GB2054383A - Plugs for the medullary canal of a bone - Google Patents

Plugs for the medullary canal of a bone Download PDF

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Publication number
GB2054383A
GB2054383A GB8023535A GB8023535A GB2054383A GB 2054383 A GB2054383 A GB 2054383A GB 8023535 A GB8023535 A GB 8023535A GB 8023535 A GB8023535 A GB 8023535A GB 2054383 A GB2054383 A GB 2054383A
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United Kingdom
Prior art keywords
plug
bone
cement
medullary canal
canal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8023535A
Other versions
GB2054383B (en
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University of Exeter
Original Assignee
University of Exeter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Exeter filed Critical University of Exeter
Priority to GB8023535A priority Critical patent/GB2054383B/en
Publication of GB2054383A publication Critical patent/GB2054383A/en
Application granted granted Critical
Publication of GB2054383B publication Critical patent/GB2054383B/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30721—Accessories
    • A61F2/30723—Plugs or restrictors for sealing a cement-receiving space
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30594—Special structural features of bone or joint prostheses not otherwise provided for slotted, e.g. radial or meridian slot ending in a polar aperture, non-polar slots, horizontal or arcuate slots
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2002/4631—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor the prosthesis being specially adapted for being cemented
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A61F2310/00377—Fibrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

An implant 22, e.g. for locating a hip prosthesis, is placed in the medullary canal 18 of a bone 20 (e.g. the femur) and secured by pressurised cement 24. A push-fit plug 10 prevents cement penetrating down the canal. The plug can be biodegradable so that in time it dissolves away and does not modify the flexural rigidity of the cement/bone system and the risk of fractures occurring at the level of the plug is reduced. Additionally or alternatively, the outwardly facing end portion 16 of the plug may be generally conical so that the thickness of the cement increases gradually and the flexural rigidity likewise changes gradually. <IMAGE>

Description

SPECIFICATION Plugs for the medullary canal of a bone This invention relates to surgery in which an implant is placed in the medullary canal of a bone, and more particularly to plugs for insertion in the medullary canal in such surgery.
An implant has to be placed in the medullary canal of a femur when a patient is to be given an artificial hip joint, in orderto locate the hip prosthesis. The implant is located in the medullary canal by use of a bone cement, e.g. polymethylmethacrylate cement.
Such cement does not have any appreciable adhesive qualities, and relies for its security on obtaining a mechanical interlock with irregularities in the bone.
Such mechanical interlocking is greatly enhanced if the cement is introduced into the canal under pressure. However, there is a tendency for the cement to flow down the medullary canal so it is not possible to use much pressure. To overcome this, it is known to insert a plug which is a push fit inside the medullary canal and which prevents the cement flowing down the canal and permits greater pressurisation of the cement. It is known for such plugs to be formed from bone, or from bone cement. An improved plug made from a plastics material is the Seidel plug. Such a plastics plug will of course remain inside the medullary canal when the surgery is completed. A problem with all such known plugs is that because of such factors as the difference in Young's modulus between the bone and the bone cement, there is an abrupt change in the flexural rigidity of the bone at the plug.This has not uncommonly led to fractures at the level of the plug, for example if the patient should suffer a fall. A fracture at this level is very difficult to set.
According to one aspect of the present invention we provide a plug for the medullary canal of a bone, having a portion with sides adapted to be a push fit in the medullary canal, the plug being made of a biodegradable material.
Preferably the plug has a tapering end portion, which preferably is generally conical. The plug can then be inserted in the medullary canal with the con icallytapering portion facing into the part of the canal into which cement is to be introduced, so that when the cement is introduced the conically tapering portion forms a mould so that there is a gradually increasing thickness of cement in contact with the bone along the length of the tapering portion. This car then provide a gradual change in flexural rigidity of the cement/bone system along the plug. Being biodegradable, the plug will eventually dissolve, and so have no effect on flexural rigidity.
According to a second aspect of the invention we provide a plug for the medullary canal of a bone, comprising a portion having sides adapted to be a push fit in the medullary canal, and a tapering end portion, preferably a generally conically tapering end portion. This plug can be of plastics material.
The portion which has sides adapted to be a push fit in the medullary canal may be hollow, and may also have one or more slits in a longitudinal plane which permit flexing of said sides to facilitate insertion in the canal.
The invention will be more clearly understood by reference to the accompanying drawings, wherein Figs. 1 and 2 are schematic sectional views of two plugs embodying the invention, in situ in a bone.
Referring to Fig. 1, the plug 10 has a generally cylindrical portion 12 with generally parallel serrated sides 14. The sides 14 merge into a generally coni callytapered portion 16 of the plug. During surgery, the medullary canal 18 of the bone 20 such as a femur will be reamed out, and a plug 10 of suitable size for the reamed out canal will be introduced with the cylindrical portion 12 leading so that the conically tapering portion 16 faces outwardly. The portion 12 is a push fit inside the canal 18, assisted by the serrations 14, and the plug is inserted for a sufficient distance to permit filling of the canal with cement as desired.
Bone cement 24, e.g. polymethylmethacrylate bone cement, is introduced into the open end of the medullary canal 18, suitably by retrograde filling above the plug 10, and pressurised. The desired implant 22 such as a hip prosthesis is then introduced into the medullary canal 18 by being inserted down the centre of the previously placed bone cement. Further pressurisation of the bone cement is achieved at this stage by occluding the top of the medullary canal and allowing the generally wedgeshaped stem of the implant to force bone cement further into the medullary canal of the femur. Pressurisation of the cement ensures that it is forced into the intertrabecularspaces of the bone structure thereby providing a good mechanical interlock so as to anchor the implant securely. The plug 10 prevents pressurised cement flowing further down the medullary canal.
Because the conically tapering portion 16 of the plug faces into the reamed out cavity of the canal 18 which is filled with cement, it forms a mould for the cement so that the thickness of cement which is in contact with and mechanically interlocking with the bone 20 increases gradually along the length of the tapering portion 16. This means that the flexural rigidity of the cement/bone system also changes gradually in this region. The risk of the bone fractu ring in this region is therefore reduced.
The plug 10 is manufactured from a biodegradable material comprising stabilised oxfibrin, mixed with 35% glycerol as a plasticizer. This material is described by lan Cappernauld, P. Lawrie and D. A.
French in "Properties of Bovine Fibrin Absorbable Implants", Surgery: Gynecology & Obstetrics, January 1977, Vol. 144,3-7. It is available from Ethnor Division, Ethicon Limited, P.O. Box 408, Bankhead Avenue, Edinburgh, EH11 4HE, under the Trade Mark BIETHIUM. The plug 10 can be made by compression moulding the powdered material, or by machining from a round bar. Other biodegradable materials could of course be used. Because it is made of biodegradable material, the plug 10 eventually dissolves, leaving behind the cement 24 with its gradually increasing thickness around the region once occupied by the portion 16. Once this has happened, the flexural rigidity of the cement/bone system is unmodified by the plug, and so the risk of a fracture occuring in this area is reduced even further.
Referring now to Fig. 2, a plug 26 is shown which is moulded in the usual way from a non biodegradable plastics material. A suitable material is ultra-high molecular weight polyethylene. It is generally similar to the plug 10 shown in Fig. 1, and in particular has a conically tapering portion 28 which behaves in exactly the same manner as in Fig.
1. There is also a generally cylindrical portion 30 which has serrated sides 32 which are a push fit in the medullary canal 18, as before. However, the por tion 30 is hollowed out to give a recess 34 open at the end of the plug remote from the portion 28. Two slits 36 are provided through the walls of the portion 30, the slits being open at the end of the plug remote from the portion 28, and being in a longitudinal plane with respect to the plug. This effectively divides the portion 30 into two halves which can flex slightly towards each other. This facilitates insertion of the plug 26 into the canal 18.

Claims (12)

1. A plug for the medullary canal of a bone, com prising a first portion having sides adapted to be a push fit in the medullary canal, and a second portion at one end thereof which tapers in the direction away from the first portion.
2. A plug according to claim 1 made from plastics material.
3. A plug according to claim 1 made from a biodegradable material.
4. A plug according to claim 3 wherein the biodegradable material comprises oxfibrin.
5. A plug according to claim 4 wherein the biodegradable material contains glycerol as a plasti cizer.
6. A plug according to claim 1 wherein the first portion is hollow.
7. A plug according to claim 6 wherein the hol low first portion has one or more slits in a longitudi nal plane which permit flexing of said sides to facili tate insertion in the canal.
8. A plug according to claim 1 wherein the taper ing second portion is generally conical.
9. A plug for the medullary canal of a bone, hav ing a first portion with sides adapted to be a push fit in the medullary canal, wherein the plug is made of a biodegradable material.
10. A plug according to claim 9 wherein the biodegradable material comprises ox fibrin.
11. A plug according to claim 10 wherein the biodegradable material contains glycerol as a plasti cizer.
12. A plug for the meduilary canal of a bone, substantially as described herein with reference to Fig. 1 or Fig. 2 of the accompanying drawings.
GB8023535A 1979-07-25 1980-07-18 Plugs for the medullary canal of a bone Expired GB2054383B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8023535A GB2054383B (en) 1979-07-25 1980-07-18 Plugs for the medullary canal of a bone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7925892 1979-07-25
GB8023535A GB2054383B (en) 1979-07-25 1980-07-18 Plugs for the medullary canal of a bone

Publications (2)

Publication Number Publication Date
GB2054383A true GB2054383A (en) 1981-02-18
GB2054383B GB2054383B (en) 1983-08-03

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543820A1 (en) * 1983-04-09 1984-10-12 Mitsubishi Mining & Cement Co SEALING ANCHOR FOR SEALING A CAVITY OF THE BONE MARROW
WO1986003667A1 (en) * 1984-12-14 1986-07-03 Klaus Draenert Occlusion device made of surgical material
EP0444197A1 (en) * 1989-09-15 1991-09-04 Nauchno-Proizvodstvennoe Obiedinenie Komplexnogo Razvitia Meditsinskoi Tekhniki I Izdely Meditsinskogo Naznachenia "Ekran" Endoprosthesis of the hip joint
WO1994012122A1 (en) * 1992-12-03 1994-06-09 Protek Synthes Sa Device for positioning a total hip prosthesis
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7846208B2 (en) 1999-10-20 2010-12-07 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US9737294B2 (en) 2013-01-28 2017-08-22 Cartiva, Inc. Method and system for orthopedic repair
US9795372B2 (en) 2010-01-11 2017-10-24 Krt Investors, Inc. Intervertebral disc annulus repair system and bone anchor delivery tool
US10179012B2 (en) 2013-01-28 2019-01-15 Cartiva, Inc. Systems and methods for orthopedic repair

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7004970B2 (en) 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US7615076B2 (en) 1999-10-20 2009-11-10 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US7052516B2 (en) 1999-10-20 2006-05-30 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US7951201B2 (en) 1999-10-20 2011-05-31 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8632590B2 (en) 1999-10-20 2014-01-21 Anulex Technologies, Inc. Apparatus and methods for the treatment of the intervertebral disc
US7935147B2 (en) 1999-10-20 2011-05-03 Anulex Technologies, Inc. Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus
US8128698B2 (en) 1999-10-20 2012-03-06 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus
US8163022B2 (en) 2008-10-14 2012-04-24 Anulex Technologies, Inc. Method and apparatus for the treatment of the intervertebral disc annulus

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543820A1 (en) * 1983-04-09 1984-10-12 Mitsubishi Mining & Cement Co SEALING ANCHOR FOR SEALING A CAVITY OF THE BONE MARROW
WO1986003667A1 (en) * 1984-12-14 1986-07-03 Klaus Draenert Occlusion device made of surgical material
EP0444197A1 (en) * 1989-09-15 1991-09-04 Nauchno-Proizvodstvennoe Obiedinenie Komplexnogo Razvitia Meditsinskoi Tekhniki I Izdely Meditsinskogo Naznachenia "Ekran" Endoprosthesis of the hip joint
EP0444197A4 (en) * 1989-09-15 1992-01-15 Nauchno-Proizvodstvennoe Obiedinenie Komplexnogo Razvitia Meditsinskoi Tekhniki I Izdely Meditsinskogo Naznachenia "Ekran" Endoprosthesis of the hip joint
WO1994012122A1 (en) * 1992-12-03 1994-06-09 Protek Synthes Sa Device for positioning a total hip prosthesis
FR2698783A1 (en) * 1992-12-03 1994-06-10 Aebi Jurg Centering device for total hip prosthesis.
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
US7670380B2 (en) 1999-10-20 2010-03-02 Anulex Technologies, Inc. Intervertebral disc annulus stent
US7846208B2 (en) 1999-10-20 2010-12-07 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and deformable spinal disc annulus stent
US9795372B2 (en) 2010-01-11 2017-10-24 Krt Investors, Inc. Intervertebral disc annulus repair system and bone anchor delivery tool
US9737294B2 (en) 2013-01-28 2017-08-22 Cartiva, Inc. Method and system for orthopedic repair
US10179012B2 (en) 2013-01-28 2019-01-15 Cartiva, Inc. Systems and methods for orthopedic repair
US11471199B2 (en) 2013-01-28 2022-10-18 Cartiva, Inc. Systems and methods for orthopedic repair

Also Published As

Publication number Publication date
GB2054383B (en) 1983-08-03

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 20000717