GB1489623A - Process for the preparation of an immuno-sorbent and method for its use - Google Patents

Process for the preparation of an immuno-sorbent and method for its use

Info

Publication number
GB1489623A
GB1489623A GB46990/74A GB4699074A GB1489623A GB 1489623 A GB1489623 A GB 1489623A GB 46990/74 A GB46990/74 A GB 46990/74A GB 4699074 A GB4699074 A GB 4699074A GB 1489623 A GB1489623 A GB 1489623A
Authority
GB
United Kingdom
Prior art keywords
aqueous
antibody
solvent systems
isoenzyme
ldh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46990/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB1489623A publication Critical patent/GB1489623A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material

Abstract

1489623 Entrapped proteins MILES LABORATORIES Inc 30 Oct 1974 [7 Dec 1973] 46990/74 Heading C3H [Also in Division G1] A material useful for removing an antigen from an aqueous fluid comprises an antibody to said antigen entrapped in a solid, substantially non-hydrophilic polymer matrix which is insoluble and substantially non-swellable in water, said matrix having been prepared by interfacial polymerization between two immiscible solvent systems comprising monomers of said polymer, one of which solvent systems is aqueous and contains said antibody, and both solvent systems being substantially inert with respect to the immunological activity of the antibody. The material may be in the form of a membrane formed by dipping a metal loop carrying a film of the aqueous solvent system containing antibody (e.g. aqueous 1 : 6-hexamethylenediamine and bovine serum containing a specific antibody) into a non-aqueous solvent system (e.g. sebacoyl chloride in chloroform/cyclohexane mixture); or the material may be made in particulate form by stirring the two solvent systems together. In Examples 3 and 4, membranes containing the anti-bodies anti-M 4 isoenzyme of lactic dehydrogenase (LDH) and antiplacental alkaline phosphatase are used respectively to remove the antigens M 4 LDH isoenzyme and placental alkaline phosphatase isoenzyme from aqueous solutions thereof.
GB46990/74A 1973-12-07 1974-10-30 Process for the preparation of an immuno-sorbent and method for its use Expired GB1489623A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42278473A 1973-12-07 1973-12-07

Publications (1)

Publication Number Publication Date
GB1489623A true GB1489623A (en) 1977-10-26

Family

ID=23676357

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46990/74A Expired GB1489623A (en) 1973-12-07 1974-10-30 Process for the preparation of an immuno-sorbent and method for its use

Country Status (4)

Country Link
JP (1) JPS5089523A (en)
FR (1) FR2253552A1 (en)
GB (1) GB1489623A (en)
SE (1) SE396225B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640760A (en) * 1979-09-10 1981-04-17 Japan Atom Energy Res Inst Medical analysis use unit and its manufacture
DE2952478A1 (en) * 1979-12-27 1981-07-30 Merck Patent Gmbh, 6100 Darmstadt METHOD AND MEANS FOR THE IMMUNOLOGICAL DETERMINATION OF ENZYMES
JPS56110053A (en) * 1980-02-05 1981-09-01 Japan Atom Energy Res Inst Unit system for medical analysis and preparation thereof
JPS56110052A (en) * 1980-02-05 1981-09-01 Japan Atom Energy Res Inst Manufacture of unit system for medical analysis
EP0186100B1 (en) * 1984-12-24 1992-04-01 Abbott Laboratories Analytical device and method for using same

Also Published As

Publication number Publication date
SE396225B (en) 1977-09-12
DE2457845A1 (en) 1975-06-19
DE2457845B2 (en) 1976-01-22
JPS5089523A (en) 1975-07-18
FR2253552A1 (en) 1975-07-04
SE7409785L (en) 1975-06-09
AU7019174A (en) 1975-12-18

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee