GB189816994A - Improvements in the Manufacture of Fine Chemical Products for Use in Pharmacy and other Purposes. - Google Patents

Abstract

16,994. Wellcome, H. S., and Schryver, S. B. Aug. 6. Medicinal preparations.-Acid phenolic salts of dibasic acids, for use in pharmacy, are produced by acting with a sodium phenol compound upon an anhydride of a dibasic acid in the presence of a chemically-inactive liquid, and then decomposing the sodium phenolic salt of the acid thus produced by a dilute mineral acid. In most cases it is convenient to mix the phenol with a solvent, such as xylene or benzene, to dissolve metallic sodium in the phenol solution, heat being applied if necessary, and then to add the anhydride to the solution. A gelatinous precipitate of the sodium phenolic salt separates, and this is usually washed out with water. The acid phenolic salt is precipitated from the washings by a mineral acid, and it is purified by recrystallization from a suitable solvent. When the sodium phenolic salt is very easily hydrolysed by water, it is separated from the solvent, pressed, dried, and powdered, and is then decomposed by a ten per cent. sulphuric-acid solution covered by ether, which will dissolve the liberated acid phenolic salt. The following acid salts are produced by the foregoing processes, viz. :-hydrogen thymol succinate, camphorate, and phthalate ; hydrogen guaiacol camphorate and succinate; hydrogen carvacrol camphorate ; hydrogen #-naphthol camphorate ; hydrogen salol camphorate; hydrogen p-bromophenol camphorate ; hydrogen 2 : 4 dibromophenol camphorate; and hydrogen m-nitrophenol camphorate. The acid phenolic salts may be converted into metallic, alkylic, and phenylic derivatives.