GB202108444D0 - Sub-micron particle - Google Patents

Sub-micron particle

Info

Publication number
GB202108444D0
GB202108444D0 GBGB2108444.7A GB202108444A GB202108444D0 GB 202108444 D0 GB202108444 D0 GB 202108444D0 GB 202108444 A GB202108444 A GB 202108444A GB 202108444 D0 GB202108444 D0 GB 202108444D0
Authority
GB
United Kingdom
Prior art keywords
sub
micron particle
micron
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2108444.7A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Original Assignee
Imperial College Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College Innovations Ltd filed Critical Imperial College Innovations Ltd
Priority to GBGB2108444.7A priority Critical patent/GB202108444D0/en
Publication of GB202108444D0 publication Critical patent/GB202108444D0/en
Priority to JP2023577253A priority patent/JP2024523304A/ja
Priority to PCT/GB2022/051493 priority patent/WO2022263808A1/en
Priority to EP22732305.2A priority patent/EP4355303A1/en
Priority to US18/570,611 priority patent/US20240315981A1/en
Priority to CN202280055882.4A priority patent/CN118234485A/zh
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB2108444.7A 2021-06-14 2021-06-14 Sub-micron particle Ceased GB202108444D0 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GBGB2108444.7A GB202108444D0 (en) 2021-06-14 2021-06-14 Sub-micron particle
JP2023577253A JP2024523304A (ja) 2021-06-14 2022-06-14 サブミクロン粒子
PCT/GB2022/051493 WO2022263808A1 (en) 2021-06-14 2022-06-14 Sub-micron particle
EP22732305.2A EP4355303A1 (en) 2021-06-14 2022-06-14 Sub-micron particle
US18/570,611 US20240315981A1 (en) 2021-06-14 2022-06-14 Sub-micron particle
CN202280055882.4A CN118234485A (zh) 2021-06-14 2022-06-14 亚微米颗粒

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2108444.7A GB202108444D0 (en) 2021-06-14 2021-06-14 Sub-micron particle

Publications (1)

Publication Number Publication Date
GB202108444D0 true GB202108444D0 (en) 2021-07-28

Family

ID=76954481

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2108444.7A Ceased GB202108444D0 (en) 2021-06-14 2021-06-14 Sub-micron particle

Country Status (6)

Country Link
US (1) US20240315981A1 (https=)
EP (1) EP4355303A1 (https=)
JP (1) JP2024523304A (https=)
CN (1) CN118234485A (https=)
GB (1) GB202108444D0 (https=)
WO (1) WO2022263808A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116004728B (zh) * 2021-10-21 2025-02-28 深圳大学总医院 一种聚合物包裹的脂质纳米粒及其制备方法、药物制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL4023249T3 (pl) * 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
SG11201802073YA (en) * 2015-09-15 2018-04-27 Samyang Biopharmaceuticals Pharmaceutical composition containing anionic drug, and preparation method therefor
WO2017218704A1 (en) * 2016-06-14 2017-12-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
KR102259513B1 (ko) * 2017-11-16 2021-06-02 주식회사 삼양홀딩스 음이온성 약물 함유 약제학적 조성물의 동결건조 조성물 및 방법
CA3146675A1 (en) * 2019-07-23 2021-01-28 Translate Bio, Inc. Stable compositions of mrna-loaded lipid nanoparticles and processes of making
US20210330597A1 (en) * 2020-04-27 2021-10-28 New Jersey Institute Of Technology Nanoparticle Depot For Controlled And Sustained Gene Delivery

Non-Patent Citations (31)

* Cited by examiner, † Cited by third party
Title
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CHAHAL, J. S.KHAN, O. F.COOPER, C. L.MCPARTLAN, J. S.TSOSIE, J. K.TILLEY, L. D.SIDIK, S. M.LOURIDO, S.LANGER, R.BAVARI, S.: "Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H N influenza, and Toxoplasma gondii challenges with a single dose", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113, no. 29, 2016, pages E4133 - 42, XP055329399, DOI: 10.1073/pnas.1600299113
CHEMIN, M.BRUN, P. M.LECOMMANDOUX, S.SANDRE, O.LE MEINS, J. F.: "Hybrid polymer/lipid vesicles: fine control of the lipid and polymer distribution in the binary membrane", SOFT MATTER, vol. 8, no. 10, 2012, pages 2867 - 2874
DAO, T. P. T.FERNANDES, F.ER-RAFIK, M.SALVA, R.SCHMUTZ, M.BRULET, A.PRIETO, M.SANDRE, O.LE MEINS, J. F.: "Phase Separation and Nanodomain Formation in Hybrid Polymer/Lipid Vesicles", ACS MACRO LETTERS, vol. 4, no. 2, 2015, pages 182 - 186
FLEETON, M. N.CHEN, M.BERGLUND, P.RHODES, G.PARKER, S. E.MURPHY, M.;ATKINS, G. J.LILJESTROM, P.: "Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus", J INFECT DIS, vol. 183, no. 9, 2001, pages 1395 - 8, XP002224503, DOI: 10.1086/319857
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KACZMAREK, J. C.PATEL, A. K.KAUFFMAN, K. J.FENTON, O. S.WEBBER, M. J.;HEARTLEIN, M. W.DEROSA, F.ANDERSON, D. G.: "Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs", ANGEWANDTE CHEMIE, vol. 55, no. 44, 2016, pages 13808 - 13812, XP055504238, DOI: 10.1002/anie.201608450
KALLEN, K. J.HEIDENREICH, R.SCHNEE, M.PETSCH, B.SCHLAKE, T.THESS, A.BAUMHOF, P.SCHEEL, B.KOCH, S. D.FOTIN-MLECZEK, M.: "A novel, disruptive vaccination technology: self-adjuvanted RNActive((R)) vaccines", HUM VACCIN IMMUNOTHER, vol. 9, no. 10, 2013, pages 2263 - 76, XP055126357, DOI: 10.4161/hv.25181
KIM, Y.TEWARI, M.PAJEROWSKI, J. D.CAI, S.SEN, S.WILLIAMS, J. H.SIRSI, S. R.LUTZ, G. J.DISCHER, D. E.: "Polymersome delivery of siRNA and antisense oligonucleotides. Journal of controlled release : official journal of the", CONTROLLED RELEASE SOCIETY, vol. 134, no. 2, 2009, pages 132 - 40
KULKARNI, C. V.: "Lipid crystallization: from self-assembly to hierarchical and biological ordering.", NANOSCALE, vol. 4, no. 19, 2012, pages 5779 - 91
LEE, J. S.FEIJEN, J.: "Polymersomes for drug delivery: design, formation and characterization", JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY, vol. 161, no. 2, 2012, pages 473 - 83, XP028927180, DOI: 10.1016/j.jconrel.2011.10.005
LOPRESTI, C.LOMAS, H.MASSIGNANI, M.SMART, T.BATTAGLIA, G.: "Polymersomes: nature inspired nanometer sized compartments", JOURNAL OF MATERIALS CHEMISTRY, vol. 19, no. 22, 2009, XP055075601, DOI: 10.1039/b818869f
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MARTINON, F.KRISHNAN, S.LENZEN, G.MAGNE, R.GOMARD, E.GUILLET, J. G.LEVY, J. P.MEULIEN, P.: "Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA", EUR J IMMUNOL, vol. 23, no. 7, 1993, pages 1719 - 22, XP002660045
MCKINLAY, C. J.BENNER, N. L.HAABETH, O. A.WAYMOUTH, R. M.WENDER, P. A.: "Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 115, no. 26, 2018, pages E5859 - E5866
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RAHMAN, M. M.UEDA, M.HIROSE, T.ITO, Y.: "Spontaneous Formation of Gating Lipid Domain in Uniform-Size Peptide Vesicles for Controlled Release", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 51, 2018, pages 17956 - 17961
SCHNEE, M.VOGEL, A. B.VOSS, D.PETSCH, B.BAUMHOF, P.KRAMPS, T.STITZ, L.: "An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs", PLOS NEGL TROP DIS, vol. 10, no. 6, 2016, pages 60004746, XP055440536, DOI: 10.1371/journal.pntd.0004746
SEBASTIAN, M.PAPACHRISTOFILOU, A.WEISS, C.FRUH, M.CATHOMAS, R.HILBE, W.WEHLER, T.RIPPIN, G.KOCH, S. D.SCHEEL, B.: "Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive(R)) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer", BMC CANCER, vol. 14, 2014, pages 748, XP021199227, DOI: 10.1186/1471-2407-14-748
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SIZOVS, A.XUE, L.TOLSTYKA, Z. P.INGLE, N. P.WU, Y.CORTEZ, M.REINEKE, T. M.: "Poly(trehalose): sugar-coated nanocomplexes promote stabilization and effective polyplex-mediated siRNA delivery", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 41, 2013, pages 15417 - 24, XP055261776, DOI: 10.1021/ja404941p
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ZOU, Y.ZHENG, M.YANG, W.MENG, F.MIYATA, K.KIM, H. J.KATAOKA, K.ZHONG, Z.: "Virus-Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo", ADV MATER, vol. 29, no. 42, 2017

Also Published As

Publication number Publication date
CN118234485A (zh) 2024-06-21
JP2024523304A (ja) 2024-06-28
EP4355303A1 (en) 2024-04-24
US20240315981A1 (en) 2024-09-26
WO2022263808A1 (en) 2022-12-22

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AT Applications terminated before publication under section 16(1)