GB1530077A - 5-isothiocyanatoisoquinoline and uses thereof - Google Patents

5-isothiocyanatoisoquinoline and uses thereof

Info

Publication number
GB1530077A
GB1530077A GB2055777A GB2055777A GB1530077A GB 1530077 A GB1530077 A GB 1530077A GB 2055777 A GB2055777 A GB 2055777A GB 2055777 A GB2055777 A GB 2055777A GB 1530077 A GB1530077 A GB 1530077A
Authority
GB
United Kingdom
Prior art keywords
isoquinoline
isoquinol
isothiocyanato
tetrahydroisoquinoline
novel compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2055777A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of GB1530077A publication Critical patent/GB1530077A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1530077 5 - Isothiocyanato - isoquinoline and uses thereof RHONE-POULENC INDUSTRIES 16 May 1977 [18 May 1976] 20557/77 Heading C2C The novel compound 5-isothiocyanato-isoquinoline is prepared by reacting 5-amino-isoquinoline with carbon disulphide and then N,N<SP>1</SP>-dicyclohexylcarbodiimide. The novel compound may be reacted with a 3 - hydroxmethyl - 1,2,3,4 - tetrahydroisoquinoline to form a 3-hydroxymethyl-N-(isoquinol - 5 - yl) - 1,2,3,4 - tetrahydroisoquinoline-2- carbothioamide, which in turn may be cyclized to a 3-(isoquinol-5-ylimino)-1,5,10,10a-tetrahydrothiazolo[3,4-6]-isoquinoline, which as the free base or an acid addition salt shows analgesic and antipyretic activity.
GB2055777A 1976-05-18 1977-05-16 5-isothiocyanatoisoquinoline and uses thereof Expired GB1530077A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7614936A FR2351966A1 (en) 1976-05-18 1976-05-18 NEW DERIVATIVE OF ISOQUINOLEINE

Publications (1)

Publication Number Publication Date
GB1530077A true GB1530077A (en) 1978-10-25

Family

ID=9173278

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2055777A Expired GB1530077A (en) 1976-05-18 1977-05-16 5-isothiocyanatoisoquinoline and uses thereof

Country Status (7)

Country Link
BE (1) BE854761A (en)
DE (1) DE2722637A1 (en)
DK (1) DK214477A (en)
FR (1) FR2351966A1 (en)
GB (1) GB1530077A (en)
NL (1) NL7705151A (en)
SE (1) SE7705848L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3830119A1 (en) * 1988-09-05 1990-03-15 Standard Elektrik Lorenz Ag Optical coupling device

Also Published As

Publication number Publication date
FR2351966A1 (en) 1977-12-16
BE854761A (en) 1977-11-17
NL7705151A (en) 1977-11-22
SE7705848L (en) 1977-11-19
DK214477A (en) 1977-11-19
DE2722637A1 (en) 1977-12-08

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee