GB2003858A - PYRAZOLO[1,5-c] QUINAZOLINE DERIVATIVES AND RELATED COMPOUNDS - Google Patents

PYRAZOLO[1,5-c] QUINAZOLINE DERIVATIVES AND RELATED COMPOUNDS

Info

Publication number
GB2003858A
GB2003858A GB7831343A GB7831343A GB2003858A GB 2003858 A GB2003858 A GB 2003858A GB 7831343 A GB7831343 A GB 7831343A GB 7831343 A GB7831343 A GB 7831343A GB 2003858 A GB2003858 A GB 2003858A
Authority
GB
United Kingdom
Prior art keywords
alkyl
image
hydrogen
carbons
dialkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7831343A
Other versions
GB2003858B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/820,289 external-priority patent/US4128644A/en
Priority claimed from US05/842,776 external-priority patent/US4110452A/en
Priority claimed from US05/842,718 external-priority patent/US4112098A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB2003858A publication Critical patent/GB2003858A/en
Application granted granted Critical
Publication of GB2003858B publication Critical patent/GB2003858B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds are provided having the structure <IMAGE> wherein R<1> is hydrogen, alkyl of 1-3 carbons, 1-hydroxy-imino)alkyl, alkanoylamino, amino, alkylamino, dialkylamino, <IMAGE> wherein the above groups contains 1 to 4 carbons, or phenyl optionally substituted by R<4>; R<2> is alkylamido, dialkylamino, 1-hydroxy- imino)alkyl, alkanoylamino, amino, <IMAGE> hydrogen, lower alkyl, phenyl (optionally substituted by R<4>) wherein alkyl in the above groups contains 1 to 4 carbons or cyano; <IMAGE> (wherein Z is a single bond or <IMAGE> X is O or S; <IMAGE> (wherein R<9> is hydrogen or alkyl, Q is CH or N); <IMAGE> wherein R<6> is amino, alkylamino, dialkylamino, amino, haloalkyl or <IMAGE> R<3> is hydrogen, lower alkyl, benzyl or phenyl (optionally substituted with R<4>) dialkylamino alkyl, hydroxyalkyl, or <IMAGE> (wherein R<10> is hydrogen, amino, alkyl, alkylamino or dialkylamino and R<11> is alkyl); R<4> and R<5> are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, substituted benzyloxy, hydroxy, halogen, nitro and trifluoromethyl; R<7> and R<8> may be the same or different and represent hydrogen, lower alkyl containing 1-3 carbons, phenyl optionally substituted with X1 or benzyl optionally substituted with X1; (CH2)m and (CH2)n represent a single bond or straight or branched chain alkylene radicals; and m and n represent the number of carbons in the longest normal chain and may be the same or different and are 0 to 10, preferably 0 to 5, but m plus n is 10 or less, preferably 0 to 5, or such compound in physiologically acceptable salt form.
GB7831343A 1977-07-29 1978-07-27 Pyrazolo(1,5c)quinazoline derivatives and related compounds Expired GB2003858B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/820,289 US4128644A (en) 1977-07-29 1977-07-29 Pyrazolo(1,5-c)quinazoline derivatives and related compounds
US05/842,776 US4110452A (en) 1977-10-17 1977-10-17 Pyrazolo (1,5-c) quinazoline derivatives and related compounds
US05/842,718 US4112098A (en) 1977-10-17 1977-10-17 Pyrazolo[1,5-c]quinazoline derivatives and related compounds

Publications (2)

Publication Number Publication Date
GB2003858A true GB2003858A (en) 1979-03-21
GB2003858B GB2003858B (en) 1982-01-06

Family

ID=27420136

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7831343A Expired GB2003858B (en) 1977-07-29 1978-07-27 Pyrazolo(1,5c)quinazoline derivatives and related compounds

Country Status (4)

Country Link
JP (1) JPS5427600A (en)
DE (1) DE2833212A1 (en)
FR (1) FR2398749A1 (en)
GB (1) GB2003858B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313815A (en) * 1964-05-04 1967-04-11 Sterling Drug Inc 8-chloropyrazolo-[1, 5-c]quinazoline derivatives and methods of preparing same
US3772336A (en) 1972-04-25 1973-11-13 Upjohn Co 4h-(1)benzothieno(3,2-beta)pyran-4-one-2-carboxylic acids and related compounds
US3897434A (en) * 1974-04-12 1975-07-29 Lilly Co Eli Pyrazolo{8 1,5-c{9 quinazolin-5(6H)-ones

Also Published As

Publication number Publication date
DE2833212A1 (en) 1979-02-08
JPS5427600A (en) 1979-03-01
GB2003858B (en) 1982-01-06
FR2398749A1 (en) 1979-02-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee