GB1551388A - Thizotropic topical fluoride-phosphate gel compositions useful for the prevention of dental caries - Google Patents

Thizotropic topical fluoride-phosphate gel compositions useful for the prevention of dental caries

Info

Publication number
GB1551388A
GB1551388A GB28408/76A GB2840876A GB1551388A GB 1551388 A GB1551388 A GB 1551388A GB 28408/76 A GB28408/76 A GB 28408/76A GB 2840876 A GB2840876 A GB 2840876A GB 1551388 A GB1551388 A GB 1551388A
Authority
GB
United Kingdom
Prior art keywords
composition
fluoride
thixotropic
gel
dental
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28408/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacemaker Corp
Original Assignee
Pacemaker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacemaker Corp filed Critical Pacemaker Corp
Publication of GB1551388A publication Critical patent/GB1551388A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/65—Dyes
    • A61K6/66—Photochromic dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/76—Fillers comprising silicon-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Dental Preparations (AREA)
  • Medicinal Preparation (AREA)

Abstract

DENTAL THIXOTROPIC FLUORIDE PHOSPHATE COMPOSITION A fluoride-phosphate dental composition, for topical application to the teeth for the control and prevention of dental caries, which is comprised of active fluoride and phosphate ions in an acid solution with a thixotropic carrier which imparts gel-like properties to the resulting composition. The thixotropic properties of the carrier enable the composition to be handled like a liquid during filling and dispensing by simple agitation of the mixture whereas, when held stationary, the solution sets up very quickly into a gel-like material which enables it to be applied to and retained by a dental applicator tray when inserted in a patient's mouth. The fluoride-phosphate composition, besides its thixotropic gel-like characteristics, is heat- and acid-stable, deep-penetrating to the interproximal surfaces of the teeth and, following set up, will not drip, run or thin out in use, even when used in an inverted tray to treat the lower teeth. In a preferred embodiment the carrier comprises about 10% by weight of the total composition of complex colloidal magnesium aluminum silicate to provide thixotropic properties, and about 1% by weight silica dioxide powder used as an acid-stabilizing and thickening agent, either alone or with additional thickening agents provided, if desired, by carboxymethyl cellulose, hydroxyethyl cellulose or other cellulose gums. Sweeteners, flavoring and coloring agents are also included to improve the appearance, taste and acceptability of the fluoride "gel" composition.
GB28408/76A 1975-10-28 1976-07-08 Thizotropic topical fluoride-phosphate gel compositions useful for the prevention of dental caries Expired GB1551388A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62606875A 1975-10-28 1975-10-28

Publications (1)

Publication Number Publication Date
GB1551388A true GB1551388A (en) 1979-08-30

Family

ID=24508818

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28408/76A Expired GB1551388A (en) 1975-10-28 1976-07-08 Thizotropic topical fluoride-phosphate gel compositions useful for the prevention of dental caries

Country Status (4)

Country Link
AU (1) AU502755B2 (en)
CA (1) CA1092512A (en)
GB (1) GB1551388A (en)
MX (1) MX4362E (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124905A (en) * 1982-08-13 1984-02-29 Nabisco Brands Inc Anti-caries compositions containing saccharin and fluoride
EP0102200A2 (en) * 1982-08-02 1984-03-07 JOHNSON & JOHNSON DENTAL PRODUCTS COMPANY Neutral topical sodium fluoride gel
US4732617A (en) * 1982-08-24 1988-03-22 National Research Development Corporation Fluoride-containing compositions
WO1989010113A1 (en) * 1988-04-26 1989-11-02 Rijksuniversiteit Te Groningen Antimicrobial composition with long-term activity

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0102200A2 (en) * 1982-08-02 1984-03-07 JOHNSON & JOHNSON DENTAL PRODUCTS COMPANY Neutral topical sodium fluoride gel
EP0102200A3 (en) * 1982-08-02 1984-06-13 Johnson & Johnson Dental Products Company Neutral topical sodium fluoride gel
GB2124905A (en) * 1982-08-13 1984-02-29 Nabisco Brands Inc Anti-caries compositions containing saccharin and fluoride
US4732617A (en) * 1982-08-24 1988-03-22 National Research Development Corporation Fluoride-containing compositions
WO1989010113A1 (en) * 1988-04-26 1989-11-02 Rijksuniversiteit Te Groningen Antimicrobial composition with long-term activity

Also Published As

Publication number Publication date
MX4362E (en) 1982-04-19
AU1695376A (en) 1978-02-23
CA1092512A (en) 1980-12-30
AU502755B2 (en) 1979-08-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee