GB1493605A - Preparation of aminophenylalkyl ethers - Google Patents

Abstract

1493605 Preparation of aminophenylalkylethers HOECHST AG 28 Oct 1974 [30 Oct 1973] 46526/74 Addition to 1323440 Heading C2C A process for the preparation of an aminophenyl alkyl ether of formula wherein z represents 0 or an integer from 1 to 3, each of the Y moieties, any two or more of which may be the same or different represents a C 1-4 alkyl group, n represents an integer from 1 to 3, and each of the X moieties, any two or more of which may be the same or different represents a C 1-4 alkyl group, comprises catalytically hydrogenating the corresponding nitroderivatives in the presence of (i) an inert aromatic hydrocarbon which has a dielectric constant in the range of from 2 to 3 and which under the reaction conditions is immiscible with water but capable of dissolving the starting material and amino end product, e.g. benzene, toluene, isomeric xylenes, ethylbenzene and cumene; (ii) an inorganic salt which maintains a pH in the range of from 8 to 10 during the reaction. The preferred inorganic salts are disodium hydrogen phosphate, disodium tetraborate, disodium diborate, sodium acetate, sodium formate or dipotassium hydrogen phosphate, dipotassium tetraborate, dipotassium diborate, potassium acetate or potassium formate. The following compounds are prepared in the examples: resorcinol dimethyl ether, o- and p-anisidine and aminohydroquinonedimethylether.