GB2019838A - Salts of DELTA <3>-cephem compounds with low water-solubility - Google Patents

Salts of DELTA <3>-cephem compounds with low water-solubility

Info

Publication number
GB2019838A
GB2019838A GB7912516A GB7912516A GB2019838A GB 2019838 A GB2019838 A GB 2019838A GB 7912516 A GB7912516 A GB 7912516A GB 7912516 A GB7912516 A GB 7912516A GB 2019838 A GB2019838 A GB 2019838A
Authority
GB
United Kingdom
Prior art keywords
solubility
low water
delta
salts
cephem compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7912516A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Publication of GB2019838A publication Critical patent/GB2019838A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula: <IMAGE> [where R1 represents an acyl group; R2 is hydrogen or an alkyl or alkoxy group; R3 is hydrogen alkyl, hydroxy, alkoxy, acyloxy, alkylthio or substituted or unsubstituted heterocyclyl-thio; R4 and R6 represent alkyl, cycloalkyl, aryl or aralkyl groups; R5 represents an alkylenic bridge of from 1 to 10 carbon atoms; n is 1 or 2 and m is 0 or 1] have anti-bacterial activity and low water-solubility.
GB7912516A 1978-04-24 1979-04-10 Salts of DELTA <3>-cephem compounds with low water-solubility Withdrawn GB2019838A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES469096A ES469096A1 (en) 1978-04-24 1978-04-24 Salts of DELTA <3>-cephem compounds with low water-solubility

Publications (1)

Publication Number Publication Date
GB2019838A true GB2019838A (en) 1979-11-07

Family

ID=8475913

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7912516A Withdrawn GB2019838A (en) 1978-04-24 1979-04-10 Salts of DELTA <3>-cephem compounds with low water-solubility

Country Status (6)

Country Link
JP (1) JPS54154783A (en)
DE (1) DE2914191A1 (en)
ES (1) ES469096A1 (en)
FR (1) FR2424279A1 (en)
GB (1) GB2019838A (en)
IT (1) IT1166759B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7358239B2 (en) 1999-06-02 2008-04-15 Janssen Pharmaceutica, N.V. Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531609D0 (en) * 1985-12-23 1986-02-05 Beecham Group Plc Compounds
JPH059107Y2 (en) * 1989-09-14 1993-03-05

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830809A (en) * 1972-08-25 1974-08-20 Bristol Myers Co Bis-dicyclohexylamine n-carbisobutoxycephalosporin c
ES425601A1 (en) * 1974-04-23 1976-06-16 Lafarquim Procedure for the obtaining of insoluble or small soluble cefalexine sales. (Machine-translation by Google Translate, not legally binding)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7358239B2 (en) 1999-06-02 2008-04-15 Janssen Pharmaceutica, N.V. Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Also Published As

Publication number Publication date
DE2914191A1 (en) 1979-10-31
FR2424279B1 (en) 1983-02-04
IT1166759B (en) 1987-05-06
JPS54154783A (en) 1979-12-06
IT7922063A0 (en) 1979-04-23
FR2424279A1 (en) 1979-11-23
ES469096A1 (en) 1978-11-16

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)