GB1521747A - Prostaglandin analogues - Google Patents
Prostaglandin analoguesInfo
- Publication number
- GB1521747A GB1521747A GB34688/75A GB3468875A GB1521747A GB 1521747 A GB1521747 A GB 1521747A GB 34688/75 A GB34688/75 A GB 34688/75A GB 3468875 A GB3468875 A GB 3468875A GB 1521747 A GB1521747 A GB 1521747A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aug
- alkyl
- formula
- prostaglandin analogues
- cyclodextrin clathrates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1521747 Cyclodextrin clathrates of prostaglandin derivatives ONO PHARMACEUTICAL CO Ltd 10 Aug 1976 [20 Aug 1975 22 Oct 1975] 34688/75 and 43464/75 Heading C3U [Also in Division C2] The invention comprises cyclodextrin clathrates of 2,3-didehydroprostaglandins of the formula wherein B is O or S; R<1> and R<2> each are H, halogen, CF3, C1-4 alkyl or C1-4 alkoxy; R is COOR<3> or CH2OR<4>, where R<3> is H or C1-12 alkyl and R<4> is H or C2-5 alkanoyl and A is a grouping of the formula and their preparation by known methods.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB34688/75A GB1521747A (en) | 1975-08-20 | 1975-08-20 | Prostaglandin analogues |
US05/713,941 US4065632A (en) | 1975-08-20 | 1976-08-12 | 16-Phenoxy and phenylthio prostaglandin derivatives |
DK370576A DK370576A (en) | 1975-08-20 | 1976-08-17 | PROSTAGLAND INNALOGUE PROCEDURE |
IE1815/76A IE44161B1 (en) | 1975-08-20 | 1976-08-17 | Prostaglandin analogues |
CA259,219A CA1091663A (en) | 1975-08-20 | 1976-08-17 | Prostaglandin analogues |
NL7609134A NL7609134A (en) | 1975-08-20 | 1976-08-17 | PROSTAGLANDIN DERIVATIVES. |
AU16913/76A AU501896B2 (en) | 1975-08-20 | 1976-08-17 | Prostaglandin analogues |
ZA764935A ZA764935B (en) | 1975-08-20 | 1976-08-17 | Prostaglandin analogues |
DE2637393A DE2637393C2 (en) | 1975-08-20 | 1976-08-19 | Prostaglandin analogs, processes for their production and pharmaceutical compositions containing them |
CH1057876A CH613950A5 (en) | 1975-08-20 | 1976-08-19 | |
FR7625179A FR2321277A1 (en) | 1975-08-20 | 1976-08-19 | ANALOGUES OF PROSTAGLANDINS AND METHODS FOR PREPARING THEM |
BE169940A BE845348A (en) | 1975-08-20 | 1976-08-19 | ANALOGUES OF PROSTAGLANDINS AND METHODS FOR PREPARING THEM |
JP51098219A JPS5825669B2 (en) | 1975-08-20 | 1976-08-19 | Prostaglandin-like compounds and their production methods |
LU75622A LU75622A1 (en) | 1975-08-20 | 1976-08-19 | |
HK70/81A HK7081A (en) | 1975-08-20 | 1981-03-05 | Prostaglandin analogues |
JP57127492A JPS5823625A (en) | 1975-08-20 | 1982-07-23 | Corpus luteum contractor or uterotonic agent containing prostaglandin f2 analog |
DK494289A DK494289A (en) | 1975-08-20 | 1989-10-06 | METHOD OF ANALOGY FOR THE PREPARATION OF THERAPEUTICALLY APPLIED PROSTAGLANDIANALOGUE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB34688/75A GB1521747A (en) | 1975-08-20 | 1975-08-20 | Prostaglandin analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1521747A true GB1521747A (en) | 1978-08-16 |
Family
ID=10368733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB34688/75A Expired GB1521747A (en) | 1975-08-20 | 1975-08-20 | Prostaglandin analogues |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5823625A (en) |
BE (1) | BE845348A (en) |
GB (1) | GB1521747A (en) |
ZA (1) | ZA764935B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100347010B1 (en) * | 2000-07-19 | 2002-08-03 | 한국에너지기술연구원 | A method of manufacturing single side corrugated ceramic sheet for gas adsorption. |
-
1975
- 1975-08-20 GB GB34688/75A patent/GB1521747A/en not_active Expired
-
1976
- 1976-08-17 ZA ZA764935A patent/ZA764935B/en unknown
- 1976-08-19 BE BE169940A patent/BE845348A/en not_active IP Right Cessation
-
1982
- 1982-07-23 JP JP57127492A patent/JPS5823625A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5823625A (en) | 1983-02-12 |
BE845348A (en) | 1977-02-21 |
JPS6124369B2 (en) | 1986-06-10 |
ZA764935B (en) | 1977-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |