GB2064334A - Inhalation valve for administering powdered medicaments - Google Patents
Inhalation valve for administering powdered medicaments Download PDFInfo
- Publication number
- GB2064334A GB2064334A GB7935928A GB7935928A GB2064334A GB 2064334 A GB2064334 A GB 2064334A GB 7935928 A GB7935928 A GB 7935928A GB 7935928 A GB7935928 A GB 7935928A GB 2064334 A GB2064334 A GB 2064334A
- Authority
- GB
- United Kingdom
- Prior art keywords
- capsule
- retaining means
- sleeve
- body shell
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Abstract
An inhalation device for administering medicaments contained in capsules has a cylindrical body shell 1 defining a portion of a dispersion chamber 2. A nozzle 3 is provided at the forward end of the body shell 1. The body shell is open at the rear end. Air inlets 5, 5a lead through the cylindrical wall of the body shell 1 and open into the dispersion chamber 2. A sleeve 6 is rotatably mounted on the outside of the body shell and has a wall or partition 7 which closes the open rear end of the chamber 2. A capsule retaining means 8 extends through the wall or partition 7 lengthwise of the sleeve 6 and retains a two-part capsule CB, CC in the manner shown in Figure 4. A rib 11 forms an abutment inside the chamber 2 and is so positioned with respect to the capsule retaining means 8 that the capsule retained in the retaining means will engage the rib when the sleeve is rotated with respect to the body shell 1 so that the projecting portion CB of the capsule is separated from the remainder CC of the capsule. A guard 4 prevents the separated portion of the capsule from passing through the nozzle 3. A cylindrical extension compartment 16 preferably extends to the rear of the wall or partition 7. <IMAGE>
Description
SPECIFICATION
Device for dispensing medicaments
This invention relates to inhalation devices by which powdered medicaments can be orally or nasally administered to a patient.
It is well known to administer powdered medicaments to the lung bronchioles of a patient by means of inhalation devices having mouthpieces which enable the medicament to be inhaled through the mouth of the patient. The "mouthpiece" may if desired, be modified so that it is possible to inhale through a nostril of the patient. The medicament in such cases is supplied in gelatine capsules which are inserted in the device and opened in some suitable way after which inhalation through the mouthpiece will cause the powdered medicament to be released from the capsule and pass into the patient.
Capsules containing such medicaments are gen erallyofgelatine and of elongated "torpedo" shape and are constructed in two parts, one of which (called the capsule body) is partly enclosed within the other (called the capsule cap). The contacting portions of the two capsule parts are often provided with grooves and/or ribs which have the effect of "locking" the two capsule parts together. The inhalation devices for use with such capsules normally have a chamber arranged to receive a capsule containing the medicament. An air inlet aperture, or a plurality of such apertures, lead into the chamber and air from the chamber can be inhaled through a nozzle.The air inlet aperture or apertures is/are so arranged that the air flow caused by inhalation through the nozzle will cause the contents of an opened capsule within the chamber to be released and withdrawn through the nozzle.
Such an inhalation device is described in the specification of Patent Application No. 17976/77.
This device comprises a hollow body shell which defines a chamber and has an air inlet. A nozzle through which a patient can inhale air leads out from the chamber. A capsule retaining means is provided and has an inlet opening outside the chamber through which thecapsule can be inserted. This capsule retaining means is arranged to retain an inserted capsule with a portion of the capsule body projecting into the chamber as well as to squeeze and deform the overlapping portions of the capsule body and the capsule cap thereby to weaken or break the lock between the capsule body and the capsule cap.A capsule opening means is located inside the chamber and this opening means and the retaining means are relatively movable and are also so disposed that relative movement between them will bring the projecting portion (i.e. the capsule body) of an inserted capsule and the opening means into engagement with one another thereby to separate the capsule body from the capsule cap. A guard is provided to prevent the separated capsule body from passing through the nozzle when air is aspirated therethrough.According to the present invention, there is provided a device comprising a body shell defining a portion of a chamber which has a nozzle at one end and which is open at the other end, a sleeve fitted on the outside of the body shell and rotatable with respect to it and having a wall closing the open end of the chamber, the retaining means extending through the wall and having an entry opening for a capsule outside the chamber, an abutment fixed inside the chamber in such a position with respect to the capsule retaining means that a capsule retained in the retaining means and projecting into the chamber will engage the abutment when the sleeve is rotated with respect to the body shell thereby to separate the projecting portion of the capsule from the remainder of the capsule and a guard for preventing the separated portion of the capsule from passing through the nozzle.The nozzle may be considered as being fitted on the front end of the body shell and the sleeve on the rear end. The retaining means can extend rearwards of the wall carried by the sleeve and may if desired be located inside a rearwardly extending compartment carried by the sleeve and having an opening which can be closed by a suitable removable cover. The sleeve is not only rotatable on the body shell, but is also axially movable on the shell. For this reason, a protuberance, such as a peg, may project outwardly from the body shell and be engaged in a slot in the sleeve so disposed that when the sleeve is rotated with respect to the body shell the sleeve will also move axially of the body shell.With such an arrangement the sleeve may be of such a length that air inlet slots leading through the wall of the body shell into the chamber are closed when the sleeve is in a retracted position and are open when the sleeve is in an extended position.
An embodiment of the invention is illustrated in the accompanying schematic drawings in which:
Figure 1 is a sectional elevation of a device accord- ing to the invention,
Figure 2 is an elevation of part of the device,
Figure 3 is a transverse section of a capsule retaining means.
Figure 4 is a longitudinal section of the retaining means,
Figure 5 is an underplan view of a capsule magazine, and,
Figure 6 is a section on the line A-A of Figure 5.
In the illustrated embodiment of the invention, an inhalation device is conveniently, but not essentially, of a plastics material. The device comprises a cylindrical body shell 1 the interior of which defines a portion of a cylindrical capsule receiving chamber 2.
Secured to one end of the bodyshell 1, herein considered to be the front end, is a nozzle or mouthpiece 3 containing a perforated grid or guard 4 which defines the front end of the chamber and which prevents portions of a capsule inside the chamber 2 being withdrawn through the nozzle 3 when a patient inhales. A plurality of air inlet slots 5 lead through the wall of the body shell into the chamber 2 immediately behind the grid or guard. These air inlet
slots are angled with respect to a chord extending
through the chamber 2. They do not extend the full
length of the chamber. There are preferably not less
than two nor more than four of these inlet slots. An
additional air inlet 5a is provided in the body shell 1 to the rear of the slots 5.A sleeve 6 is fitted on the
rear end of the body shell 1 and is rotatable and axially movable with respect to the body shell. This sleeve 6 includes a wall or partition 7 which defines the rear wall of the chamber 2. The sleeve is axially movable between an extended or open position (as illustrated in Figure 1) and a retracted position in which the wall 7 is close to or abuts the end edges of the body shell 1. A capsule retaining means 8 in the form of a tube is carried by, and extends through, the wall or partition 7. This capsule retaining means has a capsule entry opening 9 outside the chamber 2.
The retaining means 8 is of such a length that when a capsule is pushed, body first, into the retaining means, the capsule cap (CC) will be retained in the retaining means and the capsule body (CB) will protrude into the chamber. The capsule retaining means may be constructed as described in the specification of the aforesaid co-pending patent application No.
17976/77. This capsule retaining means is inthe form of a tube or sleeve 10 in which a capsule can be inserted. This tube or sleeve 10 is of such a length that when a capsule is pushed, body first, fully into the tube or sleeve 10, the capsule body (CB) of the capsule will protrude into the chamber 2. The tube or sleeve 10, may be a separate member fitted into the wall 7 or it may be an integral part of the closure, i.e.
the closure and tube or sleeve may be a single moulding. As shown in Figure 3 (which is a section on the line A-A of Figure 4) at least part of the tube or sleeve 10 (the portion 10a) is square in cross-section, with rounded corners, the remaining portion (1 or) of the tube or sleeve being ofgreaterdiameterto provide a lead-in-portion for the capsule. The size and shape of the portion 10a of the tube or sleeve 10 is such that it will squeeze and deform at least the overlapping portions of the capsule body CB and the capsule cap CC, thereby to break or weaken the lock between the two capsule parts.
An abutment 11 in the form of a rib is fixed to the inside of the chamber 2. The rib 11 and the retaining means 8 are so disposed with respect to each other so that when a capsule inserted into the retaining means and projects into the chamber, the projecting portion (CB) of the capsule will engage a side of a rib when the sleeve is rotated with respect to the body shell thereby to separate the two capsule parts.
When the capsule is agitated by aspiration of air by a patient through the nozzle, the rib also serves to assist in emptying powder from the separated capsule body (CB) because it acts as a "kick-bar" in that the capsule body repeatedly collides with the rib.
The agitation and vibration produced by such collision greatly assists in the emptying operation. If desired, the rib 11 may be shorter than as illustrated in Figure 1, and only of sufficient length to engage the projecting portion of a capsule held in the retaining means 8 and a separate"kick-bar" or a plurality
of such kick-bars may then be provided.
The sleeve 6 is of such a length and/or shape that
it normally,i.e. when the device is not in use, covers the air inlet slots. The body shell can have a project
ing peg 13 acting as a cam follower which is engaged in a suitably inclined cam slot 14 in the sleeve 6. Thus, when the sleeve is rotated with respect to the body shell, it will also be forced to make some axial movement sufficient to open the air inlet slots 5. The rear air inlet 5a will register with the slot 14 when the sleeve is in this position so that this inlet will also be open. The cam slot 14 has an open portion 15 which permits the sleeve 6 to be withdrawn from the body shell to permit spent capsule parts to be removed after an inhalation and for cleaning purposes.If desired, the open portion of the cam slot 14 may be bridged in such a way as to allow the peg 13 to enter the slot 14.
In a modification, the sleeve and body shell do not have any cam arrangement. In that event, the sleeve has to be shaped so as to cover the slot 5 and the rear air inlet 5a in one angular position and to uncoverthem in another.
The retaining means 8 is preferably contained in a compartment 16 which is a rearward extension of the sleeve and which is closed by a removable cover 17. This extension chamber may be used for the storage of a supply of capsules. The cover 17 has an inwardly projecting ring 18 of sufficient depth to engage the cap CC of a capsule engaged in the entry opening 9 and press it forward when the cover 17 is fitted in its closed position. The wall of the retaining means must then have a suitable groove 9a so that the ring can enter the opening 9 as shown in Figure 1. When a new capsule is inserted in the retaining means 8, the entering capsule body CB will push the capsule cap CC of the previously used capsule out of the retaining means and into the chamber 2.
In a modification (not illustrated), the ring 18 inside the cover and the groove 9a are omitted.
The cover 17 has an external flange 19 which serves to locate a dust cap 20 which may be slid over the sleeve when the device is not in use.
If desired, the closure 17 may be modified as illustrated in Figures 5 and 6 to provide a magazine in which a supply of capsules can be located in positions convenient for entry into the capsule retaining means 8. In this modification, a wall 21 of the closure has internal grooves 22 opposite each of which is a recess 23 or a pin 24. Each of the recesses 23 is adapted to receive a capsule, cap first, and retain it therein. In this modification the sleeve 6 has an internal protuberance (not illustrated) which can enter one of the grooves 22 when the closure is fitted on the sleeve. When the protuberance is engaged in a groove 22, either a pin 24 or a recess 23 will be registered with the capsule retaining means 8. To load a capsule in the retaining means 8, the closure is fitted on the sleeve in such a position that the capsule retained in one of the recesses 23 will enter the retaining means 8, the engagement of the protuberance in a groove 22 ensuring correct location.
The closure is then removed and rotated to the next angular position such that one of the pins 24 is registered with the retaining means 8. The cover is then fitted back on the sleeve so that the pin 24 will press against the end of the capsule in the retaining means and push it into the retaining means.
Claims (8)
1. An inhalation device by which powdered medicaments can be orally or nasally administered to a patient, the said device comprising a cylindrical body shell defining a portion of a dispersion chamber which has a nozzle at a forward end and which is open at a rear end, an air inlet leading through the cylindrical wall of the body shell and opening into the dispersion chamber, a sleeve rotatably mounted on the outside of the body shell and having a wall or partition which closes the rear end of the chamber, capsule retaining means extending through the said wall or partition lengthwise of the sleeve, the said retaining means having a forward opening through which a portion of a capsule retained in the retaining means can project into the dispersion chamber and a rear opening through which a capsule can be inserted into the retaining means, an abutment fixed inside the chamber in such a position with respect to the capsule retaining means that the capsule retained in the retaining means and projecting into the chamber will engage the abutment when the sleeve is rotated with respect to the body shell thereby to separate the projecting portion of the capsule from the remainder of the capsule, and a guard for preventing the separated portion of the capsule from passing through the nozzle.
2. A device as claimed in claim 1, wherein the sleeve has a cylindrical extension compartment which extends to the rear of the wall or partition and which is open at its rear end and a removable closure is provided at the rear end of the compartment, the rear opening of the retaining means being located within the extension compartment.
3. A device as claimed in claim 2, wherein the removable closure of the extension compartment has a projection extending towards the rear opening of the capsule retaining means, the said projection being engaged in the capsule retaining means when the closure is in its closed position and being adapted to engage an end of a capsule located in the retaining means and press it forwards so that a forward portion of the capsule projects into the dispersing chamber.
4. A device as claimed in claim 2, wherein the removable closure of the extension compartment has an inwardly projecting ring which, when the closure is in its closed position, is engaged in a groove in the retaining means to enter the ring in the entry opening of the retaining means, whereby the ring will engage an end of a capsule in the retaining means when the closure is fitted in its closed position and press the capsule forward so that the capsule will project into the dispersing chamber.
5. A device as claimed in any one of claims 2 or 3, wherein the closure is provided with a plurality of recesses in which capsules may be stored.
6. A device as claimed in claim 5, wherein the recesses are arranged so that, depending on the angular position of the closure with respect to the sleeve, each recess may be registered in turn with the retaining means whereby a capsule located in the registering recess may be introduced into the retaining means, and a plurality of projections inside the closure which, depending on the angular position of the closure with respect to the sleeve, may be registered with the capsule retaining means to press a capsule previously located in the retaining means forwards.
7. A device as claimed in any one of the preceding claims, wherein the body shell is provided with a projecting cam follower member which is engaged in an inclined cam slot in the sleeve whereby when the sleeve is rotated with respect to the body shell it will also be forced to move axially with respect to the body shell, the sleeve being arranged to cover the air inlet when it is in one axial position and to uncover it when it is in another axial position.
8. A device as claimed in any one of the preceding claims, wherein a plurality of first air inlets are provided in the cylindrical wall of the body shell and an additional air inlet is also provided in the cylindrical wall of the body shell to the rear of the first air inlets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7935928A GB2064334B (en) | 1979-10-16 | 1979-10-16 | Inhalation device for administering powdered medicaments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7935928A GB2064334B (en) | 1979-10-16 | 1979-10-16 | Inhalation device for administering powdered medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2064334A true GB2064334A (en) | 1981-06-17 |
| GB2064334B GB2064334B (en) | 1984-03-14 |
Family
ID=10508554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7935928A Expired GB2064334B (en) | 1979-10-16 | 1979-10-16 | Inhalation device for administering powdered medicaments |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2064334B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4860740A (en) * | 1980-10-30 | 1989-08-29 | Riker Laboratories, Inc. | Powder inhalation device |
| WO1994028958A1 (en) * | 1993-06-03 | 1994-12-22 | Boehringer Ingelheim Kg | Capsule holder |
| US5379763A (en) * | 1992-07-28 | 1995-01-10 | Bespak Plc | Dispensing apparatus for powdered medicaments |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| US5857456A (en) * | 1996-06-10 | 1999-01-12 | Sarnoff Corporation | Inhaler apparatus with an electronic means for enhanced release of dry powders |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US6575160B1 (en) | 1997-08-07 | 2003-06-10 | Art Slutsky | Inhalation device |
| EP1404400A1 (en) | 2001-06-20 | 2004-04-07 | Orion Corporation | Powder inhaler |
| US7252087B2 (en) | 2003-11-08 | 2007-08-07 | Boehringer Ingelheim International Gmbh | Powder inhaler |
| WO2012004524A1 (en) * | 2010-07-07 | 2012-01-12 | Valois Sas | Dry powder inhaler |
| WO2012004517A1 (en) * | 2010-07-07 | 2012-01-12 | Valois Sas | Dry-powder inhaler |
| WO2012004518A1 (en) * | 2010-07-07 | 2012-01-12 | Valois Sas | Dry powder inhaler |
| US20130186398A1 (en) * | 2010-07-07 | 2013-07-25 | Aptar France Sas | Dry powder inhaler |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109847158B (en) * | 2019-03-08 | 2021-05-18 | 上海久融塑料制品有限公司 | Capsule type dry powder inhaler |
-
1979
- 1979-10-16 GB GB7935928A patent/GB2064334B/en not_active Expired
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4860740A (en) * | 1980-10-30 | 1989-08-29 | Riker Laboratories, Inc. | Powder inhalation device |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| US5379763A (en) * | 1992-07-28 | 1995-01-10 | Bespak Plc | Dispensing apparatus for powdered medicaments |
| WO1994028958A1 (en) * | 1993-06-03 | 1994-12-22 | Boehringer Ingelheim Kg | Capsule holder |
| US5947118A (en) * | 1993-06-03 | 1999-09-07 | Boehringer Ingelheim Kg | Capsule holder |
| US5857456A (en) * | 1996-06-10 | 1999-01-12 | Sarnoff Corporation | Inhaler apparatus with an electronic means for enhanced release of dry powders |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US6591833B2 (en) | 1996-06-10 | 2003-07-15 | Delsys Pharmaceutical Corp. | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US6575160B1 (en) | 1997-08-07 | 2003-06-10 | Art Slutsky | Inhalation device |
| US8550070B2 (en) | 2001-06-20 | 2013-10-08 | Orion Corporation | Powder inhaler |
| EP1404400A1 (en) | 2001-06-20 | 2004-04-07 | Orion Corporation | Powder inhaler |
| EP1404400B1 (en) * | 2001-06-20 | 2009-01-07 | Orion Corporation | Powder inhaler |
| US7252087B2 (en) | 2003-11-08 | 2007-08-07 | Boehringer Ingelheim International Gmbh | Powder inhaler |
| WO2012004517A1 (en) * | 2010-07-07 | 2012-01-12 | Valois Sas | Dry-powder inhaler |
| WO2012004518A1 (en) * | 2010-07-07 | 2012-01-12 | Valois Sas | Dry powder inhaler |
| FR2962341A1 (en) * | 2010-07-07 | 2012-01-13 | Valois Sas | DRY POWDER INHALER. |
| FR2962340A1 (en) * | 2010-07-07 | 2012-01-13 | Valois Sas | DRY POWDER INHALER. |
| FR2962342A1 (en) * | 2010-07-07 | 2012-01-13 | Valois Sas | DRY POWDER INHALER. |
| US20130186398A1 (en) * | 2010-07-07 | 2013-07-25 | Aptar France Sas | Dry powder inhaler |
| WO2012004524A1 (en) * | 2010-07-07 | 2012-01-12 | Valois Sas | Dry powder inhaler |
| US9415177B2 (en) * | 2010-07-07 | 2016-08-16 | Aptar France Sas | Dry powder inhaler with movable portion to open a capsule |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2064334B (en) | 1984-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |