GB2155786A

GB2155786A - Pharmaceutical composition for treating trichophytosis

Info

Publication number: GB2155786A
Application number: GB08407291A
Authority: GB
Inventors: Mamoru Orita
Original assignee: Individual
Current assignee: Individual
Priority date: 1984-03-21
Filing date: 1984-03-21
Publication date: 1985-10-02
Also published as: GB8407291D0

Abstract

A pharmaceutical composition for sterilizing and treating trichophytosis is obtained by heating a mixture consisting of sterilized water, ethyl alcohol, a small amount of oxalic acid and a small amount of boric acid to about 90 DEG C to obtain a base solution, gradually decreasing the temperature of the resulting base solution to about 55 DEG C, adding glacial acetic acid to said base solution at about 55 DEG C and then stirring the resulting solution until the temperature thereof reaches room temperature.

Description

SPECIFICATION Medicine for Sterilizing and Treating Trichophytosis The present invention relates to a medicine for sterilizing and treating skin diseases owing to trichophytosic bacteria and bacteria of the same tribe as trichophytosic bacteria.

Various kinds of medicine have been proposed for treating "vesicular eczema" which is prickly heatlike superficial trichophytosis broken out of the palm of the hand, the sole of a foot, between fingers and the like owing to the parasite of the trichophytosic bacteria which are bacteria belonging to one kind of mold. For example, in general an ointment is applied on wet vesicular eczema as a medicine for external application while a tincture is applied on dry vesicular eczema as a medicine for external application. In addition, internal medicines such as Glyceofuluvin have been applied on vesicular eczema which is broken out on the sole of a foot and the palm of the hand, leading to thick and hard skin.

However, none of the prior art proposals has been satisfactory.

According to the present invention, there is provided a pharmaceutical composition for sterilizing and treating trichophytosiswhich is obtained by heating the mixture consisting of sterilized water, ethyl alcohol, a small amount of oxalic acid and a small amount of boric acid to about 90"C to obtain the base solution, gradually decreasing a temperature of the resulting base solution to about 55"C, adding glacial acetic acid to said base solution at about 55"C and then stirring the resulting solution until the temperature thereof reaches room temperature.

The present applicant has discovered that oxalic acid has an effect on trichophytosis and that the application thereof in the form of an aqueous solution on the vicinity of, for example, the toes, led to an effective treatment of trichophytosis which had broken out there. It was found, however, that in some cases the affected part was damaged by the extremely fine white powder of oxalic acid obtained as the solution dried. Accordingly, boric acid was added in order to prevent such damage and keep the affected part clean. However, this was unsatisfactory since a horney layer of matter attacked by the trichophytosic bacteria, was formed and in addition, a sufficiently speedy treatment could not be achieved owing to insufficient penetration of the ointment into a skin.The present applicant found that the addition of acetic acid resulted in the rotted horney layer being removed and the ointment was able to penetrate into the depth of skin. That is to say, spore bacteria, which had been broken out in the vicinity of the affected part, rose to the surface owing to the metabolism of the horney layer while the ointment was repeatedly applied and fell down from the cuticle with gradually changing colour thereof from the initial light pink to light brown and finally freckle colour.

The slightly dented portions remained, but they were soon recovered to the ordinal cuticle.

Furthermore, the portion, in which bacteria collected, was wet. But it was cured with being gradually dried by continuously applying the ointment thereon. At this time, the affected part shown a milk-white colour but this colour disappeared in the mean time.

The present applicant further found that the addition of ethyl alcohol assisted in maintaining cleaniness and in the removal of extraneous matter from the area being treated.

Following is a description by way of example only of methods of carrying the invention into effect.

EXAMPLE 1 This example relates to the treatment of prickly heat-like trichophytosis and the type trichophytosis occurring between the toes of the foot. A solution consisting of sterilized water of 204 cc, ethyl alcohol of 75 cc, oxalic acid of 7.5 g and boric acid of 6 g is heated to about 90"C and is maintained at that temperature about 15 or more minutes. The resulting base solution is gradually cooled to about 55"C and glacial acetic acid in an amount of 7.5 cc is added to the base solution under that condition.

Then the resulting mixture is stirred for about 15 or more minutes until a temperature thereof reaches room temperature to obtain a medicine for sterilizing and treating trichophytosis.

The glacial acetic acid is added at a temperature of the base solution of about 55"C in this preferred embodiment of the present invention so that the constituent substances of the medicine are prevented from separating out during long-term storage thereof.

On application of the medicine, the itchy feel incidental to trichophytosis disappears after a few days from the commencement of the application of the medicine. In addition, although an irritative pain is produced if the medicine is applied on the affected part when it is sore, that also disappears in two or three days. Furthermore, although fingers and the like are sometimes swollen owing to an inflammation by miscellaneous bacteria and the like in a serious case, the application of the medicine changes the degenerated tissue into a bloody pus which is discharged from the affected part. At this time, the application of the medicine on the swollen part is stopped. The bloody pus must be completely discharged, a dull pain, which is similar to that in the suppuration of eruption, is produced.In the case when the part suffered from trichophytosis is still remained at the time when the swelling went down and the part suffered from trichophytosis was recovered, the medicine may be applied again there after 10 or more days. Also eczema, which has been regarded as quite different from trichophytosis, can be completely cured by applying the medicine for about three days to such a degree that an irritative pain disappears if it is a blister.

EXAMPLE 2 This example relates to the treatment of thick hypodermic trichophytosis. Oxalic acid of 9 g and boric acid of 6 g are added to a mixture consisting of sterilized water of 201 cc and ethyl alcohol of 75 cc and the resulting mixture is heated with stirring. The stirring is stopped when a temperature of the solution reached about 85"C. The solution is continued to heat until a temperature thereof reaches about 90"C and kept at about 90"C about 15 minutes to obtain the base solution. The resulting base solution is cooled to about 55"C with stirring.

Glacial acetic acid of 9 cc is added (sterilized water may be added to glacial acetic acid at a ratio of 1 :1).

The mixture is sufficiently stirred about 15 or more minutes. The stirring is stopped when a temperature of a solution reaches room temperature to obtain a medicine for sterilizing and treating trichophytosis.

In the case when an itchy feel is produced under the skin of the palm of the hand and the like although nothing is the matter on the surface of the skin, the application of the medicine obtained in this preferred embodiment makes the skin rise to the surface owing to the metabolism before long. In the case when the skin is thick as in this preferred embodiment, the affected part must be erased sometimes. Although the erased part, where bacteria are collected, is wet alike to the case of wet trichophytosis, the continuous application of the medicine obtained in this preferred embodiment leads to the gradual desiccation of the wet erased part and subsequently to the cure thereof. In the case when spore bacteria are broken out in the vicinity of the wet erased part, as described above, it changes its colour to a freckle-like colour at last and fallen down.

Claims

1. A pharmaceutical composition for sterilizing and treating trichophytosis which is obtained by heating the mixture consisting of sterilized water, ethyl alcohol, a small amount of oxalic acid and a small amount of boric acid to about 90"C to obtain the base solution, gradually decreasing a temperature of the resulting base solution to about 55"C, adding glacial acetic acid to said base solution at about 55"C and then stirring the resulting solution until the temperature thereof reaches room temperature.

2. A pharmaceutical composition as claimed in claim 1 and substantially as described in either of the specific examples herein set forth.

3. Each and every novel embodiment herein set forth either separately or in combination.