GB2077265B - N-trifluoroacetyladriamycin-14-o-hemiglutarate and hemiadipate and therapeutic compositions containing the same - Google Patents

N-trifluoroacetyladriamycin-14-o-hemiglutarate and hemiadipate and therapeutic compositions containing the same

Info

Publication number
GB2077265B
GB2077265B GB8117474A GB8117474A GB2077265B GB 2077265 B GB2077265 B GB 2077265B GB 8117474 A GB8117474 A GB 8117474A GB 8117474 A GB8117474 A GB 8117474A GB 2077265 B GB2077265 B GB 2077265B
Authority
GB
United Kingdom
Prior art keywords
hemiadipate
trifluoroacetyladriamycin
hemiglutarate
same
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8117474A
Other languages
English (en)
Other versions
GB2077265A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Sidney Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidney Farber Cancer Institute Inc filed Critical Sidney Farber Cancer Institute Inc
Publication of GB2077265A publication Critical patent/GB2077265A/en
Application granted granted Critical
Publication of GB2077265B publication Critical patent/GB2077265B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
GB8117474A 1980-06-09 1981-06-08 N-trifluoroacetyladriamycin-14-o-hemiglutarate and hemiadipate and therapeutic compositions containing the same Expired GB2077265B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/157,861 US4299822A (en) 1980-06-09 1980-06-09 N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same

Publications (2)

Publication Number Publication Date
GB2077265A GB2077265A (en) 1981-12-16
GB2077265B true GB2077265B (en) 1984-01-11

Family

ID=22565590

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8117474A Expired GB2077265B (en) 1980-06-09 1981-06-08 N-trifluoroacetyladriamycin-14-o-hemiglutarate and hemiadipate and therapeutic compositions containing the same

Country Status (8)

Country Link
US (1) US4299822A (US20080094685A1-20080424-C00004.png)
JP (1) JPS5767596A (US20080094685A1-20080424-C00004.png)
CA (1) CA1150245A (US20080094685A1-20080424-C00004.png)
CH (1) CH645387A5 (US20080094685A1-20080424-C00004.png)
DE (1) DE3122689C2 (US20080094685A1-20080424-C00004.png)
FR (1) FR2483928A1 (US20080094685A1-20080424-C00004.png)
GB (1) GB2077265B (US20080094685A1-20080424-C00004.png)
NL (1) NL184420C (US20080094685A1-20080424-C00004.png)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
RU2758670C1 (ru) * 2020-12-30 2021-11-01 федеральное государственное бюджетное образовательное учреждение высшего образования «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) Новое химическое соединение 5-фторурацила и доксорубицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2135221A1 (en) * 1971-05-04 1972-12-15 Farmaceutici Italia Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid
GB1368680A (en) * 1972-12-09 1974-10-02 Farmaceutici Italia Adriamycin derivatives
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives

Also Published As

Publication number Publication date
FR2483928B1 (US20080094685A1-20080424-C00004.png) 1984-01-06
FR2483928A1 (fr) 1981-12-11
NL8102730A (nl) 1982-01-04
NL184420C (nl) 1989-07-17
GB2077265A (en) 1981-12-16
CA1150245A (en) 1983-07-19
JPS632440B2 (US20080094685A1-20080424-C00004.png) 1988-01-19
DE3122689A1 (de) 1982-05-06
US4299822A (en) 1981-11-10
DE3122689C2 (de) 1985-07-04
CH645387A5 (de) 1984-09-28
JPS5767596A (en) 1982-04-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950608