GB1524221A - Cancer diagnostic agents - Google Patents
Cancer diagnostic agentsInfo
- Publication number
- GB1524221A GB1524221A GB32336/75A GB3233675A GB1524221A GB 1524221 A GB1524221 A GB 1524221A GB 32336/75 A GB32336/75 A GB 32336/75A GB 3233675 A GB3233675 A GB 3233675A GB 1524221 A GB1524221 A GB 1524221A
- Authority
- GB
- United Kingdom
- Prior art keywords
- recognins
- tests
- gliana
- aqueous solutions
- single line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 238000012360 testing method Methods 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000012817 gel-diffusion technique Methods 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- 108010068258 recognins Proteins 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
1524221 Antigens and antibodies S BOGOCH 1 Aug 1975 32336/75 Heading C3H Compounds, termed Anti-Recognins, characterized by (a) attachment preferentially to tumour cells in histological sections (b) being cytotoxic for gliana brain tumour cells grown in tissue culture in vitro (c) being capable of forming a single line precipitate with "recognins" in quantitative precipitation tests and in Ouchterlony gel diffusion tests and (d) producing fluorescence of gliana cells when coupled with fluorescein are claimed per se. Recognins themselves are characterized by (a) being capable of forming a single line precipitate with its specific antibody in quantitative precipitation tests and Ouchterlony gel diffusion tests (b) being soluble in water and aqueous solutions at acid or neutral pH (c) being insoluble in aqueous solutions at alkaline pH (d) having a spectrophotometric absorption peak wavelength of 280 mÁ and a molecular weight of 3000-25,000 and (e) high concentrations of glutamic and aspartic acid and a high ratio of these acids to histidine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB32336/75A GB1524221A (en) | 1975-08-01 | 1975-08-01 | Cancer diagnostic agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB32336/75A GB1524221A (en) | 1975-08-01 | 1975-08-01 | Cancer diagnostic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1524221A true GB1524221A (en) | 1978-09-06 |
Family
ID=10337026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32336/75A Expired GB1524221A (en) | 1975-08-01 | 1975-08-01 | Cancer diagnostic agents |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1524221A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0006357A1 (en) * | 1978-06-16 | 1980-01-09 | Sankyo Company Limited | Composition and method for detecting gastric cancer |
| EP0007214A1 (en) * | 1978-07-07 | 1980-01-23 | Samuel Dr. Bogoch | Product for detecting the presence of cancerous or malignant tumor cells |
| EP0015755A2 (en) * | 1979-03-09 | 1980-09-17 | Samuel Dr. Bogoch | Recognins, their chemoreciprocals, target attaching globulins and processes for producing these products; methods of detecting cancer tumors |
-
1975
- 1975-08-01 GB GB32336/75A patent/GB1524221A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0006357A1 (en) * | 1978-06-16 | 1980-01-09 | Sankyo Company Limited | Composition and method for detecting gastric cancer |
| EP0007214A1 (en) * | 1978-07-07 | 1980-01-23 | Samuel Dr. Bogoch | Product for detecting the presence of cancerous or malignant tumor cells |
| EP0015755A2 (en) * | 1979-03-09 | 1980-09-17 | Samuel Dr. Bogoch | Recognins, their chemoreciprocals, target attaching globulins and processes for producing these products; methods of detecting cancer tumors |
| EP0015755A3 (en) * | 1979-03-09 | 1980-12-10 | Samuel Dr. Bogoch | Recognins, their chemoreciprocals, target attaching globulins and processes for producing these products; methods of detecting cancer tumors |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |