GB1499768A - Manufacture of pyrazines - Google Patents

Manufacture of pyrazines

Info

Publication number
GB1499768A
GB1499768A GB1977075A GB1977075A GB1499768A GB 1499768 A GB1499768 A GB 1499768A GB 1977075 A GB1977075 A GB 1977075A GB 1977075 A GB1977075 A GB 1977075A GB 1499768 A GB1499768 A GB 1499768A
Authority
GB
United Kingdom
Prior art keywords
manufacture
pyrazines
nitrooxirane
ammonia
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1977075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of GB1499768A publication Critical patent/GB1499768A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1499768 Manufacture of pyrazines BASF AG 12 May 1975 [25 May 1974] 19770/75 Heading C2C The invention comprises a process for the manufacture of a pyrazine wherein a 2-nitrooxirane bearing a free hydrogen atom in the 3 position is reacted with ammonia. Preferably from 5 to 50 moles of ammonia are used per mole of 2-nitrooxirane. The reaction is generally carried out at from 20‹ to 200‹ C. preferably at from 10 to 100 atmospheres. If necessary, solvents which are inert under the reaction conditions are used to dissolve or suspend the starting mixture and reaction mixtures. Examples describe the preparation of 2,3,5,6- bishexamethylenopyrizine, 2,3,5,6 - tetraphenylpyrazine, 2,5 - dimethyl - 3,6 - diphenyl pyrazine and 2,5-dimethyl-3,6-diphenylpyrazine
GB1977075A 1974-05-25 1975-05-12 Manufacture of pyrazines Expired GB1499768A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742425355 DE2425355A1 (en) 1974-05-25 1974-05-25 METHOD FOR MANUFACTURING PYRAZINES

Publications (1)

Publication Number Publication Date
GB1499768A true GB1499768A (en) 1978-02-01

Family

ID=5916449

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1977075A Expired GB1499768A (en) 1974-05-25 1975-05-12 Manufacture of pyrazines

Country Status (9)

Country Link
JP (1) JPS511483A (en)
BE (1) BE829444A (en)
CA (1) CA1041510A (en)
CH (1) CH593268A5 (en)
DE (1) DE2425355A1 (en)
FR (1) FR2272086B3 (en)
GB (1) GB1499768A (en)
IT (1) IT1037680B (en)
NL (1) NL7506038A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995161B2 (en) 2000-02-16 2006-02-07 Neurogen Corporation Substituted arylpyrazines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995161B2 (en) 2000-02-16 2006-02-07 Neurogen Corporation Substituted arylpyrazines
US7202250B2 (en) 2000-02-16 2007-04-10 Neurogen Corporation Substituted arylpyrazines

Also Published As

Publication number Publication date
BE829444A (en) 1975-11-24
FR2272086B3 (en) 1978-12-01
FR2272086A1 (en) 1975-12-19
IT1037680B (en) 1979-11-20
DE2425355A1 (en) 1975-12-04
JPS511483A (en) 1976-01-08
CH593268A5 (en) 1977-11-30
NL7506038A (en) 1975-11-27
CA1041510A (en) 1978-10-31

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee