GB2015875A - Solid oral pharmaceutical product with increased efficacy and predetermined steady state of solubility - Google Patents

Solid oral pharmaceutical product with increased efficacy and predetermined steady state of solubility

Info

Publication number
GB2015875A
GB2015875A GB7905298A GB7905298A GB2015875A GB 2015875 A GB2015875 A GB 2015875A GB 7905298 A GB7905298 A GB 7905298A GB 7905298 A GB7905298 A GB 7905298A GB 2015875 A GB2015875 A GB 2015875A
Authority
GB
United Kingdom
Prior art keywords
granules
solid
active ingredient
oral pharmaceutical
solid oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7905298A
Other versions
GB2015875B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOVEX FOREIGN TRADE CO Ltd
Original Assignee
NOVEX FOREIGN TRADE CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NOVEX FOREIGN TRADE CO Ltd filed Critical NOVEX FOREIGN TRADE CO Ltd
Publication of GB2015875A publication Critical patent/GB2015875A/en
Application granted granted Critical
Publication of GB2015875B publication Critical patent/GB2015875B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A solid oral pharmaceutical preparation with protracted release of the active ingredient consists of discrete solid granules containing the active ingredient soluble in the stomach and auxiliary agents and of an equally solid external phase surrounding the said granules, whereby the granules forming the internal phase consist of granules prepared from a powder mixture which contains as active ingredient, or in addition to it a pharmaceutically acceptable basic bismuth salt, particularly bismuth subnitrate /basic bismuth nitrate/or bismuth subcarbonate and auxiliary materials prepared with an aqueous emulsion containing a hydrophobic component and hydrophylic emulsifiers, and the external phase contains a solid, dry, amphoteric gel forming substance preferably tragacanth in an amount of 1-50 per cent w/w related to the total weight of the preparation in admixture with auxiliary agents.
GB7905298A 1978-02-24 1979-02-14 Solid oral pharaceutical product with increased efficacy and predetermined steady state of solubility Expired GB2015875B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUIO001247 1978-02-24

Publications (2)

Publication Number Publication Date
GB2015875A true GB2015875A (en) 1979-09-19
GB2015875B GB2015875B (en) 1982-10-20

Family

ID=10997585

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7905298A Expired GB2015875B (en) 1978-02-24 1979-02-14 Solid oral pharaceutical product with increased efficacy and predetermined steady state of solubility

Country Status (1)

Country Link
GB (1) GB2015875B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126086A (en) * 1982-08-24 1984-03-21 Cilag Ag Medicated suppository containing gel-forming and gel-dispersing agents
US4938967A (en) * 1986-09-18 1990-07-03 London School Of Pharmacy Innovations Ltd. Pharmaceutical formulations
EP0455475A2 (en) * 1990-05-03 1991-11-06 Reckitt And Colman Products Limited Use of triclosan in the treatment of diseases of the gastrointestinal tract

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126086A (en) * 1982-08-24 1984-03-21 Cilag Ag Medicated suppository containing gel-forming and gel-dispersing agents
US4938967A (en) * 1986-09-18 1990-07-03 London School Of Pharmacy Innovations Ltd. Pharmaceutical formulations
EP0455475A2 (en) * 1990-05-03 1991-11-06 Reckitt And Colman Products Limited Use of triclosan in the treatment of diseases of the gastrointestinal tract
EP0455475A3 (en) * 1990-05-03 1992-02-26 Reckitt And Colman Products Limited Use of triclosan in the treatment of diseases of the gastrointestinal tract
US5286492A (en) * 1990-05-03 1994-02-15 Reckitt & Colman Products Limited Method of treatment of Heliobacter pylori infections with triclosan

Also Published As

Publication number Publication date
GB2015875B (en) 1982-10-20

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee