate "subbing" layer to stick to the surface and to the sample, but in particular may be a treatment of the plastic support with poly-l-lysine using a predeposition procedure.
The indicia providing characterising data may be any conventional ones and may take any desired form which can be imposed on or in the plastic support and can be read by an appropriate reader or sensor instrument. They should be of such form that they can survive the various treatment stages through which the samples have to pass, and also survive storage,. without the recorded indicia becoming debased and difficult to decipher or read again. Especially they may be optical, mechanical or magnetic indicia, or any combination of these, and application of them to the plastic support may be by conventional processes that are known in the art.
The means for recording results of examination, especially microscopical study and analysis, (i.e. examination data) on to the plastic support in step (c) above may be such as to record on to the plastic support itself, in register with the characterising data.
Alternatively, the examination data may be recorded on to a separate record which can be read in conjunction with the data on the original plastic support and the two sets of data can then be correlated. This can be done for example by feeding the examination data into a customised computer database and then reading this in conjunction with the original sample-carrying plastic support or a second database incorporating its data. The data can readily be correlated by computer processing to produce any desired output. For example, the plastic support itself may be manipulated to give access to samples on it having any desired property or identity, or the data can be interpreted or analysed to provide a display or print-out of any desired data in any desired format.The data may even be processed to produce a fresh database, optionally with provision for enhancement by addition of results of a subsequent further examination to augment the store of information relating to the samples.
The nature, form or other characteristics of the biological samples which may be dealt with by the method of the present invention include any convenient or accessible form of sample material, for example tissue samples, blood or other body fluid samples, including cervial smears, histological preparations of botanical or mammalian tissues, blood smears for diagnostic or pathological study, and teaching materials--indeed, for example, any biological material. These may be kept in treated or untreated form, or re-treated, as required.
The procedures and apparatus of the present invention may be used for the examination and study of any other samples, whether of biological nature or non-biological nature, which are susceptible to being carried upon the plastic support and examined upon it, in a manner analogous to that described in more detail for biological samples.
The protection and/or preservation of biological samples when carried on the support may be any of the conventional ones known in the art, for example treating them with coverants or mountants, which may conveniently be applied by aerosol spray techniques, and sealing them in with a coating of a plastic film, for example a pre-coated adhesive selfsealing film, to seal in and protect-the sample and indicia.
The prior treatment of the sample, treat-ment of the sample after deposition on the support, and the procedures and the materials which may be used (e.g. preservative compositions or formulations and ingredients for these) are those known for the purpose and conventionally used and available.
The invention offers the advantages of handing large numbers of samples in a speedy fashion, and also permits a degree of computer intervention (i.e. recording and processing of data by computer) that wou!d be totally impracticable with the conventional glass supports.
Claims (26)
1. Method for the examination of a series of samples which comprises depositing the said samples in succession upon a continuous plastic support, and treating the said samples upon the said plastic support
(i) to secure the said samples to the said support
(ii) to process the said samples appropriately for examination, and
(iii) to protect and preserve the said samples.
2. Method for the examination of a series of samples, as claimed in Claim 1 wherein the samples are deposited for examination as a series in succession on a continuous plastic support and data relevant to the said samples is recorded on the said plastic support in register with the said samples.
3. Method for the examination of a series of samples, as claimed in Claim 1 or Claim 2 which comprises depositing the said samples in succession upon a continuous plastic support, and treating the said samples upon the said plastic support in the manner specified above, and also
(a) marking the said plastic support with indicia providing characteristic unique data for each sample and correlated with it,
(b) passing the said plastic support, with the samples and indicia thereon, through apparatus which is adapted to examine and analyse the samples, and
(c) recording the data of the examination results (from b) and correlating it with the indicia (a).
4. Method for the examination of a series of samples, as claimed in Claim 3 wherein the correlated data (from a and c) is processed to give an output of the relationship between the examination data and the characterising data of samples in selected report form.
5. Method for the examination as a sequential series of samples as claimed in any one of Claims 1 to 4 wherein the materials for the plastic support is selected so as to be sufficiently durable and stable to survive the processes of treatment and examination to which they may be submitted.
6. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 5 wherein the continuous plastic support is made of an optically clear material.
7. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 6 wherein the continuous plastic support is made of polyester.
8. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 7 wherein the continuous plastic support has a thickness less than
175um, and preferably about 100um.
9. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 8 wherein the continuous plastic support material is treated to give it the ability to take up or hold the samples, for example biological samples.
10. Method for the examination of a sequential series of samples as claimed in Claim 9 wherein the treatment of the plastic support is with poly-l-lysine using a pre-deposition procedure.
11. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 10 wherein the indicia providing characterising data is of such form that they can survive the various treatment stages through which the samples have to pass, and also survive storage, without the recorded indicia becoming debased and difficult to decipher or read again.
12. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 11 wherein examination data is recorded for correlation with the samples on the continuous plastic support.
13. Method for the examination of a sequential series of samples as claimed in Claim 1 2 wherein the examination data is recorded on to the continuous plastic support itself, in register with the characterising data.
14. Method for the examination of a sequential series of samples as claimed in Claim 12 wherein the examination data is recorded on to a separate record which can be read in conjunction with the data on the original plastic support and the two sets of data can then be correlated.
15. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 14 wherein the plastic support itself is mainipulated to give access to samples on it having any desired property or identity or the data is interpreted or analysed to provide a display or print-out of any desired data in any desired format.
16. Method for the examination of a se
quential series of samples as claimed in Claim
15 wherein the data is processed to produce
a fresh database, optionally possibly with pro
vision for enhancement by addition of results
of a subsequent further examination to aug
ment the store of information relating to the
samples.
17. Method for the examination of a series
of samples, as claimed in any one of Claims 1 to 16 wherein the samples are biological
samples.
18. Method for the examination of a se
quential series of samples as claimed in Claim 1 7 wherein the biological samples are tissue samples, blood or other body fluid samples,
19. Method for the examination of a sequential series of samples as claimed in Claim
18 wherein the samples are cervical smears, histological preparations of botanical or mammalian tissues, or blood smears, for diagnostic or pathological study,
20. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 19 wherein the samples are treated with a coating of a plastic film, for example a pre-coated adhesive self-sealing film, to seal in and protect the sample and/or indicia.
21. Method for the examination of a sequential series of samples as claimed in any one of Claims 1 to 20 wherein the examination is by microscopical study and analysis.
22. Method for the examination of a sequential series of samples substantially as described.
23. Apparatus for the examination of a sequential series of samples by a method claimed in any one of Claims 1 to 22.
24. Apparatus for the examination of a sequential series of samples which comprises:
A. means for depositing the said samples in succession upon a continuous plastic support,
B. means for treating the said samples upon the plastic support to prepare the said samples appropriately for microscopical study and analysis,
C. means for securing the said samples to the said plastic support,
D. means for protecting and preserving the said samples upon the said plastic support,
E. means for marking the said plastic support with indicia providing data characterising each sample and correlated with each sample,
F. means for enabling plastic support with the samples and indicia thereon through apparatus which is adapted to allow examination of the samples for microscopical study and analysis,
G. means for recording the dataof the examination results (from F) and correlating them with the indicia (from E),
H. means for processing and storing the correlated data (from G) to give and output of the data relationship of examination data to samples in selected report form.
25. Apparatus for the examination of a sequential series of samples comprising one or more of the features A to H specific in Claim 24 above, adapted to be used for assembly into an apparatus for operation of a method as claimed in any one of Claim 1 to 22.
26. Apparatus for the examination of a sequential series of samples substantially as described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868626920A GB8626920D0 (en) | 1986-11-11 | 1986-11-11 | Examination of multiple samples for analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB8725600D0 GB8725600D0 (en) | 1987-12-09 |
| GB2197471A true GB2197471A (en) | 1988-05-18 |
Family
ID=10607141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB868626920A Pending GB8626920D0 (en) | 1986-11-11 | 1986-11-11 | Examination of multiple samples for analysis |
| GB08725600A Withdrawn GB2197471A (en) | 1986-11-11 | 1987-11-02 | Method for the preparation and examination of multiple samples for microscopical and scientific study and analysis |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB868626920A Pending GB8626920D0 (en) | 1986-11-11 | 1986-11-11 | Examination of multiple samples for analysis |
Country Status (1)
| Country | Link |
|---|---|
| GB (2) | GB8626920D0 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999044063A2 (en) * | 1998-02-25 | 1999-09-02 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
| US6699710B1 (en) | 1998-02-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
| US7854899B2 (en) | 2004-08-26 | 2010-12-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Template methods and devices for preparing sample arrays |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1036776A (en) * | 1963-12-04 | 1966-07-20 | Peter Adrian Rock | Method of, and apparatus for, the preparation of specimens for microscopic examination |
| GB1218749A (en) * | 1966-12-15 | 1971-01-13 | Xerox Corp | An analytical tape for use in automatic chemical analysis |
| GB1383681A (en) * | 1971-11-19 | 1974-02-12 | Technicon Instr | Photometric analysis |
| GB1367706A (en) * | 1969-06-02 | 1974-09-18 | Automated Analyzers Inc | Chemical analyzing apparatus |
| GB1454510A (en) * | 1973-05-22 | 1976-11-03 | Tetronics Research Dev Co Ltd | Laying blood traces |
| GB1461319A (en) * | 1974-01-21 | 1977-01-13 | Miles Lab | Test system device with identification code |
| GB1538755A (en) * | 1975-06-23 | 1979-01-24 | Technicon Instr | Method and apparatus for the preparation of biological smears |
| GB2046940A (en) * | 1979-04-20 | 1980-11-19 | Technicon Instr | Tissue specimen labelling |
| EP0088549A1 (en) * | 1982-03-04 | 1983-09-14 | TECHNICON INSTRUMENTS CORPORATION (a New York corporation) | Sectioning apparatus, section supporting device and method |
| EP0159603A2 (en) * | 1984-04-23 | 1985-10-30 | Abbott Laboratories | Immunocytochemical microscope control slides |
-
1986
- 1986-11-11 GB GB868626920A patent/GB8626920D0/en active Pending
-
1987
- 1987-11-02 GB GB08725600A patent/GB2197471A/en not_active Withdrawn
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1036776A (en) * | 1963-12-04 | 1966-07-20 | Peter Adrian Rock | Method of, and apparatus for, the preparation of specimens for microscopic examination |
| GB1218749A (en) * | 1966-12-15 | 1971-01-13 | Xerox Corp | An analytical tape for use in automatic chemical analysis |
| GB1367706A (en) * | 1969-06-02 | 1974-09-18 | Automated Analyzers Inc | Chemical analyzing apparatus |
| GB1383681A (en) * | 1971-11-19 | 1974-02-12 | Technicon Instr | Photometric analysis |
| GB1454510A (en) * | 1973-05-22 | 1976-11-03 | Tetronics Research Dev Co Ltd | Laying blood traces |
| GB1461319A (en) * | 1974-01-21 | 1977-01-13 | Miles Lab | Test system device with identification code |
| GB1538755A (en) * | 1975-06-23 | 1979-01-24 | Technicon Instr | Method and apparatus for the preparation of biological smears |
| GB2046940A (en) * | 1979-04-20 | 1980-11-19 | Technicon Instr | Tissue specimen labelling |
| EP0088549A1 (en) * | 1982-03-04 | 1983-09-14 | TECHNICON INSTRUMENTS CORPORATION (a New York corporation) | Sectioning apparatus, section supporting device and method |
| EP0159603A2 (en) * | 1984-04-23 | 1985-10-30 | Abbott Laboratories | Immunocytochemical microscope control slides |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999044063A2 (en) * | 1998-02-25 | 1999-09-02 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
| WO1999044063A3 (en) * | 1998-02-25 | 1999-11-04 | Us Health | Tumor tissue microarrays for rapid molecular profiling |
| US6699710B1 (en) | 1998-02-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
| EP1715340A2 (en) * | 1998-02-25 | 2006-10-25 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method and apparatus for making an array for rapid molecular profiling |
| EP1715340A3 (en) * | 1998-02-25 | 2006-11-29 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method and apparatus for parallel analysis of tissue specimens |
| EP1980852A1 (en) * | 1998-02-25 | 2008-10-15 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method and apparatus for parallel analysis of tissue specimens |
| US7854899B2 (en) | 2004-08-26 | 2010-12-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Template methods and devices for preparing sample arrays |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8626920D0 (en) | 1986-12-10 |
| GB8725600D0 (en) | 1987-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |