GB2008570A - The preparation of thiophene 2- and 3-malonic and acetic acids and esters - Google Patents

The preparation of thiophene 2- and 3-malonic and acetic acids and esters

Info

Publication number
GB2008570A
GB2008570A GB7834389A GB7834389A GB2008570A GB 2008570 A GB2008570 A GB 2008570A GB 7834389 A GB7834389 A GB 7834389A GB 7834389 A GB7834389 A GB 7834389A GB 2008570 A GB2008570 A GB 2008570A
Authority
GB
United Kingdom
Prior art keywords
thiophene
malonic
esters
acetic acids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7834389A
Other versions
GB2008570B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PILOT CHEMICAL CO Ltd GILLESPI
Willmott W E
Original Assignee
PILOT CHEMICAL CO Ltd GILLESPI
Willmott W E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PILOT CHEMICAL CO Ltd GILLESPI, Willmott W E filed Critical PILOT CHEMICAL CO Ltd GILLESPI
Priority to GB7834389A priority Critical patent/GB2008570B/en
Publication of GB2008570A publication Critical patent/GB2008570A/en
Application granted granted Critical
Publication of GB2008570B publication Critical patent/GB2008570B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)

Abstract

Thiophene 2- and 3-malonic and acetic acids and esters are made by reacting a thiophene or a derivative thereof with a diazo compound in the presence, as catalyst, of a rhodium (II) carboxylate. The process may be a one stage process, or a two stage process via thiophenium ylid or a cyclopropane derivative as an intermediate compound. The product is useful in the synthesis of penicillin and cephalosporin.
GB7834389A 1977-05-27 1978-08-24 Preparation of 2-and3-substituted thiophene derivatives Expired GB2008570B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7834389A GB2008570B (en) 1977-05-27 1978-08-24 Preparation of 2-and3-substituted thiophene derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2262577 1977-05-27
GB7834389A GB2008570B (en) 1977-05-27 1978-08-24 Preparation of 2-and3-substituted thiophene derivatives

Publications (2)

Publication Number Publication Date
GB2008570A true GB2008570A (en) 1979-06-06
GB2008570B GB2008570B (en) 1982-02-03

Family

ID=26256033

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7834389A Expired GB2008570B (en) 1977-05-27 1978-08-24 Preparation of 2-and3-substituted thiophene derivatives

Country Status (1)

Country Link
GB (1) GB2008570B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007006724A1 (en) * 2005-07-13 2007-01-18 Basf Aktiengesellschaft 5-alkyl-7-amino-6-heteroaryl-1,2,4-triazolo[1,5-a]pyrimidine compounds and use thereof for the prevention of fungal pests

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007006724A1 (en) * 2005-07-13 2007-01-18 Basf Aktiengesellschaft 5-alkyl-7-amino-6-heteroaryl-1,2,4-triazolo[1,5-a]pyrimidine compounds and use thereof for the prevention of fungal pests

Also Published As

Publication number Publication date
GB2008570B (en) 1982-02-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee