GB2010273A - Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dione - Google Patents

Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dione

Info

Publication number
GB2010273A
GB2010273A GB7842884A GB7842884A GB2010273A GB 2010273 A GB2010273 A GB 2010273A GB 7842884 A GB7842884 A GB 7842884A GB 7842884 A GB7842884 A GB 7842884A GB 2010273 A GB2010273 A GB 2010273A
Authority
GB
United Kingdom
Prior art keywords
derivatives
dioxabicyclo
octane
dione
dipnenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7842884A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Microbial Chemistry Research Foundation
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Kanegafuchi Chemical Industry Co Ltd filed Critical Microbial Chemistry Research Foundation
Publication of GB2010273A publication Critical patent/GB2010273A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New derivatives of 2,6-diphenyl- 3,7-dioxabicyclo-[3,3,0]-octane-4,8- dione substituted on the phenyl rings have been found to have an anti-tumor, catechol-0-methyltransferase inhibitory and cyclic AMP phosphodiesterase inhibitory activity. The derivatives are prepared by subjecting cinnamic acid derivatives to an oxidative coupling reaction in the presence of an oxidizing agent.
GB7842884A 1977-11-15 1978-11-02 Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dione Withdrawn GB2010273A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13742077A JPS5473789A (en) 1977-11-15 1977-11-15 2,6-diphenyl-3,7-dioxabicyclo-3.3.0-octane 4,8-dione derivative and anticarcinogens, catechol-o-methyl transferase inhibitors and adenosine 3',5'-cyclic phosphoric acid phosphodiesterase inhibitors containing the derivative as active component

Publications (1)

Publication Number Publication Date
GB2010273A true GB2010273A (en) 1979-06-27

Family

ID=15198205

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7842884A Withdrawn GB2010273A (en) 1977-11-15 1978-11-02 Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dione

Country Status (10)

Country Link
JP (1) JPS5473789A (en)
AR (1) AR217335A1 (en)
BE (1) BE871994A (en)
DE (1) DE2849107A1 (en)
ES (1) ES475050A1 (en)
FR (1) FR2408610A1 (en)
GB (1) GB2010273A (en)
IT (1) IT1109272B (en)
NL (1) NL7811308A (en)
SE (1) SE7811759L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207735A1 (en) * 1985-06-26 1987-01-07 Takemoto Yushi Kabushiki Kaisha Method of manufacturing phenol-type natural antioxidants

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6330416A (en) * 1986-07-24 1988-02-09 Wakunaga Pharmaceut Co Ltd Agent for improving cerebral circulation and metabolism
US6588625B2 (en) 2001-04-24 2003-07-08 Abbott Laboratories Sample handling system
KR100479405B1 (en) * 2002-05-24 2005-03-30 주식회사 싸이제닉 Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease
JP2011195465A (en) * 2010-03-17 2011-10-06 Wakayama Prefecture Process for manufacturing cinnamic acid derivative, and cinnamic acid derivative
JP5914897B2 (en) * 2012-03-08 2016-05-11 和歌山県 Method for producing furofuran derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52102433A (en) * 1976-02-19 1977-08-27 Microbial Chem Res Found Hypotensive agents containing 1,4-dihydroxy-1,4-di-(3,5-dimethoxy-4-hy droxyphenyl)butane-2,3-dicarboxylic acid dilactone as main component
JPS52136193A (en) * 1976-05-10 1977-11-14 Microbial Chem Res Found Novel dehydrodicaffeic acid dilactone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207735A1 (en) * 1985-06-26 1987-01-07 Takemoto Yushi Kabushiki Kaisha Method of manufacturing phenol-type natural antioxidants

Also Published As

Publication number Publication date
SE7811759L (en) 1979-05-16
JPS5473789A (en) 1979-06-13
IT7851906A0 (en) 1978-11-15
IT1109272B (en) 1985-12-16
BE871994A (en) 1979-05-14
AR217335A1 (en) 1980-03-14
NL7811308A (en) 1979-05-17
ES475050A1 (en) 1979-04-16
FR2408610A1 (en) 1979-06-08
DE2849107A1 (en) 1979-05-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)