GB2002231A - Hypertension treating composition - Google Patents

Hypertension treating composition

Info

Publication number
GB2002231A
GB2002231A GB7832816A GB7832816A GB2002231A GB 2002231 A GB2002231 A GB 2002231A GB 7832816 A GB7832816 A GB 7832816A GB 7832816 A GB7832816 A GB 7832816A GB 2002231 A GB2002231 A GB 2002231A
Authority
GB
United Kingdom
Prior art keywords
group
image
halogen atom
treating composition
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7832816A
Other versions
GB2002231B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9496577A external-priority patent/JPS5432632A/en
Priority claimed from JP13300877A external-priority patent/JPS5467037A/en
Priority claimed from JP13944377A external-priority patent/JPS5476513A/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of GB2002231A publication Critical patent/GB2002231A/en
Application granted granted Critical
Publication of GB2002231B publication Critical patent/GB2002231B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/048—Acyclic alcohols with carbon-to-carbon triple bonds with double and triple bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The active agent comprises polyprenyl alcohol (or its ester) of formula <IMAGE> wherein n represents an integer of 7 to 10 and A a group of the general formula: <IMAGE> in which a and b each represent hydrogen or form a bond, or <IMAGE> where R represents hydrogen or -COR', R' being a saturated or unsaturated alkyl group having 1 to 17 carbon atoms; a cyclohexyl group; an unsubstituted phenyl group or a phenyl group substituted with a halogen atom or a lower alkoxy group; a (halogen atom- substituted phenoxy)-lower alkyl group; or a pyridyl group.
GB7832816A 1977-08-10 1978-08-09 Hypertension treating agent Expired GB2002231B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9496577A JPS5432632A (en) 1977-08-10 1977-08-10 Depressors containing polyprenyl alcohols
JP13300877A JPS5467037A (en) 1977-11-08 1977-11-08 Hypotensive agent containing polyprenyl alcohol as main component
JP13944377A JPS5476513A (en) 1977-11-22 1977-11-22 Polyprenyl alcohol ester and hypotensives containing it

Publications (2)

Publication Number Publication Date
GB2002231A true GB2002231A (en) 1979-02-21
GB2002231B GB2002231B (en) 1982-03-17

Family

ID=27307697

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7832816A Expired GB2002231B (en) 1977-08-10 1978-08-09 Hypertension treating agent

Country Status (3)

Country Link
DE (1) DE2834911C2 (en)
FR (1) FR2399993A1 (en)
GB (1) GB2002231B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122610B (en) * 1982-05-28 1987-04-01 Eisai Co Ltd A polyprenyl compound and a pharmaceutical composition containing a polyprenyl compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1179929A (en) * 1954-05-11 1959-05-29 Hoffmann La Roche Process for preparing esters of olefinic tertiary alcohols
FR1341487A (en) * 1959-10-09 1963-11-02 Hoffmann La Roche Process for the preparation of derivatives of 2, 3-dimethoxy-5-methyl-benzohydroquinone- (1, 4)
DE2019835C3 (en) * 1969-04-24 1974-08-15 Nisshin Flour Milling Co. Ltd., Tokio Process for obtaining solanesol
US4059641A (en) * 1975-11-18 1977-11-22 Sankyo Company Limited Polyprenyl derivatives
JPS52144614A (en) * 1976-05-27 1977-12-02 Eisai Co Ltd Polyprenyl carboxylic acid compounds and hypo-tensor containing same

Also Published As

Publication number Publication date
FR2399993B1 (en) 1983-11-18
GB2002231B (en) 1982-03-17
DE2834911A1 (en) 1979-03-01
FR2399993A1 (en) 1979-03-09
DE2834911C2 (en) 1985-11-21

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee