GB2021579A - Glyceride analogues - Google Patents

Glyceride analogues

Info

Publication number
GB2021579A
GB2021579A GB7916401A GB7916401A GB2021579A GB 2021579 A GB2021579 A GB 2021579A GB 7916401 A GB7916401 A GB 7916401A GB 7916401 A GB7916401 A GB 7916401A GB 2021579 A GB2021579 A GB 2021579A
Authority
GB
United Kingdom
Prior art keywords
glyceride
analogues
antiatherosclerotics
antilipemics
antiprostaglandins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7916401A
Other versions
GB2021579B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Natterman und Cie GmbH
Original Assignee
A Natterman und Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Natterman und Cie GmbH filed Critical A Natterman und Cie GmbH
Publication of GB2021579A publication Critical patent/GB2021579A/en
Application granted granted Critical
Publication of GB2021579B publication Critical patent/GB2021579B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Glyceride analogues of the formula: <IMAGE> where R1, and R2 represent hydrogen or saturated or unsaturated straight or branched chain acyl radicals of 2-24 carbon atoms, at least one of R1 and R2 being an acyl radical, are useful as antilipemics, antiatherosclerotics, dehydrators of tissue, inhibitors of tumour growth, suppressers of immunity, retardants of platelet aggregation, and antiprostaglandins. They promote in vivo the formation of natural phospholipids.
GB7916401A 1978-05-12 1979-05-11 Glyceride analogues Expired GB2021579B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782820892 DE2820892A1 (en) 1978-05-12 1978-05-12 NEW STRUCTURAL ANALOGS OF GLYVERIDES AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
GB2021579A true GB2021579A (en) 1979-12-05
GB2021579B GB2021579B (en) 1982-10-27

Family

ID=6039264

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7916401A Expired GB2021579B (en) 1978-05-12 1979-05-11 Glyceride analogues

Country Status (5)

Country Link
JP (1) JPS54148709A (en)
DE (1) DE2820892A1 (en)
FR (1) FR2425424A1 (en)
GB (1) GB2021579B (en)
ZA (1) ZA792283B (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227994A1 (en) * 1985-12-20 1987-07-08 Kao Corporation Amide derivative and external medicament comprising same
AU597090B2 (en) * 1986-07-30 1990-05-24 Godecke Aktiengesellschaft 2-acyloxypropylamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5045338A (en) * 1989-09-19 1991-09-03 Nabisco Brands, Inc. Secondary amide esters as low calorie fat mimetics
US5059442A (en) * 1989-09-19 1991-10-22 Nabisco Brands, Inc. Primary amide esters as low calorie fat mimetics
US5063075A (en) * 1990-08-01 1991-11-05 Nabisco Brands, Inc. Amide ether derivatives as low calorie fat mimetics
US5068120A (en) * 1990-08-01 1991-11-26 Nabisco Brands, Inc. Amine ester derivatives as low calorie fat mimetics
US5082683A (en) * 1990-08-01 1992-01-21 Nabisco Brands, Inc. Amide/amine ester derivatives as low calorie fat mimetics
US5190783A (en) * 1989-09-19 1993-03-02 Nabisco, Inc. Primary amide esters as low calorie fat mimetics
FR2924429A1 (en) * 2007-02-15 2009-06-05 Biochimie Appliquee Sa Soc PSEUDO-CERAMIDES DERIVED FROM VEGETABLE OR ANIMAL OILS AND COSMETIC AND / OR DERMATOLOGICAL COMPOSITIONS CONTAINING SAME
CN112041297A (en) * 2018-04-23 2020-12-04 株式会社Enzychem生命科学 Glycerol derivative, process for producing the same, and immunomodulator comprising the same as active ingredient

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK160818C (en) * 1983-12-30 1991-10-07 Hoffmann La Roche N-RING containing glycerol derivatives, processes for their preparation, their use for the preparation of a platelet activation factor inhibitor, and drugs containing such a compound
TR22593A (en) * 1987-05-18 1987-12-15 Ahmet Ecevit SELF STORED UECGEN PRISM TYPE DUEZ GUENES COLLECTOR
JP2604268B2 (en) * 1990-04-09 1997-04-30 富士写真フイルム株式会社 Liposomes and thin films using peptide derivative amphiphilic compounds, intermediates thereof, and peptide derivative amphiphilic compounds
US5223179A (en) * 1992-03-26 1993-06-29 The Procter & Gamble Company Cleaning compositions with glycerol amides
JP2001131132A (en) * 1999-08-26 2001-05-15 Kawaken Fine Chem Co Ltd New fatty acid alkanolamide compound and surfactant composition comprising the same
JP2002301352A (en) * 2001-04-09 2002-10-15 Kawaken Fine Chem Co Ltd Emulsifier containing 1,3-propanediol derivative and emulsified composition containing the same
CA3144493A1 (en) * 2006-10-03 2008-04-10 Arbutus Biopharma Corporation Lipid containing formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE173631C (en) * 1905-01-26
GB613835A (en) * 1945-09-13 1948-12-03 John Wesley Orelup Fatty acid esters having amphoteric properties
NL264794A (en) * 1961-05-16
FR1417582A (en) * 1963-12-16 1965-11-12 Eastman Kodak Co New hydrophilic films and products used in their manufacture
GB1106987A (en) * 1964-11-27 1968-03-20 Du Pont Paint compositions
US3259615A (en) * 1965-01-14 1966-07-05 Arizona Chem 3-amino-2-hydroxypropyl esters of rosin acids and methods for preparing the same
FR1488815A (en) * 1965-08-05 1967-07-13 American Cyanamid Co Novel nu- (2, 3-dihydroxypropyl) -substituted aliphatic amides, antistatic soil protection compositions for textiles containing these amides and their preparation process

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227994A1 (en) * 1985-12-20 1987-07-08 Kao Corporation Amide derivative and external medicament comprising same
AU597090B2 (en) * 1986-07-30 1990-05-24 Godecke Aktiengesellschaft 2-acyloxypropylamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5045338A (en) * 1989-09-19 1991-09-03 Nabisco Brands, Inc. Secondary amide esters as low calorie fat mimetics
US5059442A (en) * 1989-09-19 1991-10-22 Nabisco Brands, Inc. Primary amide esters as low calorie fat mimetics
US5190783A (en) * 1989-09-19 1993-03-02 Nabisco, Inc. Primary amide esters as low calorie fat mimetics
US5063075A (en) * 1990-08-01 1991-11-05 Nabisco Brands, Inc. Amide ether derivatives as low calorie fat mimetics
US5068120A (en) * 1990-08-01 1991-11-26 Nabisco Brands, Inc. Amine ester derivatives as low calorie fat mimetics
US5082683A (en) * 1990-08-01 1992-01-21 Nabisco Brands, Inc. Amide/amine ester derivatives as low calorie fat mimetics
FR2924429A1 (en) * 2007-02-15 2009-06-05 Biochimie Appliquee Sa Soc PSEUDO-CERAMIDES DERIVED FROM VEGETABLE OR ANIMAL OILS AND COSMETIC AND / OR DERMATOLOGICAL COMPOSITIONS CONTAINING SAME
CN112041297A (en) * 2018-04-23 2020-12-04 株式会社Enzychem生命科学 Glycerol derivative, process for producing the same, and immunomodulator comprising the same as active ingredient
EP3778558A4 (en) * 2018-04-23 2022-08-10 Enzychem Lifesciences Corporation Glycerol derivative, preparation method therefor, and immunomodulator comprising same as effective ingredient
CN112041297B (en) * 2018-04-23 2023-10-20 株式会社Enzychem生命科学 Glycerol derivative, process for producing the same, and immunomodulator containing the same as active ingredient

Also Published As

Publication number Publication date
JPS54148709A (en) 1979-11-21
FR2425424A1 (en) 1979-12-07
ZA792283B (en) 1980-06-25
DE2820892A1 (en) 1979-11-22
GB2021579B (en) 1982-10-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee