GB1482785A - Method of preparing a homogeneous lyophilised composition - Google Patents

Method of preparing a homogeneous lyophilised composition

Info

Publication number
GB1482785A
GB1482785A GB4705874A GB4705874A GB1482785A GB 1482785 A GB1482785 A GB 1482785A GB 4705874 A GB4705874 A GB 4705874A GB 4705874 A GB4705874 A GB 4705874A GB 1482785 A GB1482785 A GB 1482785A
Authority
GB
United Kingdom
Prior art keywords
droplets
liquid
substance
lyophilised
homogeneous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4705874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Priority to GB4705874A priority Critical patent/GB1482785A/en
Publication of GB1482785A publication Critical patent/GB1482785A/en
Expired legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1482785 Lyophilised products E I DU PONT DE NEMOURS & CO 30 Oct 1974 47058/74 Addition to 1316522 Heading A5B An homogeneous lyophilised biologically active substance is prepared by a method which comprises (a) spraying a solution or colloidal suspension of the substance in a liquid, which will both freeze and vaporise from the solid state at a temperature at which the biological activity of the substance is not destroyed, in the form of droplets into a stirred boiling fluorocarbon refrigerant at below -20‹C to freeze the droplets, (b) subjecting the frozen droplets to a vacuum at a temperature such that substantially all the frozen liquid sublimes from the droplets; and (c) allowing the particles to come to room temperature and pressure. The liquid may be organio or water. The active substance may be a vitamin, hormone, tranquilizer, antibiotic, an enzyme, gelatine or other protein. The products of the Examples are bacitracin, polymyxin B, tetracycline, chlorpromazine testosterone, cholesterol and gelatine. The refrigerant may be dichlorofluoromethane. The product is in the form of spheres of diameter not greater than 1 mm and a "standard dissolution time" (defined) not exceeding 2 minutes, at least 90% of the particles being pores.
GB4705874A 1974-10-30 1974-10-30 Method of preparing a homogeneous lyophilised composition Expired GB1482785A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4705874A GB1482785A (en) 1974-10-30 1974-10-30 Method of preparing a homogeneous lyophilised composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4705874A GB1482785A (en) 1974-10-30 1974-10-30 Method of preparing a homogeneous lyophilised composition

Publications (1)

Publication Number Publication Date
GB1482785A true GB1482785A (en) 1977-08-17

Family

ID=10443553

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4705874A Expired GB1482785A (en) 1974-10-30 1974-10-30 Method of preparing a homogeneous lyophilised composition

Country Status (1)

Country Link
GB (1) GB1482785A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133983A (en) * 1983-01-25 1984-08-08 Lafon Labor Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses
EP0475409A2 (en) * 1990-09-12 1992-03-18 Lifecell Corporation Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
WO2006008006A1 (en) * 2004-07-23 2006-01-26 Bayer Technology Services Gmbh Sterile freezing, drying, storing, assaying and filling process (sfd-saf process) (pellet freeze-drying process for parenteral biopharmaceuticals)
US7358284B2 (en) 1998-06-19 2008-04-15 Lifecell Corporation Particulate acellular tissue matrix
US8067149B2 (en) 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133983A (en) * 1983-01-25 1984-08-08 Lafon Labor Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses
EP0475409A2 (en) * 1990-09-12 1992-03-18 Lifecell Corporation Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
EP0475409A3 (en) * 1990-09-12 1993-09-01 Lifecell Corporation Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5364756A (en) * 1990-09-12 1994-11-15 Lifecell Method of cryopreserving a suspension of biological material
US5780295A (en) * 1990-09-12 1998-07-14 Life Cell Corporation Apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
US6194136B1 (en) 1990-09-12 2001-02-27 Lifecell Corporation Cryoprotective solutions comprising DMSO, PG, 2,3-butanediol,raffinose and PVP
US8067149B2 (en) 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US7358284B2 (en) 1998-06-19 2008-04-15 Lifecell Corporation Particulate acellular tissue matrix
WO2006008006A1 (en) * 2004-07-23 2006-01-26 Bayer Technology Services Gmbh Sterile freezing, drying, storing, assaying and filling process (sfd-saf process) (pellet freeze-drying process for parenteral biopharmaceuticals)
US7836606B2 (en) 2004-07-23 2010-11-23 Bayer Technology Services Gmbh Sterile freezing, drying, storing, assaying and filling process

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Legal Events

Date Code Title Description
PS Patent sealed