GB1603034A - Skin treatment - Google Patents

Description

(54) IMPROVEMENTS IN OR RELATING TO SKIN TREATMENT (71) I, FRANCO DONADELLI, of Via Bronzino 6, Milan, Italy, an Italian citizen, do hereby declare the invention, for which I pray that a patent may be granted to me, and the method by which it is to be performed, to be particularly described in and by the following statement:- This invention relates to to a preparation for use in skin regeneration.

In normal skin the collagen fibrilles are constant in size and lie parallel one to another, while in healed scars the fibres are of different sizes and lie in all directions.

From the histological point of view intradermal tears represent the external part of a dermic wound and, subsequently, of a dermic cicatrix.

A number of methods are known the purpose of which is to assist regeneration of open skin tissue (lesions) or of partially broken tissues as in the case of intradermal tears and similar kinds, such methods consisting, for example, in application of vegetable extracts, scorching with electromagnetic waves at high frequency, plastic surgery, exposure to an electro-magnetic field combined with a simultaneous treatment with irradiated water.

Especially in the case of intradermal tears, all these methods, some of which are difficult and painful to apply, have shown themselves to be only partially effective or entirely ineffective.

The following in particular have been found to be ineffective: exposure to weak electric fields; application of saline and ammine solutions, protein and embryonic tissues.

Starting from a theoretical basis borne out by considerable experience, the preparation and method of this invention, have been found to stimulate the cicatrized skin obtaining thereby the formation of normal skin, namely with the fibres lying parallel and compactly, restoring tissue continuity, as will be described and proved by a statement of the theoretical and practical results achieved.

According to the invention there is provided a preparation for application to skin comprising an aqueous solution of a tissue regenerating extract made from animal organs which has been subjected to incomplete electrolysis.

The solution may also be subjected to an exposure to the ionizing action of an electric field of a frequency below 10 K Hz.

It is well known that the stage of passing over to cell reproduction requires a failure of internal cohesion and activation of proteinic synthesis, namely an increase in the concentration of the S-H groups (primary factors of proteinic synthesis). It is considered that all these changes are caused by an alteration balance between electron "donors" and "receivers" which facilitates a breakdown between S-S and disulphide links and the formation of active S-H links.

It is a known fact that the S-S links possess a degree of energy equivalent to about 63 Kcal/mol, while that of the S-H links reach about 87 Kcal/mol.

It has been found by experiment that, in an electric or magnetic field, a solution of polypeptides forms clusters of rectilinear molecules, orientated in the direction of the field in respect of their bipolar moment. Each cluster is composed of polymerized molecules parallel to the direction of the field.

Bearing in mind the phenomena described above, the cicatrized skin is stimulated causing a breakdown of the S-S links and formation of the S-H links, supplying the needed energy by a double electric field, the first one at surface level and the other at dermic level.

The first electric field is obtained by application of a proteinic solution, made from tissue regenerating extracts from animal organs, to the skin, these being substances which exist in the skin itself and which, by partial electrolysis, are split up into groups of aminoacids. By applying an electric field clusters of molecules are obtained and electrical excitation (ionization) of the most active groups with an increased electrical moment of the molecules themselves.

The second electric field is obtained by applying a low frequency sinusoidal electric field to the scarred area of the skin in such a way as to give an electric charge to the layers underlying the lesions. The effect of this double electric field is that the molecules forming the solution. and those in the electrically charged layers of the skin, react together producing something very like an electromagnetic "mirror" effect and involving the skin in this reaction throughout its whole depth.

The results obtained in a considerable number of experiences and applications have fully borne out this theoretical approach, achieving elmination, or reduction, of the cicatrices and lesions and forming real regenerated tissue.

Below a description is given of a case where the invention has been applied, together with full details of how it was done and of the results that were achieved.

In order that the invention and its various other preferred features may be understood more easily, embodiments thereof will now be described some of which are illustrated in the drawings in which: Figure 1 is an apparatus for producing an electric field in accordance with one aspect of the invention; Figure 2 is a block diagram of the circuitry of the apparatus of Figure 1; Figure 3 is an apparatus for preparing a preparation in accordance with another aspect of the invention, and Figure 4 is a block diagram of the apparatus of Figure 3.

Example of an application: Composition of the preparation: a solution of embryonic placenta, collagen and vitreous humor extracts diluted in distilled water.

Treatment given to the preparation: Phase one: an electrolysis reaction is set up in the solution for several days (about 5) by two gold electrodes connected to a square wave, electric field generator.

Phase two: a low frequency alternate electric field is applied to the solution treated as above for another period of about 5 days (frequency below 10,000 Hz).

The apparatus shown in Figure 1 for generating an electric field in the derm is housed in container 10 and has a switch 11 to connect to the mains, a pilot light 12, knob 13, field voltage changer from 1 to 9 volt, six outputs 14 carrying current to six pairs of electrodes 15 covered with sponges. The circuit schematic is shown in Figure 2. A transformer 16 connected to the mains, supplies current at a maximum of 9V to a sine wave generator 17 the frequency of which is automatically changed in cycles by an automatic frequency changer 18 served by timer 19. Through a signal attenuator 20 sinusoidal waves pass to outputs 21. A display 22 (shown in Figure 5 by number 23) shows actual voltage values. The frequency, in accordance with 60 second sweeps between 1.5 and 4 KHz. or in accordance with other values as the case may be, is automatically changed through the above described circuits.

Figure 3 shows an apparatus for producing the solution which is housed in container 24 and has a switch 25 to connect to the mains together with a pilot light 26. A key 27 which is visible, enables transfer from a square wave field to a sinusoidal wave field. Knobs 28 and 29 are respectively for a frequency changer and voltage changer. Outputs 30 are connected to pairs of electrodes for treating the solution. The block diagram of the electronic, circuit, which is shown in Figure 4, has a transformer 31 connected to the mains and through which a sinusoidal and square wave generator 32 is supplied with current at from 15 to 20 volt. From the generator a signal passes to a signal attenuator 33 and from there to pairs of outputs 34.

Treatment on the patient: The electrodes, coupled with the output of the electric field generator, covered with spongy material and damped with "aqua fontis" to which one ml of solution is added, are applied in counterposed pairs to the boundaries of the area of skin for treatment. Utilising half the maximum voltage (4 or 5V), the skin is charged for 20 to 30 minutes with a weak electric field. The electrodes are then removed and the part is damped with a few ml of solution.

This treatment is repeated two or three times a week. The first results may be seen after a month or two.

Other ways of applying the treatment have resulted in favourable effects as follows: addition to the solution of small quantities (1-2 x 1,000) of glycine and methionine to assist formation of the S-H groups; dilution of the solution with 1/3 vol-vol of double distilled glycerine after the electrical and chemical treatments, in order to get an even film on the skin; addition to the solution-after the initial phase of partial electrolysis-- of catalysts corresponding to the following two groups: vitamins (traces of E, C, H, PP), metals (eg zinc, magnesium and cobalt).

Advantages given by the invention: The invention has been applied to a great number of cases some of which are mentioned below: (a) Intradermal tears on the thigh of a 30year old woman; (b) The abdomen of a 27-year old woman having many very fine intradermal tears; (c) The abdomen or a 30-year old woman having a scar.

(d) Post chicken-pox scars in a 25-year old person.

The tears and scars either disappeared or were much fainter after three months of treatment whilst the post chicken-pox scars benefited from a longer treatment of seven months.

Inside the pock marks, still visible after treatment, the presence of parallel fibres, undoubtedly like those in ordinary skin tissue, were observed. Experience in practical application hitherto gained, confirm the validity of the invention and all the advantages it can offer.

WHAT I CLAIM IS: 1. A preparation for application to skin comprising an aqueous solution of a tissue regenerating extract made from animal organs which has been subjected to incomplete electrolysis.

2. A preparation as claimed in claim 1, wherein the aqueous solution has also been subjected to an exposure to the ionizing action of an electric field of a frequency below 10 KHz.

3. A preparation, as claimed in claim 1 or 2, wherein the regenerating extract comprises an extract of a embryonic placenta and/or collagen and/or vitreous humour.

4. A preparation as claimed in claim 1, 2 or 3, wherein the preparation is produced by an electrical and chemical pretreatment carried out in two stages, each one lasting several days; during the first stage cariable electric impulses are applied which, by a reaction of incomplete electrolysis, give rise to the formation of groups of amino acids; in the second stage, in which a low frequency sinusoidal electric field is applied, this frequency being less than 10,000 Hz, clusters of ionized molecules are formed and their electrical moment is increased.

5. A preparation as claimed in claim 4, wherein the pretreatment of the solution by the electrical and chemical processes is such as to create what amounts to a superficial electric field so that when applied to an area of damaged skin the damage skin lies between two electric fields which give rise to what may be described as an electromagnetic "mirror" reaction, and in this way the clusters of skin molecules recieve the energy needed by the S-S groups for transforming them into S-H groups, this being the energy necessary to provoke the reaction leading to proteinic synthesis.

6. A preparation as claimed in any one of claims 1 to 4, wherein after the incomplete electrolysis reaction, some or all of the following types of catalysts are added to the solution: vitamins such as E, C, H, PP, and metals such as zinc, magnesium, cobalt.

7. A preparation as claimed in any one of claims 1 to 5, wherein solution is obtained by diluting the preparation with "aqua fontis" in the volume proportion of 1/1000.

8. A preparation as claimed in any one of claims 1 to 7, wherein an apparatus used for treating the solution electrically and chemically comprises an electronic circuit which, by means of electrodes immersed in the solution, automatically sets up the pulsating electric field and then the sinusoidal wave field.

9. A preparation for application to skin according to claim 1 substantially as described herein.

**WARNING** end of DESC field may overlap start of CLMS **.

Claims (9)

**WARNING** start of CLMS field may overlap end of DESC **. having many very fine intradermal tears; (c) The abdomen or a 30-year old woman having a scar. (d) Post chicken-pox scars in a 25-year old person. The tears and scars either disappeared or were much fainter after three months of treatment whilst the post chicken-pox scars benefited from a longer treatment of seven months. Inside the pock marks, still visible after treatment, the presence of parallel fibres, undoubtedly like those in ordinary skin tissue, were observed. Experience in practical application hitherto gained, confirm the validity of the invention and all the advantages it can offer. WHAT I CLAIM IS:

1. A preparation for application to skin comprising an aqueous solution of a tissue regenerating extract made from animal organs which has been subjected to incomplete electrolysis.

2. A preparation as claimed in claim 1, wherein the aqueous solution has also been subjected to an exposure to the ionizing action of an electric field of a frequency below 10 KHz.

3. A preparation, as claimed in claim 1 or 2, wherein the regenerating extract comprises an extract of a embryonic placenta and/or collagen and/or vitreous humour.

4. A preparation as claimed in claim 1, 2 or 3, wherein the preparation is produced by an electrical and chemical pretreatment carried out in two stages, each one lasting several days; during the first stage cariable electric impulses are applied which, by a reaction of incomplete electrolysis, give rise to the formation of groups of amino acids; in the second stage, in which a low frequency sinusoidal electric field is applied, this frequency being less than 10,000 Hz, clusters of ionized molecules are formed and their electrical moment is increased.

5. A preparation as claimed in claim 4, wherein the pretreatment of the solution by the electrical and chemical processes is such as to create what amounts to a superficial electric field so that when applied to an area of damaged skin the damage skin lies between two electric fields which give rise to what may be described as an electromagnetic "mirror" reaction, and in this way the clusters of skin molecules recieve the energy needed by the S-S groups for transforming them into S-H groups, this being the energy necessary to provoke the reaction leading to proteinic synthesis.

6. A preparation as claimed in any one of claims 1 to 4, wherein after the incomplete electrolysis reaction, some or all of the following types of catalysts are added to the solution: vitamins such as E, C, H, PP, and metals such as zinc, magnesium, cobalt.

7. A preparation as claimed in any one of claims 1 to 5, wherein solution is obtained by diluting the preparation with "aqua fontis" in the volume proportion of 1/1000.

8. A preparation as claimed in any one of claims 1 to 7, wherein an apparatus used for treating the solution electrically and chemically comprises an electronic circuit which, by means of electrodes immersed in the solution, automatically sets up the pulsating electric field and then the sinusoidal wave field.

9. A preparation for application to skin according to claim 1 substantially as described herein.