GB2165239A - Fluorinated isophthalonitrile compound and nonmedical fungicide containing the same - Google Patents

Fluorinated isophthalonitrile compound and nonmedical fungicide containing the same Download PDF

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GB2165239A
GB2165239A GB08521070A GB8521070A GB2165239A GB 2165239 A GB2165239 A GB 2165239A GB 08521070 A GB08521070 A GB 08521070A GB 8521070 A GB8521070 A GB 8521070A GB 2165239 A GB2165239 A GB 2165239A
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group
trifluoro
compound
isophthalonitrile
jff
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GB8521070D0 (en
GB2165239B (en
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Nobuo Ishikawa
Akio Takaoka
Takashi Isono
Masatoshi Motoyoshi
Kazuhiro Kojima
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SDS Biotech Corp
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SDS Biotech Corp
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Priority claimed from JP59178413A external-priority patent/JPS6157544A/en
Priority claimed from JP17841484A external-priority patent/JPS6157542A/en
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Publication of GB8521070D0 publication Critical patent/GB8521070D0/en
Publication of GB2165239A publication Critical patent/GB2165239A/en
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
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    • A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

A fluorinated isophthalonitrile compound having the general formula <IMAGE> wherein Y is -O, -S, or -N(R'), R and R' are independently hydrogen, an alkyl group, an alkyl group, an alkynyl group, a haloalkyl group, an alkoxyl group, alkoxyalkyl group, a phenyl group which may be substituted, a tetrahydrofurfuryl group, or a cycloalkyl group, provided that, in the case of Y = -N(R'), R and R' or Y may be a tetrahydrofurfuryl group, or a cycloalkyl group, a heterocyclic compound residue, is suitable for use as an agricultural fungicide.

Description

SPECIFICATION Fluorinated isophthalonitrile compound and nonmedical fungicide containing the same Background of the invention 1. Field of the invention The present invention relates to a novel fluorinated isophthalonitrile compound suitable for use as an agricultural fungicide or germicide as well as antibacterial and mildewproofing agent for various industrial products and the raw materials thereof. The present invention also relates to a npnmedical fungicide.
2. Description of the related art It is heretofore known, as shown in, for example, Japanese Examined Patent Publication (Kokoku) No.
41-11358, that halogenated aromatic dinitriles have biological activities suitable for use as a fungicide, a bactericide, a nematocide, and a herbicide. 4-Alkoxy-2,5,6-trichlorooisophthalonitrile compounds are also known as a mildewproofing agent as shown in, for example, Japanese Unexamined Patent Publication (Kokai) No. 50-121424. Furthermore, it has recently become problems that various industrial products and the raw materials thereof are damaged by microorganisms such as bacteria, fungi, and yeasts. These damages not only detract from the external appearance and health and sanitary properties, but also detrimentally affect performance and qualities.In order to prevent these damages, it is strongly desired in the art to develop antibacterial and mildewproofing agent having large antibacterial and mildewproofing effects, wide antibacterial spectra, and other properties depending upon the usage thereof (e.g., water resistance, heat resistance, light resistance, decomposability, and stability).
Summary of the invention Accordingly, the objects of the present invention are to provide novel compounds having the abovementioned desired antibacterial and mildewproofing effects and having excellent agricultural fungicidal properties.
Other objects and advantages of the present invention will be apparent from the following description.
In accordance with the present invention, there is provided a fluorinated isophthalonitrile compound having the general formula
wherein Y is -O, -S, or -N(R'), R and R' and independently hydrogen, an alkyl group, preferably having 1 to 10 carbon atoms, an alkenyl group, preferably having 3 to 10 carbon atoms, an alkynyl group, preferably having 3 to 10 carbon atoms a haloalkyl group preferably having 1 to 10 carbon atoms, an alkoxyl group, preferably having 1 to 10 carbon atoms, an alkoxyalkyl group, preferably having 2 to 10 carbon atoms, a phenyl group which may be substituted, a tetrahydrofurfuryl group, or a cycloalkyl group, preferably having 3 to 8 carbon atoms, provide that, in the case of Y =' -N(R'), R and R' or Y may be a heterocyclic compound residue, preferably pyrazol-3-yl, 1,2,4-triazol-3-yl, benzimidazol-2-yl, 2(1H)-pyrimidinon-6-yl, imidazol-1 -yl, pyrazol-1 -yl, pyrimidine-2,4(1 H,3H)-dion-1 -yl, morpholino, piperidino group which may be substituted.
In accordance with the present invention, there is also provided a nonmedical fungicide comprising, as an effective ingredient, the fluorinated isophthalonitrile having the above-mentioned general formula (I).
Description of the preferred embodiments According to the present invention, there is propided novel fluorinated isophthalonitrile compounds having the above-mentioned general formula (I). Typical examples of such compounds are shown in Table 1.
Table 1
Physical Property Compound -YR in No. formula (I) Melting point (mp), Boiling point (bp), Refractive index (nD) 1 NH2 mop191 - 1930C 2 -NHCH3 mp107- 1090C 3 -NHC2H5 mp75 - 770C 4 -NHC4H9~n bp165 - 1670C/2.5 mmHg 5 -N(C4H9 n)2 bp137 - 1390C/2.5 mmHg 6 -NH e mp131.5- 1340C 7 -NH e C1 mp1670C C1 8 -NH O C1 mp1580C H N - N 9 -NH, mp260 C 10 -NH < X mp2600C or more H T-H 11 -N X mp2600C or more 12 -N 9 mp64 - 660C F 13 -NEa 19O N mp90 - 1910C NH4o 14 (C2H5)2 bpl44 - 1460C/7 mmHg N 15 -N -\ 2O9 - 2100C N Table 1 (Continued)
Physical Property compound -YR in No. formula (I) Melting point (mp), Boiling point (bp), Refractive index H N 16 -N > -0 mp2600C or more F .n 17 -N mp2110C ,CH3 18 -N O mpl38 - 1390C CH3 19 -OH mpl68 - 1720C 20 oCH3 mp71 - 72"C 21 -GC2H5 mp59 - 620C 22 -SC2H5 18.5 1.5610 nD bop115 - 118"C/0.3 mnHg 23 -0-n-C3H2 mp54 - 560C 24 -0-i-C3H7 mp63 - 640C C,, 25 -0-n-C4Hg bp134 - 136"C/0.3 mmHg 26 -0-i-C4H8 bop121 - 1230C/0.3 mmHg 30 27 OCH2CH=CH2 mp50 C or less, nD 1.5136 28 -CCF3CH2 27 nD7 1.4635 nD 29 - e mp81 - 850C 30 e mpll9 - 1210C CH 31 - e 3 mp550C or less 32CH3 mp99 - 1010C 3 Table 1 (Continued)
Physical Property Compound -YR in No. formula (I) Melting point (mp), Boiling point (bp), Refractive index (nod) C1mp96 - 98"0 33 - t mp96 - 98 C 34 -O e C1 nD6 1.5608 C1 35 oC1 it550C or less CH 36 o$\CH3 mp88 - 910C CH3 D mpllO - 1l50C CH3 38 off e F mp55 C or less C1 39 - b CH3 rrq?840C 40 - e NT02 mp90 - 950C 41 -S mop90 - 920C bp65 - 670C/0.7 mmHg 42 - -CH2C=cH2 np500C or less 21 2 CH3 24 43 -0-CH2ChT20CH3 nD 1.5030 44 -O-CH2-Q 1.5186 n, 1.5186 45 -0-n-C6H13 nD4 1.4937 46 n C8H17 nD4 1.4906 47 24 i.5036 no 48 0oH23 bp1130C/0.21 mnHg CH3 CH3 Table 1 (Continued) Physical Property Compound -YR in No. formula (I) Melting point (mp), Boiling point (bp), Refractive index (nD) 49 -S-CH3 mp50 C or less, nD40 1.5651 50 -S-n-C3H7 mp50 C or less, nD 1.5524 51 -s-iso-C3H7 mp50 C or less, 40 1.5495 nD 52 -S-n-C4Hg bp138 - 1390C/0.3 mmHg, 28 no 1.5486 53 -s-iso-C4Hg bp120 - 1210C/0.18 mmHg, 1.5403 54 -S-sec-C4Hg bp106 - 108 C/0.15 mmHg, 40 no 1.5440 The fluorinated isophthalonitrile compounds having the general formula (I) according to the present invention can be prepared as follows.
wherein Y and R are the same as defined above.
Thus, the starting materials (II) and (III) are mixed to allow to be reacted in the presence or absence of a solvent to form the desired fluorinated iso-phthalonitrile compounds (I). The reaction is preferably carried out at a temperature between -20 C and the reflux temperature of a solvent. The starting material (Ill) may be used as a reaction solvent. Alternatively, aprotic solvents such as acetonitrile, chloroform, dichloromethane, benzene, toluene, dioxane, ethyl ether, tetrahydrofuran, and ethyl acetate may be used as a reaction solvent.Furthermore, the above-mentioned reaction can be advantageously accelerated when a catalytic amount, or an amount equimolecular to 10 times the starting material (II), of a base such as an alkali hydroxide, triethylamine, pyridine, an alkali carbonate, or potassium fluoride is used.
The starting compound (II), i.e., tetrafluoro-isophthalonitrile, can be prepared from tetrachloroisophthalonitrile in a known manner (see, for example, British Patent No. 1026290 (1966), Bull. Chem. Soc.
Japan 40, 688 (1966), Kagaku Kogyo Zasshi (Japan) 73, 447 (1970), and Japanese Examined Patent Publication No. 41-11358).
The fluorinated isophthalonitrile compounds according to the present invention have excellent and remarkable mildewproofing action and antibacterial action and also have wide action spectra and are very stable against ultraviolet light. Furthermore, when the fluorinated isophthalonitrile compounds according to the present invention are used as an agricultural fungicide in the field or as an industrial antibacterial and mildewproofing agent outdoors, the compounds exhibit excellent prolonged activity.
The nonmedical fungicides according to the present invention contain, as an effective or active ingredient, one or more of the above-mentioned fluorinated iso-phthalonitrile compounds, preferably in an amount of 1% to 95% by weight, more preferably 10% to 80% by weight, of the total amount of the composition. Thus, the present fungicide has excellent curative effects (i.e., effects obtained by directly applying the present agent to the portion where harmful fungi or bacteria are generated) and excellent preventive effects (i.e., effects obtained by applying the present agent to the portion where harmful fungi or bacteria are expected to be generated).
The above-mentioned effective compounds according to the present invention can be directly used as a nonmedical fungicide. Furthermore, the present compounds can be formulated with bases to form various forms of preparations such as powder, wettable powder, tablets, oily agents, gaseous agents, emulsions, aerosols, and fumigants.
These bases usable in the formulation of the present fungicides may be in the form of solid, liquid, or gas. Examples of the solid bases usable in the present invention are talc, clay, kaolin, diatomaceous earth, calcium carbonate, potassium chlorate, silica, niter, woodmeal, nitrocellulose, starch, wheat flour, soybean flour, and gum arabic.
Examples of the liquid bases usable in the present invention are water and organic solvents. Typical examples of the organic solvents are hydrocarbons such as benzene, toluene, xylene, kerosine, diesel oil, fuel oil, petroleum, and naphtha; ketones such as acetone, methylethyl ketone, and cyclohexanone; chlorinated hydrocarbons such as carbon tetrachloride, chloroform, trichloroethylene, and perchloroethylene; amyl acetate and butyl acetate; monoalkyl ethers, e.g., monomethyl ether and monoethyl ether, of ethylene glycol; and alcohols such as methanol, ethanol, isopropanol, and amyl alcohol.
Examples of the gaseous bases usable in the present invention are air, nitrogen, carbon dioxide, Freon (registered trademark of DuPont for fluorohydrocarbons), propane, and butane.
In addition to the above-mentioned bases, various conventional ingredients can be optionally incorporated into the present germicide. For example, nonionic, anionic, cationic, or ampholytic surfactants can be used as an adjuvant (i.e., a wetting agent, emulsifier, dispersing agent, spreader).
The nonmedical germicides according to the present invention are effective for controlling a wide variety of diseases of various agricultural and garden crops and are also effective against microorganisms, such as fungi, algae, bacteria, and organisms of slime, which adversely affect industrial products or the starting materials thereof. Examples of such diseases and microorganisms are as follows.
Group llDiseasesJ Crops Diseases Rice Blast Brown spot Sheath blight Bacterial leaf blight Wheat Spot blotch Snow mold Typhula snow blight Potato Late blight Early blight Black scurf Pulse Brown spot Frog-eye leaf spot Downy mildew Stem rot Tobacco Wild fire Black shank Tea Bacterial shoot blight Blister blight Net blister blight Anthracnose Gray blight Sugar beet Downy mildew Cercospora leaf spot Damping-off Tomato Bacterial canker Late blight Gray mold leaf mold Fusarium wilt Stem rot Damping-off Early blight Cucumber Gray mold Downy mildew Phytophthora rot Scab Damping-off Anth racnose Gummy stem blight Fusarium wilt Japanese raddish Black rot (daikon) Bacterial soft rot Yellows (wilt) Gray leaf spot (Alternaria leaf spot) Downy mildew Onion Bacterial soft rot Downy mildew Gray-mold neck rot Lettuce Bacterial soft rot Stem rot Citrus fruit Gray mold Canker Melanose Scab Apple Blossom blight Scab Alternaria leaf spot Japanese persimmon Gray mold (kaki) Circular leaf spot Angular leaf spot Anth racnose Japanese pear Scab Black spot Peach Brown rot Scab Phomopsis rot Bacterial shot hole Grape Downy mildew Anthracnose Gray mold Ripe rot Group Il rMicroorganisms which adversely affect industrial products and the raw materials thereof) Bacillus spp., Staphylococcus spp., Escherichia spp., Pseudomonas spp., Serratia spp., Alternaria spp., Aspergillus spp., Penicillium spp., Cladosporium spp., Mucor spp., Rhizopus spp., Gliocladium spp., Eurotium spp., Aureobasidium spp., Chaetomium spp., Fusarium spp., Myrothecium spp., Rhodotorula spp., and Saccharomyces spp.
The nonmedical fungicide according to the present invention can be preferably used in a concentration of 1 to 1000 ppm, more preferably 10 to 500 ppm, in the formulated composition, although the concentration of the active component depends upon the kinds of diseases and microorganisms. Thus, the above-mentioned diseases can be effectively controlled and industrial products and the raw materials thereof can be advantageously, protected from damages caused by various microorganisms.
The germicide according to the present invention can be used alone in the preparations thereof. It should be noted, however, that the active component of the present germicide can also be formulated into the preparations together with one or more agents such as various conventional insecticides, bactericides, fungicides, herbicides, plant growth regulaters miticides, nematocides, attractants, repellents, nutrients, fertilizers, and soil structure conditioning agents. Thus, these preparations are expected to exhibit various wide effects.
The nonmedical fungicides can be used as a fungicide, in addition to the above-mentioned agricultural and garden fungicides, for preventing the industrial products and the raw materials thereof from adverse effects or damage caused by various microorganisms. Examples of such industrial products and the raw materials thereof are plastics, plasters, carpets, adhesives, emulsions (or emulsified liquids), paints, coating agents, hides, glues, wood (or timbers), fibers, paper, and cardboard. Furthermore, the present fungicides can be similarly applied to the portions of industrial plants such as cooling water circulation system and cooling lubricating oil circulation system.
EXAMPLE The present invention will be further explained by, but is by means limited to, the follow Synthetic Examples, Formulation Examples, and Test Examples. In Synthetic Examples,19Fnmr and 1Hnmr are the NMR data determined by using trifluoro acetic acid as an outer standard and tetramethyl silane as an inner standard, respectively, unless otherwise specified.
Synthetic example 1 Synthesis of 4-Amino-2,5,6-trifluoroisophthaionitrile (i.e., Compound No. 1) To a solution of 2.0 g of tetrafluoroisophthalonitrile in 20 ml of acetonitrile, 0.6 ml of 28% aqueous ammonia was dropwise added. After the dropwise addition, the mixture was stirred at room temperature for one hour. An aqueous sodium bicarbonate solution was added to the mixture and the resultant mixture was extracted with chloroform and was washed with an aqueous sodium chloride solution. After drying with sodium sulfate, the chloroform was distilled off to obtain yellow crystal. The resultant crystal was recrystallized from chloroform to obtain 1.2 g (61% yield) of the desired compound No. 1.
The analytical results are as follows.
'9Four (CCIJDMSOd6) 825.0 (d,JFF = 9.4 Hz, 1F) 46.7 (d,JFP = 18.8 Hz,1F) 80.0 (dd, JFF = 18.8 Hz, 9.4 Hz, iF) Hnmr (CCIJDMSOd6) 82.8 (s) Synthetic example 2 Synthesis of 4-Anilino-2,4,6-trifluoroisophthaloni-trile (i.e., Compound No. 6) A solution of 0.85 g of aniline in 20 ml of aceto-nitrile was dropwise added, while stirring, to a solution of 2.0 g of tetrafluoroisophthalonitrile and 2.0 g of triethylamine in 30 ml of acetonitrile. After dropwise adding, the mixture was stirred at room temperature for 1 hour and an aqueous sodium bicarbonate solution was then added.The mixture was extracted with chloroform and the chloroform extract was washed 5 times with an aqueous sodium chloride solution. After drying with magnesium sulfate, the chloroform was distilled off. The resultant crude crystal was purified by silica gel chromatography (solvent:hexane). Thus, 2.3 g (87% yield) of the desired compound No. 6 was obtained.
The analytical results are as follows.
lSFnmr (CCIJDMSOd6) 824.3 (d, JFF = 9.4 Hz, 1F) 45.4 (d, JFF = 19.0 Hz, 1F) 72.7 (dd, JFF = 19.0 Hz, 9.4 Hz, 1F) 'Hnmr (CCl4/DMSOd6) 83.7 (s, 1H) 7.4 (s, 5H) Synthetic example 3 Synthesis of 4-Diethylamino-2,5,6-trifluoroiso-phthalonitrile (i.e., Compound No. 14) The desired compound was prepared in the same manner as in Synthetic Example 2 by using diethyl amine in lieu of the aniline. The resultant yellow liquid was distilled in vacuo to obtain 2.0 g (91% yield) of the desired compound No. 14 as a fraction at a boiling point of 144 C to 146 C/7 mmHg.
The analytical results are as follows.
rsFnmr (CCIJDMSO-d6) 823.4 (dd, JFF = 9 Hz, 1.8 Hz, 1F) 43.2 (dd, JFF = 18 Hz, 1.8 Hz, 1F) 69.5 (ddd, JFF = 18 Hz, 9 Hz, 1F) Hnmr (CCIJDMSO-d6) 81.2 (t, 3H) 3.4 (q, 2H) Synthetic example 4 Synthesis of 2,4,5-Trifluoro-6-hydroxyisophthalo-nitrile (i.e., Compound No. 19) A 2.0 g amount of tetrafluoroisophthalonitrile and 0.7 g of sodium hydroxide were added to 40 ml of water and the mixture was heated under reflux for 1.5 hours. After cooling, the mixture was neutralized with concentrated hydrochloric acid and was then extracted with ether. After the ether extract was washed with water, the extract was dried with magnesium sulfate.The solvent was distilled off and the resultant crude crystal was recrystallized to obtain 1.39 g of the desired compound No. 19.
The analytical results are as follows.
Elementary analysis C, Found 48.32% Calc. 48.5% H Found 0.51% Calc. 0.55% N Found 14.0% Calc. 14.1% sFnmr (CCIJDMSOd4) 825.5 (d, JFF = 9.35 Hz, 1 F) 43.0 (d, JFF = 19.6 Hz, 1F) 78.7 (dd, JFF = 9.35 Hz, JFF = 19.6 Hz, 1F) Hnmr (CCl4iDMSOd6) ô2.50 (S, 1H) Synthetic example 5 Synthesis of 2,4,5-Trifluoro-6-methoxyisophthalo-nitrile (i.e., Compound No. 20) A 2.0 g amount of tetrafluoroisophthalonitrile was heated under reflux in 40 ml of methanol for 4 hours. The methanol was distilled off in vacuo to approximately one-fifth volume and ice water was then poured to the resultant mixture. The precipitated crystal was collected by filtration and was then washed with water and a small amount of cold methanol. After drying in vacuo, 1.6 g of the desired compound No. 20 was obtained.
The analytical results are as follows.
19Fnmr (CCIJDMSOd6) 324 (d, JFF = 13 Hz, 1F) 38 (d, JFF = 20 Hz, 1F) 75 (dd, JFF = 20 Hz, JFF = 13 Hz, 1F) aHnmr (CCl4/DMSOd6) 84.3 (S, 3H) Synthetic example 6 Synthesis of 4-Ethoxy-2,5,6-trifluoroisophthalo-nitrile (i.e., Compound No. 21) The desired compound was obtained in the same manner as in Synthetic Example 5, except that ethanol was used in lieu of methanol. The yield was 90%.
The analytical results are as follows.
19Fnmr (CCI4/DMSOd6 822.7 (d, JFF = 10.2 Hz, 1F) 32.7 (d, JFF = 18.7 Hz, 1F) 75.2 (dd, JF, = 18.7 Hz, JFF = 10.1 Hz, 1F) zHnmr (CCI41DMSOd6) 81.5 (t, HH = 8 Hz, 3H) 4.7 (q, JHH = 8 Hz, 2H) Synthetic example 7 Synthesis of 2,5,6-Trifluoro-4-isopropoxyiso-phthalonitrile (i.e., Compound No. 24) The desired compound was obtained in the same manner as in Synthetic Example 5, except that isopropanol was used in lieu of methanol.
The yield was 86%.
Synthetic example 8 Synthesis of 2,4,5-Trifluoro-6-phenoxyisophthalo-nitrile (i.e., Compound No. 29) A mixture of 2.0 g of isotetrafluorophthalonitrile, 1.0 g of phenol, and 3 g of potassium fluoride was heated under reflux for 1.5 hours in 30 ml of acetonitrile. After adding 40 ml of water, the reaction mixture was extracted with chloroform. After washing with water, the extract was dried with magnesium sulfate and the solvent was then distilled off to obtain 2.6 g of the residue. The crude product thus obtained was treated by silica gel chromatography (solvent: chloroform) to obta in 1.7 g (64% yield) of the desired compound in the form of crystal.
The analytical results are as follows.
19Fnmr (CCI4/DMSOd6) 834.5 (d, JFF = 12 Hz, 1F) 57.0 (d, JFF = 18 Hz, 1F) 85.5 (dd, JFF = 18 Hz, JFF = 12 Hz, 1F) 'Hnmr (CCI4/DMSOd6) 87 - 8 (m) Synthetic example 9 Synthesis of 2,4,5-trifluoro-6-(2,6-xylyioxy)iso-phthalonitrile (i.e., Compound No. 37) A solution of 1.2 g (10 x 10-3 mol) of 2,6-di-methylphenol in 40 ml of acetonitriie was dropwise added at a temperature of -10 C to a solution of 2.0 g (10 x 10-3 mol) of tetrafluoroisophthalonitrile and 2.9 g (50 x 10-3 mol) of potassium fluoride.The mixture was allowed to stand at a temperature of -10 C to 0 C for 1 hour while stirring and the undissolved potassium fluoride was separated by filtration. The filtrate was concentrated to dryness in vacuo. The resultant residue was dissolved in a mixed solvent of acetone and cyclo-hexane and 2.3 g (77% yield) of the desired compound No. 37 was obtained as white crystal.
The analytical results are as follows.
'SF-NMR (acetone) 826.0 (d, JpF = 8.7 Hz, 1F) 41.0 (d, JFF = 16.4 Hz, 1F) 80.0 (dd, JFF = 8.7, 16.4 Hz, 1F) H-NMR (CDCl3) 82.15 (S, 6H) 6.95 - 7.1 (m, 3H) Synthetic example 10 Synthesis of 2,4,5-Trifluoro-6-phenylthioiso-phthalonitrile (i.e., Compound No. 41) A 2.0 g amount of tetrafluoroisophthalonitrile and 0.87 g of potassium fluoride were dissolved in 10 ml of acetonitrile. After cooling the mixture to a temperature of 0 C by an ice-water bath, 1.1 g of phenyl mercaptan was dropwise added by a syringe.While mixture was maintained at a temperature of about 0 C, the mixture was stirred for 8 hours and the solvent was then distilled off. A 50 ml amount of water was added to the mixture and potassium fluoride was dissolved. The mixture was extracted with chloroform, and the extract was dried with magnesium sulfate. The chloroform was distilled off in vacuo and the resultant liquid was then distilled in vacuo to obtain 1.8 g (63% yield) of the desired compound No.
41 at a boiling point of 65"C to 670C/0.7 mmHg.
The analytical results are as follows.
19Fnmr (CCi4/DMSOd6) 823.1 (d, JFF = 11.9 Hz, 1F) 38.2 (d, JFF = 18.9 Hz, 1F) 49.4 (dd, JFF = 18.9 Hz, 11.9 Hz, 1F) Hnmr (CCl4/DMSOd6) 3 7.4 (S) Synthetic example 11 Synthesis of 2,4,5-Trifluoro-6-methallyloxyiso.pthalonitrile (i.e., Compound No. 42) The mixture of 3.0 g of tetrafluoroisophthaloni-trile, 1.2 g of -methallyl alcohol and 1.8 g of potassium fluoride in 30 ml of acetonitrile was stirred at room temperature for 10 hours. The mixture was cooled and filtered. The filtrate was evaporated under reduced pressure. After 50 ml of water was added to the residue, the mixture was extracted with carbon tetrachloride, washed with water, and dried over sodium sulfate.After evaporating carbon tetrachloride, the residue of 2.9 g (crystal) was obtained.
The analytical results are as follows.
mp < 50 C 'Hnmr (CDCl3) 31.88(3H, s), 34.9 - 5.2 (H, m) Synthetic example 12 Synthesis of 4-Allyloxy-2,5,6-trifluoloisophthalo-nitrile (i.e., Compound No. 27) The desired compound was obtained in the same manner as in Synthetic Example 11, except that allyl alcohol vvas used in lieu of methallyl alcohol.
The analytical results are as follows.
'9Fnmr (CCl4/DMSOd6) 825.5 (d, JFF = 9.0 Hz, 1F) 39.8 (d, JFF = 18.4 Hz, 1F) 75.3 (m, 1F) Synthetic example 13 Synthesis of 2,4,5-Trifluoro-6-(2.methoxyethoxy)iso-phthalonitrile (i.e., Compound No. 43) The mixture of 3.0 g tetrafluoroisophthalonitrile, 1.2 g of methyl cellosolve, and 1.8 g of potassium fluoride in 30 ml of acetonitrile was stirred at room temperature for 8 hours. The mixture was filtered.
The filtrate was evaporated under reduced pressure. After 50 ml of water was added to the residue, the mixture was extracted with dichloromethane, washed with water, and dried over sodium sulfate. After evaporating dichloro-methane, residue of 3.4 g was obtained. By column chromatography (Wakogel C200; solvent-CH2CI2) pure oil (3.0 g) was isolated.
'Hnmr (CDCl3)3.38 (3H, s), 3.83 (2H, t, J = 6 Hz), 4.63 (2H, m) Synthetic example 14 Synthesis of 2,4,5-Trifluoro-6-tetrahydrofur-furyloxyisophthalonitrile (i.e., Compound No. 44) The mixture of 3.0 g of tetrafluoroisophthaloni-trile, 1.7 g of furfuryl alcohol, and 1.8 g of potassium fluoride in 30 ml of acetonitrile was stirred at room temperature for 10 hours. The mixture was filtered.
The filtrate was evaporated under reduced pressure After 50 ml of water was added to the residue, the mixture was extracted with chloroform, washed with water and dried over magnesium sulfate. After evaporating chloroform, residue of 3.8 g was obtained. By column chromatography (florisil; solvent-chloroform) pure oil (3.2 g) was isolated.
Synthetic example 15 Synthesis of 2,4,5-Trifluoro-6-cyclohexanyloxyiso-phthalonitrile (i.e., Compound No. 46) A 5.0 g amount of tetrafluoroisophthalonitrile and 2.18 g of potassium fluoride were dissolved in 25 ml of acetonitrile, and 3.83 g of cyclohexanol was then dropwise added to the mixture. After the dropwise addition, the mixture was stirred at room temperature for 24 hours. The reaction mixture was filtered, the filtrate was concentrated in vacuo, and the concentrated liquid was poured to 50 ml of water. The resultant mixture was extracted with carbon tetrachloride. After washing with water, the extract was dried with anhydrous magnesium sulfate and the solvent was then distilled off. Thus, 6.2 g (88% yield) of the desired compound No. 47 was obtained.
The analytical results are as follows.
59Four (CDCla) 8: 26.0 (d, JFF = 9.4 Hz, 1F) 41.0 (d, JFf = 16.9 Hz, 1F) 75.5 (ddt, JFF = 9.4 Hz, JFF = 16.9 Hz, 1F) Synthetic example 16 Synthesis of 2,4,5-Trifluoro-6-sec-butoxyiso-phthalonitrile (i.e., Compound No. 48) A 3.0 g amount of tetrafluoroisophthalonitrile and 1.26 g of 20 ml acetonitrile were dissolved in 20 ml of acetonitrile. A 1.66 g amount of sec-butanol was dropwise added to the mixture and the mixture was then stirred at room temperature for 24 hours. After the mixture was filtered, the filtrate was concentrated in vacuo and the concentrated liquid was poured into 50 mi of water. The mixture was extracted with carbon tetrachloride.After washing with water, the resultant mixture was dried with an hydros magnesium sulfate and the solvent was then distilled off. Thus, 3.4 g (89% yield) of the desired compound No. 48 was obtained.
The analytical results are as follows.
'9Fnmr (CDCl3) 8: 23.7 (d, JFF = 9.6 Hz, 1F) 38.7 (d, JFF = 16.9 Hz, 1F) 74.3 (dd, JFF = 16.9 Hz, JFF = 9.6 Hz, 1F) IR (KB,) 2250 cm 1 (C = N) Synthetic example 17 Synthesis of 2,4,5-Trifluoro-6-propylthioiso-phthalonitrile (i.e., Compound No. 50) A 2.0 g amount of tetrafluoroisophthalonitrile and 0.87 g of potassium fluoride were dissolved in 10 ml of acetonitrile. After cooling the mixture to a temperature of 0 C, 0.76 g of n-propylmercaptan was gradually dropwise added to the mixture and the resultant mixture was stirred at a temperature of 0 C or less for 12 hours. To the reaction mixture, 50 ml of water was added. The mixture was then extracted with chloroform.After washing with a saturated aqueous sodium bicarbonate solution, the mixture was dried with anhydrous magnesium sulfate. The chloroform was distilled off and the crude product was treated by silica gel column chromatography (solvent: n-hexane/ethyl acetate = 3/1).
Thus, 1.7 g (66% yield) of the desired compound No. 52 was obtained. The analytical results are as follows.
lSFnmr (CCl4) 8: 22.0 (d, JFF = 13.2 Hz, 1F) 38.7 (d, JFF = 20.7 Hz, 1F) 51.7 (ddt, JFF = 13.2 Hz, JpF = 20.7 Hz, 1F) Synthetic example 18 Synthesis of 2,4,5-Trifluoro-6-isopropylthioiso-phthalonitrile (i.e., Compound No. 51) The desired compound was prepared in the same manner as in Synthetic Example 17, except that isopro-pylmercaptan was used in lieu of n-propylmercaptan. Thus, 1.6 g (63% yield) of the desired compound No. 51 was obtained.
The analytical results are as follows.
'9Fnmr (CCl4) 8: 22.3 (d, JFF = 13.0 Hz, 1F) 38.3 (d, JFF = 20.2 Hz, 1 F) 50.5 (ddt, JFF = 13.0 Hz, JFF = 20.2 Hz, 1F) Synthetic example 19 Synthesis of 2,4,5-Trifluoro-6-n-butylthioiso-phthalonitrile (i.e., Compound No. 52) A 2.0 g amount of tetrafluoroisophthalonitrile and 0.87 g of potassium fluoride were dissolved in 10 ml of acetonitrile. After cooling to a temperature of 0 C, 0.90 g (1.04 ml) of n-butylmercaptan was gradually dropwise added to the mixture and the resultant mixture was stirred at a temperature of 0 C or less for 12 hours.After 50 ml of water was added to the reaction mixture, the reaction mixture was extracted with chloroform and the extract was then washed with a saturated aqueous sodium bicarbonate solution, followed by drying with an hydros magnesium sulfate. After distilling off the chloroform, the resultant crude product was distilled in vacuo. Thus, 2.08 g (77% yield) of the desired compound No. 52 was obtained.
The analytical results are as follows.
'9Fnmr (CCI4) 8: 23.3 (d, JFF = 14.1 Hz, 1F) 39.2 (d, J,F = 21.4 Hz, 1F) 52.3 (ddt, JFF = 14.1 Hz, JFF = 21.4 Hz, 1F) Synthetic example 20 Synthesis of 2,4,5-Trifluoro-6-isobutylthioiso-phthalonitrile (i.e., Compound No. 53) The desired compound was obtained in the same manner as in Synthetic Example 19, except that isobutyl-mercaptan was used in lieu of n-butylmercaptan.
Thus, 2.02 g (75% yield) of the desired compound was obtained.
The analytical results are as follows.
19Fnmr (CCl4) 8: 22.0 (d, JFF = 11.3 Hz, 1F) 38.3 (d, JFF = 18.8 Hz, 1F) 51.5 (ddt, JFP = 11.3 Hz, JFF = 18.8 Hz, 1F) Formulation example 1 Powder germicides having the following compositions were prepared by mixing the ingredients listed below at room temperature.
Ingredient Parts by weight Compound listed in Table 1 3 Clay 40 Talc 57 The powder germicides thus obtained were evaluated in the Test Examples below.
Formulation example 2 Wettable powder germicides having the following compositions were prepared by mixing the ingredients listed below at room temperature.
Ingredient Parts by weight Compound listed in Table 1 75 Polyoxyethylele alkylallylether 9 White carbon 16 The wettable powder germicides thus obtained were evaluated in the Test Examples below.
Test Example 1 Evaluation test of antibacterial and antifungal activity against pathogenic bacteria and fungi of plant Conidia of pathogenic fungi and bacteria of plants cultivated on culture media were uniformly mixed in a PSA culture medium and a constant amount of the resultant mixture was poured into a vessel. Thus, uniform plates were prepared.
After solidifying, a filter paper having a diameter of 8mm, which was prepared by absorbing a certain amount of the active compound, followed by air drying, was placed on the plate. After 48 hour incubation, the diameter of the inhibited circle was measured. Two tests were carried out in each run.
The results are shown in Table 2.
TABLE 2 Compound Concentration Diameter (mm) of Inhibited Circle No. (a.i. ppm) B.C.*1 A.k*1 P.o*1 X.c*1 1 500 0 0 30.5 16.8 2 " 0 0 14.3 15.0 3 " 0 0 14.0 22.5 4 " 0 17.3 19.8 20.0 5 " 0 0 15.5 13.3 6 " 0 0 22.5 13.8 7 " 0 0 10.2 0 8 " 0 0 15.5 0 9 C, 31.5 0 30.8 0 10 " 0 0 10.2 0 11 " 31.0 0 18.5 30.0 12 " 30.8 14.5 34.3 0 13 " 0 0 10.2 0 14 " 22.5 22.5 34.3 0 15 " 0 0 13.3 0 16 " 0 0 11.5 0 17 " 0 10.2 10.2 0 18 " 0 0 10.2 0 19 11 31.2 0 33.7 0 20 500 38.9 29.0 35.2 28.0 21 " 33.0 13.4 19.8 30.5 22 " 30.2 31.5 21.5 16.4 23 C, 31.5 32.3 30.2 30.4 24 " 33.5 33.5 34.1 30.5 25 " 32.1 31.5 33.0 31.5 26 " 15.0 30.5 29.0 28.0 27 " 30 30 34.8 28.8 28 " 22.5 29.0 30.5 28.2 29 " 29.8 30.5 33.0 0 30 " 17.0 12.5 12.3 0 31 " 30.3 17.7 24.5 10.0 32 " 18.0 12.5 13.8 11.0 33 " 20.0 13.8 15.0 12.3 34 " 20.5 15.0 15.5 11.8 35 " 20.0 19.2 15.5 12.5 36 " 18.0 16.0 16.0 0 37 " 13.5 0 13.5 10.0 38 " 22.5 13.2 14.0 0 39 500 19.8 12.5 12.2 0 40 " 21.3 13.8 15.3 0 42 " 30.0 33.5 34.1 29.2 43 " 28.5 30.8 32.8 22.5 44 " 27.8 29.2 30.5 19.8 45 C, 19.8 22.5 21.5 28.0 46 " 13.5 15.8 18.3 0 47 " 31.0 33.2 32.5 29.0 48 " 14.8 30.0 28.0 27.5 49 " 30.2 15.5 31.5 10.0 50 C, 30.0 30.5 28.2 29.8 51 " 32.2 31.0 32.5 28.8 52 " 30.0 29.8 30.5 28.0 53 " 15.0 28.2 27.0 26.0 54 " 15.0 28.8 28.0 26.8 Daconil*2 " 16.1 15.4 15.5 *1: B.c: Gray mold of vegetables A.k: Black spot of pear P.o: Blast of rice X.c: Canker of citrus fruit *2: Comparative test, available from SDS Biotech K.K.
Test example 2 Evaluation test of antifungal activity against black spot of pear A sample agent diluted to a certain concentration was uniformly sprayed on the developed leaves of pear trees (variety: Nijyusseiki) in an amount of 20 ml per 5 leaves and was dried in a room.
After air drying, conidia of Alternaria kikuchiana formed on an apricot culture medium were sprayed on and was inoculated on the leaves. The incubation was carried out at a temperature of 25 C and a relative humidity of 100% for 3 days. After 3 days, the infected area was measured. Five tests were carried out in each run.
The results are shown in Table 3.
TABLE 3 Compound Concentration Average infected Controlled No. (a.i. ppm) area (%) value (%) 1 500 0.3 99.7 2 CC 0 100 3 " 5.3 94.7 6 CC 0 100 7 " 10.0 90.0 12 " 5.6 94.4 20 " 15.0 85.0 23 " 5.1 94.9 24 " 3.2 96.8 25 " 41.0 59.0 26 CC 65.0 35.0 28 " 28.5 71.5 Rovral+ " 5.2 94.8 Control~2 - 100 *1:Comparative test, available from RHONE POULENC *2: No treatment Test example 3 Evaluation test of antifungal effect against rice blast disease A sample liquid agent containing a certain amount of an active compound was uniformly sprayed on rice seedlings (variety: Jyukkoku) at true leaf stage in a pot with the volume of 200 litre/l0 a and was airdried in a green house.
After air drying, a spore suspension previously prepared in such a way that 40 conidia of rice blast fungus were present in a visual area of a 100 magnification microscope was uniformly sprayed and inoculated. Immediately, the sprayed rice seedlings were allowed to stand under dark conditions of a temperature of 23 C and a relative humidity of 100%. After 48 hours, the rice seedlings were transferred to a green house and, after 10 days from the inocuration, the degree of the infection was determined. The inhibition value was calculated as follows. Three tests were carried out in each run.
Degree of infection = ### wherein n: Number of leaves in each infection degree f: index of infection degree N: Number of leaves examined Index of infection Number of lesion degree per leaf 0 0 1 1-3 2 4-6 3 7-10 4 11 or more The results are as shown in Table 4.
TABLE 4 Concen- No. of leaves in % of in Compound tration No. of leaves each infection fected Infection Chemical No. (a.i. ppm) examined degree leaves degree injury 0 1 2 3 4 38 500 185 163 19 3 0 0 13.5 3.4 Fujione* 500 180 152 22 6 0 0 15.6 4.7 Control* - 184 0 50 85 40 9 100 51.1 *1: Comparative test, commercially available from NIPPON NOHYAKU K.K..
*2: No treatment Test example 4 Evaluation test of antifungal effect against rice blast disease Test Example 3 was repeated except that the active compound was changed.
The results are as shown in Table 5.
TABLE 5 Concen- No. of leaves in % of in Compound tration No. of leaves each infection fected Infection Chemical No. (a.i.ppm) examined degree leaves degree injury 0 1 2 3 4 44 500 249 168 57 24 0 0 32.5 10.5 Fujione* 500 280 190 70 10 10 0 32.1 10.7 Control* - 270 20 110 90 40 10 92.6 41.7 *1: Comparative test, commercially available from NIPPON NOKYAKU K.K..
*2: No treatment Test example 5 Antifungal spectrum test against spores by agar dilution streak method A 10 ml amount of a potato-agar medium containing a certain concentration of each active ingredient was poured into a petri dish. After solidifying, a spore suspension of each test microorganism having 2.00 to 3.00 x 106 spores/ml was inoculated in the form of streaks with a platinum loop amount. The petri dish was allowed to stand in a constant temperature room at 25"C for 3 days. Thereafter, the degree of growth was examined and the minimum inhibition concentration (i.e., "MIC") was determined. Four tests were carried out in each run.
The results are shown in Table 6.
TABLE 6 MIC (ppm) Compound Microorganism No.
A B C D E 14 < 5 < 5 50 50 > 50 20 < 5 < 5 < 5 5 10 21 < 5 < 5 < 5 < 5 25 22 < 5 < 5 < 5 < 5 > 50 23 < 5 < 5 < 5 10 50 24 < 5 < 5 < 5 10 25 25 < 5 < 5 < 5 10 25 26 < 5 < 5 10 25 50 27 < 5 < 5 5 5 10 28 < 5 < 5 10 10 25 31 < 5 < 5 < 5 10 > 50 42 < 5 < 5 5 10 20 43 < 5 < 5 10 20 20 44 5 10 20 20 20 47 < 5 < 5 5 10 10 48 < 5 < 5 5 10 10 50 < 5 < 5 10 10 20 51 < 5 < 5 10 20 10 53 < 5 < 5 20 20 ' 20 54 < 5 5 20 20 20 Daconilk2 < 5 50 10 5 > 50 *1: A: Peniclllium funiculosum B: Aspergillus niger C: Fusarium proliferatum D: Gliocladium virens E: Rhizopus storonffer *2: Comparative test, available from SDS Biotech K.K.
Test example 6 Antifungal spectrum test against conidium by agar dilution method A 10 ml amount of a potato-agar medium containing a certain concentration of each active ingredient was poured into a petri dish. After solidifying, the tip portion of the flora of each test microorganism previously incubated on a plate culture medium, which was punched with a 8 cm cork borer, was inoculated in the active ingredient containing culture medium. The culture medium thus obtained was allowed to stand in a constant temperature room at 280C for 3 days. Therefore, the growth of the microorganism was examined and the MIC was determined. Four tests were carried out in each run.
The results are as shown in Table 7.
TABLE 7 MlC(ppmj Microorganism e1 Compound A B C D E 14 10 10 < 50 10 10 20 5 5 10 10 10 21 5 10 10 10 10 22 25 25 25 10 25 23 5 10 10 10 < 5 24 10 10 10 10 10 25 10 25 10 5 10 26 10 25 10 5 5 < 5 27 20 10 20 5 20 28 10 25 25 10 -:5 31 10 50 25 25 25 42 20 20 10 10 10 43 20 100 50 20 10 44 20 20 50 20 20 47 20 20 50 10 10 48 20 10 20 5 10 50 20 20 20 20 20 51 20 50 20 10 20 53 20 50 50 20 20 54 20 50 50 20 50 Daconil*' 50 ,50 50 50 50 *1: See Remarks of Table 6 Test example 7 Antibacterial spectrum test against bacteria by agar dilution streak method A 10 ml amount of a normal bouillon-agar culture medium was poured into a petri dish. After solidifying, a bacterial suspension previously obtained from the cultivation in the same liquid medium was inoculated in the form of streaks with a platinum ioop amount. The petri dish was allowed to stand for 2 days in a constant temperature room at 30 C. Thereafter, the growth of the microorganism was examined and the MIC was determined. Four tests were carried out in each run.
The results are as shown in Table 8.
TABLE 8 M I C (ppm) Microorganism*1 F G H Compound No. 14 < 5 10 50 > 50 Daconil 2 =5 10 > 50, > 50 *1: F: Bacillus subtilia G: Staphylococcus aureus H: Esherichia coli I: Pseudomonas fluorescens *2: Commercially available from SDS Biotech K.K.
Test example 8 For evaluation test of antibacterial action against bacterial soft rot disease of Japanese raddish the rhizome portion of Japanese raddish was cut to the form of a ring having a thickness of 1 cm with a 18 cm cork borer to form raddish chips. The chips were dipped in a liquid containing a certain concentration of an active ingredient for one hour. After air drying, one drop of a culture liquid containing bacterial soft rot bacteria which was cultivated at 27"C for 24 hours in a normal bouillon medium by shaking culture, was inoculated in the center of the raddish chip. The raddish chip was allowed to stand at a temperature of 27"C for 2 days under a high humidity condition. Therefore, the putrefaction degree of the raddish chip was examined. Five tests were carried out in each run.
The results are as shown in Table 9.
TABLE 9 Compound Concentration Degree of putrefaction*3 No. fa.i., ppm) 27 500 0 42 500 1 43 500 0 44 500 0 45 500 3 46 500 4 Copper 520 (as Cu) 2 hydroxide Strepto- 200 0 mycin *1: Commercially available from Sankyoh K.K.
*2: Commercially available from Meiji Seika K.K.
*3: Degree of Putrefaction Putrefaction (%) 0 0 1 1-10 2 11-25 3 26-50 4 51-75 5 76-100

Claims (5)

1. A fluorinated isophthalonitrile compound having the general formula
wherein Y is -O, -S, or -N(R'), R and R' are independently hydrogen, an alkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, an alkoxyl group, an alkoxyalkyl group, a phenyl group which may be substituted, a tetrahydrofurfuryl group, or a cycloalkyl group, provided that, in the case of Y = -N(R'), R and R' or Y may be a heterocyclic compound residue.
2. A fluorinated isophthalonitrile compound as claimed in claim 1, wherein said compound is 2,4,5 trifluoro-6-methylamino-isophthalonitrile, 4-ethylamino-2,5,64rifluoroisophthalonitrile, 4-diethylamino2,5,6-trifl uoroisophthalonitrile, 2,4,5-trifluoro-6-methoxy-isophthalonitrile, 4-ethoxy-2,5,6-trifluoroisophthalo-nitrile, 2,4,5-trifluoro-6-propoxyisophthalonitrile, 2,4,5-trifluoro-6-isopoxyisophthalonitrile, 4-bu toxy-2,5,6-trifl uoroisophtha lonitrile, 2,4,5-trifluoro-6-isobutoxyisophthalonitrile, 4-al lyloxy-2,5,6- trifluoroisophtha lonitrile, 2,4,5-trifluoro-6-methallyloxy-isophthalonitrile, 2,4,5-trifluoro-6-(2-methoxy- ethoxy)isophthalon itrile, 2,4,5-trifl uoro-6-methylthioisophthalonitrile, 4-ethylthio-2,5,6-trifluoroisophthalonitrile, 2,4,5-trifluoro-6-propylthioisophthalonitrile, 2,4,5-trifluoro-6-isopropylthioisophthalonitrile, 4 butylthio-2,5,6-trifluoroisophthalonitrile, 2,4,5-trifluoro-6-isobutylthioisophthalonitrile, or 2,4,5-trifluoro-6-sec-butylthioisophthalonitrile.
3. A nonmedial fungicide comprising, as an effective ingredient, a fluorinated isophthalonitrile having the general formula
wherein Y is -O, -S, or -N(R'), R and R' and independently hydrogen, an alkyl group, an alkenyl group, an alkynyl group, a haloalkyl group, an alkoxyl group, alkoxyalkyl group, a phenyl group which may be substituted, a tetrahydrofurfuryl group, or a cycloalkyl group, provided that, in the case of Y = -N(R'), R and R' or Y may be a heterocyclic compound residue.
4. A nonmedical germicide as claimed in claim 3, wherein said fungicide contains 1% to 95% by weight of the fluorinate isophthalonitrile.
5. A fluorinated isophthalonitrile compound according to Claim 1 substantially as hereinbefore described.
GB08521070A 1984-08-29 1985-08-22 Fluorinated isophthalonitrile compound and nonmedical fungicide containing the same Expired GB2165239B (en)

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JP59178413A JPS6157544A (en) 1984-08-29 1984-08-29 Isophthalonitrile compound and nonmedical fungicide
JP17841484A JPS6157542A (en) 1984-08-29 1984-08-29 Fluorinated isophthalonitrile compound and nonmedical fungicide

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307897A1 (en) * 1987-09-14 1989-03-22 SDS Biotech K.K. Trifluorobenzene compounds and process for producing the same
EP0415585A1 (en) * 1989-08-31 1991-03-06 Imperial Chemical Industries Plc Fluorobenzene derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919679D0 (en) * 1989-08-31 1989-10-11 Ici Plc Fluorobenzene derivatives
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7622874A (en) * 1973-12-12 1976-06-10 Diamond Shamrock Corp Benzenes pesticidal organosulfur derivatives of tetrachlorodicyano

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307897A1 (en) * 1987-09-14 1989-03-22 SDS Biotech K.K. Trifluorobenzene compounds and process for producing the same
US4925966A (en) * 1987-09-14 1990-05-15 Sds Biotech K.K. Process for producing trifluorobenzene compounds
US5021605A (en) * 1987-09-14 1991-06-04 Sds Biotech K.K. Trifluorobenzene compounds
US5068411A (en) * 1987-09-14 1991-11-26 Sds Biotech K.K. Trifluorobenzene compounds and process for producing the same
EP0415585A1 (en) * 1989-08-31 1991-03-06 Imperial Chemical Industries Plc Fluorobenzene derivatives

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DE3530941A1 (en) 1986-03-13
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DE3530941C2 (en) 1990-05-10

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