GB201715496D0 - Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit - Google Patents

Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit

Info

Publication number
GB201715496D0
GB201715496D0 GBGB1715496.4A GB201715496A GB201715496D0 GB 201715496 D0 GB201715496 D0 GB 201715496D0 GB 201715496 A GB201715496 A GB 201715496A GB 201715496 D0 GB201715496 D0 GB 201715496D0
Authority
GB
United Kingdom
Prior art keywords
model
pluripotent stem
human blood
brain
microvascular endothelial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1715496.4A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to GBGB1715496.4A priority Critical patent/GB201715496D0/en
Publication of GB201715496D0 publication Critical patent/GB201715496D0/en
Priority to PCT/GB2018/052709 priority patent/WO2019058140A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0692—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
GBGB1715496.4A 2017-09-25 2017-09-25 Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit Ceased GB201715496D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB1715496.4A GB201715496D0 (en) 2017-09-25 2017-09-25 Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit
PCT/GB2018/052709 WO2019058140A1 (en) 2017-09-25 2018-09-24 Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1715496.4A GB201715496D0 (en) 2017-09-25 2017-09-25 Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit

Publications (1)

Publication Number Publication Date
GB201715496D0 true GB201715496D0 (en) 2017-11-08

Family

ID=60244242

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1715496.4A Ceased GB201715496D0 (en) 2017-09-25 2017-09-25 Generating brain microvascular endothelial cells from pluripotent stem cells to model the human blood-brain barrier and the neurovascular unit

Country Status (2)

Country Link
GB (1) GB201715496D0 (en)
WO (1) WO2019058140A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019208736A1 (en) * 2018-04-27 2019-10-31 公立大学法人名古屋市立大学 Method for inducing differentiation of pluripotent stem cells into brain microvascular endothelial cells
US20240058388A1 (en) * 2019-10-19 2024-02-22 The Mclean Hospital Corporation Human Periventricular Endothelial Cell Therapy for Neuropsychiatric Disorders
CN114606178B (en) * 2022-03-28 2023-08-22 上海市中医老年医学研究所 Culture medium for preparing brain/nerve organoids, application of culture medium, brain/nerve organoids and preparation method of culture medium

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10590393B2 (en) * 2012-11-08 2020-03-17 Wisconsin Alumni Research Foundation Retinoic acid enhanced human stem cell derived blood brain barrier model
KR101816281B1 (en) * 2015-06-26 2018-01-08 한국생명공학연구원 Method for preparing brain microvascular endothelial cells from pluripotent stem cells and use thereof
SG11201806453TA (en) * 2016-02-16 2018-08-30 Harvard College Improved blood-brain barrier endothelial cells derived from pluripotent stem cells for blood-brain barrier models

Also Published As

Publication number Publication date
WO2019058140A1 (en) 2019-03-28

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)