GB1580204A - 2-cyanohexanoic acid derivatives - Google Patents
2-cyanohexanoic acid derivatives Download PDFInfo
- Publication number
- GB1580204A GB1580204A GB2826276A GB2826276A GB1580204A GB 1580204 A GB1580204 A GB 1580204A GB 2826276 A GB2826276 A GB 2826276A GB 2826276 A GB2826276 A GB 2826276A GB 1580204 A GB1580204 A GB 1580204A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- process according
- compound
- catalyst
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Abstract
The compounds of the general formula I in which the symbols have the meaning given in Claim 1 are suitable as intermediates for the preparation of insecticidally active compounds. These compounds are prepared by reacting a compound of the general formula II with a compound of the general formula III in the presence of a catalyst and in an inert solvent. <IMAGE>
Description
(54) 2-CYANOHEXANOIC ACID DERIVATIVES
(71) We, SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V, a company organised under the laws of The Netherlands, of 30 Carel van
Bylandtlaan, The Hague, The Netherlands, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:- This invention relates to 2-cyanohexanoic acid derivatives which are useful intermediates in the preparation of insecticidally-active compounds.
Accordingly the invention provides 2-cyanohexanoic acid derivatives of the general formula:
wherein X and Y each represent a chlorine or bromine atom, each Hat independently represents a fluorine, chlorine or bromine atom and R1 and R2 each independently represent an alkyl group of one to four carbon atoms or a salt thereof, preferably an alkali metal or ammonium salt.
A particularly preferred novel compound is 4,6,6,6 - tetrachloro - 2 - cyano 3,3 - dimethylhexanoic acid, together with its alkali metal ahd ammonium salts.
These compounds are useful intermediates in the preparation of 2 - (2,2 dichlorovinyl) - 3,3 - dimethylcyclopropanecarboxylic acid, certain esters of which possess insecticidal activity.
The invention also relates to a process for the preparation of the 2cyanohexanoic acid derivatives of the general formula I, which comprises reacting a pentenoic acid compound of the general formula:
wherein R1 and R2 have the same meaning as in the general formula I, with a tetrahalomethane compound of the general formula
CHal2XY (sir) wherein Hal, X and Y have the same meaning as in the general formula I, in the presence of a catalyst, preferably a compound of copper iron, and a solvent capable of dissolving the reactants and the catalyst.
R' and R2 in the general formula II preferably represent methyl groups.
Carbon tetrachloride is the preferred compound of the general formula III.
Suitable solvents for the reaction are polar solvents, for example, acetonitrile, methylene chloride and benzene, and tetrahalomethane compounds of the general formula III; in order to use tetrahalomethane compound as a solvent in the process according to the invention it will have to be used in excess over the amount required as reactant. Mixtures of solvents may also be used.
Examples of suitable catalysts are ferric, cupric or ruthenium chloride, naphthenate, stearate or acetylacetonate. Very good results have been obtained with ferric or cupric chloride.
The process is preferably conducted in the presence of a solubilizer for the catalyst and/or reducing agent. Examples of compounds which enhance the solubility of the catalyst in the solvent are alkylammonium halides, for example diethylammonium chloride, di - n - butylammonium bromide, diethylpropylammonium chloride and trioctylammonium chloride. Examples of reducing agents are benzoin, hydroquinone, aldehydes, stannous chloride and alkali metal sulphites.
The molar ratios of solubilizer to compound of the general formula II and of catalyst to compound of the general formula II may vary within wide limits. Very good yields of compounds of the general formula I are usually obtained when these molar ratios are between 0.001 and 0.2.
An attractive feature of the process according to the invention is that the carboxylic acids of the general formulae I and II do not undergo decarboxylation reactions to any appreciable extent.
The following Examples further illustrate the invention.
EXAMPLE I
A 250 ml glass autoclave was charged with 0.3 mol of 2 - cyano - 3,3 - di methyl - 4- pentenoic acid, 0.9 mol of carbon tetrachloride, 0.6 mol of acetonitrile, 0.03 mol of ferric chloride, 6H2O, 0.03 mol of benzoin and 0.0.z8 mol of diethylammonium chloride. The contents of the autoclave were stirred with a turbine stirrer (620 revolutions per minute), first for two hours at 1050C and then for 18 hours at 750C. Subsequently, the contents of the flask were cooled to 220C, 150 ml of diethyl ether was added and the solution formed was washed four times with 50 ml portions of 10% w aqueous hydrochloric acid to remove most of the iron salt. Then the organic phase was contacted with a 50 ml bed of grains of silica gel for further removal of iron salt. The organic phase thus obtained was boiled down at 30"C and 12 mm Hg. The NMR spectrum of the residue showed that no starting acid and no decarboxylation products were present. The yield of 4,6,6,6 tetrachloro - 2 - cyano - 3,3 - dimethylhexanoic acid was more than 85%, calculated on starting acid.
The NMR spectrum of the product acid measured at 60 MHz in deuterochloroform solution showed the following absorptions relative to a tetramethylsilane standard. On the basis of the spectrum it was established that the acid consisted of two geometric isomers, configuration 1 and configuration 2.
, ppm, configuration
2
CH2 1H doublet 3.42 3.18
CH2 1H singlet 4.23 4.33 CHCl 1H quartet 4.57 4.90
HCCN 1H doublet 3.58 3.58
CH3 3H singlet 1.40 1.40
CH3 3H singlet 1.53 1.53
COOH 1H singlet 8.92 8.92
EXAMPLE II The experiment of Example I was repeated, but 0.1 mol of 2 - cyano - 3,3 dimethyl - 4 - pentenoic acid, 0.01 mol of ferric chloride 6H2O, 0.01 mol of benzoin and 0.006 mol of diethylammonium chloride were used. The contents of the autoclave were stirred for 20 hours at 980C. The yield of 4,6,6,6 - tetrachloro 2 - cyano - 3,3 - dimethylhexanoic acid was more than 90%, calculated on starting acid.
Claims (13)
1. 2-Cyanohexanoic acid derivatives having the general formula:
wherein X and Y each represent a chlorine or bromine atom, each Hal independently represents a fluorine, chlorine or bromine atom and R1 and R2 each independently represent an alkyl group of one to four carbon atoms, or a salt thereof.
2. The compound 4,6,6,6 - tetrachloro - 2 - cyano - 3,3 - dimethylhexanoic acid and its alkali metal and ammonium salts.
3. A process for the preparation of 2-cyanohexanoic acid derivatives of the general formula I, which comprises reacting a pentenoic acid compound of the general formula:
wherein R1 and R2 have the same meaning as in the general formula I, with a tetrahalomethane compound of the general formula: CHal2XY (III) wherein Hal, X and Y have the same meaning as in the general formula I, in the presence of a catalyst and a solvent capable of dissolving the reactants and the catalyst.
4. A process according to claim 3 wherein the tetrahalomethane compound of general formula III is carbon tetrachloride.
5. A process according to claim 3 or 4 wherein the solvent is a polar solvent.
6. A process according to claim 3 or 4 wherein the solvent is acetonitrile, methylene chloride, benzene, or a tetrahalomethane compound of general formula
III.
7. A process according to any one of claims 3 to 6 wherein the catalyst is ferric, cupric or ruthenium chloride, napthenate, stearate or acetylacetonate.
8. A process according to claim 7 wherein the catalyst is ferric or cupric chloride.
9. A process according to any one of claims 3 to 8 wherein the reaction is carried out in the presence of a solubilizer for the catalyst and/or a reducing agent.
10. A process according to claim 9 wherein the solubilizer is an alkylammonium halide.
I 1. A process according to claim 9, wherein the reducing agent is benzoin, hydroquinone, an aldehyde, stannous chloride or an alkali metal sulphite.
12. A process according to claim 3 substantially as hereinbefore described and with reference to Example I or II.
13. 2-Cyanohexanoic acid derivatives prepared by the process claimed in any one of claims 3 to 12.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2826276A GB1580204A (en) | 1976-07-07 | 1976-07-07 | 2-cyanohexanoic acid derivatives |
CA278,776A CA1094103A (en) | 1976-07-07 | 1977-05-19 | 2-cyanohexanoic acid derivatives |
CH825077A CH628878A5 (en) | 1976-07-07 | 1977-07-05 | Process for the preparation of 2-cyanohexanoic acid derivatives |
BR7704406A BR7704406A (en) | 1976-07-07 | 1977-07-05 | PROCESS OF PREPARATION OF 2-CYAN-HEXANOIC ACID DERIVATIVES |
BE179092A BE856490A (en) | 1976-07-07 | 1977-07-05 | 2-CYANOHEXANOIC ACID DERIVATIVES |
IT2541077A IT1081510B (en) | 1976-07-07 | 1977-07-05 | DERIVATIVES OF 2-CYANESANOIC ACID |
DE19772730359 DE2730359A1 (en) | 1976-07-07 | 1977-07-05 | 2-CYANOHEXANOIC ACID DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
FR7720605A FR2357534A1 (en) | 1976-07-07 | 1977-07-05 | 2-CYANOHEXANOIC ACID DERIVATIVES |
MX587477U MX4912E (en) | 1976-07-07 | 1977-07-05 | PROCEDURE FOR PREPARING DERIVATIVES OF 2-CYANOHEXANOIC ACID |
NL7707416A NL7707416A (en) | 1976-07-07 | 1977-07-05 | PROCESS FOR PREPARING 2-CYANHEXAN CARBONIC ACID DERIVATIVES. |
DK302577A DK159265C (en) | 1976-07-07 | 1977-07-05 | PROCEDURE FOR PREPARING 2-CYANOHEXANIC ACID DERIVATIVES |
JP7957777A JPS537622A (en) | 1976-07-07 | 1977-07-05 | Derivatives of 22cyanohexanic acid and method of its manufacturing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2826276A GB1580204A (en) | 1976-07-07 | 1976-07-07 | 2-cyanohexanoic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1580204A true GB1580204A (en) | 1980-11-26 |
Family
ID=10272872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2826276A Expired GB1580204A (en) | 1976-07-07 | 1976-07-07 | 2-cyanohexanoic acid derivatives |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS537622A (en) |
BE (1) | BE856490A (en) |
BR (1) | BR7704406A (en) |
CA (1) | CA1094103A (en) |
CH (1) | CH628878A5 (en) |
DE (1) | DE2730359A1 (en) |
DK (1) | DK159265C (en) |
FR (1) | FR2357534A1 (en) |
GB (1) | GB1580204A (en) |
IT (1) | IT1081510B (en) |
MX (1) | MX4912E (en) |
NL (1) | NL7707416A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1115730A (en) * | 1978-02-20 | 1982-01-05 | Roger A. Sheldon | Preparation of 2-cyanohexanoic acid derivatives and the derivatives prepared by the process |
JP4958428B2 (en) * | 2005-11-25 | 2012-06-20 | Fdkエナジー株式会社 | Alkaline battery |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN142702B (en) * | 1974-09-10 | 1977-08-20 | Sagami Chem Res | |
JPS5159839A (en) * | 1974-10-23 | 1976-05-25 | Sankyo Co | SHIKUROPUROPANKARUBONSANJUDOTAINO SEIZOHO |
LU73349A1 (en) * | 1975-09-08 | 1976-04-13 |
-
1976
- 1976-07-07 GB GB2826276A patent/GB1580204A/en not_active Expired
-
1977
- 1977-05-19 CA CA278,776A patent/CA1094103A/en not_active Expired
- 1977-07-05 BE BE179092A patent/BE856490A/en not_active IP Right Cessation
- 1977-07-05 JP JP7957777A patent/JPS537622A/en active Granted
- 1977-07-05 CH CH825077A patent/CH628878A5/en not_active IP Right Cessation
- 1977-07-05 NL NL7707416A patent/NL7707416A/en not_active Application Discontinuation
- 1977-07-05 IT IT2541077A patent/IT1081510B/en active
- 1977-07-05 FR FR7720605A patent/FR2357534A1/en active Granted
- 1977-07-05 BR BR7704406A patent/BR7704406A/en unknown
- 1977-07-05 DK DK302577A patent/DK159265C/en not_active IP Right Cessation
- 1977-07-05 DE DE19772730359 patent/DE2730359A1/en not_active Withdrawn
- 1977-07-05 MX MX587477U patent/MX4912E/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK159265B (en) | 1990-09-24 |
FR2357534A1 (en) | 1978-02-03 |
DK302577A (en) | 1978-01-08 |
CA1094103A (en) | 1981-01-20 |
DE2730359A1 (en) | 1978-01-12 |
CH628878A5 (en) | 1982-03-31 |
JPS537622A (en) | 1978-01-24 |
JPS616814B2 (en) | 1986-03-01 |
IT1081510B (en) | 1985-05-21 |
MX4912E (en) | 1983-01-03 |
BR7704406A (en) | 1978-05-02 |
FR2357534B1 (en) | 1978-11-03 |
BE856490A (en) | 1978-01-05 |
DK159265C (en) | 1991-02-18 |
NL7707416A (en) | 1978-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940705 |