GB1489541A - Process for preparing 2-(n-(2-dimethylamino ethyl)-n-(p-methoxybenzyl)-amino)pyridine 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-acetate - Google Patents

Process for preparing 2-(n-(2-dimethylamino ethyl)-n-(p-methoxybenzyl)-amino)pyridine 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-acetate

Info

Publication number
GB1489541A
GB1489541A GB7263/76A GB726376A GB1489541A GB 1489541 A GB1489541 A GB 1489541A GB 7263/76 A GB7263/76 A GB 7263/76A GB 726376 A GB726376 A GB 726376A GB 1489541 A GB1489541 A GB 1489541A
Authority
GB
United Kingdom
Prior art keywords
dioxopurin
tetrahydro
dimethyl
amino
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7263/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Publication of GB1489541A publication Critical patent/GB1489541A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

1489541 Mepyramine theophylline acetate LABORATORIOS MADE SA 24 Feb 1976 [1 March 1975] 07263/76 Addition to 1438529 Heading C2C 2 - [N - (2 - Dimethylaminoethyl) - N - (pmethoxybenzyl) - amino] - pyridine 1,2,3,6- tetrahydro - 1,3, - dimethyl - 2,6 - dioxopurin-7- acetate is obtained by slowly adding 2[N-(2- dimethylaminoethyl) - N - (p - methoxybenzyl)- amino]-pyridine dissolved in a solvent, e.g. an alkanol to a suspension of 1,2,3,6-tetrahydro- 1,3 - dimethyl - 2,6 - dioxopurin - 7 - acetic acid in the same solvent and evaporating the resulting solution of the product to dryness to yield a crude product which is then treated with a solvent, e.g. an ester solvent, from which the product is crystallized.
GB7263/76A 1975-03-01 1976-02-24 Process for preparing 2-(n-(2-dimethylamino ethyl)-n-(p-methoxybenzyl)-amino)pyridine 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-acetate Expired GB1489541A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES435215A ES435215A1 (en) 1975-03-01 1975-03-01 Process for preparing 2-(n-(2-dimethylamino ethyl)-n-(p-methoxybenzyl)-amino)pyridine 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-acetate

Publications (1)

Publication Number Publication Date
GB1489541A true GB1489541A (en) 1977-10-19

Family

ID=8468754

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7263/76A Expired GB1489541A (en) 1975-03-01 1976-02-24 Process for preparing 2-(n-(2-dimethylamino ethyl)-n-(p-methoxybenzyl)-amino)pyridine 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-acetate

Country Status (6)

Country Link
JP (1) JPS51118793A (en)
AR (1) AR213826A1 (en)
BE (1) BE838551R (en)
ES (1) ES435215A1 (en)
FR (1) FR2303015A2 (en)
GB (1) GB1489541A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2606329B1 (en) * 2015-09-21 2018-02-28 Fundación Universitaria San Pablo - Ceu A new synthesis and new galenic presentations of mepyramine 7-theophyllinacetate

Also Published As

Publication number Publication date
JPS51118793A (en) 1976-10-18
AR213826A1 (en) 1979-03-30
ES435215A1 (en) 1976-11-16
BE838551R (en) 1976-08-13
FR2303015B2 (en) 1978-05-05
JPS5242800B2 (en) 1977-10-26
FR2303015A2 (en) 1976-10-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee