GB1497316A - Peptides for control of intestinal motility - Google Patents

Peptides for control of intestinal motility

Info

Publication number
GB1497316A
GB1497316A GB46577/75A GB4657775A GB1497316A GB 1497316 A GB1497316 A GB 1497316A GB 46577/75 A GB46577/75 A GB 46577/75A GB 4657775 A GB4657775 A GB 4657775A GB 1497316 A GB1497316 A GB 1497316A
Authority
GB
United Kingdom
Prior art keywords
water
volume
acetic acid
value
butanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46577/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp filed Critical Research Corp
Publication of GB1497316A publication Critical patent/GB1497316A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1497316 Pituitary polypeptide compositions RESEARCH CORP 11 Nov 1975 [14 Nov 1974 3 Nov 1975] 46577/75 Heading A5B [Also in Division C3] A pharmaceutical composition, which may be used for the control of intestinal mobility and which also has vasoconstrictor activity comprises a pharmaceutically acceptable carrier and a compound which is selected from (1) a peptide designated coherin A having the following characteristics (i) contains glycine (ii) is soluble in water, slightly soluble in absolute ethanol, insoluble in acetone and diethyl ether (iii) has the following ultra-violet spectrum; # max, 274 nm (pH 1), 240 nm and 290 nm (pH 11); # min, 248 nm (pH 1), 233 nm and 272 nm (pH 11) (iv) has a molecular weight of 300 to 600 (v) has a melting point of 200 to 205‹C (vi) has an isoelectric point at pH 6.0 (vii) has an Rf value of 0.70 (n-butanol/pyridene/acetic acid/ water, 60:40:12:48 by volume); an Rf value of 0.33 (n-butanol/acetic acid/water, 4:1:5 by volume) by thin-layer chromatography on silica gel on glass; (2) a peptide designated coherin B having the following characteristics (i) contains glycine, serine and glutamic acid (ii) is soluble in water, slightly soluble in absolute ethanol, insoluble in acetone and diethyl ether (iii) has the following ultra - violet spectrum; # max 276 nm (pH 1), 239 nm and 290 nm (pH 11); # min 236 nm (pH 1), 253 nm and 276 nm (pH 11) (iv) has an isoelectric point at pH 8.5 (v) has an Rf value of 0.58 (nbutanol/pyridene/acetic acid/water, 60:40:12:48 by volume), an Rf value of 0.03 (n-butanol/ acetic acid/water, 4:1:5 by volume) by thinlayer chromatograph on silica gel on glass and pharmaceutically-acceptable salts of (I) and (2). The peptides (I) and (2) may be obtained from bovine posterior pituary.
GB46577/75A 1974-11-14 1975-11-11 Peptides for control of intestinal motility Expired GB1497316A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52380674A 1974-11-14 1974-11-14
US62777775A 1975-11-03 1975-11-03

Publications (1)

Publication Number Publication Date
GB1497316A true GB1497316A (en) 1978-01-05

Family

ID=27061272

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46577/75A Expired GB1497316A (en) 1974-11-14 1975-11-11 Peptides for control of intestinal motility

Country Status (5)

Country Link
JP (1) JPS6114126B2 (en)
CA (1) CA1052772A (en)
DE (1) DE2550992A1 (en)
FR (1) FR2290911A1 (en)
GB (1) GB1497316A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707965A (en) * 1974-11-14 1998-01-13 Intesco Laboratories, Inc. Peptides for control of intestinal motility
EP1609375A1 (en) * 2004-01-14 2005-12-28 Ajinomoto Co., Inc. Glycine-containing food and use thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707965A (en) * 1974-11-14 1998-01-13 Intesco Laboratories, Inc. Peptides for control of intestinal motility
EP1609375A1 (en) * 2004-01-14 2005-12-28 Ajinomoto Co., Inc. Glycine-containing food and use thereof
EP1609375A4 (en) * 2004-01-14 2006-08-30 Ajinomoto Kk Glycine-containing food and use thereof
US10561629B2 (en) 2004-01-14 2020-02-18 Ajinomoto Co., Inc. Food containing glycine and use thereof

Also Published As

Publication number Publication date
FR2290911B1 (en) 1982-07-02
CA1052772A (en) 1979-04-17
JPS6114126B2 (en) 1986-04-17
JPS5191311A (en) 1976-08-10
DE2550992C2 (en) 1988-01-28
DE2550992A1 (en) 1976-05-20
FR2290911A1 (en) 1976-06-11

Similar Documents

Publication Publication Date Title
US3862925A (en) Preparation of somatotropin release inhibiting factor and intermediates therefor
Yamashiro et al. Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method
Ostrowski et al. Purification and cell-free synthesis of a major protein from rat seminal vesicle secretion
Bietz et al. Isolation and characterization of gliadin-like subunits from glutenin
Scott et al. Corticotrophin-like peptides in the rat pituitary
Schally et al. Evidence for the existence of two corticotrophin-releasing factors, α and β
IE46104L (en) Gamma globulin fraction suitable for intravenous injection
Meyers et al. Highly active position eight analogs of somatostatin and separation of peptide diastereomers by partition chromatography
US4271068A (en) Process for the manufacture of cystine-containing peptides
GB1394846A (en) Polypeptides
Russell et al. Rat serum albumin biosynthesis: evidence for a precursor
US4275001A (en) Process for the manufacture of LH-RH and LH-RH analogs using Glu-His(DnP)-OH
Canova-Davis et al. Chemical modification of the tryptophan residue in adrenocorticotropin
SE7511924L (en) PROCEDURE FOR THE PRODUCTION OF BIOLOGICALLY ACTIVE PEPTIDES
RASMUSSEN et al. The isolation of arginine vasotocin from fish pituitary glands
GB1497316A (en) Peptides for control of intestinal motility
SE7708678L (en) PROTEIN HORMONES
Kornguth et al. The Stability and Rearrangement of iε-N-Glutamyl-Lysines
DE3151738C2 (en)
Prasad et al. Structure-activity relationships in luteinizing hormone-releasing hormone
Yamaji et al. On the biosynthesis of insulin in anglerfish islets
Flouret et al. Synthesis and biological activity of the hypothalamic LH-and FSH-releasing decapeptide
US4062816A (en) D-Ala5 -somatostatin and intermediates thereto
Tamura et al. Purification and Properties of Whale Thyroid-stimulating Hormone I. Evidence for the Presence of Multiple Components and Their Origin
Wolfenstein et al. Structure of immunoglobulin AI Interchain disulfide bridges of a γAl myeloma protein

Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19951110