GB1521747A - Prostaglandin analogues - Google Patents

Prostaglandin analogues

Info

Publication number
GB1521747A
GB1521747A GB34688/75A GB3468875A GB1521747A GB 1521747 A GB1521747 A GB 1521747A GB 34688/75 A GB34688/75 A GB 34688/75A GB 3468875 A GB3468875 A GB 3468875A GB 1521747 A GB1521747 A GB 1521747A
Authority
GB
United Kingdom
Prior art keywords
aug
alkyl
formula
prostaglandin analogues
cyclodextrin clathrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34688/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to GB34688/75A priority Critical patent/GB1521747A/en
Priority to US05/713,941 priority patent/US4065632A/en
Priority to CA259,219A priority patent/CA1091663A/en
Priority to AU16913/76A priority patent/AU501896B2/en
Priority to NL7609134A priority patent/NL7609134A/en
Priority to ZA764935A priority patent/ZA764935B/en
Priority to DK370576A priority patent/DK370576A/en
Priority to IE1815/76A priority patent/IE44161B1/en
Priority to FR7625179A priority patent/FR2321277A1/en
Priority to JP51098219A priority patent/JPS5825669B2/en
Priority to DE2637393A priority patent/DE2637393C2/en
Priority to CH1057876A priority patent/CH613950A5/xx
Priority to LU75622A priority patent/LU75622A1/xx
Priority to BE169940A priority patent/BE845348A/en
Publication of GB1521747A publication Critical patent/GB1521747A/en
Priority to HK70/81A priority patent/HK7081A/en
Priority to JP57127492A priority patent/JPS5823625A/en
Priority to DK494289A priority patent/DK494289A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1521747 Cyclodextrin clathrates of prostaglandin derivatives ONO PHARMACEUTICAL CO Ltd 10 Aug 1976 [20 Aug 1975 22 Oct 1975] 34688/75 and 43464/75 Heading C3U [Also in Division C2] The invention comprises cyclodextrin clathrates of 2,3-didehydroprostaglandins of the formula wherein B is O or S; R<1> and R<2> each are H, halogen, CF3, C1-4 alkyl or C1-4 alkoxy; R is COOR<3> or CH2OR<4>, where R<3> is H or C1-12 alkyl and R<4> is H or C2-5 alkanoyl and A is a grouping of the formula and their preparation by known methods.
GB34688/75A 1975-08-20 1975-08-20 Prostaglandin analogues Expired GB1521747A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB34688/75A GB1521747A (en) 1975-08-20 1975-08-20 Prostaglandin analogues
US05/713,941 US4065632A (en) 1975-08-20 1976-08-12 16-Phenoxy and phenylthio prostaglandin derivatives
CA259,219A CA1091663A (en) 1975-08-20 1976-08-17 Prostaglandin analogues
AU16913/76A AU501896B2 (en) 1975-08-20 1976-08-17 Prostaglandin analogues
NL7609134A NL7609134A (en) 1975-08-20 1976-08-17 PROSTAGLANDIN DERIVATIVES.
ZA764935A ZA764935B (en) 1975-08-20 1976-08-17 Prostaglandin analogues
DK370576A DK370576A (en) 1975-08-20 1976-08-17 PROSTAGLAND INNALOGUE PROCEDURE
IE1815/76A IE44161B1 (en) 1975-08-20 1976-08-17 Prostaglandin analogues
JP51098219A JPS5825669B2 (en) 1975-08-20 1976-08-19 Prostaglandin-like compounds and their production methods
FR7625179A FR2321277A1 (en) 1975-08-20 1976-08-19 ANALOGUES OF PROSTAGLANDINS AND METHODS FOR PREPARING THEM
DE2637393A DE2637393C2 (en) 1975-08-20 1976-08-19 Prostaglandin analogs, processes for their production and pharmaceutical compositions containing them
CH1057876A CH613950A5 (en) 1975-08-20 1976-08-19
LU75622A LU75622A1 (en) 1975-08-20 1976-08-19
BE169940A BE845348A (en) 1975-08-20 1976-08-19 ANALOGUES OF PROSTAGLANDINS AND METHODS FOR PREPARING THEM
HK70/81A HK7081A (en) 1975-08-20 1981-03-05 Prostaglandin analogues
JP57127492A JPS5823625A (en) 1975-08-20 1982-07-23 Corpus luteum contractor or uterotonic agent containing prostaglandin f2 analog
DK494289A DK494289A (en) 1975-08-20 1989-10-06 METHOD OF ANALOGY FOR THE PREPARATION OF THERAPEUTICALLY APPLIED PROSTAGLANDIANALOGUE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB34688/75A GB1521747A (en) 1975-08-20 1975-08-20 Prostaglandin analogues

Publications (1)

Publication Number Publication Date
GB1521747A true GB1521747A (en) 1978-08-16

Family

ID=10368733

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34688/75A Expired GB1521747A (en) 1975-08-20 1975-08-20 Prostaglandin analogues

Country Status (4)

Country Link
JP (1) JPS5823625A (en)
BE (1) BE845348A (en)
GB (1) GB1521747A (en)
ZA (1) ZA764935B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100347010B1 (en) * 2000-07-19 2002-08-03 한국에너지기술연구원 A method of manufacturing single side corrugated ceramic sheet for gas adsorption.

Also Published As

Publication number Publication date
BE845348A (en) 1977-02-21
JPS5823625A (en) 1983-02-12
JPS6124369B2 (en) 1986-06-10
ZA764935B (en) 1977-07-27

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee