GB2072669A - Biocidal 4-halooxetan-2-one derivatives - Google Patents
Biocidal 4-halooxetan-2-one derivatives Download PDFInfo
- Publication number
- GB2072669A GB2072669A GB8108662A GB8108662A GB2072669A GB 2072669 A GB2072669 A GB 2072669A GB 8108662 A GB8108662 A GB 8108662A GB 8108662 A GB8108662 A GB 8108662A GB 2072669 A GB2072669 A GB 2072669A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- chlorine
- oxetan
- formula
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/20—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom three- or four-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
- A01N57/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/34—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-halogen bonds; Phosphonium salts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
Abstract
Novel 4-halooxetan-2-one derivatives having the formula: <IMAGE> wherein X is a chlorine, bromine or iodine atom and Y is a residue having the formula: R<1>R<2>R<3>C- wherein R<1> and R<2> are the same or different and each is a fluorine, chlorine or bromine atom and R<3> is a hydrogen, fluorine, chlorine or bromine atom, a group -CR<4>R<5>R<6> where R<4>,R<5>,R<6>, independently, are F, Cl, Br, a cyano group or a group COR<7> or -PO(R<8>)2 wherein R<7> and R<8> are the same or different and each is a chlorine atom or a group -OR<9> wherein R<9> is a C1 - C4 straight chain or branched alkyl group with the proviso that when X is a chlorine atom, none of R<1>, R<2>, R<3>, R<4>, R<5> and R<6> can be a bromine atom, possess biocidal properties.
Description
SPECIFICATION
Chemical compounds
The present invention relates to new chemical compounds, more particularly to 4-halogeno-oxetan-2-ones and to processes for their production.
According to the present invention, there are provided compounds having the formula
wherein X is a chlorine, bromine or iodine atom and Y is a residue having the formula: RlR2R3C- wherein R1 and R2 are the same or different and each is a fluorine, chlorine or bromine atom and R3 is a hydrogen fluorine, chlorine or bromine atom, a group -CR4R5R5 where R4,R5,R6, independently, are F, Cl, Br, a cyano group, or a group COR7 or -PO(R8)2 wherein R7 and RB are the same or different and each is a chlorine atom or a group -OR9 wherein R9 is a C1 - C4 straight chain or branched alkyl group with the proviso that when Xis a chlorine atom, none of R1, R2, R3, R4, R5 and R6, can be a bromine atom.
When R9 is a C1-C4 alkyl group, it may be a methyl, ethyl, n-propyl, isopropyl, n-butyl, sec.butyl ort-butyl group. Specific Examples of compounds of formula I include: 4-Chloro-4-(2,2,2-trich loroethyl )oxetan-2-one 4-Bromo-4-(2-chloro-2,2-difluoroethyl)oxetan-2-one 4-Bromo-4-(2-bromo-2,2-difluoroethyl)oxetan-2-one 4-Bromo-4-(2,2,2-trichloroethyl)oxetan-2-one 4-Bromo-4-(2-bromo-2,2-dich loroethyl)oxetan-2-one 4-Bromo-4-(2,2,2-tribromoethyl)oxetan-2-one 4-Chloro-4-(2-ch lorocarbonyl-2,2-dichloroethyl )oxeta n-2-one 4-Chloro-4-(2,2-dich loro-2-methoxycarbonylethyl )oxetan-2-one 4-Ch loro-4-(2,2-dich loro-2-ethoxycarbonylethyl)oxetan-2-one 4-Chloro-4-(2,2-dich loro-2-n-butoxycarbonylethyl )oxetan-2-one 4.Chloro-4-(2,2-dichloro-2-dichlorophosphonylethyl)oxetan-2-one 4-Chloro-4-(2,2-dichloro-2-diethylphosphonoethyl)oxetan-2-one 4-Chloro-4-(2,2-dichloro-2-cyanoethyl)oxetan-2-one 4-Bromo-4-(2,2-dibromo-2-methoxycarbonylethyl )oxetan-2-one 4-Bromo-4-(2,2-dibromo-2-cyanoethyl)oxetan-2-one 4-Chloro-4-(2,2,3,3,3-pentachloropropyl)oxetan-2-one 4-Bromo-4-(2-bromo-2,3,3.34etrachloropropyl)oxetan-2-one 4-Bromo-4-(2-bromo-2-chloro-3,3,3-trifluoropropyl)oxetan-2-one 4-lodo-4-(2,2,2-trifluoroethyl)oxeta n-2-one.
Preferred compounds of formula I include: 4-Chloro-4-(2,2,2-trich loroethyl)oxetan-2-one 4-Bromo-4-(2,2,2-trichloroethyl)oxetan-2-one 4-Bromo-4-(2,2,2-tribromoethyl)oxetan-2-one The present invention also provides a process for the production of compounds of formula I comprising reacting diketene with a compound XY in the presence of an agent capable of forming free radicals.
Examples of compound XY are tetrahalomethanes such as carbontetrachloride, carbontetrabromide or bromotrichloromethane; trihalomethyl compounds such as ethyltrichloroacetate, trichloromethylphos phonyldichloride, trichloroacetonitrile, 1 -chloro-1 ,1-dibromotrifluroethane or hexachloroethane.
Agents forming free radicals include:
i) lonising radiation
ii) Ultraviolet radiation
iii) Organic peroxides e.g. t-butylperacetate
t-butyl perbenzoate acetyl peroxide
benzoyl peroxide di-isopropylperdicarbonate
bis-(t-butylcyclohexyl)
perdicarbonate
di-t-butylperoxide
t-butylhydroperoxide
iv) Inorganic peroxy compounds e.g. hydrogen peroxide, ammonium persulphate
v) Organic azo compounds e.g. azobisisobutyronitrile
azobisisopropane
vi) Combination of iii or v with ultraviolet radiation
vii) Combination of iii or iv, with a metal ion catalyst e.g. CU, V, Fe to give a radical producing redox-system e.g.
H202 + Fe2+ NH4O3S-O-O-SQ-NH4+ + Cu+
t-Butylhydroperoxide + Ti2+
Preferred agents forming free radicals are organic peroxides organic azo compounds, and combinations of organic peroxides or organic azo compounds with ultraviolet radiation.
The radical forming substances may be used advantageously in catalytic amounts of 0.1-10 mol% preferably 1-5 mol % based on diketene. The preferred molar ratio of halo compound to diketene is from 1:1 to 20:1. In the above process, the reactant XY may act as the solvent but, if desired, the reaction may optionally be carried out in the presence of a solvent inert under the reaction conditions e.g. petroleum ether in low temperature reactions; benzene, toluene or carbon tetrachloride in moderate temperature reactions; or chlorobenzene in high temperature reactions.The reaction may be effected under conditions well-known per se e.g. in the temprature range -20 to 1 50 C., according to the radical producing method employed, preferably between 0 to 1 00 C; and, if the compound XY is a gas, optionally in an inert gas atmosphere and optionally under pressure. The reactions can be carried out batchwise, or in a continuous manner, for example in a cascade reactor. Compounds of formula I show broad spectrum biocidal activity in the range of
1000 ,ug/ml and lower against a range of organisms. In particular the compounds of formula I control the growth of bacteria, fungi and algae, at low concentration. The compounds of formula I are also useful as intermediates for a wide variety of chemicals.
They are particularly effective in controlling the growth of bacteria, fungi and algae in still or circulating water systems, for example in industrial cooling towers, swimming pools etc; in other aqueous-based or oil-based systems e.g. cutting fluids and secondary oil recovery processes; in industrial processing waters e.g. processing waters in wood, pulp, paper, textiles and leather processing; and in surface disinfection e.g.
in hospitals, dairies etc.
The compounds of formula I can be applied as biocides in pure form or as concentrated or dilute solutions
or emulsions, which may be optionally stabilised with alkali- or alkaline earth metal carbonates. It is also
possible to apply them in admixture with solid carriers. The compounds can also be applied as suspensions
in liquid compositions, in which case wetting agents or emulsifiers may be used to assist the distribution of the active ingredient to form homogeneous dispersions. If desired, the compounds may be used together with other biocides. One field of application is the treatment of cooling water. For protection against the growth of microorganisms, the active compounds can advantageously be added direct to the cooling water.
When using the compounds for treating water, it is possible to add simultaneously other additives, for example, corrosion inhibitors, antiincrustants, water softeners, complexing agents and low foaming surfactants or penetrants, for example, polymeric phosphites, phosphates, amides of phosphoric acids, polymeric carboxylic acids or anhydrides, for example polyacrylic acids or polymaleic acids, or salts thereof and other additives.
Organisms whose growth is controlled include: Classitype Examples Problems caused
Algae
Green Chlorella vulgaris General matting
Chlorella pyrenoidosa
Scenedesmus spec and fouling
Ulothrix subtilissima usuaily by
Blue-green Oscillatoria geminata
Nostoc spec blocking of pipes
Phormidium foveolarum
Anacystis nidulans pumps, filters etc.
Brown Tribonema aequale
Bacteria
Gram positive Bacillus cereus var mycoides Bacterial slimes
Bacillus subtilis
Streptomyces griseus produced which
Streptomyces aureofasciculus
Staphylococcus aureus cause reduced
Gram negative Pseudomonas aeruginosa plant efficiency Aerobacter aerogenes Serratia marcescens and increased
Alcaligenes denitrificans
Escherichia coli corrosion.
Proteus vulgaris
Anaerobic Desulphovibrio desulphuricans H2S produced
Sulphate with resultant
reducing severe corrosion
Fungi Aspergillus niger Surface rot,
Aspergillus phoenicus
Penicillium funiculosam discolouration,
Alternaria alternata
Cladosporium cladosporioides slime production
Candida albicans
Endomyces geotrichum and internal
Aureobasidium pullulans
wood decay.
The following Examples, in which parts and percentages are by weight, further illustrate the present invention.
Example 1 A mixture of 25.2 parts of diketene, 62.7 parts of bromotrichloromethane and 1.5 parts of azobisisobutyronitrile dissolved in 978 parts of carbon tetrachloride was irradiated by UV light at room temperature for 5 hours. The mixture was evaporated at the water pump and theproduct, 4-bromo-4-(2,2,2trichloroethyl)oxetan-2-one, was obtained as a yellow oil which crystallised on cooling. Recrystallisation of this material three times from light petroleum ether (b.p. 40-60 ) gave white needles m.p. 55-56.
Calculated for C5H4BrCI302 C, 21.27; H, 1.43 Found C,21.09; H,1.53
Example 2
2.0 parts of benzoyl peroxide (containing 25% of water) were dissolved in 163 parts of carbon tetrachloride and dried over magnesium sulphate. To the filtered dry solution were added 42 parts of diketene and the resulting solution was added dropwise over 5 hours to 815 parts of refluxing carbon tetrachloride. After completion of the addition the mixture was heated for a further 1 hour, then evaporated to dryness on the water pump. Extraction of the product into hot petroleum ether gave 4-chloro-4-(2,2,2-trichloroethyl)oxetan2-one, shown to be 95% pure by GLC. Distillation of a portion of the extracted material gave an analytically pure sample, b.p. 70-75" at 0.0133 mb.
Calculated for C5H4C402 C, 25.25; H, 1.69; CI, 59.61
Found C, 25.47; H, 1.87; Cl, 59.62 Example 3
210 parts of freshly distilled diketene and 30 parts of bis-(t-butylcyclohexyl)peridicarbonate were dissolved in 795 parts of carbon tetrachloride. This solution was added dropwise over 1 hour, with stirring, to 3180 parts of carbon tetrachloride held at reflux temperature in an atmosphere of dry nitrogen. When the addition was complete, stirring at reflux temperature was continued for 1 hour and the solution was then allowed to cool.The excess carbon tetrachloride was distilled off on a rotary evaporator under water pump vacuum at a bath temperature of 30-40 . The crude product was purified by distillation on a wiped-wall still giving 398 parts of pure 4-chloro-4-(2,2,2-trichloroethyl)oxetan-2-one.
Example 4
Acarbon tetrachloride solution containing 26.35 parts diketene and 3.76 parts of bis-(t-butylcyclohexyl)perdicarbonate 1592 parts of carbon tertrachloride was pumped through a two vessel cascade at such a rate as to give residence time of 60 minutes (residence time = vessel volume/volume pumped per minute). The vessels were stirred vigorously and heated at carbon tetrachloride reflux temperature. The product stream contained 2.5 parts unreacted diketene and 67 parts of 4-chloro-4-(2,2,2-trichloroethyl)oxetan-2-one per 1592 parts carbon tetrachloride.
Example 5
A mixture of 8.4 parts of diketene, 33.1 parts of carbon tetrabromide, 0.5 parts of bis-(tbutylcyclohexyl)perdicarbonate and 326 parts of carbon tetrachloride was heated at 60 for 2 hours, then evaporated at the water pump. The residue was recrystallised twice from light petroleum ether (b.p. 40-60") and the product, 4-bromo-4-(2,2,2-tribromoethyl)oxetan-2-one, obtained as white needles m.p. 71-73".
Calculated for C5H4Br402 C, 14.45; H, 0.97; Br, 76.89
Found C, 14.75; H, 0.97; Br, 76.20
Example 6
A mixture of 8.4 parts of diketene, 19.2 parts of ethyl trichloroacetate and 1.3 parts of bis-(tbutylcyclohexyl)-perdicarbonate was added dropwise over 3 hours to 96 parts of ethyl trichloroacetate stirred at 85" in a nitrogen atmosphere. After the addition, the mixture was stirred at 85" for a further 1/2 hour, then the unreacted starting materials were removed on a wiped wall still at 900/0.27 mb. The residue was distilled twice in a Kugelrohr at 1000/0.133 mb.IR and NMR on the distillate showed the major component to be 4-chloro-4-(2,2-dichloro-2-ethoxycarbonyl-ethyl)oxetan-2-one.
Example 7
1.68 parts of diketene and 0.4 parts of bis-(t-butylcyclohexyl) perdicarbonate were dissolved in 25 parts hexane and added over 1 hour to a stirred solution of 5.53 parts of 1 -chlorn-1 ,1 -dibromotrifluoroethane in 25 parts hexane at 60".
The mixture was stirred a further 1.5 hours at 60 then cooled to room temperature. The solution was decanted from an insoluble oil then evaporated cold in vacuo to give 3.8 parts of 4-bromo-4-(2-chloro-2bromo-3,3,3-trifluoropropyl) oxetan-2-one as a mobile yellow oil, with a characteristic l.R. carbonyl frequency of 1860 cm Example 8
A mixed culture of slime-forming bacteria including Pseudomonas aeruginosa, Enterobacter aerogenes,
Escherichia coli, Proteus vulgaris, Bacillus mycoides and Staphyloccus aureus in saline containing 107 organisms/ml. was treated with 30 ppm of the product of Example 2. After one hour, the number of organisms had been reduced to 102 organisms/ml. and within 24 hours all the bacteria had been killed, thereby demonstrating the high bacteriocidal activity of the product of Example 2.
Example 9
Test demonstrating algistatic activity
The organisms against which the compounds are to be tested are grown in an Erlenmeyer flask in a nutrient medium under sterile conditions on a shaking water bath at 18 with exposure (14 hours in light alternating with 10 hours in the dark).
Tests are carried out against three algae, namely the blue algae
a) Phormidium foveolarum (A) which lives in polluted water or moist earth and forms trichomes, the green algae
b) The simple filament-forming Ulothrix subtilissima (B) generally found at colder times of the year in rapidly flowing water; and the algae with brown chromatophors
c) the widespread, unbranched filament-forming Tribonema aequale (C) occurring in bodies of water especially in the spring at low temperatures or in the autumn, even in mild winters.
The composition of the medium is as follows (according to Algae broth, Difco Laboratories): 1.0 of NaNO3 0.05 gofNH4CI 0.058 g of CaCI2
0.5 g of MgSO4. 7 H2O 0.25 g of K2HPO4 0.003 g of FeCI3 dissolved in 1 litre of distilled water.
The nutrient medium treated with the biocide is innoculated with the respective algae suspension such that a final dilution of 1/100 (algae divided with a stirrer) is attained.
Evaluation is made after a 3 week incubation in the Erlenmeyer flask on a shaking water bath.
The activity is reported as the minimum inhibitory concentration (MIC in mg/l) which indicates that algicide concentration at which the growth of the algae is still inhibited. The results are summarised in Table 1.
TABLE 1
Minimum inhibitory Concentration,MIC mg/l Phomidium Ulothrix Tribonema Compound of formula faveolorum subtilissima aequale e Product of Example 2 Cl3 CCH2 \ 30 30 30 U < O 31X 30
Claims (17)
1. A compound having the formula
wherein X is a chlorine, bromine or iodine atom and Y is a residue having the formula: R1 R2R3C- wherein R1 and R2 are the same or different and each is a fluorine, chlorine or bromine atom, and R3is a hydrogen, fluorine, chlorine or bromine atom, a group -CR4R5R6 where R4, R5, R6, independently, are F, Cl,
Br, or a cyano group, or a group -COR7 or -PO(R8)2 wherein R7 and R9 are the same or different and each is a chlorine atom or a group -OR9 wherein R9 is a C1 - C4 straight chain or branched alkyl group with the proviso that when X is a chlorine atom, none of R1, R2, R3, R4, R5 and R6 can be a bromine atom.
2. A compound as claimed in Claim 1 wherein Xis a chlorine or bromine atom.
3. A compound as claimed in Claim 1 or 2 wherein R', R2 and R3 are each a fluorine, chlorine or bromine atom.
4. 4-chloro-4-(2,2,2-trichloroethyl)oxetan-2-one.
5. 4-Bromo-4-(2,2,2-trichloroethyl)oxetan-2-one.
6. 4-Bromo-4-(2,2,2-tribromoethyl)oxetan-2-one.
7. 4-Chloro-4-(2,2-dichloro-2-ethoxycarbonyl-ethyl)oxetan-2-one.
8. 4-Bromo-4-(2-chloro-2-bromo-3,3,3-trifluoropropyl)-oxetan-2-one.
9. A compound of formula 1 substantially as described with reference to any of Examples 1 to 7.
10. A process of producing a compound of formula I comprising reacting diketene with a compound XY wherein X and Y are as defined in Claim 1, in the presence of an agent capable of forming free radicals.
11. A process as claimed in Claim 10 wherein the compound XY is a tetrahalomethane or a trihalomethyl compound.
12. A process as claimed in Claim 11 wherein the tetrahalomethane is carbontetrachloride, carbontetrabromide, or bromotrichloromethane.
13. A process as claimed in Claim 11 wherein the trihalomethyl compound is ethyltrichloroacetate, trichloromethylphosphonyl dichloride, trichloroacetonitrile, l-chloro-l,l -dibromotrifluoroethane or hexachloroethane.
14. A process as claimed in any of Claims 10 and 13 wherein the agent capable of forming free radicals is an organic peroxide; an organic azo compound; or a combination of an organic peroxide or an organic azo compound with ultraviolet radiation.
15. A process as claimed in Claims 10 to 14 which is carried out in a continuous manner.
16. A process of producing a compound of formula 1 substantially as described with reference to any of
Examples 1 to 7.
17. A compound of formula I when produced buy a process claimed in any of Claims 10 to 16.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8108662A GB2072669B (en) | 1980-03-27 | 1981-03-19 | Biocidal 4-halooxetan-2-one derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8010384 | 1980-03-27 | ||
GB8108662A GB2072669B (en) | 1980-03-27 | 1981-03-19 | Biocidal 4-halooxetan-2-one derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2072669A true GB2072669A (en) | 1981-10-07 |
GB2072669B GB2072669B (en) | 1984-02-29 |
Family
ID=26275001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8108662A Expired GB2072669B (en) | 1980-03-27 | 1981-03-19 | Biocidal 4-halooxetan-2-one derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2072669B (en) |
-
1981
- 1981-03-19 GB GB8108662A patent/GB2072669B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB2072669B (en) | 1984-02-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0139404B1 (en) | Biocidal water treatment | |
US5057612A (en) | N,n'-dihaloimidazolidin-4-ones | |
US4719083A (en) | Composition useful as corrosion inhibitor, anti-scalant and continuous biocide for water cooling towers and method of use | |
US5126057A (en) | Disinfecting with N,N'-dihaloimidazolidin-4-ones | |
CA2108183C (en) | Synergistic antimicrobial combination of polyether phosphonates and non-oxidizing biocides | |
WO2010143183A2 (en) | Stabilized and activated bromine solutions as a biocide and as an antifouling agent | |
CA2351619C (en) | Biocide composition and sterilization method using the same | |
AU614511B2 (en) | Biocide | |
US4363923A (en) | 4-Halgeno-oxetan-2-ones and process for their production | |
US3252855A (en) | Method of controlling algal growth | |
US4361435A (en) | Copper and amine based aquatic herbicides | |
EP0364789B1 (en) | Antimicrobial composition and method of use | |
US4489098A (en) | 2,2,3-Trihalopropionaldehydes as antimicrobial agents | |
US5171350A (en) | Biocide | |
PT827690E (en) | QUANTITY AMMONIUM IONEN POLYMERS CONTAINING SULFUR AND THEIR USE AS MICROBICIDES | |
EP0594329B1 (en) | Antimicrobial agents comprising polyquaternary ammonium compounds | |
GB2072669A (en) | Biocidal 4-halooxetan-2-one derivatives | |
CA1156247A (en) | 4-halogeno-oxetan-2-ones and process for their production | |
US3860713A (en) | Slime controlling compositions and their use | |
CN111246739B (en) | Quaternary ammonium salt of hydroxyethylphosphonic acid | |
JP3562825B2 (en) | Disinfectant algicide | |
US5162354A (en) | 3-halo-5-halomethyl-2-oxazolidinones and their use as microbicides | |
WO2012093608A1 (en) | Algicidal/microbicidal agent and algicidal/microbicidal method | |
Biocides et al. | Dialkylphosphonodibromo-Acetates and-Acetonitriles as | |
JPS6126521B2 (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) | ||
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |
Free format text: 4868,PAGE 1927 |
|
PCNP | Patent ceased through non-payment of renewal fee |