GB2035080A - Treating skin blemishes with platinum compounds - Google Patents

Treating skin blemishes with platinum compounds Download PDF

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Publication number
GB2035080A
GB2035080A GB7845646A GB7845646A GB2035080A GB 2035080 A GB2035080 A GB 2035080A GB 7845646 A GB7845646 A GB 7845646A GB 7845646 A GB7845646 A GB 7845646A GB 2035080 A GB2035080 A GB 2035080A
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United Kingdom
Prior art keywords
cis
platinum
groups
blemishes
halogens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7845646A
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Johnson Matthey PLC
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Johnson Matthey PLC
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Filing date
Publication date
Application filed by Johnson Matthey PLC filed Critical Johnson Matthey PLC
Priority to GB7845646A priority Critical patent/GB2035080A/en
Publication of GB2035080A publication Critical patent/GB2035080A/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method of treating external skin blemishes comprises applying to the skin an effective amount of a platinum compound having the structures: <IMAGE> wherein X and Y are either halogens or the oxygen atoms of a carboxylate bidentete ligand and A and B comprise NH3 groups or organic amines. In the octahedral case (Pt valence = IV) Z is either halogens or hydroxyl (OH) groups.

Description

SPECIFICATION Improvements in the treatment of skin blemishes The present invention relates to the treatment of external skin blemishes, e.g., warts and moles, on humans using a platinum compound.
Various platinum compounds have been proposed for use against tumors (see Rosenberg et al., Nature 222 (1969), pages 385-386; and U.S Patents 3,892,790 and 3,904,663). One such compound is cis-dichloro diamine platinum (II) which may also be called cis-platinum diamino dichloride or Cis Pt II form convenience, and may be represented by the following formula:
The present invention is based on the unexpected finding that Cis Pt II can be effectively used for the treatment of external skin blemishes such as warts or moles. In particular, it has been found that the application of Cis Pt II to warts and moles, or the like, eliminates these external skin blemishes. The Cis Pt II may be applied in any conventional fashion, for example, in a cream base, ointment, salve, lotion or solution (aqueous or organic solvent base).
The amount of Cis Pt II applied to the skin can be widely varied and the amount used in any specific situation, and the number of applications, will depend to some extent on the size and nature of the blemishes involved.
A typical application may involve thoroughly wetting the blemishes with, for example, a saturated aqueous solution of Cis Pt II. One such application may be adequate or the treatment may be repeated one or more times.
As a typical illustration, a saturated solution of Cis Pt II in 0.1 N aqueous sodium chloride was applied to a wart of long standing (at least several years). The application was repeated once daily for several days and then discontinued. After several more days, the wart began to gradually diminish in size, and within several weeks, had completely disappeared.
In another instance, the application of a solution of Cis Pt II (again in the form of an 0.1 N aqueous sodium chloride solution saturate with Cis Pt II), to a skin mole resulted in the complete disappearance of the mole within a short period of time.
While the invention has been specifically described above with respect to the use of Cis Pt II, it is believed that the invention is of broader application to the use of compounds related to Cis Pt II, e.g., those described and claimed in U.S. Patents 3,892,790 and 3,904,663, and other types as detailed in Coordination Chemistry Review, 12(1974) 349-405, Dr. M. J. Cleare, "Transition Metal Complexes in Cancer Chemotherapy" (1973).
Thus, in a broad sense, the invention contemplates the use of platinum compounds or coordination complexes shown by the formulas:
Pt valence = II
Pt valence = IV wherein X and Y are halogens, preferably chlorine or the oxygen atoms of a carboxylate bidentete ligand such as oxalate and malonate and A and B are NH3 groups or organic amines such as isopropylamine, n-butylamine, cyclopentylamine, benzylamine, ethylenediamine, or, together, represent the atoms necessary to complete a phenylenediamine ring wherein the diamine groups are coordinated with the Pt atoms.
In the case of the platinum atom valence IV, A, B, X and Y represent groups as defined above, and Z represents either halogens or hydroxyl (OH) groups.
It will be appreciated that various modifications may be made in the invention as described above. Hence, the scope of the invention is defined in the following claims wherein:
CLAIMS 1. A method of treating external skin blemishes which comprises applying to the skin an effective amount of a platinum compound having the structure:
wherein X and Y are halogens or the oxygen atoms of a carboxylate bidentete ligand and A and B comprise NH3 groups or organic amines.
2. A method of treating external skin
**WARNING** end of DESC field may overlap start of CLMS **.

Claims (4)

**WARNING** start of CLMS field may overlap end of DESC **. SPECIFICATION Improvements in the treatment of skin blemishes The present invention relates to the treatment of external skin blemishes, e.g., warts and moles, on humans using a platinum compound. Various platinum compounds have been proposed for use against tumors (see Rosenberg et al., Nature 222 (1969), pages 385-386; and U.S Patents 3,892,790 and 3,904,663). One such compound is cis-dichloro diamine platinum (II) which may also be called cis-platinum diamino dichloride or Cis Pt II form convenience, and may be represented by the following formula: The present invention is based on the unexpected finding that Cis Pt II can be effectively used for the treatment of external skin blemishes such as warts or moles. In particular, it has been found that the application of Cis Pt II to warts and moles, or the like, eliminates these external skin blemishes. The Cis Pt II may be applied in any conventional fashion, for example, in a cream base, ointment, salve, lotion or solution (aqueous or organic solvent base). The amount of Cis Pt II applied to the skin can be widely varied and the amount used in any specific situation, and the number of applications, will depend to some extent on the size and nature of the blemishes involved. A typical application may involve thoroughly wetting the blemishes with, for example, a saturated aqueous solution of Cis Pt II. One such application may be adequate or the treatment may be repeated one or more times. As a typical illustration, a saturated solution of Cis Pt II in 0.1 N aqueous sodium chloride was applied to a wart of long standing (at least several years). The application was repeated once daily for several days and then discontinued. After several more days, the wart began to gradually diminish in size, and within several weeks, had completely disappeared. In another instance, the application of a solution of Cis Pt II (again in the form of an 0.1 N aqueous sodium chloride solution saturate with Cis Pt II), to a skin mole resulted in the complete disappearance of the mole within a short period of time. While the invention has been specifically described above with respect to the use of Cis Pt II, it is believed that the invention is of broader application to the use of compounds related to Cis Pt II, e.g., those described and claimed in U.S. Patents 3,892,790 and 3,904,663, and other types as detailed in Coordination Chemistry Review, 12(1974) 349-405, Dr. M. J. Cleare, "Transition Metal Complexes in Cancer Chemotherapy" (1973). Thus, in a broad sense, the invention contemplates the use of platinum compounds or coordination complexes shown by the formulas: Pt valence = II Pt valence = IV wherein X and Y are halogens, preferably chlorine or the oxygen atoms of a carboxylate bidentete ligand such as oxalate and malonate and A and B are NH3 groups or organic amines such as isopropylamine, n-butylamine, cyclopentylamine, benzylamine, ethylenediamine, or, together, represent the atoms necessary to complete a phenylenediamine ring wherein the diamine groups are coordinated with the Pt atoms. In the case of the platinum atom valence IV, A, B, X and Y represent groups as defined above, and Z represents either halogens or hydroxyl (OH) groups. It will be appreciated that various modifications may be made in the invention as described above. Hence, the scope of the invention is defined in the following claims wherein: CLAIMS
1. A method of treating external skin blemishes which comprises applying to the skin an effective amount of a platinum compound having the structure:
wherein X and Y are halogens or the oxygen atoms of a carboxylate bidentete ligand and A and B comprise NH3 groups or organic amines.
2. A method of treating external skin blemishes which comprises applying to the skin an effective amount of platinum compound having the structure:
wherein X and Y halogens or oxygen atoms of a carboxylate bidentete ligand, A and B comprise NH3 groups or organic amines, and Z represents halogens (X, Y) or hydroxyl groups OH).
3. The method of Claims 1 and 2 wherein the skin blemishes are moles or warts.
4. The method of Claim 1 wherein the compound is cis platinum diamino dichloride.
GB7845646A 1978-11-22 1978-11-22 Treating skin blemishes with platinum compounds Withdrawn GB2035080A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7845646A GB2035080A (en) 1978-11-22 1978-11-22 Treating skin blemishes with platinum compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7845646A GB2035080A (en) 1978-11-22 1978-11-22 Treating skin blemishes with platinum compounds

Publications (1)

Publication Number Publication Date
GB2035080A true GB2035080A (en) 1980-06-18

Family

ID=10501237

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7845646A Withdrawn GB2035080A (en) 1978-11-22 1978-11-22 Treating skin blemishes with platinum compounds

Country Status (1)

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GB (1) GB2035080A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041792A1 (en) * 1980-06-11 1981-12-16 Kureha Kagaku Kogyo Kabushiki Kaisha Platinum compounds having antitumor or antimicrobial activity, and pharmaceutical preparations containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041792A1 (en) * 1980-06-11 1981-12-16 Kureha Kagaku Kogyo Kabushiki Kaisha Platinum compounds having antitumor or antimicrobial activity, and pharmaceutical preparations containing them

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