GB2060606A - Propionamidoxime Derivatives - Google Patents
Propionamidoxime Derivatives Download PDFInfo
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- GB2060606A GB2060606A GB7935197A GB7935197A GB2060606A GB 2060606 A GB2060606 A GB 2060606A GB 7935197 A GB7935197 A GB 7935197A GB 7935197 A GB7935197 A GB 7935197A GB 2060606 A GB2060606 A GB 2060606A
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- propionamidoxime
- mixture
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- derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Propionamidoxime derivatives which are compounds of formula (I> <IMAGE> in which A is a tetrahydronaphthyl or dihydronaphthyl radical and their pharmaceutically acceptable salts are valuable for treatment of the central nervous system and depression. The above compounds are prepared by reacting the nitrile (II> <IMAGE> with hydroxylamine hydrochloride.
Description
SPECIFICATION
Propionamidoxime Derivatives
The present invention relates to propionamidoxime derivatives, their preparation and pharmaceutical compositions containing them.
The propionamidoxime derivatives of the invention are compounds of formula (I)
in which A is a tetrahydronaphthyl or dihydronaphthyl radical and their pharmaceutically acceptable acid addition salts.
These compounds possess an asymmetric carbon. The invention therefore includes the racemates and the optically active isomers of the compounds (I).
According to the invention, the propionamidoxime derivatives can be prepared by a process which comprises reacting the nitrile
with hydroxylamine hydrochloride, normally under substantially anhydrous reaction conditions, effective to prevent hydrolysis of the nitrile to the acid as a predominant reaction, preferably at a temperature of from 50 to 1 200C and preferably in an inert organic solvent. A free base thereby obtained can be converted to its acid addition salt.
The nitriles (II), which are new intermediates, can be obtained from the corresponding naphthols by conventional reactions, namely esterification of the naphthol, formation of the amide and then dehydration of the amide, or direct nitrilation of the naphthol with a 2halopropionitrile.
The process according to the invention can be carried out in a solvent, e.g. ethanol, in the presence of sodium ethylate (sodium ethoxide), at e.g. the reflux temperature of the solvent.
The following Examples illustrate the invention.
The analyses and the IR and NMR spectra confirmed the structure of the compounds.
Example 1: 2-(5,6,7,8-Tetrahydrnnaphthyl-1 oxy)-propion-amidoxime and its Hydrochloride.
1. Methyl 2-(5,6,7,8-tetrahydronaphthyl 1 -oxy)-propionate 39.87 g (0.270 mol) of 5,6,7,8-tetrahydro-naphthol and 37.3 g (0.270 mol) of potassium carbonate in 100 cm3 of methyl ethyl ketone are heated under reflux for half an hour.
The mixture is cooled and 50.1 g (0.3 mol) of methyl 2-bromopropionate are added. The mixture is heated under reflux for 20 hours. It is cooled and filtered.
The filtrate is evaporated to dryness. The product obtained is taken up in ether and the mixture is washed with 5% strength sodium hydroxide solution and with water and then dried over magnesium sulphate. Boiling point (0.05 mm Hg)=1 250C.
2. 2-(5,6,7,8-Tetrahydronaphthyl-l -oxy)- propionamide
54.93 g (0.235 mol) of the above ester in 220 cm3 of ethanol and 220 cm3 of concentrated ammonia solution are stirred at ambient temperature.
After one hour, the product starts to precipitate. 200 cm3 of water are added. The mixture is stirred for 2 hours. 200 cm3 of icecooled water are added and the solid is filtered off, washed with water and dried. The desired product is obtained. Melting point=l 61--1630C.
3.2-(5,6,7,8-Tetrahydronaphthyl-1-oxy)- propionitrile
45.2 g (0.206 mol) of the above amide and 1 50 g of phosphorus pentoxidein 1 litre of dry toluene are heated under reflux for 3 hours in a 2 litre reactor equipped with a stirrer. The toluene layer is decanted, the gummy part is washed with chloroform, the chloroform extracts are combined with the toluene layer, the whole is washed with water until the washings are neutral, dried over magnesium sulphate and filtered, the solvent is evaporated off from the filtrate and the residue is rectified. Boiling point (0.15 mm Hg)=133- 134 C.
4.2-(5,6,7,8-Tetrahydronaphthyl-1-oxy)- propionamidoxime
26.99 g (0.134 mol) of the above nitrile in 200 cm of anhydrous ethanol are heated to the reflux temperature. 16.75 g (0.241 mol) of hydroxylamine hydrochloride, dissolved in 300 cm3 of dry ethanol, are added.
A solution of sodium ethylate, prepared beforehand by dissolving 5.54 g (0.24t mol) of sodium in about 1 50 cm3 of dry ethanol, is added dropwise. Heating under reflux is continued for 5 hours, the mixture is filtered, the solvent is evaporated off from the filtrate, the residue is taken up in chloroform, the chloroform solution is washed with water and dried over magnesium sulphate, the solvent is evaporated off and the oily residue is crystallised from petroleum ether. After recrystallisation from cyclohexane, the product melts at 102-1 030C.
5. Hydrochloride
23 g (0.0983 mol) of 2-(5,6,7,8-tetrahydronaphthyl- 1 -oxy)-propionamidoxime are dissolved in a small amount of ethanol. A solution of hydrogen chloride in ether is added and the mixture is evaporated to dryness. The resulting solid is triturated in ether and washed with ether and then washed once with a small amount of acetone. It is recrystallised from an ethanol/ether mixture. The hydrochloride is obtained. Melting point=1 87-1 88.50C.
Example 2: 2-(5,8-Dihydronaphthyl-1 -oxy)propionamid-oxime and its hydrochloride.
1. 5,8-Dihydro-1-naphthol 108 g (0.75 mol) of ar-naphthol are placed in a 4 litre reactor. The round-bottomed flask is cooled in a bath of solid carbon dioxide and alcohol, and about 1 litre of liquid ammonia is introduced, whilst stirring vigorously. When the naphthol has almost dissolved, 20.9 g of lithium wire are added in small pieces and the mixture is then stirred for T hour. 170 ml of ethyl alcohol are then poured in dropwise. The round-bottomed flask is then left to warm up and nitrogen is bubbled into the mixture in order to drive off the ammonia. The grey pasty residue is taken up in 1 litre of water and-the mixture is extracted 3 times with 100 ml of ether.
The aqueous phase is cooled and acidified with
concentrated HCI until the pH is acid. The brown oil which has appeared is extracted 3 times with ether and the ether fraction is washed 3 times with water before being dried over magnesium sulphate. After filtration and evaporation to dryness, the solid is taken up in ether and the mixture is dried over MgSO4 in the presence of charcoal. The mixture is filtered and the filtrate is evaporated to dryness. A yellow solid is obtained.
After recrystallisation, a white solid is finally obtained. Melting point=73-74.50C.
2. 2-(5,8-Dihydronaphthyl-1 -oxy)-propionitrile 3.85 g (0.08 mol) of sodium hydride are placed in a 250 ml Erlenmeyer flask, washed 4 times with petroleum ether and then covered with 100 ml of DMF. A solution of 11.7 g (0.08 mol) of 5,8 dihydro-1 -naphthol in 25 ml of DMF is poured dropwise into the mixture. A small amount of potassium iodide is added to the resulting brown solution, and a solution of 7.3 g (0.08 mol) of 2chloropropionitrile in 25 ml of DMF is then added dropwise. The mixture is left to react over night at ambient temperature and then for 6 hours at 900 C. The DMF is evaporated off in vacuo. The residue is taken up between water and ether, a black resin is filtered off and the ether phase is decanted, washed several times with water and dried over magnesium sulphate.After filtration and evaporation to dryness, a pale yellow solid remains. It is recrystallised from hexane. A light beige solid is obtained. Melting point=60 61.50C.
3. 2-(5,8-Dihydronaphthyl-1 -oxy)- propionamidoxime
8.95 g (0.0449 mol) of the above nitrile and 3.12 g (0.0449 mol) of hydroxylamine hydrochloride are mixed with 75 cm3 of ethanol, and a solution of sodium ethylate, prepared from 1.03 g of sodium in 40 ml of ethanol, is then added dropwise. The mixture is subsequently heated under reflux for 5 hours. The precipitate of
NaCI is filtered off and the filtrate is evaporated to dryness. The residue is taken up in ether, a small amount of benzene and water, the mixture is stirred and the organic phase is decanted. It is washed with water and then dried over magnesium sulphate and charcoal. The mixture is filtered and the filtrate is evaporated to dryness. A spontaneousiy crystalline white solid is obtained.
It is recrystallised twice from cyclohexane containing a small amount of benzene. Melting point=1 17-1180C.
4. Hydrochloride
5 g (0.021 5 mol) of the above base are dissolved in about 1 50 ml of ether and a few ml of ethanol, and a solution of hydrochloride in ether is added dropwise until the pH is acid. A fine' white solid precipitates immediately. The crystallisation is allowed to proceed to completion in the cold and this solid is then filtered off, washed with ether and dried.
After recrystallisation, a fine white solid is obtained. Melting point=l 72--1730C (decomposition).
Example 3: 2-(7.8-Dihydronaphthyl-l -oxy-)propionamid-oxime and its hydrochloride.
1. 7,8-Dihydro-1 -naphthol 57 g of extremely pure dimethylsulphoxide are placed in a 1 00 ml Erlenmeyer flask with a ground glass joint and its temperature is stabilised at 1600.19 g (0.1157 mol) of 1,5-dihydroxy 1,2,3,4-tetralin are then added thereto and the reaction mixture is kept at this temperature for 4 hours 30 minutes. The greatest possible amount of DMSO is evaporated off using a vacuum pump and the residue is taken up between 400 ml of ether and 90 ml of water. A black resin is filtered off and the filtrate is separated by decantation.
The organic phase is subsequently washed 6 times with water and then dried over magnesium sulphate in the presence of charcoal. The mixture is filtered and the filtrate is evaporated to dryness..
A brown oil is obtained. After sublimation of the oil, a solid is obtained which is recrystallised from a mixture of heptane and hexane (50/50). After further sublimation of the reaction mixture on an adiabatic column, the product is recrystallised from hexane and a solid is recovered in the form of fine white needles. Melting point=67-680 C.
2. 2-(7,8-Dihydronaphthyl-1 oxy)-propionitrile 4.6 g (0.0958 mol) of a 50% strength dispersion of sodium hydride in oil are placed in a round-bottomed flask with a ground glass joint, washed 4 times with petroleum ether by decantation and then covered with 125 ml of extremely pure DMF. The atmosphere is purged with nitrogen and a solution of 13.7 g (0.0937 mol) of the above naphthol in 30 ml of DMF is introduced dropwise onto this stirred suspension.
A slight warming and the appearance of a uniform evolution of gas are observed. After the addition, the introduction of sodium is left to proceed to completion for a further 1 hour at ambient temperature. A solution of 8.4 g (0.0937 mol) of 2-chloropropionitrile in 30 ml of DMF is subsequently poured in dropwise and the mixture is then stirred for 2 hours and left to stand overnight.
The DMF is evaporated off to dryness, the residue is taken up between water and ether and the ether phase is decanted. The aqueous phase is re-extracted twice with ether and the organic phases are combined and washed several times with water until the washings are neutral. The organic phase is dried over magnesium sulphate in the presence of charcoal, the mixture is filtered and the filtrate is evaporated. A light yellow oil is recovered.
After elution of the product with toluene on a dry alumina column (TSC Woelm), the product is extracted with ether and the mixture is evaporated to dryness. A pale yellow oil is obtained which crystallises to give a white solid.
Melting point=45-46.50C.
3. 2-(7,8-Dihydronaphthyl-1 -oxy)- propionamidoxime
6.97 g (0.035 mol) of the above nitrile and 2.43 g (0.035 mol) of hydroxylamine hydrochloride are introduced into a 100 ml
Erlenmeyer flask with a ground glass joint and 60 ml of ethanol are added thereto. This suspension is stirred magnetically for a few minutes and a solution of sodium ethylate, prepared from 0.8 g (0.035 mol) of sodium in 35 ml of ethanol, is then poured in slowly. The disappearance of the hydrochloride and the concomitant appearance of a fine precipitate of sodium chloride are observed.
The mixture is heated to the reflux temperature of the solvent and kept at this temperature for 5 hours. The precipitate is filtered off and washed with alcohol and the filtrate is evaporated to dryness. The resulting viscous oil is taken up in ether and benzene and the mixture is then washed several times with water and dried over magnesium sulphate. After filtration and evaporation of the filtrate, a thick yellow oil remains which is dissolved in hot cyclohexane; a light beige solid crystallises from this solution and is filtered off, washed and dried.
After recrystallisation from cyclohexane and drying in vacuo, the solid melts at 77.5-78.50C.
4. Hydrochloride
5.1 g (0.0219 mol) of the above base are dissolved in ether and a few drops of acetone, and a solution of hydrogen chloride in ether is then poured slowly therein until the pH is acid. A fine
white solid appears; the mixture is stirred for 2 hours and the solid is then filtered off and washed with ether.
This solid is placed in contact for half an hour with refluxing methyl ethyl ketone containing a few drops of isopropanol, the mixture is then left to cool and the solid is filtered off, washed carefully and dried in vacuo at 800C. It is a finely crystalline white compound. Melting point=1 71.5-1 72.50C (decomposition).
The propionamidoxime derivatives were subjected to various biological tests which demonstrated their activity in the field of the central nervous system.
The acute toxicity was determined on mice after intraperitoneal injection.
It is of the order of 50 to 200 mg/kg.
The therapeutic activity of the propionamidoxime derivatives was determined in several fields.
1. The action on the central nervous system was determined using the "Eating test" (described by R. J. Stevens, Brit. J. Pharmacol., 49, 146(1973)).
In this test, the propionamidoxime derivatives favour the intake of food by the animals, this behaviour reflecting an anxiolytic action.
2. The antidepressive action was determined by the test for the antagonism towards ptosis caused by reserpine (C. Gouret et al., J.
Pharmacol. (Paris), 8, 333-350 (1977)).
The mice (male, CD1 Charles River, France, weighing 1 8-22 g) simultaneously received the products to be studied or the solvent (administered intraperitoneally) and reserpine (4 mg/kg, administered subcutaneously).
After sixty minutes, the degree of palperbral ptosis is estimated for each mouse by means of a rating scale (0 to 4).
For each dose, the mean rating and the percentage variation relative to the control batch are calculated.
For each product, the AD 50, namely the dose which reduces the mean ptosis score by 50%, relative to the controls, is determined graphically.
The AD 50 varies from 2 to 10 mg/kg, administered intraperitoneally.
These data show that the propionamidoxime derivatives can be used for the treatment of various affections, in particular for the treatment of various affections of the central nervous system and for the treatment of depression.
The propionamidoxime derivatives can be formulated as a pharmaceutical composition containing a said derivative and a pharmaceutically acceptable excipient. The composition can be in any form which is suitable for oral, parenteral or endorectal adminstration, for example in the form of tablets, dragees, sugarcoated pills, solutions to be taken orally or injected.
The daily posology can range from 5 to 500 mg.
Claims (9)
1. Propionamidoxime derivatives, in the form of racemates or optically active isomers, having the formula (I)
in which A is a tetrahydronaphthyl or dihydronaphthyl radical, and their pharmaceutically acceptable acid addition salts.
2. Derivatives according to Claim 1, wherein A is the 5,6,7,8-tetrahydronaphth-1 -yI, 5,8- dihydronaphth- 1 -yl or 7,8-dihydronaphth- 1 -yl radical.
3. Each of the derivatives according to Claim 1 specifically hereinbefore mentioned.
4. A process for the preparation of propionamidoxime derivatives according to Claim 1, which process comprises reacting a nitrile of formula (II)
wherein A is as defined in Claim 1, with hydroxylamine hydrochloride.
5. A process according to Claim 4 wherein the reaction is carried out in ethanol and sodium ethoxide, under substantially anhydrous conditions and under reflux.
6. A process according to Claim 4 substantially as hereinbefore described in any one of the
Examples.
7. Propionamidoxime derivatives according to
Claim 1 when obtained by a process claimed in
Claim 4, 5 or 6.
8. A pharmaceutical composition containing a propionamidoxime derivative claimed in Claim 1, 2, 3 or 7 and a pharmaceutically acceptable excipient.
9. Nitriles of the formula (II)
wherein A is as defined in Claim 1 or 2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7935197A GB2060606B (en) | 1979-10-10 | 1979-10-10 | Propionamidoxime derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GB7935197A GB2060606B (en) | 1979-10-10 | 1979-10-10 | Propionamidoxime derivatives |
Publications (2)
Publication Number | Publication Date |
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GB2060606A true GB2060606A (en) | 1981-05-07 |
GB2060606B GB2060606B (en) | 1983-05-25 |
Family
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Family Applications (1)
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GB7935197A Expired GB2060606B (en) | 1979-10-10 | 1979-10-10 | Propionamidoxime derivatives |
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GB (1) | GB2060606B (en) |
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1979
- 1979-10-10 GB GB7935197A patent/GB2060606B/en not_active Expired
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GB2060606B (en) | 1983-05-25 |
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PCNP | Patent ceased through non-payment of renewal fee |