GB201200259D0 - Novel therapies - Google Patents
Novel therapiesInfo
- Publication number
- GB201200259D0 GB201200259D0 GB201200259A GB201200259A GB201200259D0 GB 201200259 D0 GB201200259 D0 GB 201200259D0 GB 201200259 A GB201200259 A GB 201200259A GB 201200259 A GB201200259 A GB 201200259A GB 201200259 D0 GB201200259 D0 GB 201200259D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- polypeptides
- seq
- acid sequence
- amino acid
- pollen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention provides hypoallergenic polypeptides comprising or consisting of a variant of the amino acid sequence of SEQ ID NO: 1 wherein one or more amino acids of SEQ 1 within an IgE-binding epitope is mutated and wherein the polypeptide exhibits reduced IgE-reactivity compared to a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1. The invention further provides pharmaceutical compositions of such polypeptides, as well as methods for making and using said polypeptides, for example in the prevention of pollen grass allergies. Related aspects of the invention provide antibody polypeptides for passive immunisation against pollen grass allergies.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201200259A GB201200259D0 (en) | 2012-01-09 | 2012-01-09 | Novel therapies |
GB201212649A GB201212649D0 (en) | 2012-01-09 | 2012-07-16 | Novel therapies |
PCT/GB2013/050032 WO2013104901A2 (en) | 2012-01-09 | 2013-01-09 | Novel therapies |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201200259A GB201200259D0 (en) | 2012-01-09 | 2012-01-09 | Novel therapies |
Publications (1)
Publication Number | Publication Date |
---|---|
GB201200259D0 true GB201200259D0 (en) | 2012-02-22 |
Family
ID=45788631
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB201200259A Ceased GB201200259D0 (en) | 2012-01-09 | 2012-01-09 | Novel therapies |
GB201212649A Ceased GB201212649D0 (en) | 2012-01-09 | 2012-07-16 | Novel therapies |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB201212649A Ceased GB201212649D0 (en) | 2012-01-09 | 2012-07-16 | Novel therapies |
Country Status (2)
Country | Link |
---|---|
GB (2) | GB201200259D0 (en) |
WO (1) | WO2013104901A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11013781B2 (en) | 2015-07-01 | 2021-05-25 | Alk-Abelló As | Peptide combinations and uses thereof for treating grass allergy |
WO2018026642A1 (en) * | 2016-08-03 | 2018-02-08 | The Feinstein Institute For Medical Research | C1q and hmgb1 fusion proteins and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8205892D0 (en) | 1982-10-18 | 1982-10-18 | Bror Morein | IMMUNOGENT MEMBRANE PROTEIN COMPLEX, SET FOR PREPARATION AND USE THEREOF |
SE8405493D0 (en) | 1984-11-01 | 1984-11-01 | Bror Morein | IMMUNOGENT COMPLEX AND KITCHEN FOR PREPARING IT AND USING IT AS IMMUNOSTIMENTING AGENTS |
DK166762B1 (en) | 1986-01-14 | 1993-07-12 | Nederlanden Staat | PROCEDURE FOR PREPARING IMMUNOGENIC COMPLEXES AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPLEXES |
US4806352A (en) | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
DE3852304T3 (en) | 1987-03-02 | 1999-07-01 | Enzon Lab Inc | Organism as carrier for "Single Chain Antibody Domain (SCAD)". |
US5643872A (en) | 1989-10-23 | 1997-07-01 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP0614989A1 (en) | 1993-02-17 | 1994-09-14 | MorphoSys AG | A method for in vivo selection of ligand-binding proteins |
US6008058A (en) | 1993-06-18 | 1999-12-28 | University Of Louisville | Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis |
SE9304060D0 (en) | 1993-12-06 | 1993-12-06 | Bioinvent Int Ab | Methods to select specific bacteriophages |
GB9716900D0 (en) | 1997-08-08 | 1997-10-15 | Bioinvent Int Ab | Method for selecting phage displaying ligand binders |
IT1318692B1 (en) * | 2000-09-12 | 2003-08-27 | Consiglio Nazionale Ricerche | VARIATIONS OF ALLERGENIC PROTEINS OF PHLEUM PRATENSE. |
-
2012
- 2012-01-09 GB GB201200259A patent/GB201200259D0/en not_active Ceased
- 2012-07-16 GB GB201212649A patent/GB201212649D0/en not_active Ceased
-
2013
- 2013-01-09 WO PCT/GB2013/050032 patent/WO2013104901A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2013104901A3 (en) | 2013-12-05 |
GB201212649D0 (en) | 2012-08-29 |
WO2013104901A2 (en) | 2013-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AT | Applications terminated before publication under section 16(1) |