GB1480975A - Thiazole derivatives - Google Patents

Thiazole derivatives

Info

Publication number
GB1480975A
GB1480975A GB20147/75A GB2014775A GB1480975A GB 1480975 A GB1480975 A GB 1480975A GB 20147/75 A GB20147/75 A GB 20147/75A GB 2014775 A GB2014775 A GB 2014775A GB 1480975 A GB1480975 A GB 1480975A
Authority
GB
United Kingdom
Prior art keywords
thiazole derivatives
synthesis
natural prostaglandins
novel
carbalkoxyheptanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20147/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Institute for Drugs Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Drugs Research Ltd filed Critical Institute for Drugs Research Ltd
Publication of GB1480975A publication Critical patent/GB1480975A/en
Expired legal-status Critical Current

Links

Classifications

    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21D—SHAFTS; TUNNELS; GALLERIES; LARGE UNDERGROUND CHAMBERS
    • E21D23/00—Mine roof supports for step- by- step movement, e.g. in combination with provisions for shifting of conveyors, mining machines, or guides therefor
    • E21D23/0004—Mine roof supports for step- by- step movement, e.g. in combination with provisions for shifting of conveyors, mining machines, or guides therefor along the working face
    • E21D23/0017—Pile type supports
    • E21D23/0021—Pile type supports comprising two walking elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21D—SHAFTS; TUNNELS; GALLERIES; LARGE UNDERGROUND CHAMBERS
    • E21D23/00—Mine roof supports for step- by- step movement, e.g. in combination with provisions for shifting of conveyors, mining machines, or guides therefor
    • E21D23/04—Structural features of the supporting construction, e.g. linking members between adjacent frames or sets of props; Means for counteracting lateral sliding on inclined floor
    • E21D23/0409—Aligning or guiding means for the supports or for the constitutive parts of the supports

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mining & Mineral Resources (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Geology (AREA)
  • Architecture (AREA)
  • Structural Engineering (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel thiazole derivatives with prostaglandin side chains, of the formula I are prepared starting from acetoacetic ester and 7-carbalkoxyheptanoyl chloride in a 13-stage synthesis, where the individual stages comprise known methods. The synthesis is described in the Patent Claim. The novel compounds exert on certain organs an effect which is similar to but more selective than that of the natural prostaglandins. In addition, they inhibit the activity of those enzymes which promote breakdown of the natural prostaglandins in the organism.
GB20147/75A 1974-05-14 1975-05-13 Thiazole derivatives Expired GB1480975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUGO1269A HU169072B (en) 1974-05-14 1974-05-14

Publications (1)

Publication Number Publication Date
GB1480975A true GB1480975A (en) 1977-07-27

Family

ID=10996766

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20147/75A Expired GB1480975A (en) 1974-05-14 1975-05-13 Thiazole derivatives

Country Status (15)

Country Link
JP (1) JPS5163171A (en)
AT (1) AT351525B (en)
BE (1) BE828994A (en)
CA (1) CA1053683A (en)
CH (1) CH613959A5 (en)
DD (1) DD117462A1 (en)
DE (1) DE2521517A1 (en)
DK (1) DK144065C (en)
FR (1) FR2270872B1 (en)
GB (1) GB1480975A (en)
HU (1) HU169072B (en)
NL (1) NL7505585A (en)
PL (1) PL107592B1 (en)
SE (1) SE421918B (en)
SU (1) SU755197A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022794A (en) * 1976-05-24 1977-05-10 Merck & Co., Inc. Novel analogs of prostaglandins with 4-oxo-thiazolidinyl nucleus and method of preparation thereof
DE2946810A1 (en) * 1979-11-20 1981-05-27 A. Nattermann & Cie GmbH, 5000 Köln ALKENYL-THIENYL-ALKANIC CARBONIC ACID AND ITS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME

Also Published As

Publication number Publication date
DE2521517A1 (en) 1975-11-27
SU755197A3 (en) 1980-08-07
DD117462A1 (en) 1976-01-12
PL107592B1 (en) 1980-02-29
ATA366775A (en) 1979-01-15
AT351525B (en) 1979-07-25
FR2270872A1 (en) 1975-12-12
BE828994A (en) 1975-09-01
CA1053683A (en) 1979-05-01
JPS5163171A (en) 1976-06-01
DK144065C (en) 1982-05-17
NL7505585A (en) 1975-11-18
HU169072B (en) 1976-09-28
AU8113575A (en) 1976-11-18
DK144065B (en) 1981-11-30
SE7505494L (en) 1975-11-17
DK210175A (en) 1975-11-15
FR2270872B1 (en) 1978-10-06
SE421918B (en) 1982-02-08
CH613959A5 (en) 1979-10-31

Similar Documents

Publication Publication Date Title
SE7513990L (en) METHODS OF PRODUCING 3-AMINO-INDIAZOLE CARBONIC ACID DERIVATIVES
MX2953E (en) METHOD TO OBTAIN A LIPOLYTIC ENZYMATIC FLAVOR
ZA755289B (en) Conversion of modified synthesis gas to oxygenated organic chemicals
CA1005772A (en) Enzymatic treatment of hides
IT1043579B (en) PROCEDURE TO PRODUCE SEQUENCES OF DINARY SIGNALS SIMILAR BY CASE
IT1056395B (en) METHOD TO PRODUCE CATALYSTS FOR THE TREATMENT OF EXHAUST GAS
GB1480975A (en) Thiazole derivatives
IT1048346B (en) PROCEDURE TO PRODUCE STIROLO
SE407944B (en) WAY TO PRODUCE COKE
BG27915A3 (en) Method of obtaining of moenomyzin
TR19137A (en) TREATMENT OF MEAT EXTENDERS
ZA746785B (en) Phenyl and naphtyl esters of pga, pge and pgf2 &prostaglandins
NL7500094A (en) ARYLPIPERAZINE DERIVATIVES OF ADENINE.
IT1026306B (en) ENZYMATIC PROCEDURE FOR THE PRODUCTION OF MALTOSE
SE417694B (en) CONTINUE TO CONTINUOUSLY BUILD SHIPS
GB1490290A (en) Preparation of penicillanic acid derivatives
SE7504745L (en) PROCEDURE FOR NATURAL VITAMINATION OF CEREALS.
SE7508779L (en) WAY TO PRODUCE PROSTANIC ACID DERIVATIVES
NL7512062A (en) NEW UNSATURATED PHOSPHORIC CARBONIC ACID DERIVATIVES.
IT1008980B (en) PROCEDURE AND PLANT TO PRODUCE CHLOROPRENE
SU476855A1 (en) The method of harvesting trees with root
CA1033768A (en) Production of acetone
CS185680B2 (en) Mixture for conservation treatment of agricultural products
FR2427323A1 (en) NEW ESTERS OF SAFRANIC ACIDS
SE7507788L (en) WAY TO TREAT SKIN

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746 Register noted 'licences of right' (sect. 46/1977)
PCNP Patent ceased through non-payment of renewal fee