GB1473433A - - Google Patents
Info
- Publication number
- GB1473433A GB1473433A GB4148275A GB4148275A GB1473433A GB 1473433 A GB1473433 A GB 1473433A GB 4148275 A GB4148275 A GB 4148275A GB 4148275 A GB4148275 A GB 4148275A GB 1473433 A GB1473433 A GB 1473433A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- arylsulphonamido
- alkylamines
- compounds
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1473433 #-(Arylsulphonamido)-alkylamines BANYU PHARMACEUTICAL CO Ltd H HIDAKA and N AOKI 9 Oct 1975 41482/75 Heading C2C The invention comprises #-(arylsulphonamido) alkylamines of the formula wherein R represents an amino group or an acylated amino group, R<SP>1</SP> represents a halonaphthyl group; and n represents an integer of 5 to 8. The compounds of the invention may be prepared by (i) reacting an aliphatic diamine of formula R(CH 2 ) n NH 2 with an arylsulphonyl halide of formula R<SP>1</SP>SO 2 X where X represents a halogen atom; and then if necessary removing the acyl protecting group or (ii) converting an #-(arylsulphamide)-alkanoic azide of formula R<SP>1</SP>SO 2 NH(CH 2 ) n CON 3 to the corresponding amine by the Curtins rearrangement reaction. The compounds of the invention are used as pharmaceuticals.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4148275A GB1473433A (en) | 1975-10-09 | 1975-10-09 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4148275A GB1473433A (en) | 1975-10-09 | 1975-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1473433A true GB1473433A (en) | 1977-05-11 |
Family
ID=10419896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4148275A Expired GB1473433A (en) | 1975-10-09 | 1975-10-09 |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1473433A (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0558258A1 (en) * | 1992-02-24 | 1993-09-01 | E.R. SQUIBB & SONS, INC. | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists |
US5378715A (en) * | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5916907A (en) * | 1997-01-30 | 1999-06-29 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6043265A (en) * | 1997-01-30 | 2000-03-28 | Bristol-Myers Squibb Co. | Isoxazolyl endothelin antagonists |
US6080774A (en) * | 1995-10-11 | 2000-06-27 | Bristol-Myers Squibb Company | Substituted biphenylsulfonamide endothelin antagonists |
US6248767B1 (en) | 1997-04-28 | 2001-06-19 | Texas Biotechnology Corp. | Formulation of sulfonamides for treatment of endothelin-mediated disorders |
US6313308B1 (en) | 1999-03-19 | 2001-11-06 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6432994B1 (en) | 1997-04-28 | 2002-08-13 | Texas Biotechnology Corporation | Sulfonamides for treatment of endothelin-mediated disorders |
US6515136B1 (en) | 1996-02-20 | 2003-02-04 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
-
1975
- 1975-10-09 GB GB4148275A patent/GB1473433A/en not_active Expired
Cited By (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
EP0558258A1 (en) * | 1992-02-24 | 1993-09-01 | E.R. SQUIBB & SONS, INC. | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists |
US5378715A (en) * | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
CN1044235C (en) * | 1992-02-24 | 1999-07-21 | E·R·斯奎布父子公司 | Sulfonamide endothelin antagonists |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US6107320A (en) * | 1992-05-06 | 2000-08-22 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
US6331637B1 (en) | 1993-10-21 | 2001-12-18 | Texas Biotechnology Corporation | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5827869A (en) * | 1994-08-26 | 1998-10-27 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US6080774A (en) * | 1995-10-11 | 2000-06-27 | Bristol-Myers Squibb Company | Substituted biphenylsulfonamide endothelin antagonists |
US6271248B1 (en) | 1995-10-11 | 2001-08-07 | Bristol-Myers Squibb Company | Substituted biphenysulfonamide endothelin antagonists |
US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US6265428B1 (en) | 1996-01-05 | 2001-07-24 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US6515136B1 (en) | 1996-02-20 | 2003-02-04 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6384261B1 (en) | 1996-03-26 | 2002-05-07 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US6632829B2 (en) | 1996-04-04 | 2003-10-14 | Texas Biotechnology Corp. | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US6013655A (en) * | 1996-04-15 | 2000-01-11 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US6329387B2 (en) | 1996-04-15 | 2001-12-11 | Texas Biotechnology Corporation. | Use of thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US6545014B2 (en) | 1996-04-15 | 2003-04-08 | Texas Biotechnology Corporation | Method of treating glaucoma |
US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US6420567B1 (en) | 1996-09-27 | 2002-07-16 | Texas Biotechnology Corporation | N-heteroaryl aryl-substituted thienyl-furyl-and pyrrolyl-sulfonamides and derviatives thereof that modulate the activity of endothelin |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6043265A (en) * | 1997-01-30 | 2000-03-28 | Bristol-Myers Squibb Co. | Isoxazolyl endothelin antagonists |
US5916907A (en) * | 1997-01-30 | 1999-06-29 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
US6248767B1 (en) | 1997-04-28 | 2001-06-19 | Texas Biotechnology Corp. | Formulation of sulfonamides for treatment of endothelin-mediated disorders |
US6432994B1 (en) | 1997-04-28 | 2002-08-13 | Texas Biotechnology Corporation | Sulfonamides for treatment of endothelin-mediated disorders |
US6458805B2 (en) | 1997-04-28 | 2002-10-01 | Texas Biotechnology Corporation | Formulation of sulfonamides for treatment of endothelin-mediated disorders |
US6683103B2 (en) | 1997-04-28 | 2004-01-27 | Texas Biotechnology Corporation | Sulfonamides for treatment of endothelin-mediated disorders |
US6313308B1 (en) | 1999-03-19 | 2001-11-06 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |