GB202108820D0 - Nucleic acid nanopore with enhanced sensing functionality - Google Patents

Nucleic acid nanopore with enhanced sensing functionality

Info

Publication number
GB202108820D0
GB202108820D0 GBGB2108820.8A GB202108820A GB202108820D0 GB 202108820 D0 GB202108820 D0 GB 202108820D0 GB 202108820 A GB202108820 A GB 202108820A GB 202108820 D0 GB202108820 D0 GB 202108820D0
Authority
GB
United Kingdom
Prior art keywords
nanopore
nucleic acid
sensing functionality
enhanced sensing
enhanced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2108820.8A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCL Business Ltd
Original Assignee
UCL Business Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCL Business Ltd filed Critical UCL Business Ltd
Priority to GBGB2108820.8A priority Critical patent/GB202108820D0/en
Publication of GB202108820D0 publication Critical patent/GB202108820D0/en
Priority to EP22737421.2A priority patent/EP4355904A1/en
Priority to PCT/EP2022/066626 priority patent/WO2022263669A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
GBGB2108820.8A 2021-06-18 2021-06-18 Nucleic acid nanopore with enhanced sensing functionality Ceased GB202108820D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB2108820.8A GB202108820D0 (en) 2021-06-18 2021-06-18 Nucleic acid nanopore with enhanced sensing functionality
EP22737421.2A EP4355904A1 (en) 2021-06-18 2022-06-17 Nucleic acid nanopore with enhanced sensing functionality
PCT/EP2022/066626 WO2022263669A1 (en) 2021-06-18 2022-06-17 Nucleic acid nanopore with enhanced sensing functionality

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2108820.8A GB202108820D0 (en) 2021-06-18 2021-06-18 Nucleic acid nanopore with enhanced sensing functionality

Publications (1)

Publication Number Publication Date
GB202108820D0 true GB202108820D0 (en) 2021-08-04

Family

ID=77050671

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2108820.8A Ceased GB202108820D0 (en) 2021-06-18 2021-06-18 Nucleic acid nanopore with enhanced sensing functionality

Country Status (1)

Country Link
GB (1) GB202108820D0 (en)

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003003446A2 (en) 2001-06-27 2003-01-09 President And Fellows Of Harvard College Control of solid state dimensional features
US6627067B1 (en) 1999-06-22 2003-09-30 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
WO2005124888A1 (en) 2004-06-08 2005-12-29 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
US20070117109A1 (en) 2005-06-14 2007-05-24 California Institute Of Technology Nanostructures, methods of making and using the same
US20080287668A1 (en) 2007-05-14 2008-11-20 Tihamer Thomas Toth-Fejel Nanostructures and methods of making
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
US20100069621A1 (en) 2008-08-13 2010-03-18 Maune Hareem T Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems
US20100216978A1 (en) 2007-04-17 2010-08-26 Dsna-Farber Cancer Institute Inc. Wireframe nanostructures
WO2013083983A1 (en) 2011-12-06 2013-06-13 Cambridge Enterprise Limited Nanopore functionality control
US20130309776A1 (en) 2011-07-22 2013-11-21 The Trustees Of The University Of Pennsylvania Graphene-Based Nanopore and Nanostructure Devices and Methods for Macromolecular Analysis
US8698481B2 (en) 2007-09-12 2014-04-15 President And Fellows Of Harvard College High-resolution molecular sensor
US20140174927A1 (en) 2011-07-27 2014-06-26 Rashid Bashir Nanopore Sensors for Biomolecular Characterization
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
WO2016187519A1 (en) 2015-05-20 2016-11-24 Oxford Nanopore Inc. Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown
US20170023544A1 (en) 2011-03-01 2017-01-26 The Regents Of The University Of Michigan Controlling translocation through nanopores with fluid walls
WO2018011603A1 (en) 2016-07-14 2018-01-18 Stefan Howorka Membrane-spanning nanopores
WO2020025974A1 (en) 2018-08-02 2020-02-06 Ucl Business Ltd Membrane bound nucleic acid nanopores

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627067B1 (en) 1999-06-22 2003-09-30 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
WO2003003446A2 (en) 2001-06-27 2003-01-09 President And Fellows Of Harvard College Control of solid state dimensional features
WO2005124888A1 (en) 2004-06-08 2005-12-29 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
US20070117109A1 (en) 2005-06-14 2007-05-24 California Institute Of Technology Nanostructures, methods of making and using the same
US20100216978A1 (en) 2007-04-17 2010-08-26 Dsna-Farber Cancer Institute Inc. Wireframe nanostructures
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
US20110053284A1 (en) 2007-05-08 2011-03-03 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
US20080287668A1 (en) 2007-05-14 2008-11-20 Tihamer Thomas Toth-Fejel Nanostructures and methods of making
US8698481B2 (en) 2007-09-12 2014-04-15 President And Fellows Of Harvard College High-resolution molecular sensor
US20100069621A1 (en) 2008-08-13 2010-03-18 Maune Hareem T Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
US20170023544A1 (en) 2011-03-01 2017-01-26 The Regents Of The University Of Michigan Controlling translocation through nanopores with fluid walls
US20130309776A1 (en) 2011-07-22 2013-11-21 The Trustees Of The University Of Pennsylvania Graphene-Based Nanopore and Nanostructure Devices and Methods for Macromolecular Analysis
US20140174927A1 (en) 2011-07-27 2014-06-26 Rashid Bashir Nanopore Sensors for Biomolecular Characterization
WO2013083983A1 (en) 2011-12-06 2013-06-13 Cambridge Enterprise Limited Nanopore functionality control
WO2016187519A1 (en) 2015-05-20 2016-11-24 Oxford Nanopore Inc. Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown
WO2018011603A1 (en) 2016-07-14 2018-01-18 Stefan Howorka Membrane-spanning nanopores
WO2020025974A1 (en) 2018-08-02 2020-02-06 Ucl Business Ltd Membrane bound nucleic acid nanopores

Non-Patent Citations (26)

* Cited by examiner, † Cited by third party
Title
"Oligonucleotide Synthesis: A Practical Approach", 1984, IRL PRESS
"Synthetic Biology, Part A, Methods in Enzymology", vol. 498, 2011, article "Synthetic Biology, Part B, Computer Aided Design and DNA Assembly", pages: 2 - 500
B. ROEJ. CRABTREEA. KAHN: "DNA Isolation and Sequencing: Essential Techniques", 1996, JOHN WILEY & SONS
BURNS J. R ET AL., ANGEW. CHEM., vol. 52, 2013, pages 12069 - 12072
BURNS J. R.SEIFERT A.FERTIG N.HOWORKA S. A., NAT. NANOTECHNOL., vol. 11, 2016, pages 152 - 156
D. M. J. LILLEYJ. E. DAHLBERG: "Synthesis and Physical Analysis of DNA Methods in Enzymology", 1992, ACADEMIC PRESS, article "Methods of Enzymology: DNA Structure Part A"
DAVID R. ENGELKEJOHN J. ROSSI: "RNA Interference, Methods in Enzymology", vol. 392, 2005, pages: 1 - 454
DIETZ ET AL., SCIENCE, vol. 325, 2009, pages 725 - 730
DOUGLAS S. M.MARBLESTONE A. H.TEERAPITTAYANON S.VAZQUEZ A.CHURCH G. M.SHIH W. M., NUCLEIC ACIDS RES., vol. 37, 2009, pages 5001 - 5006
FU J. ET AL., NAT. NANOTECHNOL., vol. 9, 2014, pages 531 - 536
GONZALEZ-PEREZ ET AL., LANGMUIR, vol. 25, 2009, pages 10447 - 10450
GOPFRICH ET AL., NANO. LETT., vol. 15, no. 5, 2015, pages 3134 - 3138
HUANG ET AL., NAT NANOTECHNOL., vol. 10, no. 11, November 2015 (2015-11-01), pages 986 - 991
IVANOV AP ET AL., NANO LETT., vol. 11, no. 1, 12 January 2011 (2011-01-12), pages 279 - 85
J. M. POLAKJAMES O'D. MCGEE: "Situ Hybridisation: Principles and Practice", 1990, OXFORD UNIVERSITY PRESS
LEHNINGER, A. L.: "Biochemistry", 1975, WORTH PUBLISHERS, pages: 71 - 92
M.R. GREENJ. SAMBROOK: "Molecular Cloning: A Laboratory Manual", vol. 1-3, 2012, COLD SPRING HARBOR LABORATORY PRESS
MONTALMUELLER, PROC. NATL. ACAD. SCI. USA., vol. 69, 1972, pages 3561 - 3566
ROBERTSVELLACCIO: "The Peptides: Analysis, Synthesis, Biology, Gross and Meiehofer", vol. 5, 1983, ACADEMIC PRESS, INC., pages: 341
ROTHEMUND, P.W., NATURE, vol. 440, 2006, pages 297 - 302
SAMBROOK J. ET AL.: "Molecular Cloning: a Laboratory Manual", vol. 440, 2006, COLD SPRING HARBOR PRESS, pages: 297 - 302
SEIFERT A.GOPFRICH K.BURNS J. R.FERTIG N.KEYSER U. F.HOWORKA S, ACS NANO, vol. 9, 2015, pages 1117 - 1126
SHIMADA ET AL., BIOTECHNOLOGY LETTERS, vol. 30, 2008, pages 2001 - 2006
SONI GV ET AL., REV SCI INSTRUM., vol. 81, no. 1, January 2010 (2010-01-01), pages 014301
ZHENG ET AL., J. AM. CHEM. SOC., vol. 136, 2014, pages 10194 - 10197
ZHENG J. ET AL., NATURE, vol. 459, 2009, pages 414 - 418

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)