GB2046774A - Articles of Manufacture Having Adhesive Properties - Google Patents
Articles of Manufacture Having Adhesive Properties Download PDFInfo
- Publication number
- GB2046774A GB2046774A GB8009733A GB8009733A GB2046774A GB 2046774 A GB2046774 A GB 2046774A GB 8009733 A GB8009733 A GB 8009733A GB 8009733 A GB8009733 A GB 8009733A GB 2046774 A GB2046774 A GB 2046774A
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- United Kingdom
- Prior art keywords
- article according
- article
- grams
- manufacture
- gum
- Prior art date
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- 230000001070 adhesive effect Effects 0.000 title claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 239000000853 adhesive Substances 0.000 claims abstract description 30
- 229920003023 plastic Polymers 0.000 claims abstract description 19
- 239000004033 plastic Substances 0.000 claims abstract description 19
- 229920001577 copolymer Polymers 0.000 claims abstract description 12
- 239000011159 matrix material Substances 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims abstract description 11
- 239000011347 resin Substances 0.000 claims abstract description 11
- 108010010803 Gelatin Proteins 0.000 claims abstract description 7
- 239000008273 gelatin Substances 0.000 claims abstract description 7
- 229920000159 gelatin Polymers 0.000 claims abstract description 7
- 235000019322 gelatine Nutrition 0.000 claims abstract description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 7
- 150000004676 glycans Chemical class 0.000 claims abstract description 7
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 7
- 239000005017 polysaccharide Substances 0.000 claims abstract description 7
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims abstract description 5
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims abstract description 3
- 150000007524 organic acids Chemical class 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- 229920000569 Gum karaya Polymers 0.000 claims description 8
- 235000010494 karaya gum Nutrition 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- 230000001681 protective effect Effects 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 5
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 4
- 239000005977 Ethylene Substances 0.000 claims description 4
- 229920000084 Gum arabic Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000011505 plaster Substances 0.000 claims description 4
- -1 polyethylene Polymers 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 3
- 241000416162 Astragalus gummifer Species 0.000 claims description 3
- HHLFWLYXYJOTON-UHFFFAOYSA-N Glyoxylic acid Natural products OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims description 3
- 239000004640 Melamine resin Substances 0.000 claims description 3
- 229920000877 Melamine resin Polymers 0.000 claims description 3
- 229920002367 Polyisobutene Polymers 0.000 claims description 3
- 229920001615 Tragacanth Polymers 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 229940015043 glyoxal Drugs 0.000 claims description 3
- 238000011065 in-situ storage Methods 0.000 claims description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
- 239000003607 modifier Substances 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000005662 Paraffin oil Substances 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 229920006026 co-polymeric resin Polymers 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 2
- 229910002055 micronized silica Inorganic materials 0.000 claims description 2
- 235000006491 Acacia senegal Nutrition 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 229920003346 Levapren® Polymers 0.000 description 12
- 238000000034 method Methods 0.000 description 9
- 241000934878 Sterculia Species 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 239000000231 karaya gum Substances 0.000 description 7
- 229940039371 karaya gum Drugs 0.000 description 7
- 238000007789 sealing Methods 0.000 description 6
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 5
- 239000000416 hydrocolloid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 150000002314 glycerols Chemical class 0.000 description 2
- 238000007455 ileostomy Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- AEMOLEFTQBMNLQ-DTEWXJGMSA-N D-Galacturonic acid Natural products O[C@@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-DTEWXJGMSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 244000004005 Nypa fruticans Species 0.000 description 1
- 235000005305 Nypa fruticans Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
- C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
- C09J123/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
- C09J123/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
- C09J123/22—Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L28/00—Materials for colostomy devices
- A61L28/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L28/008—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L28/0096—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J105/00—Adhesives based on polysaccharides or on their derivatives, not provided for in groups C09J101/00 or C09J103/00
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J135/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least another carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J135/08—Copolymers with vinyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/14—Adhesives for ostomy devices
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/28—Non-macromolecular organic substances
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Various articles of manufacture are described, each such article having adhesive properties and comprising a plastics matrix in which is dispersed a gelatinous adhesive composition comprising the product resulting from heating together components (a) and (b) to promote chemical reaction between the two said components, component (a) being at least one polyhydric alcohol, and component (b) being a material selected from gelatin, naturally occurring high molecular weight polysaccharide gums, and resins which are a copolymer of a vinyl ether and an organic acid anhydride or its free acid.
Description
SPECIFICATION
Articles of Manufacture Having Adhesive
Properties
This invention relates to articles of manufacture having adhesive properties, and useful, for example, as protective plasters or dressings or as rings, washers or the like in surgical appliances such as ostomy appliances.
Conventional pressure-senstive plasters comprise an adhesive based on a rubbet/resin mixture. Such plasters adhere with difficulty to moist body surfaces and, even then, under movement of the body they may easily detach from the skin. There is a particular need for improved protective plasters which may be used in the management of colostomies and ileostomies and similar surgical operations. The ostomy appliances provided for patients who have had such an operation have generally included a sealing ring supposedly for preventing draining waste material which commonly includes active gastric juices from coming into contact with the patient's skin surrounding the stoma, and thereby attacking the skin, or from leaking thereby producing embarrasing odour and soiling of the patient's clothing.Such ostomy sealing rings have not always proved reliable and additional sealing compositions in paste form which may be squeezed from a toothpaste-like tube have been suggested to overcome this problem but have not found wide application, being difficult for the patient himself to use.
In one aspect of the present invention, we provide an article of manufacture, having adhesive properties, and comprising a plastics matrix in which is dispersed a gelatinous adhesive composition comprising the product resulting from heating together:
(a) one or more polyhydric alcohols, and
(b) gelatin, and/or a naturally occurring high molecular weight polysaccharide gum, and/or a resin which is a copolymer of a vinyl ether and an organic acid anhydride and/or its corresponding free acid, to promote chemical reaction between components (a) and (b).
The chemical reaction which occurs on heating between the said components (a) and (b) is essentially the formation of an ester.
We believe many of the said adhesive compositions to be novel, and certain of the said novel adhesive compositions comprise one aspect of our co-pending British Patent Application
No. (Lloyd Wise, Tregear s Co's Folio
No. AP 1 9/43T), filed the same day as this
Application and which claims priority from our earlier British Patent Application No. 7,099,967, to which reference may also be made.
The gelatinous adhesive compositions described herein may be regarded as means relating to an essential element of the present invention for putting that invention into effect.
The preferred polysaccharide gum is Karaya, a natural substance occurring in the bark of certain trees and which appears to be a high molecular weight polysaccharide formed by the condensation of certain unhydro-monosaccharide units, of which those derived from D-galacturonic acid, D-galactose and L-rhammose are the most important. Other naturally occurring high molecular weight polysaccharide gums which we have found to be useful include gum Tragacanth and gum Arabic.
The preferred resin is a methyl vinyl ether/maleic anhydride copolymer of which a range of suitable resins is available under the trade name Gantrez from Gaf (G.B.) Limited and under the trade name Viscofas from Imperial
Chemical Industries Ltd. We prefer to use Gantrez
An139, orViscofas L.30.
Suitable polyhydric alcohols include but are not limited to glycerol, sorbitol, pentaerythritol and polyvinylalcohol.
Our gelatinous adhesive compositions have inherent tack and water swelling (absorbing) purposes. The resultant article of manufacture in which the adhesive composition is dispersed in a suitable plastics matrix must retain these properties. Any of the conventionai film forming elastic binder plastics materials which are compatible with skin tissue may be employed, though we have found that best results are obtained when at least the major part of the plastics matrix material comprises one or more copolymers of ethylene and vinyl acetate. A range of such copolymers is available from Bayer AG.
under the trade name Levapren. We have obtained good results by employing a blend of a high molecular weight such copolymer, Levapren
L452, and a low molecular weight such copolymer, Levapren KH8 160. Other film forming plastics such as polyisobutylene may optionally be added to the blend or substituted.
The gelatinous adhesive composition can be made either in a heated reaction vessel or preferably in situ during blending with the other ingredients forming the article in a heated Z-blade mixer, the blend being subsequently allowed to solidify, suitably in a mould.
The specific gel content of the gelatinous adhesive composition may readily be adjusted to obtain a desired degree of water swelling (absorbing) capability. The gel structure may be altered by varying the proportions of the reacting ingredients and by employing a crosslinking resin such as glyoxal or citric acid. Melamine resin is also an effective crosslinking agent for the composition but may sensitise the skin of some people and is therefore less preferred.
Our gelatinous adhesive compositions have very useful inherent pressure-sensitive properties, enabling them to act as the sole or main tackifying agent in adhesive articles in accordance with this invention, such as protective plasters or dressings, or rings, washers, or the like, in surgical appliances such as ostomy appiicances. The resultant articles adhere readily to dry or moist human body surfaces.
The physical characteristics of the adhesive articles such as tack, plasticity, cohesive strength
and moisture absorbency, may be modified by
admixing other substances such as: viscosity
modifiers, e.g. micronised silica; tack modifiers,
e.g. polyvinylprrolidone resin (which in glycerol
forms a tacky viscous compound); fillers e.g.
calcium carbonate; crosslinking agents, e.g.
glyoxal or citric acid; antimicrobial agents; and
plasticisers, e.g. paraffin oil. Selection of the
polyhydric alcohol may also be used to adjust the
physical properties of the articles. Thus when the
polyhydric alcohol is glycerol the article has
substantial water absorbing properties, and may
eventually swell unduly or even begin to dissolve;
substitution of glycerol wholly or partially by
sorbitol may avoid this. Pentaerythritol is not
soluble to any great extent. The presence of
polyvinylalcohol enhances adhesion to the skin.
We have found that particularly satisfactory
ostomy plasters result when the gelatinous
adhesive composition is present in an amount
from 30 to 55 per cent by weight.
The most satisfactory blends for forming
ostomy plasters are those comprising 40 to 50
per cent by weight of an adhesive composition
resulting from the chemical reaction between
sorbitol and/or glycerol and Karaya gum. The ostomy plasters we have made from this blend are soft and pliable, have good adhering qualities to dry and. moist skin, are resistant to plastic flow at body temperature and, owing to the Karaya gum content, also possess skin healing properties. When an adhesive article in
accordance with this invention is embodied as a
protective plaster or dressing, it preferably has a backing sheet to prevent the tacky plaster or dressing from sticking to clothing etc. A thin, suitably water impermeable, plastics film, for
example of polyethylene may be employed.The film is suitably provided with perforations which
assist in getting rid of occluded air bubbles during
the lamination process. The plasters may be
formed as a sheet which may be cut into desired
shapes and sizes in a subsequent operation.
The following examples will illustrate the invention: Example 1
300 grams of high molecular weight
ethylene/vinyl acetate copolymer, manufactured
under the trade name Levapren L452, and 100
grams of low molecular weight ethylene/vinyl
acetate copolymer, manufactured under the trade
name Levapren KH 8160, were placed in a Z
blade mixer heated at 800--900 and mixed until
a uniform dough was obtained. Then 85 grams of -glycerine, 80 grams of Karava gum and 2 grams
of Nipastat (a mixture of p-hydro-benzoic acid
esters produced by Nipa Laboratories Limited and
having anti-microbial properties) were added and
mixed for one hour at 800--900C, when at the
end of this period a uniform dispersion of the
gelatinous adhesive composition was obtained in
the plastics matrix.Part of the dispersion was
pressed to a thin sheet in an hydraulic press
maintained at 1 300 C. The thus formed adhesive
sheet was laminated to a perforated thin
polyethylene film and then cut into plasters of
desired shapes and sizes. The remainder of the
dispersion was moulded to produce a solid mass.
Example 2
The procedure of Example 1 was repeated but
with the quantity of Nipastat reduced to 1 gram.
Comparison of the products of the two examples
showed that the reduced Nipastat content
products were less likely to sensitise skin.
Example 3
300 grams of Levapren L452 and 300 grams
of Levapren KH 8160 were placed in a Z-blade
mixer heated at 800--900C and mixed until a
uniform dough was obtained. Then 450 grams of
glycerine, 60 grams of Kollidon 90 (polyvinyl
pyrrolidone resin manufactured by BASF Limited),
1 50 grams of Gantrez AN 139 (methyl vinyl
ether/maleic anhydride copolymer resin soid by
Gaf (GB) Limited) and2 grams of Nipastat were
added and mixed for one hour at 800--900C.
Part of the dispersion was pressed to a thin sheet
in an hydraulic press maintained at 1 300C, and the resultant adhesive sheet laminated to a perforated thin polythene film. Satisfactory ostomy plasters were obtained.
Example 4
The procedure of Example 3 was repeated but with the Nipastat content reduced to 1 gram.
Comparison of the resulting ostomy plasters showed that those of Example 4 exhibited less likelihood of sensitising skin as compared with those of Example 3.
Example 5
The process of Example 1 was followed except that 20 grams of the Karaya gum was replaced by 20 grams of Gantrez AN 139.
Example 6
200 grams of Levapren 452 and 200 grams of polyisobutylene (Vistanex LM-M H manufactured by Esso Co. Ltd) were blended in a Z-blade mixer at 900 C. Then were added: 2 grams of Nipastat,
100 grams of micronised amorphous silica (Syloid 244 manufactured by Grace GmbH), 50 grams of Kollidon 90, and 110 grams of Karaya gum. The blend was mixed to obtain uniform dispersion. Next 1 50 grams of glycerol and 100 grams of paraffin were added, followed by mixing, still maintaining a temperature of 900C, for one hour. The further stages were as per Example 1.
Example 7
Example 6 was repeated with 1 gram only of
Nipastat and the results compared. The reduced
Nipastat content plasters of Example 7 were found less likely to sensitise skin.
Example 8
1500 grams of Vistanex LM-MH and 500 grams of Levapren 452 were placed in a Z-blade
mixer heated at 900--1000C and mixed until a
uniform plastics dough was obtained. Then 900
grams of Karaya gum, 600 grams of glycerol, 400
grams of sorbitol and 2 grams of Nipastat were
added and mixed for one hour at 900--1000C, when at the end of this time a uniform dispersion
of the hydrocolloid gelatinous adhesive
composition in the plastics matrix was obtained.
Part of the dispersion was pressed to a thin sheet
in a hydraulic press maintained at-i 200 C. The
resulting adhesive sheet was laminated to
perforated thin polyethylene film and then
converted into plasters of desired shapes and
sizes. Satisfactory ostomy plasters were obtained.
Example 9
200 grams of sorbitol and 200 grams of
Karaya gum were placed in a glass container and heated at 1 200C in an oven for one hour, stirring the contents every 1 5 minutes. After cooling to room temperature, a brittle mass resulted. Test showed that this mass was a gelatinous hydrocolloid adhesive composition. It was found to swell and eventually break up into gel particles in water at ambient temperature, but it did not completely dissolve.
200 grams of the sorbitol/Karaya gum hydrocolloid adhesive composition was blended with 1 50 grams of Vistanex LM-MH and 50 grams of Levapren 452 and moulded in an open dished mould at 1 200C to produce an ostomy sealing ring.
Example 10
The procedure of Example 9 was repeated first with 200 grams of pentaerythritol and second with 200 grams of polyvinylalcohol substituted for the sorbitol and the results compared. The ostomy sealing rings formed using pentaerythritol tended to remain relatively hard and not greatly to swell absorbing moisture when in contact with the skin and are therefore in our view less preferable. The rings formed with polyvinylalcohol exhibited particularly good adhesion to skin.
The above Examples all involve production of the gelatinous adhesive compositions in situ in the plastics matrix. We shall now describe below further Examples in which production of the gelatinous adhesive composition is performed as
a first step.
Example 11
40 grams of glycerine and 30 grams of gelatin were placed in a glass jar and heated at 11 00C in an oven for 2 hours, stirring the contents every 1 5 minutes. At the end of the curing cycle a thick viscous mass resulted. Part of this glycerin/gelatin adhesive composition was blended with about the same weight of a mixture of equal parts of
Levapren L452 and Levapren KH 8160 and moulded in an open dished mould at 1 200C. to produce an ostomy sealing ring or washer.
Example 12
The process of Example 11 was followed
except that instead of 30 grams of gelatin 35
grams of gum Tragacanth was used.
Example 13
The procedure of Example 11 was followed
except that instead of 30 grams of gelatin, there
was substituted a mixture of 27 grams of-gum
acacia and 2 grams of Madurit 5458 (a melamine
resin manufactured by Hoechst of Germany).
Example 14
The procedure of Example 13 was repeated first with 2 grams of citric acid substituted for the
Madurit 5458 and second with 2 grams of
glycoxal obtained from BDH Chemicals Ltd.
substituted for the Madurit 5458. The products
resulting were found superior in each case to
those of Example 13 in being less likely to induce
sensitivity in skin.
Pressure-sensitive plasters produced in
accordance with this invention are useful in the
management of colostomies and ileostomies. We
have found that the specific plasters-described
adhere firmly and for extended period of time to
moist human body surfaces. Unlike conventional
pressure-sensitive plasters comprising an
adhesive based on rubber-resin mixture, our
plasters will adhere firmly over long periods of time. They are soft and pliable, conform to the
contours of the body surface and do not peel or detach even from moist skin during the normal
acitivities of the person wearing them. Indeed
moisture seems to-assist adhesion.
Articles having inherent pressure-sensitive characteristics can readily be moulded in a variety of shapes and configurations by following our techniques. The specific examples given are not intended to be limiting.
Protective plasters and dressings and ostomy rings and washers produced in accordance with the present invention possess one notable advantage as compared with those ostomy rings, washers, and plasters of which we are aware and which are on general use in the United Kingdom at the date of this Application: namely, our plasters, dressings, rings and washers are markedly less liable to y-radiation embrittlement or softening and so can readily be sterilized by subjection to y-radiation.
When rings or washers in accordance with this invention are to be used in ostomy appliances, a base such as aluminium hydoxide may be added to the blend prior to moulding to neutralize acid present in the drainage into the appliance.
Claims (14)
1. An article of manufacture, having adhesive properties, and comprising a plastics matrix in which is dispersed a gelatinous adhesive composition comprising the product resulting from heating together:
(a) one or more polyhydric alcohols, and
(b) gelatin, and/or a naturally occurring high molecular weight polysaccharide gum, and/or a resin which is a copolymer of a vinyl ether and an organic acid anhydride and/or its corresponding free acid, to promote chemical reaction between components (a) and (b).
2. An article according to Claim 1, wherein the one or-more naturally occurring high molecular weight polysaccharide gums comprise gum Karaya and/or gum Tragacanth and/or gum
Arabic (gum Acacia).
3. An article according to Claim 1 or Claim 2, wherein the one or more polyhydric alcohols are selected from glycerol, sorbitol, pentaerythritol and polyvinylalcohol.
4. An article according to any preceding Claim wherein the said copolymer resin comprises a copolymer of a a methyl vinyl ether and maleic anhydride or its free acid.
5. An article according to any preceding Claim wherein the physical characteristics of the said article including tack, plasticity, cohesive strength and moisture absorbency are modified by the incorporation into said article of one or more viscosity modifiers and/or tack modifiers and/or fillers and/or crosslinking agents and/or antimicrobial agents and/or plasticisers.
6. An article according to Claim 5, wherein micronised silica is present as a viscosity modifier.
7. An article according to Claim 5, wherein polyvinyl-pyrrolldone resin is presentas a tack modifier.
8. An article according to Claim 5, wherein
glyoxal and/or citric acid and/or melamine resin is present as a crosslinking agent.
9. An article according to Claim 5, wherein paraffin oil is present as a plasticiser.
10. An article according to any preceding
Claim, wherein the gelatinous adhesive composition is formed in situ in the plastics matrix.
11. An article according to any preceding
Claim, wherein the plastics matrix material is selected from elastic binder plastics materials which are compatible with skin tissues.
12. An article according to Claim 11 , wherein at least the major part of the plastics matrix material comprises one or more copolymers of ethylene and vinyl acetate.
13. An article according to Claims 11 or 12, wherein the plastics matrix material includes polyisobutylene.
14. An article according to any preceding
Claim when moulded to form a component of a surgical appliance or the like.
1 5. An-article of manufacture according to any of Claims 1 to 13 moulded to form an ostomy ring or washer.
1 6. A plaster or protective dressing consisting of an article of manufacture according to any of
Claims 1 to 1 3 which has been pressed to a thin adhesive sheet in an hydraulic press and then cut into required shapes.
1 7. A plaster or protective dressing according to Claim 16 provided with a backing sheet in the form of a thin water. impermeable plastics film, for example of polyethylene.
1 8. An article of manufacture substantially as hereinbefore described with reference to the
Examples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8009733A GB2046774B (en) | 1979-03-21 | 1980-03-21 | Articles of manufacture having adhesive properties |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7909956 | 1979-03-21 | ||
| GB8009733A GB2046774B (en) | 1979-03-21 | 1980-03-21 | Articles of manufacture having adhesive properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2046774A true GB2046774A (en) | 1980-11-19 |
| GB2046774B GB2046774B (en) | 1983-08-03 |
Family
ID=26270970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8009733A Expired GB2046774B (en) | 1979-03-21 | 1980-03-21 | Articles of manufacture having adhesive properties |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2046774B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4990551A (en) * | 1988-10-14 | 1991-02-05 | Chemie Linz Gesellschaft M.B.H. | Absorbing polymer |
| WO1991009633A1 (en) * | 1989-12-28 | 1991-07-11 | Minnesota Mining And Manufacturing Company | Composite of a dispersed gel in an adhesive matrix and method for preparing same |
| US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
-
1980
- 1980-03-21 GB GB8009733A patent/GB2046774B/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4990551A (en) * | 1988-10-14 | 1991-02-05 | Chemie Linz Gesellschaft M.B.H. | Absorbing polymer |
| WO1991009633A1 (en) * | 1989-12-28 | 1991-07-11 | Minnesota Mining And Manufacturing Company | Composite of a dispersed gel in an adhesive matrix and method for preparing same |
| US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
| AU648536B2 (en) * | 1989-12-28 | 1994-04-28 | Minnesota Mining And Manufacturing Company | Composite of a dispersed gel in an adhesive matrix and method for preparing same |
| US5369155A (en) * | 1989-12-28 | 1994-11-29 | Minnesota Mining And Manufacturing Company | Composite of a dispersed gel in an adhesive matrix and method for preparing same |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2046774B (en) | 1983-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |